{"id":"https://openalex.org/W1991346593","doi":"https://doi.org/10.1523/jneurosci.1487-10.2010","title":"Feeding-Mediated Distention Inhibits Swimming in the Medicinal Leech","display_name":"Feeding-Mediated Distention Inhibits Swimming in the Medicinal Leech","publication_year":2010,"publication_date":"2010-07-21","ids":{"openalex":"https://openalex.org/W1991346593","doi":"https://doi.org/10.1523/jneurosci.1487-10.2010","mag":"1991346593","pmid":"https://pubmed.ncbi.nlm.nih.gov/20660257","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2975557"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.1487-10.2010","doi":"https://doi.org/10.1523/jneurosci.1487-10.2010","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1487-10.2010","pdf_url":"https://www.jneurosci.org/content/jneuro/30/29/9753.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jneurosci.org/content/jneuro/30/29/9753.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057158857","display_name":"Quentin Gaudry","orcid":"https://orcid.org/0000-0002-6869-1253","observed_orcids":["https://orcid.org/0000-0002-6869-1253"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Q. Gaudry","raw_affiliation_strings":["Neurosciences Graduate Program, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093-0357, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurosciences Graduate Program, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093-0357, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081136571","display_name":"William B. Kristan","orcid":"https://orcid.org/0000-0001-7022-1034","observed_orcids":["https://orcid.org/0000-0001-7022-1034"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"W. B. Kristan","raw_affiliation_strings":["Neurobiology Section , Division of Biological Sci- ences , University of California , San Diego , 3119 Pacific Hall , 9500 Gilman Drive , #0357 , La Jolla , CA 92093-0357","Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093-0357"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurobiology Section , Division of Biological Sci- ences , University of California , San Diego , 3119 Pacific Hall , 9500 Gilman Drive , #0357 , La Jolla , CA 92093-0357","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093-0357","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081136571"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":1.1744,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.76432201,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"30","issue":"29","first_page":"9753","last_page":"9761"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13767","display_name":"Leech Biology and Applications","score":0.5038999915122986,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13767","display_name":"Leech Biology and Applications","score":0.5038999915122986,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.4336000084877014,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medicinal-leech","display_name":"Hirudo medicinalis","score":0.9010000228881836},{"id":"https://openalex.org/keywords/feeding-behavior","display_name":"feeding behavior","score":0.5979999899864197},{"id":"https://openalex.org/keywords/swimming-behavior","display_name":"swimming behavior","score":0.699999988079071},{"id":"https://openalex.org/keywords/behavioral-inhibition","display_name":"behavioral inhibition","score":0.5879999995231628},{"id":"https://openalex.org/keywords/presynaptic-inhibition","display_name":"presynaptic inhibition","score":0.6940000057220459},{"id":"https://openalex.org/keywords/mechanosensory-neurons","display_name":"mechanosensory neurons","score":0.9959999918937683},{"id":"https://openalex.org/keywords/central-pattern-generation","display_name":"central pattern generation","score":0.5849999785423279},{"id":"https://openalex.org/keywords/interneurons","display_name":"interneurons","score":0.8880000114440918},{"id":"https://openalex.org/keywords/behavior-selection","display_name":"behavior selection","score":0.35199999809265137},{"id":"https://openalex.org/keywords/electrical-stimulation","display_name":"electrical stimulation","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C180746962","wikidata":"https://www.wikidata.org/wiki/Q243147","display_name":"Leech","level":2,"score":0.873361349105835},{"id":"https://openalex.org/C2779918689","wikidata":"https://www.wikidata.org/wiki/Q3771842","display_name":"Stimulus (psychology)","level":2,"score":0.7192544341087341},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6588109731674194},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5708991289138794},{"id":"https://openalex.org/C3017650416","wikidata":"https://www.wikidata.org/wiki/Q3281331","display_name":"Feeding behavior","level":2,"score":0.5288903117179871},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.48288798332214355},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.47512656450271606},{"id":"https://openalex.org/C194544171","wikidata":"https://www.wikidata.org/wiki/Q21105679","display_name":"Gating","level":2,"score":0.44410067796707153},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4274226427078247},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.36805805563926697},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28560853004455566},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23396626114845276},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19747424125671387},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008465","descriptor_name":"Mechanoreceptors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013550","descriptor_name":"Swimming","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D047709","descriptor_name":"Hirudo medicinalis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1523/jneurosci.1487-10.2010","doi":"https://doi.org/10.1523/jneurosci.1487-10.2010","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1487-10.2010","pdf_url":"https://www.jneurosci.org/content/jneuro/30/29/9753.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2975557","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2975557","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:20660257","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20660257","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.1487-10.2010","doi":"https://doi.org/10.1523/jneurosci.1487-10.2010","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1487-10.2010","pdf_url":"https://www.jneurosci.org/content/jneuro/30/29/9753.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2501225754","display_name":"Development of Neuronal Circuits for Simple Behaviors","funder_award_id":"R01NS035336","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G390637897","display_name":null,"funder_award_id":"MH43396","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G783861534","display_name":null,"funder_award_id":"NS-35336","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8677642464","display_name":"Neuronal Control of Interactions Among Behaviors","funder_award_id":"R01MH043396","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1991346593.pdf","grobid_xml":"https://content.openalex.org/works/W1991346593.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W15136423","https://openalex.org/W1561619916","https://openalex.org/W1822334633","https://openalex.org/W1872585649","https://openalex.org/W1907121963","https://openalex.org/W1926035353","https://openalex.org/W1963606225","https://openalex.org/W1964961332","https://openalex.org/W1995878193","https://openalex.org/W1999546558","https://openalex.org/W2001552070","https://openalex.org/W2010227730","https://openalex.org/W2012308744","https://openalex.org/W2025102634","https://openalex.org/W2026001275","https://openalex.org/W2032931981","https://openalex.org/W2035030547","https://openalex.org/W2040955687","https://openalex.org/W2041195248","https://openalex.org/W2054316680","https://openalex.org/W2066031068","https://openalex.org/W2081599487","https://openalex.org/W2087251764","https://openalex.org/W2097778162","https://openalex.org/W2101475461","https://openalex.org/W2101620490","https://openalex.org/W2102990987","https://openalex.org/W2107886772","https://openalex.org/W2109059823","https://openalex.org/W2109902192","https://openalex.org/W2119376812","https://openalex.org/W2125692118","https://openalex.org/W2126449078","https://openalex.org/W2131045394","https://openalex.org/W2140644628","https://openalex.org/W2146179262","https://openalex.org/W2166015447","https://openalex.org/W2168091103","https://openalex.org/W2182347666","https://openalex.org/W2244530247","https://openalex.org/W2315950609","https://openalex.org/W2789500754","https://openalex.org/W2912823861","https://openalex.org/W3000127326","https://openalex.org/W3148499377"],"related_works":["https://openalex.org/W163008053","https://openalex.org/W2032931981","https://openalex.org/W2146179262","https://openalex.org/W28842204","https://openalex.org/W2156972426","https://openalex.org/W2182347666","https://openalex.org/W1910056250","https://openalex.org/W1983853047","https://openalex.org/W2101475461","https://openalex.org/W1995878193"],"abstract_inverted_index":{"An":[0],"animal's":[1,160],"response":[2],"to":[3,155,179],"a":[4,26,44,72,118,182],"stimulus":[5],"depends":[6],"on":[7,174],"many":[8],"factors":[9],"such":[10],"as":[11,43],"age,":[12],"hormonal":[13],"state,":[14],"experience,":[15],"and":[16,63,106,115],"its":[17,34,54,101],"behavioral":[18],"state.":[19,36],"For":[20],"example,":[21],"an":[22],"animal":[23],"may":[24],"suppress":[25],"behavior":[27,185],"that":[28,50,85,144,171,181],"is":[29,186],"inappropriate":[30],"or":[31],"incompatible":[32],"with":[33,164],"current":[35],"In":[37],"this":[38],"study,":[39],"we":[40,142],"show":[41,170],"that,":[42],"medicinal":[45],"leech":[46],"feeds,":[47],"the":[48,60,65,86,130,137,145,148,159],"distention":[49],"it":[51],"incurs":[52],"inhibits":[53,91],"expression":[55],"of":[56,67,89,96,139,151],"swimming.":[57],"Distention":[58,99],"slows":[59],"swimming":[61,79,152],"pattern":[62,108],"decreases":[64],"number":[66],"swim":[68],"cycles":[69],"elicited":[70],"by":[71,93,189],"test":[73],"electrical":[74],"stimulation;":[75],"large":[76],"distentions":[77],"inhibit":[78],"altogether.":[80],"We":[81],"have":[82],"previously":[83],"shown":[84],"ingestive":[87],"phase":[88],"feeding":[90],"behaviors":[92,125],"presynaptic":[94],"inhibition":[95],"mechanosensory":[97],"neurons.":[98],"has":[100],"effects":[102,138],"downstream":[103],"(e.g.,":[104],"gating":[105],"central":[107],"generating":[109],"interneurons)":[110],"from":[111],"these":[112,167],"sensory":[113],"neurons":[114],"thus":[116],"represents":[117],"novel":[119],"mechanism":[120],"for":[121],"choosing":[122],"between":[123],"conflicting":[124],"during":[126],"feeding.":[127],"Because":[128],"removing":[129],"leech's":[131],"gut":[132],"surgically":[133],"did":[134],"not":[135,187],"eliminate":[136],"body":[140,161],"distention,":[141],"conclude":[143],"receptors":[146],"mediating":[147],"distention-induced":[149],"suppression":[150],"are":[153],"likely":[154],"be":[156],"located":[157],"in":[158],"wall.":[162],"Together":[163],"previous":[165],"findings,":[166],"new":[168],"data":[169],"leeches":[172],"rely":[173],"two":[175],"different":[176],"decision-making":[177],"networks":[178],"ensure":[180],"biologically":[183],"important":[184],"disrupted":[188],"other":[190],"behaviors.":[191]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}