{"id":"https://openalex.org/W1991368085","doi":"https://doi.org/10.1097/00005072-198905000-00004","title":"Phenobarbital Lacks Promoting Activity for Neurogenic Tumors in F344 Rats Transplacentally Exposed to Ethylnitrosourea","display_name":"Phenobarbital Lacks Promoting Activity for Neurogenic Tumors in F344 Rats Transplacentally Exposed to Ethylnitrosourea","publication_year":1989,"publication_date":"1989-05-01","ids":{"openalex":"https://openalex.org/W1991368085","doi":"https://doi.org/10.1097/00005072-198905000-00004","mag":"1991368085","pmid":"https://pubmed.ncbi.nlm.nih.gov/2703856"},"language":"en","primary_location":{"id":"doi:10.1097/00005072-198905000-00004","doi":"https://doi.org/10.1097/00005072-198905000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005072-198905000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S38023437","display_name":"Journal of Neuropathology & Experimental Neurology","issn_l":"0022-3069","issn":["0022-3069","1554-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuropathology and Experimental Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039613182","display_name":"Vernon E. Walker","orcid":"https://orcid.org/0000-0003-0299-7177","observed_orcids":["https://orcid.org/0000-0003-0299-7177"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"VERNON E. WALKER","raw_affiliation_strings":["Department of Biochemical Toxicology and Pathobiology, Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709","Department of Biochemical Toxicology and Pathobiology, Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina","Department of Pathology, Duke University Medical Center, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Toxicology and Pathobiology, Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemical Toxicology and Pathobiology, Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology, Duke University Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026876414","display_name":"James A. Swenberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"JAMES A. SWENBERG","raw_affiliation_strings":["Department of Biochemical Toxicology and Pathobiology, Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Toxicology and Pathobiology, Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026876414"],"corresponding_institution_ids":[],"apc_list":{"value":5036,"currency":"USD","value_usd":5036},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.06466081,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":"3","first_page":"263","last_page":"269"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenobarbital","display_name":"phenobarbital","score":1.0},{"id":"https://openalex.org/keywords/ethylnitrosourea","display_name":"ethylnitrosourea","score":0.9259999990463257},{"id":"https://openalex.org/keywords/transplacental-carcinogenesis","display_name":"transplacental carcinogenesis","score":0.8159999847412109},{"id":"https://openalex.org/keywords/neurogenic-tumors","display_name":"neurogenic tumors","score":0.8379999995231628},{"id":"https://openalex.org/keywords/neuroectodermal-tumors","display_name":"neuroectodermal tumors","score":0.9150000214576721},{"id":"https://openalex.org/keywords/tumor-promotion","display_name":"tumor promotion","score":0.7129999995231628},{"id":"https://openalex.org/keywords/fischer-344-rats","display_name":"F344 rats","score":0.8539999723434448},{"id":"https://openalex.org/keywords/prenatal-exposure","display_name":"prenatal exposure","score":0.49799999594688416},{"id":"https://openalex.org/keywords/tumor-latency","display_name":"tumor latency","score":0.5109999775886536},{"id":"https://openalex.org/keywords/tumor-multiplicity","display_name":"tumor multiplicity","score":0.9480000138282776}],"concepts":[{"id":"https://openalex.org/C2909685333","wikidata":"https://www.wikidata.org/wiki/Q287629","display_name":"Ethylnitrosourea","level":4,"score":0.9814449548721313},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.8425634503364563},{"id":"https://openalex.org/C2778793413","wikidata":"https://www.wikidata.org/wiki/Q407241","display_name":"Phenobarbital","level":2,"score":0.7931158542633057},{"id":"https://openalex.org/C2779906218","wikidata":"https://www.wikidata.org/wiki/Q7834818","display_name":"Transplacental","level":5,"score":0.7616559267044067},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.6377108097076416},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5089318752288818},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4388960599899292},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.43387043476104736},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4331223964691162},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.4148257076740265},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41128358244895935},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3826441764831543},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.37515437602996826},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34076642990112305},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10739967226982117},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005038","descriptor_name":"Ethylnitrosourea","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005865","descriptor_name":"Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008431","descriptor_name":"Maternal-Fetal Exchange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009423","descriptor_name":"Nervous System Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D009423","descriptor_name":"Nervous System Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009442","descriptor_name":"Neurilemmoma","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009442","descriptor_name":"Neurilemmoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009837","descriptor_name":"Oligodendroglioma","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009837","descriptor_name":"Oligodendroglioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010634","descriptor_name":"Phenobarbital","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00005072-198905000-00004","doi":"https://doi.org/10.1097/00005072-198905000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005072-198905000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S38023437","display_name":"Journal of Neuropathology & Experimental Neurology","issn_l":"0022-3069","issn":["0022-3069","1554-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuropathology and Experimental Neurology","raw_type":"journal-article"},{"id":"pmid:2703856","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2703856","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuropathology and experimental neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.49000000953674316}],"study_designs":[],"awards":[{"id":"https://openalex.org/G460175554","display_name":null,"funder_award_id":"NS20023","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W158498210","https://openalex.org/W4298336990","https://openalex.org/W2336498112","https://openalex.org/W2466717317","https://openalex.org/W2218924245","https://openalex.org/W2425354977","https://openalex.org/W2073838162","https://openalex.org/W1953791435","https://openalex.org/W1557459081","https://openalex.org/W2320253170"],"abstract_inverted_index":{"A":[0,48],"chronic":[1],"rodent":[2],"study":[3],"in":[4,65,73,90,97,103,116,142,159],"F344":[5,28,160],"rats":[6,29,104,117,162],"was":[7,126],"conducted":[8],"to":[9,79,93,113,165],"investigate":[10],"the":[11,43,98,114],"promoting":[12,154],"ability":[13],"of":[14,24,36,46,50,82,100],"phenobarbital":[15],"(PB)":[16],"on":[17,42],"neurogenic":[18,157],"tumors":[19,86,102,158],"initiated":[20,108,120],"by":[21],"transplacental":[22],"administration":[23],"ethylnitrosourea":[25],"(ENU).":[26],"Pregnant":[27],"were":[30,54,87,106,119],"given":[31,122],"a":[32],"single":[33],"intravenous":[34],"dose":[35],"3.5":[37],"mg":[38],"ENU/kg":[39],"or":[40,145],"vehicle":[41],"twentieth":[44],"day":[45],"gestation.":[47],"total":[49],"192":[51],"male":[52,161],"offspring":[53],"divided":[55],"into":[56],"four":[57,78],"groups:":[58],"ENU-PB,":[59],"ENU-control,":[60],"PB-control,":[61],"and":[62,67,121,135],"control-control.":[63],"Rats":[64],"ENU-PB":[66,136],"PB-control":[68],"groups":[69,138],"received":[70],"0.05%":[71],"PB":[72,123,152],"their":[74],"drinking":[75],"water":[76],"from":[77],"78":[80],"weeks":[81],"age.":[83],"Nervous":[84],"system":[85],"induced":[88],"only":[89,109],"animals":[91],"exposed":[92,164],"ENU.":[94,166],"The":[95],"difference":[96],"incidence":[99,115],"neuroectodermal":[101],"that":[105,118,151],"ENU":[107],"(13/37;":[110],"35%)":[111],"compared":[112],"(13/57;":[124],"23%)":[125],"not":[127],"statistically":[128],"significant":[129],"(p":[130],"greater":[131],"than":[132],"0.05).":[133],"ENU-control":[134],"treatment":[137],"exhibited":[139],"no":[140],"differences":[141],"tumor":[143,146],"multiplicity":[144],"latency.":[147],"These":[148],"results":[149],"demonstrate":[150],"lacks":[153],"activity":[155],"for":[156],"transplacentally":[163]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}