{"id":"https://openalex.org/W1991247522","doi":"https://doi.org/10.1161/01.cir.0000130643.41587.db","title":"In Vivo Evidence of Angiogenesis Induced by Transcription Factor Ets-1: Ets-1 Is Located Upstream of Angiogenesis Cascade","display_name":"In Vivo Evidence of Angiogenesis Induced by Transcription Factor Ets-1: Ets-1 Is Located Upstream of Angiogenesis Cascade","publication_year":2004,"publication_date":"2004-06-08","ids":{"openalex":"https://openalex.org/W1991247522","doi":"https://doi.org/10.1161/01.cir.0000130643.41587.db","mag":"1991247522","pmid":"https://pubmed.ncbi.nlm.nih.gov/15173033"},"language":"en","primary_location":{"id":"doi:10.1161/01.cir.0000130643.41587.db","doi":"https://doi.org/10.1161/01.cir.0000130643.41587.db","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.0000130643.41587.db","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031729065","display_name":"Naotaka Hashiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]},{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naotaka Hashiya","raw_affiliation_strings":["From the Division of Clinical Gene Therapy (R.M.), Department of Geriatric Medicine (N.H., M.A., T.O.), Division of Gene Therapy Science (Y.K.), and Division of Biochemistry (K.M., T.N.), Graduate School of Medicine, Osaka University, Osaka; the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai; and the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Clinical Gene Therapy (R.M.), Department of Geriatric Medicine (N.H., M.A., T.O.), Division of Gene Therapy Science (Y.K.), and Division of Biochemistry (K.M., T.N.), Graduate School of Medicine, Osaka University, Osaka; the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai; and the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I98285908"]},{"raw_affiliation_string":"the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110210144","display_name":"Nobuo Jo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]},{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuo Jo","raw_affiliation_strings":["From the Division of Clinical Gene Therapy (R.M.), Department of Geriatric Medicine (N.H., M.A., T.O.), Division of Gene Therapy Science (Y.K.), and Division of Biochemistry (K.M., T.N.), Graduate School of Medicine, Osaka University, Osaka; the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai; and the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Clinical Gene Therapy (R.M.), Department of Geriatric Medicine (N.H., M.A., T.O.), Division of Gene Therapy Science (Y.K.), and Division of Biochemistry (K.M., T.N.), Graduate School of Medicine, Osaka University, Osaka; the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai; and the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I98285908"]},{"raw_affiliation_string":"the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037807663","display_name":"Motokuni Aoki","orcid":"https://orcid.org/0000-0002-3912-3222","observed_orcids":["https://orcid.org/0000-0002-3912-3222"]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]},{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Motokuni Aoki","raw_affiliation_strings":["From the Division of Clinical Gene Therapy (R.M.), Department of Geriatric Medicine (N.H., M.A., T.O.), Division of Gene Therapy Science (Y.K.), and Division of Biochemistry (K.M., T.N.), Graduate School of Medicine, Osaka University, Osaka; the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai; and the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Clinical Gene Therapy (R.M.), Department of Geriatric Medicine (N.H., M.A., T.O.), Division of Gene Therapy Science (Y.K.), and Division of Biochemistry (K.M., T.N.), Graduate School of Medicine, Osaka University, Osaka; the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai; and the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I98285908"]},{"raw_affiliation_string":"the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016499405","display_name":"Kunio Matsumoto","orcid":"https://orcid.org/0000-0002-6532-4482","observed_orcids":["https://orcid.org/0000-0002-6532-4482"]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]},{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kunio Matsumoto","raw_affiliation_strings":["From the Division of Clinical Gene Therapy (R.M.), Department of Geriatric Medicine (N.H., M.A., T.O.), Division of Gene Therapy Science (Y.K.), and Division of Biochemistry (K.M., T.N.), Graduate School of Medicine, Osaka University, Osaka; the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai; and the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Clinical Gene Therapy (R.M.), Department of Geriatric Medicine (N.H., M.A., T.O.), Division of Gene Therapy Science (Y.K.), and Division of Biochemistry (K.M., T.N.), Graduate School of Medicine, Osaka University, Osaka; the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai; and the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I98285908"]},{"raw_affiliation_string":"the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080102542","display_name":"Toshikazu Nakamura","orcid":"https://orcid.org/0000-0001-8672-0946","observed_orcids":["https://orcid.org/0000-0001-8672-0946"]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]},{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshikazu Nakamura","raw_affiliation_strings":["From the Division of Clinical Gene Therapy (R.M.), Department of Geriatric Medicine (N.H., M.A., T.O.), Division of Gene Therapy Science (Y.K.), and Division of Biochemistry (K.M., T.N.), Graduate School of Medicine, Osaka University, Osaka; the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai; and the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Clinical Gene Therapy (R.M.), Department of Geriatric Medicine (N.H., M.A., T.O.), Division of Gene Therapy Science (Y.K.), and Division of Biochemistry (K.M., T.N.), Graduate School of Medicine, Osaka University, Osaka; the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai; and the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I98285908"]},{"raw_affiliation_string":"the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050198503","display_name":"Yasufumi Sato","orcid":"https://orcid.org/0000-0002-6761-7553","observed_orcids":["https://orcid.org/0000-0002-6761-7553"]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]},{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasufumi Sato","raw_affiliation_strings":["From the Division of Clinical Gene Therapy (R.M.), Department of Geriatric Medicine (N.H., M.A., T.O.), Division of Gene Therapy Science (Y.K.), and Division of Biochemistry (K.M., T.N.), Graduate School of Medicine, Osaka University, Osaka; the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai; and the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Clinical Gene Therapy (R.M.), Department of Geriatric Medicine (N.H., M.A., T.O.), Division of Gene Therapy Science (Y.K.), and Division of Biochemistry (K.M., T.N.), Graduate School of Medicine, Osaka University, Osaka; the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai; and the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I98285908"]},{"raw_affiliation_string":"the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015429873","display_name":"Nahoko Ogata","orcid":"https://orcid.org/0000-0002-4157-2203","observed_orcids":["https://orcid.org/0000-0002-4157-2203"]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]},{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nahoko Ogata","raw_affiliation_strings":["From the Division of Clinical Gene Therapy (R.M.), Department of Geriatric Medicine (N.H., M.A., T.O.), Division of Gene Therapy Science (Y.K.), and Division of Biochemistry (K.M., T.N.), Graduate School of Medicine, Osaka University, Osaka; the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai; and the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Clinical Gene Therapy (R.M.), Department of Geriatric Medicine (N.H., M.A., T.O.), Division of Gene Therapy Science (Y.K.), and Division of Biochemistry (K.M., T.N.), Graduate School of Medicine, Osaka University, Osaka; the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai; and the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I98285908"]},{"raw_affiliation_string":"the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078822609","display_name":"Toshio Ogihara","orcid":"https://orcid.org/0000-0002-7119-7192","observed_orcids":["https://orcid.org/0000-0002-7119-7192"]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]},{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshio Ogihara","raw_affiliation_strings":["From the Division of Clinical Gene Therapy (R.M.), Department of Geriatric Medicine (N.H., M.A., T.O.), Division of Gene Therapy Science (Y.K.), and Division of Biochemistry (K.M., T.N.), Graduate School of Medicine, Osaka University, Osaka; the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai; and the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Clinical Gene Therapy (R.M.), Department of Geriatric Medicine (N.H., M.A., T.O.), Division of Gene Therapy Science (Y.K.), and Division of Biochemistry (K.M., T.N.), Graduate School of Medicine, Osaka University, Osaka; the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai; and the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I98285908"]},{"raw_affiliation_string":"the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102026777","display_name":"Yasufumi Kaneda","orcid":"https://orcid.org/0009-0009-6106-5434","observed_orcids":["https://orcid.org/0009-0009-6106-5434"]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]},{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasufumi Kaneda","raw_affiliation_strings":["From the Division of Clinical Gene Therapy (R.M.), Department of Geriatric Medicine (N.H., M.A., T.O.), Division of Gene Therapy Science (Y.K.), and Division of Biochemistry (K.M., T.N.), Graduate School of Medicine, Osaka University, Osaka; the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai; and the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Clinical Gene Therapy (R.M.), Department of Geriatric Medicine (N.H., M.A., T.O.), Division of Gene Therapy Science (Y.K.), and Division of Biochemistry (K.M., T.N.), Graduate School of Medicine, Osaka University, Osaka; the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai; and the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I98285908"]},{"raw_affiliation_string":"the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025005882","display_name":"Ryuichi Morishita","orcid":"https://orcid.org/0000-0002-8855-0730","observed_orcids":["https://orcid.org/0000-0002-8855-0730"]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]},{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryuichi Morishita","raw_affiliation_strings":["From the Division of Clinical Gene Therapy (R.M.), Department of Geriatric Medicine (N.H., M.A., T.O.), Division of Gene Therapy Science (Y.K.), and Division of Biochemistry (K.M., T.N.), Graduate School of Medicine, Osaka University, Osaka; the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai; and the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Clinical Gene Therapy (R.M.), Department of Geriatric Medicine (N.H., M.A., T.O.), Division of Gene Therapy Science (Y.K.), and Division of Biochemistry (K.M., T.N.), Graduate School of Medicine, Osaka University, Osaka; the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai; and the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I98285908"]},{"raw_affiliation_string":"the Department of Oncology, Graduate School of Medicine, Tohoku University (Y.S.), Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"the Department of Ophthalmology, Kansai Medical College (N.J., N.O.), Kansai","institution_ids":["https://openalex.org/I126884977"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5375,"has_fulltext":true,"cited_by_count":118,"citation_normalized_percentile":{"value":0.89788775,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"109","issue":"24","first_page":"3035","last_page":"3041"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ets-1-transcription-factor","display_name":"Ets-1 transcription factor","score":0.8349999785423279},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.996999979019165},{"id":"https://openalex.org/keywords/hindlimb-ischemia","display_name":"hindlimb ischemia","score":0.9750000238418579},{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.9789999723434448},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9940000176429749},{"id":"https://openalex.org/keywords/gene-overexpression","display_name":"gene overexpression","score":0.7710000276565552},{"id":"https://openalex.org/keywords/liposome-transfection","display_name":"liposome transfection","score":0.5649999976158142},{"id":"https://openalex.org/keywords/peripheral-arterial-disease","display_name":"peripheral arterial disease","score":0.7950000166893005},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.7670000195503235},{"id":"https://openalex.org/keywords/capillary-density","display_name":"capillary density","score":0.6230000257492065},{"id":"https://openalex.org/keywords/blood-flow","display_name":"blood flow","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8703649044036865},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7639673948287964},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6676950454711914},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.641282856464386},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43523308634757996},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4027770161628723},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21214479207992554},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11195418238639832},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07648500800132751}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006614","descriptor_name":"Hindlimb","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017078","descriptor_name":"Laser-Doppler Flowmetry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050783","descriptor_name":"Proto-Oncogene Proteins c-ets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050784","descriptor_name":"Proto-Oncogene Protein c-ets-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1161/01.cir.0000130643.41587.db","doi":"https://doi.org/10.1161/01.cir.0000130643.41587.db","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.0000130643.41587.db","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:15173033","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15173033","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.988.3206","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.988.3206","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://circ.ahajournals.org/content/circulationaha/109/24/3035.full.pdf","raw_type":"text"},{"id":"mag:2344071396","doi":null,"is_oa":false,"landing_page_url":"https://ir.library.osaka-u.ac.jp/repo/ouka/all/45506/18974_%E8%A6%81%E6%97%A8.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W183076699","https://openalex.org/W1495741757","https://openalex.org/W1515566386","https://openalex.org/W1568477382","https://openalex.org/W1967662297","https://openalex.org/W1969191130","https://openalex.org/W1978116541","https://openalex.org/W2004292941","https://openalex.org/W2015789556","https://openalex.org/W2025311714","https://openalex.org/W2034633555","https://openalex.org/W2041643473","https://openalex.org/W2045893838","https://openalex.org/W2048771206","https://openalex.org/W2061149882","https://openalex.org/W2067249488","https://openalex.org/W2068112302","https://openalex.org/W2075323420","https://openalex.org/W2077203655","https://openalex.org/W2082985735","https://openalex.org/W2083180771","https://openalex.org/W2087427182","https://openalex.org/W2106776747","https://openalex.org/W2120477615","https://openalex.org/W2120789358","https://openalex.org/W2124337564","https://openalex.org/W2140562414","https://openalex.org/W2142801965","https://openalex.org/W2143499157","https://openalex.org/W2328164564","https://openalex.org/W2401514312","https://openalex.org/W2404727911","https://openalex.org/W2418204059","https://openalex.org/W2444477924","https://openalex.org/W2466822087","https://openalex.org/W2468528850","https://openalex.org/W4249388929"],"related_works":["https://openalex.org/W7098982211","https://openalex.org/W1981550662","https://openalex.org/W2120789358","https://openalex.org/W2415663988","https://openalex.org/W4256292276","https://openalex.org/W2062930884","https://openalex.org/W2087427182","https://openalex.org/W125901892","https://openalex.org/W2082985735","https://openalex.org/W7099637270"],"abstract_inverted_index":{"BACKGROUND:":[0],"A":[1],"transcription":[2,7],"factor,":[3],"ets-1,":[4],"regulates":[5],"the":[6,11,21,44,49,74,85,94,108,122,131,143,161,196,237],"of":[8,13,23,46,48,145,164,173,188,208,239,247],"metalloproteinase":[9],"genes,":[10],"activity":[12],"which":[14,77,135],"is":[15,78],"necessary":[16],"for":[17,81],"matrix":[18],"degradation":[19],"and":[20,60,97,150,179,193,201,210,244],"migration":[22],"endothelial":[24,152],"cells.":[25,226],"However,":[26],"no":[27],"study":[28,230],"has":[29,34,121],"demonstrated":[30,118,231],"that":[31,119,232],"ets-1":[32,50,63,87,110,120,136,174,213,233],"itself":[33],"an":[35],"angiogenic":[36,157,240],"action":[37],"in":[38,54,103,127,182,198,218],"vivo.":[39,128],"Thus,":[40],"we":[41,72,139],"examined":[42],"(1)":[43],"effects":[45],"overexpression":[47,172],"gene":[51,111],"on":[52,142],"angiogenesis":[53,126,235],"a":[55,104,251],"rat":[56,183],"hindlimb":[57,105],"ischemia":[58],"model,":[59],"(2)":[61],"how":[62],"induced":[64,137,204],"angiogenesis.":[65],"METHODS":[66],"AND":[67],"RESULTS:":[68],"In":[69],"this":[70],"study,":[71],"used":[73],"HVJ-liposome":[75],"method,":[76],"highly":[79],"effective":[80],"transfection,":[82,93],"to":[83,124,255],"transfect":[84],"human":[86,109,222],"gene.":[88],"At":[89],"4":[90],"weeks":[91],"after":[92],"capillary":[95],"density":[96],"blood":[98,199],"flow":[99,200],"were":[100],"significantly":[101],"increased":[102],"transfected":[106],"with":[107,113],"compared":[112],"control.":[114],"These":[115],"data":[116],"clearly":[117],"ability":[123],"stimulate":[125],"To":[129],"elucidate":[130],"molecular":[132],"mechanisms":[133],"by":[134,205,212,217],"angiogenesis,":[138],"focused":[140],"especially":[141],"expression":[144],"hepatocyte":[146],"growth":[147,153,158,241],"factor":[148,154],"(HGF)":[149],"vascular":[151,223],"(VEGF),":[155],"potent":[156],"factors,":[159],"because":[160],"promoter":[162],"regions":[163],"both":[165,176],"genes":[166],"contain":[167],"ets":[168,248],"binding":[169],"sites.":[170],"Interestingly,":[171],"upregulated":[175],"tissue":[177],"HGF":[178,192,209],"VEGF":[180,194,211],"concentrations":[181],"hindlimb.":[184],"More":[185],"importantly,":[186],"administration":[187],"neutralizing":[189],"antibody":[190],"against":[191],"attenuated":[195],"increase":[197],"BrdU-positive":[202],"cells":[203],"ets-1.":[206],"Upregulation":[207],"was":[214],"also":[215],"confirmed":[216],"vitro":[219],"experiments":[220],"using":[221],"smooth":[224],"muscle":[225],"CONCLUSIONS:":[227],"The":[228],"present":[229],"regulated":[234],"through":[236],"induction":[238],"factors":[242],"(VEGF":[243],"HGF).":[245],"Overexpression":[246],"may":[249],"provide":[250],"new":[252],"therapeutic":[253],"strategy":[254],"treat":[256],"peripheral":[257],"arterial":[258],"disease.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}