{"id":"https://openalex.org/W1991242670","doi":"https://doi.org/10.1046/j.1474-9728.2002.00001.x","title":"Ironing out Parkinson's disease: is therapeutic treatment with iron chelators a real possibility?","display_name":"Ironing out Parkinson's disease: is therapeutic treatment with iron chelators a real possibility?","publication_year":2002,"publication_date":"2002-09-15","ids":{"openalex":"https://openalex.org/W1991242670","doi":"https://doi.org/10.1046/j.1474-9728.2002.00001.x","mag":"1991242670","pmid":"https://pubmed.ncbi.nlm.nih.gov/12882349"},"language":"en","primary_location":{"id":"doi:10.1046/j.1474-9728.2002.00001.x","doi":"https://doi.org/10.1046/j.1474-9728.2002.00001.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1474-9728.2002.00001.x","pdf_url":null,"source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112266680","display_name":"Deepinder Kaur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepinder Kaur","raw_affiliation_strings":["Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA","institution_ids":["https://openalex.org/I1337826666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085303733","display_name":"Julie Kay Andersen","orcid":"https://orcid.org/0000-0003-1324-4875","observed_orcids":["https://orcid.org/0000-0003-1324-4875"]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Julie K. Andersen","raw_affiliation_strings":["Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA","institution_ids":["https://openalex.org/I1337826666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085303733"],"corresponding_institution_ids":["https://openalex.org/I1337826666"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":2.1712,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.86076596,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"1","issue":"1","first_page":"17","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/iron-chelators","display_name":"iron chelators","score":0.8270000219345093},{"id":"https://openalex.org/keywords/brain-iron-accumulation","display_name":"brain iron accumulation","score":0.7070000171661377},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.968999981880188},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/lewy-bodies","display_name":"Lewy bodies","score":0.9660000205039978},{"id":"https://openalex.org/keywords/iron-chelation-therapy","display_name":"iron chelation therapy","score":0.6769999861717224},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7804630398750305},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.7455208897590637},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.7418150305747986},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.6171393394470215},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.582050085067749},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37053990364074707},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34030210971832275},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23154160380363464},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2262653112411499},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22152873873710632}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004660","descriptor_name":"Encephalitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004660","descriptor_name":"Encephalitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004660","descriptor_name":"Encephalitis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007502","descriptor_name":"Iron Chelating Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007502","descriptor_name":"Iron Chelating Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015913","descriptor_name":"Chelation Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015913","descriptor_name":"Chelation Therapy","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D016631","descriptor_name":"Lewy Bodies","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016631","descriptor_name":"Lewy Bodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1474-9728.2002.00001.x","doi":"https://doi.org/10.1046/j.1474-9728.2002.00001.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1474-9728.2002.00001.x","pdf_url":null,"source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},{"id":"pmid:12882349","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12882349","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging cell","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1517096773","https://openalex.org/W1530657831","https://openalex.org/W1589564633","https://openalex.org/W1972319230","https://openalex.org/W1980857402","https://openalex.org/W1989403800","https://openalex.org/W1992743303","https://openalex.org/W2003579541","https://openalex.org/W2029443966","https://openalex.org/W2030644405","https://openalex.org/W2035386076","https://openalex.org/W2047856805","https://openalex.org/W2048041654","https://openalex.org/W2051516838","https://openalex.org/W2061618733","https://openalex.org/W2064779214","https://openalex.org/W2076508298","https://openalex.org/W2078376971","https://openalex.org/W2082860227","https://openalex.org/W2085601370","https://openalex.org/W2086857730","https://openalex.org/W2088248525","https://openalex.org/W2093131325","https://openalex.org/W2098895051","https://openalex.org/W2156118851","https://openalex.org/W2161919155","https://openalex.org/W2191787796","https://openalex.org/W2204855847","https://openalex.org/W4295689620"],"related_works":["https://openalex.org/W2163156492","https://openalex.org/W3149488607","https://openalex.org/W4311027541","https://openalex.org/W95833100","https://openalex.org/W2315662623","https://openalex.org/W2044872068","https://openalex.org/W2004628001","https://openalex.org/W2352961397","https://openalex.org/W2913399989","https://openalex.org/W3005461550"],"abstract_inverted_index":{"Levels":[0],"of":[1,8,25,33,37,42,54],"iron":[2,55],"are":[3],"increased":[4],"in":[5,56],"the":[6,26,51,67],"brains":[7],"Parkinson's":[9],"disease":[10,27],"(PD)":[11],"patients":[12],"compared":[13],"to":[14,21,23],"age-matched":[15],"controls.":[16],"This":[17],"has":[18],"been":[19],"postulated":[20],"contribute":[22],"progression":[24],"via":[28],"several":[29],"mechanisms":[30],"including":[31],"exacerbation":[32],"oxidative":[34],"stress,":[35],"initiation":[36],"inflammatory":[38],"responses":[39],"and":[40,58],"triggering":[41],"Lewy":[43],"body":[44],"formation.":[45],"In":[46],"this":[47],"minireview,":[48],"we":[49],"examine":[50],"putative":[52],"role":[53],"PD":[57],"its":[59],"pharmacological":[60],"chelation":[61],"as":[62],"a":[63],"prospective":[64],"therapeutic":[65],"for":[66],"disease.":[68]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}