{"id":"https://openalex.org/W1991239481","doi":"https://doi.org/10.1179/016164105x25171","title":"Mathematical model of the rupture mechanism of intracranial saccular aneurysms through daughter aneurysm formation and growth","display_name":"Mathematical model of the rupture mechanism of intracranial saccular aneurysms through daughter aneurysm formation and growth","publication_year":2005,"publication_date":"2005-06-20","ids":{"openalex":"https://openalex.org/W1991239481","doi":"https://doi.org/10.1179/016164105x25171","mag":"1991239481","pmid":"https://pubmed.ncbi.nlm.nih.gov/15978170"},"language":"en","primary_location":{"id":"doi:10.1179/016164105x25171","doi":"https://doi.org/10.1179/016164105x25171","is_oa":false,"landing_page_url":"https://doi.org/10.1179/016164105x25171","pdf_url":null,"source":{"id":"https://openalex.org/S187584928","display_name":"Neurological Research","issn_l":"0161-6412","issn":["0161-6412","1743-1328"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurological Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100695234","display_name":"Hui Meng","orcid":"https://orcid.org/0000-0003-3884-499X","observed_orcids":["https://orcid.org/0000-0003-3884-499X"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui Meng","raw_affiliation_strings":["Mechanical and Aerospace Engineering, State University of New York at Buffalo, Buffalo, NY 14260-4400, USA. menghui@buffalo.edu","Mechanical and Aerospace EngineeringState University of New York at Buffalo, Buffalo, NY 142604400, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mechanical and Aerospace Engineering, State University of New York at Buffalo, Buffalo, NY 14260-4400, USA. menghui@buffalo.edu","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Mechanical and Aerospace EngineeringState University of New York at Buffalo, Buffalo, NY 142604400, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110232008","display_name":"Yixiang Feng","orcid":"https://orcid.org/0009-0004-3833-8995","observed_orcids":["https://orcid.org/0009-0004-3833-8995"]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yixiang Feng","raw_affiliation_strings":["Yamaguchi and Wada LaboratoryDepartment of Bioengineering and Robotics, Graduate School of Engineering, Aoba-ku, Sendai 980-8579, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yamaguchi and Wada LaboratoryDepartment of Bioengineering and Robotics, Graduate School of Engineering, Aoba-ku, Sendai 980-8579, Japan","institution_ids":["https://openalex.org/I173915773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111550661","display_name":"Scott H. Woodward","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott H. Woodward","raw_affiliation_strings":["Mechanical and Aerospace EngineeringState University of New York at Buffalo, Buffalo, NY 142604400, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mechanical and Aerospace EngineeringState University of New York at Buffalo, Buffalo, NY 142604400, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018865729","display_name":"Bernard R. Bendok","orcid":"https://orcid.org/0000-0002-3506-3074","observed_orcids":["https://orcid.org/0000-0002-3506-3074"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bernard R. Bendok","raw_affiliation_strings":["Neurological Surgery and RadiologyFeinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurological Surgery and RadiologyFeinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014450486","display_name":"Ricard\u00f3 A. Hanel","orcid":"https://orcid.org/0000-0001-7195-5806","observed_orcids":["https://orcid.org/0000-0001-7195-5806"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ricardo A. Hanel","raw_affiliation_strings":["University at Buffalo, Neurosurgery, Buffalo, NY 14209-1194, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University at Buffalo, Neurosurgery, Buffalo, NY 14209-1194, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029371485","display_name":"Lee R. Guterman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lee R. Guterman","raw_affiliation_strings":["University at Buffalo, Neurosurgery, Buffalo, NY 14209-1194, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University at Buffalo, Neurosurgery, Buffalo, NY 14209-1194, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048566091","display_name":"Leo Nelson Hopkins","orcid":"https://orcid.org/0000-0003-0339-3818","observed_orcids":["https://orcid.org/0000-0003-0339-3818"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Nelson Hopkins","raw_affiliation_strings":["University at Buffalo, Neurosurgery, Buffalo, NY 14209-1194, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University at Buffalo, Neurosurgery, Buffalo, NY 14209-1194, USA","institution_ids":["https://openalex.org/I63190737"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3765,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.87385087,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"27","issue":"5","first_page":"459","last_page":"465"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intracranial-aneurysm-rupture","display_name":"intracranial aneurysm rupture","score":0.8489999771118164},{"id":"https://openalex.org/keywords/saccular-aneurysm","display_name":"saccular aneurysm","score":0.8930000066757202},{"id":"https://openalex.org/keywords/aneurysm-growth","display_name":"aneurysm growth","score":0.8460000157356262},{"id":"https://openalex.org/keywords/aspect-ratio","display_name":"aspect ratio","score":0.9879999756813049},{"id":"https://openalex.org/keywords/aneurysm-geometry","display_name":"aneurysm geometry","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C2776098176","wikidata":"https://www.wikidata.org/wiki/Q189389","display_name":"Aneurysm","level":2,"score":0.8530758619308472},{"id":"https://openalex.org/C2779033419","wikidata":"https://www.wikidata.org/wiki/Q308194","display_name":"Daughter","level":2,"score":0.4155259132385254},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.35413026809692383},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.3462284803390503},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2802090048789978},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.23842549324035645},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.20100808143615723},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09955719113349915},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002532","descriptor_name":"Intracranial Aneurysm","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013718","descriptor_name":"Tensile Strength","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017542","descriptor_name":"Aneurysm, Ruptured","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1179/016164105x25171","doi":"https://doi.org/10.1179/016164105x25171","is_oa":false,"landing_page_url":"https://doi.org/10.1179/016164105x25171","pdf_url":null,"source":{"id":"https://openalex.org/S187584928","display_name":"Neurological Research","issn_l":"0161-6412","issn":["0161-6412","1743-1328"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurological Research","raw_type":"journal-article"},{"id":"pmid:15978170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15978170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurological research","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/16","display_name":"Peace, justice, and strong institutions","score":0.49000000953674316}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W159147631","https://openalex.org/W632722678","https://openalex.org/W658455671","https://openalex.org/W1517079913","https://openalex.org/W1534887194","https://openalex.org/W1540380277","https://openalex.org/W1598215279","https://openalex.org/W1895786087","https://openalex.org/W1974625555","https://openalex.org/W1980538112","https://openalex.org/W1983283698","https://openalex.org/W1987409750","https://openalex.org/W1987994120","https://openalex.org/W1995008935","https://openalex.org/W2001733248","https://openalex.org/W2029965129","https://openalex.org/W2033121760","https://openalex.org/W2036209074","https://openalex.org/W2050970791","https://openalex.org/W2051091107","https://openalex.org/W2059787178","https://openalex.org/W2063529851","https://openalex.org/W2068661103","https://openalex.org/W2080112851","https://openalex.org/W2080448044","https://openalex.org/W2088329791","https://openalex.org/W2102480596","https://openalex.org/W2114614826","https://openalex.org/W2134858168","https://openalex.org/W2139742240","https://openalex.org/W2166781218","https://openalex.org/W2411833761","https://openalex.org/W2413825490","https://openalex.org/W2414636249","https://openalex.org/W2416310601","https://openalex.org/W2417897854","https://openalex.org/W4234129205","https://openalex.org/W4246178624","https://openalex.org/W4318373835"],"related_works":["https://openalex.org/W7165173644","https://openalex.org/W2110878609","https://openalex.org/W2039730214","https://openalex.org/W4412397674","https://openalex.org/W2036209074","https://openalex.org/W2377573574","https://openalex.org/W4318373835","https://openalex.org/W2112409972","https://openalex.org/W2109424116","https://openalex.org/W6906454796"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Daughter":[1,273],"aneurysms":[2,82,315,360],"have":[3],"been":[4],"strongly":[5],"associated":[6,365],"with":[7,361,366],"saccular":[8,28],"aneurysm":[9,29,42,54,68,96,109,144,171,177,196,234,261,274,281,288,297,310,345],"rupture.":[10,30,77,206,271,282,330,357,371],"We":[11],"constructed":[12],"a":[13,22,44,59,66,225,249,265,277,286,295,304,318,326,353,367],"mathematical":[14,89],"model":[15,33,132],"to":[16,58,85,123,147,174,203,246,262,264,280],"help":[17],"explain":[18],"this":[19,260],"association":[20],"as":[21],"possible":[23],"hemodynamic":[24],"mechanism":[25],"for":[26,329],"intracranial":[27],"METHODS:":[31],"Our":[32],"is":[34,153,209,224,276,301],"based":[35],"on":[36,155,340],"the":[37,49,53,72,75,91,94,101,107,117,124,127,135,142,148,159,165,169,175,180,186,190,194,198,220,232,242,291,334,341],"assumption":[38],"that":[39,69,134],"when":[40],"an":[41,212,237],"reaches":[43],"state":[45],"of":[46,52,61,74,93,119,168,189,216,219,231,239,252,285,308,322,333,343,356,370],"imminent":[47],"rupture,":[48],"weakest":[50],"area":[51],"wall":[55,110,145,149],"responds":[56],"passively":[57],"surge":[60],"intra-aneurysmal":[62],"pressure":[63,113],"by":[64],"forming":[65],"daughter":[67,79,95,108,128,143,170,191,195,233,287,309,314,344,359],"will":[70],"be":[71,86,338],"site":[73],"eventual":[76],"The":[78,131,283,331],"and":[80,114,126,179],"parent":[81,125,176,296],"were":[83],"assumed":[84],"spherical.":[87],"Using":[88],"modeling,":[90],"growth":[92,230],"was":[97,121],"observed.":[98],"To":[99],"obtain":[100],"change":[102],"in":[103,106,141,236,298],"tensile":[104,139,292],"stress":[105,136,140,199,208,240,250,293],"under":[111],"constant":[112],"changing":[115],"geometry,":[116],"Law":[118],"Laplace":[120],"applied":[122],"aneurysms.":[129],"RESULTS:":[130],"reveals":[133],"factor,":[137],"i.e.":[138],"relative":[146,166],"strength":[150],"(rupture":[151],"point),":[152],"dependent":[154],"two":[156],"geometric":[157],"parameters:":[158],"orifice":[160,172,221,256],"factor":[161,200,251,257],"(mu),":[162],"which":[163,184,299],"represents":[164,185],"size":[167],"radius":[173],"radius;":[178],"aspect":[181,213,267,347],"ratio":[182,188,214,268,348],"(lambda),":[183],"height-to-orifice":[187],"aneurysm.":[192],"As":[193],"develops,":[197],"first":[201],"decreases":[202,290],"protect":[204],"against":[205],"Minimal":[207],"attained":[210],"at":[211,248,317,325],"(lambda)":[215],"0.577":[217,351],"regardless":[218],"factor.":[222],"This":[223],"relatively":[226],"stable":[227],"state.":[228],"Further":[229],"results":[235],"increase":[238],"above":[241],"minimum,":[243],"eventually":[244],"leading":[245],"rupture":[247,300,335],"1.":[253],"A":[254],"smaller":[255],"mu":[258],"allows":[259],"grow":[263],"higher":[266],"lambda":[269,349],"before":[270],"DISCUSSION:":[272],"formation":[275,284],"likely":[278],"path":[279],"temporarily":[289],"within":[294],"imminent,":[302],"indicating":[303],"temporary":[305],"protective":[306],"role":[307],"development.":[311],"Aneurysms":[312],"harboring":[313],"are":[316,364],"more":[319],"advanced":[320],"stage":[321],"development,":[323],"hence":[324],"greater":[327,354,368],"risk":[328,336,355,369],"severity":[332],"can":[337],"estimated":[339],"basis":[342],"geometry;":[346],">":[350],"indicates":[352],"Furthermore,":[358],"larger":[362],"orifices":[363]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}