{"id":"https://openalex.org/W1991367061","doi":"https://doi.org/10.1007/s00213-012-2933-4","title":"Pharmacological and behavioral profile of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-6-chinolincarboxamide (EVP-5141), a novel \u03b17 nicotinic acetylcholine receptor agonist/serotonin 5-HT3 receptor antagonist","display_name":"Pharmacological and behavioral profile of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-6-chinolincarboxamide (EVP-5141), a novel \u03b17 nicotinic acetylcholine receptor agonist/serotonin 5-HT3 receptor antagonist","publication_year":2012,"publication_date":"2012-12-15","ids":{"openalex":"https://openalex.org/W1991367061","doi":"https://doi.org/10.1007/s00213-012-2933-4","mag":"1991367061","pmid":"https://pubmed.ncbi.nlm.nih.gov/23241647"},"language":"en","primary_location":{"id":"doi:10.1007/s00213-012-2933-4","doi":"https://doi.org/10.1007/s00213-012-2933-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00213-012-2933-4","pdf_url":null,"source":{"id":"https://openalex.org/S80334769","display_name":"Psychopharmacology","issn_l":"0033-3158","issn":["0033-3158","1432-2072"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028557857","display_name":"Frank Boess","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110958","display_name":"Eli Lilly (Germany)","ror":"https://ror.org/01pmvz131","country_code":"DE","type":"company","lineage":["https://openalex.org/I168537998","https://openalex.org/I4210110958"]},{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Frank G. Boess","raw_affiliation_strings":["Pharma Research CNS, Bayer Healthcare AG, 42096, Wuppertal, Germany. frank.boess@t-online.de","Lilly Deutschland GmbH, Bad Homburg, Germany","Pharma Research CNS, Bayer Healthcare AG, Wuppertal, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharma Research CNS, Bayer Healthcare AG, 42096, Wuppertal, Germany. frank.boess@t-online.de","institution_ids":["https://openalex.org/I67348948"]},{"raw_affiliation_string":"Lilly Deutschland GmbH, Bad Homburg, Germany","institution_ids":["https://openalex.org/I4210110958"]},{"raw_affiliation_string":"Pharma Research CNS, Bayer Healthcare AG, Wuppertal, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066903149","display_name":"Jean De Vry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jean de Vry","raw_affiliation_strings":["Pharma Research CNS, Bayer Healthcare AG, 42096, Wuppertal, Germany","Pharma Research CNS, Bayer Healthcare AG, Wuppertal, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharma Research CNS, Bayer Healthcare AG, 42096, Wuppertal, Germany","institution_ids":["https://openalex.org/I67348948"]},{"raw_affiliation_string":"Pharma Research CNS, Bayer Healthcare AG, Wuppertal, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081197851","display_name":"Christina Erb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107112","display_name":"Biotest (Germany)","ror":"https://ror.org/0100f3q33","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210107112"]},{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christina Erb","raw_affiliation_strings":["Biotest AG, Dreieich, Germany","Pharma Research CNS, Bayer Healthcare AG, 42096, Wuppertal, Germany","Pharma Research CNS, Bayer Healthcare AG, Wuppertal, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotest AG, Dreieich, Germany","institution_ids":["https://openalex.org/I4210107112"]},{"raw_affiliation_string":"Pharma Research CNS, Bayer Healthcare AG, 42096, Wuppertal, Germany","institution_ids":["https://openalex.org/I67348948"]},{"raw_affiliation_string":"Pharma Research CNS, Bayer Healthcare AG, Wuppertal, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044280551","display_name":"Timo Fle\u00dfner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Timo Flessner","raw_affiliation_strings":["Medicinal Chemistry, Bayer Healthcare AG, 42096, Wuppertal, Germany","Medicinal Chemistry, Bayer Healthcare AG, Wuppertal, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry, Bayer Healthcare AG, 42096, Wuppertal, Germany","institution_ids":["https://openalex.org/I67348948"]},{"raw_affiliation_string":"Medicinal Chemistry, Bayer Healthcare AG, Wuppertal, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113616244","display_name":"Martin Hendrix","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Hendrix","raw_affiliation_strings":["Medicinal Chemistry, Bayer Healthcare AG, 42096, Wuppertal, Germany","Medicinal Chemistry, Bayer Healthcare AG, Wuppertal, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry, Bayer Healthcare AG, 42096, Wuppertal, Germany","institution_ids":["https://openalex.org/I67348948"]},{"raw_affiliation_string":"Medicinal Chemistry, Bayer Healthcare AG, Wuppertal, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014504073","display_name":"Joachim E. A. Luithle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joachim Luithle","raw_affiliation_strings":["Medicinal Chemistry, Bayer Healthcare AG, 42096, Wuppertal, Germany","Medicinal Chemistry, Bayer Healthcare AG, Wuppertal, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry, Bayer Healthcare AG, 42096, Wuppertal, Germany","institution_ids":["https://openalex.org/I67348948"]},{"raw_affiliation_string":"Medicinal Chemistry, Bayer Healthcare AG, Wuppertal, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019624032","display_name":"Christoph Methfessel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Methfessel","raw_affiliation_strings":["Bayer Technology Services GmbH Biophysics, Leverkusen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer Technology Services GmbH Biophysics, Leverkusen, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078801509","display_name":"Katrin Schnizler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]},{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katrin Schnizler","raw_affiliation_strings":["Aachen University Clinic, Aachen, Germany","Bayer Technology Services GmbH Biophysics, Leverkusen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aachen University Clinic, Aachen, Germany","institution_ids":["https://openalex.org/I4210120689"]},{"raw_affiliation_string":"Bayer Technology Services GmbH Biophysics, Leverkusen, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022063104","display_name":"F. Josef van der Staay","orcid":"https://orcid.org/0000-0002-8704-3366","observed_orcids":["https://orcid.org/0000-0002-8704-3366"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE","NL"],"is_corresponding":false,"raw_author_name":"F. Josef van der Staay","raw_affiliation_strings":["Emotion and Cognition Group, Department of Farm Animal Health, Veterinary Faculty, Utrecht University, Utrecht, The Netherlands","Pharma Research CNS, Bayer Healthcare AG, 42096, Wuppertal, Germany","Pharma Research CNS, Bayer Healthcare AG, Wuppertal, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emotion and Cognition Group, Department of Farm Animal Health, Veterinary Faculty, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]},{"raw_affiliation_string":"Pharma Research CNS, Bayer Healthcare AG, 42096, Wuppertal, Germany","institution_ids":["https://openalex.org/I67348948"]},{"raw_affiliation_string":"Pharma Research CNS, Bayer Healthcare AG, Wuppertal, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111892964","display_name":"Marja van Kampen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166732","display_name":"UCB Pharma (Germany)","ror":"https://ror.org/05pkeac16","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210166732","https://openalex.org/I85722119"]},{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marja van Kampen","raw_affiliation_strings":["Pharma Research CNS, Bayer Healthcare AG, 42096, Wuppertal, Germany","Pharma Research CNS, Bayer Healthcare AG, Wuppertal, Germany","UCB Biosciences GmbH, Monheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharma Research CNS, Bayer Healthcare AG, 42096, Wuppertal, Germany","institution_ids":["https://openalex.org/I67348948"]},{"raw_affiliation_string":"Pharma Research CNS, Bayer Healthcare AG, Wuppertal, Germany","institution_ids":["https://openalex.org/I67348948"]},{"raw_affiliation_string":"UCB Biosciences GmbH, Monheim, Germany","institution_ids":["https://openalex.org/I4210166732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032605199","display_name":"Welf\u2010Burkhard Wiese","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Welf-Burkhard Wiese","raw_affiliation_strings":["Bayer Central Research, 51373, Leverkusen, Germany","Bayer Central Research, Leverkusen, Germany","Bayer CropScience AG, Monheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer Central Research, 51373, Leverkusen, Germany","institution_ids":["https://openalex.org/I67348948"]},{"raw_affiliation_string":"Bayer Central Research, Leverkusen, Germany","institution_ids":["https://openalex.org/I67348948"]},{"raw_affiliation_string":"Bayer CropScience AG, Monheim, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"Gerhard K\u00f6nig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405270511","display_name":"FORUM Pharmaceuticals (United States)","ror":"https://ror.org/00v0h1b27","country_code":"US","type":"company","lineage":["https://openalex.org/I4405270511"]},{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Gerhard K\u00f6nig","raw_affiliation_strings":["EnVivo Pharmaceuticals, Inc, 500 Arsenal Street, Watertown, MA, 02472, USA","EnVivo Pharmaceuticals, Inc, Watertown, USA","Pharma Research CNS, Bayer Healthcare AG, 42096, Wuppertal, Germany","Pharma Research CNS, Bayer Healthcare AG, Wuppertal, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EnVivo Pharmaceuticals, Inc, 500 Arsenal Street, Watertown, MA, 02472, USA","institution_ids":["https://openalex.org/I4405270511"]},{"raw_affiliation_string":"EnVivo Pharmaceuticals, Inc, Watertown, USA","institution_ids":["https://openalex.org/I4405270511"]},{"raw_affiliation_string":"Pharma Research CNS, Bayer Healthcare AG, 42096, Wuppertal, Germany","institution_ids":["https://openalex.org/I67348948"]},{"raw_affiliation_string":"Pharma Research CNS, Bayer Healthcare AG, Wuppertal, Germany","institution_ids":["https://openalex.org/I67348948"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5028557857"],"corresponding_institution_ids":["https://openalex.org/I4210110958","https://openalex.org/I4405270511","https://openalex.org/I67348948"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.5249,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.58264371,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"227","issue":"1","first_page":"1","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha7-nicotinic-acetylcholine-receptor-agonist","display_name":"\u03b17 nicotinic acetylcholine receptor agonist","score":0.9340000152587891},{"id":"https://openalex.org/keywords/5-ht3-receptor-antagonists","display_name":"5-HT3 receptor antagonists","score":0.9509999752044678},{"id":"https://openalex.org/keywords/cognitive-enhancement","display_name":"cognitive enhancement","score":0.7599999904632568},{"id":"https://openalex.org/keywords/memory-impairment","display_name":"memory impairment","score":0.5540000200271606},{"id":"https://openalex.org/keywords/scopolamine-induced-amnesia","display_name":"scopolamine-induced amnesia","score":0.796999990940094},{"id":"https://openalex.org/keywords/spatial-working-memory","display_name":"spatial working memory","score":0.7200000286102295},{"id":"https://openalex.org/keywords/social-recognition-memory","display_name":"social recognition memory","score":0.8090000152587891},{"id":"https://openalex.org/keywords/object-recognition-memory","display_name":"object recognition memory","score":0.8949999809265137},{"id":"https://openalex.org/keywords/nicotine-discrimination","display_name":"nicotine discrimination","score":0.6240000128746033},{"id":"https://openalex.org/keywords/abuse-potential","display_name":"abuse liability","score":0.7229999899864197},{"id":"https://openalex.org/keywords/age-related-cognitive-decline","display_name":"age-related cognitive decline","score":0.503000020980835},{"id":"https://openalex.org/keywords/receptor-binding-affinity","display_name":"receptor binding affinity","score":0.5199999809265137},{"id":"https://openalex.org/keywords/behavioral-pharmacology","display_name":"behavioral pharmacology","score":0.48899999260902405},{"id":"https://openalex.org/keywords/cholinergic-agents","display_name":"cholinergic drugs","score":0.30399999022483826}],"concepts":[{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.8009465932846069},{"id":"https://openalex.org/C188987157","wikidata":"https://www.wikidata.org/wiki/Q7030581","display_name":"Nicotinic agonist","level":3,"score":0.6725226640701294},{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.5959555506706238},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5765426754951477},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.5568481683731079},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5272917747497559},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4686260521411896},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.4477432668209076},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.44252899289131165},{"id":"https://openalex.org/C80161118","wikidata":"https://www.wikidata.org/wiki/Q408520","display_name":"Acetylcholine receptor","level":3,"score":0.4143407940864563},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2783481478691101},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24896672368049622},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23984506726264954},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18498507142066956}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001362","descriptor_name":"Avoidance Learning","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001362","descriptor_name":"Avoidance Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011812","descriptor_name":"Quinuclidines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011812","descriptor_name":"Quinuclidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011812","descriptor_name":"Quinuclidines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018722","descriptor_name":"Nicotinic Agonists","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018722","descriptor_name":"Nicotinic Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018722","descriptor_name":"Nicotinic Agonists","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058831","descriptor_name":"Serotonin 5-HT3 Receptor Antagonists","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058831","descriptor_name":"Serotonin 5-HT3 Receptor Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D064569","descriptor_name":"alpha7 Nicotinic Acetylcholine Receptor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/s00213-012-2933-4","doi":"https://doi.org/10.1007/s00213-012-2933-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00213-012-2933-4","pdf_url":null,"source":{"id":"https://openalex.org/S80334769","display_name":"Psychopharmacology","issn_l":"0033-3158","issn":["0033-3158","1432-2072"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"journal-article"},{"id":"pmid:23241647","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23241647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:dspace.library.uu.nl:1874/278152","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/278152","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/278152","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/278152","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Psychopharmacology, 227, 1. Springer Verlag","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320303","display_name":"Bayer HealthCare","ror":"https://ror.org/04hmn8g73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W1533914697","https://openalex.org/W1571140265","https://openalex.org/W1919808289","https://openalex.org/W1965827417","https://openalex.org/W1972806087","https://openalex.org/W1972999527","https://openalex.org/W1974896225","https://openalex.org/W1979084018","https://openalex.org/W1981845512","https://openalex.org/W1983992895","https://openalex.org/W1984644694","https://openalex.org/W1989397869","https://openalex.org/W1993325774","https://openalex.org/W1993337719","https://openalex.org/W1995846564","https://openalex.org/W1996157865","https://openalex.org/W1999072075","https://openalex.org/W2004216163","https://openalex.org/W2008761174","https://openalex.org/W2015380548","https://openalex.org/W2016729909","https://openalex.org/W2019564822","https://openalex.org/W2021139758","https://openalex.org/W2025022649","https://openalex.org/W2026198362","https://openalex.org/W2027131229","https://openalex.org/W2036740367","https://openalex.org/W2038995429","https://openalex.org/W2040143361","https://openalex.org/W2053459721","https://openalex.org/W2055391225","https://openalex.org/W2059495695","https://openalex.org/W2067421545","https://openalex.org/W2071608242","https://openalex.org/W2074953815","https://openalex.org/W2076262451","https://openalex.org/W2076338351","https://openalex.org/W2078917784","https://openalex.org/W2085032350","https://openalex.org/W2085263815","https://openalex.org/W2085657703","https://openalex.org/W2087203192","https://openalex.org/W2088828914","https://openalex.org/W2091231277","https://openalex.org/W2093330562","https://openalex.org/W2094880226","https://openalex.org/W2104798506","https://openalex.org/W2113856487","https://openalex.org/W2120349084","https://openalex.org/W2122346217","https://openalex.org/W2123276342","https://openalex.org/W2129048423","https://openalex.org/W2129214572","https://openalex.org/W2135163605","https://openalex.org/W2137371957","https://openalex.org/W2138375529","https://openalex.org/W2140445474","https://openalex.org/W2142431889","https://openalex.org/W2145593805","https://openalex.org/W2156683441","https://openalex.org/W2159483285","https://openalex.org/W2161074753","https://openalex.org/W2162845180","https://openalex.org/W2163114360","https://openalex.org/W2166189575","https://openalex.org/W2169473035","https://openalex.org/W2326121756","https://openalex.org/W2407984403","https://openalex.org/W4406065606","https://openalex.org/W7044562599"],"related_works":["https://openalex.org/W1971998101","https://openalex.org/W2071608242","https://openalex.org/W2150790731","https://openalex.org/W2120349084","https://openalex.org/W1965386908","https://openalex.org/W2161074753","https://openalex.org/W2062607123","https://openalex.org/W2014699148","https://openalex.org/W2041988831","https://openalex.org/W7133583753"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}