{"id":"https://openalex.org/W1991237179","doi":"https://doi.org/10.1016/j.jcpa.2005.06.005","title":"Ovine Infection with the Agents of Scrapie (CH1641 Isolate) and Bovine Spongiform Encephalopathy: Immunochemical Similarities can be Resolved by Immunohistochemistry","display_name":"Ovine Infection with the Agents of Scrapie (CH1641 Isolate) and Bovine Spongiform Encephalopathy: Immunochemical Similarities can be Resolved by Immunohistochemistry","publication_year":2005,"publication_date":"2005-12-02","ids":{"openalex":"https://openalex.org/W1991237179","doi":"https://doi.org/10.1016/j.jcpa.2005.06.005","mag":"1991237179","pmid":"https://pubmed.ncbi.nlm.nih.gov/16324707"},"language":"en","primary_location":{"id":"doi:10.1016/j.jcpa.2005.06.005","doi":"https://doi.org/10.1016/j.jcpa.2005.06.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jcpa.2005.06.005","pdf_url":null,"source":{"id":"https://openalex.org/S177502829","display_name":"Journal of Comparative Pathology","issn_l":"0021-9975","issn":["0021-9975","1532-3129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Comparative Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111907659","display_name":"M. Jeffrey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174729306","display_name":"Animal and Plant Health Agency","ror":"https://ror.org/0378g3743","country_code":"GB","type":"government","lineage":["https://openalex.org/I1326803253","https://openalex.org/I174729306","https://openalex.org/I2802373619"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. Jeffrey","raw_affiliation_strings":["Veterinary Laboratories Agency (VLA-Lasswade), Pentlands Science Park, Bush Loan, Midlothian EH26 0PZ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary Laboratories Agency (VLA-Lasswade), Pentlands Science Park, Bush Loan, Midlothian EH26 0PZ, UK","institution_ids":["https://openalex.org/I174729306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057175821","display_name":"L. Gonz\u00e1lez","orcid":"https://orcid.org/0000-0001-8493-9135","observed_orcids":["https://orcid.org/0000-0001-8493-9135"]},"institutions":[{"id":"https://openalex.org/I174729306","display_name":"Animal and Plant Health Agency","ror":"https://ror.org/0378g3743","country_code":"GB","type":"government","lineage":["https://openalex.org/I1326803253","https://openalex.org/I174729306","https://openalex.org/I2802373619"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L. Gonz\u00e1lez","raw_affiliation_strings":["Veterinary Laboratories Agency (VLA-Lasswade), Pentlands Science Park, Bush Loan, Midlothian EH26 0PZ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary Laboratories Agency (VLA-Lasswade), Pentlands Science Park, Bush Loan, Midlothian EH26 0PZ, UK","institution_ids":["https://openalex.org/I174729306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113512372","display_name":"A. Chong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Chong","raw_affiliation_strings":["The Institute of Animal Health Neuropathogenesis Unit, Edinburgh EH9 3JF, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Animal Health Neuropathogenesis Unit, Edinburgh EH9 3JF, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081734448","display_name":"James D. Foster","orcid":"https://orcid.org/0000-0002-5595-0623","observed_orcids":["https://orcid.org/0000-0002-5595-0623"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Foster","raw_affiliation_strings":["The Institute of Animal Health Neuropathogenesis Unit, Edinburgh EH9 3JF, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Animal Health Neuropathogenesis Unit, Edinburgh EH9 3JF, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017463196","display_name":"Wilfred Goldmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. Goldmann","raw_affiliation_strings":["The Institute of Animal Health Neuropathogenesis Unit, Edinburgh EH9 3JF, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Animal Health Neuropathogenesis Unit, Edinburgh EH9 3JF, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102747981","display_name":"Nora Hunter","orcid":"https://orcid.org/0000-0002-2663-148X","observed_orcids":["https://orcid.org/0000-0002-2663-148X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. Hunter","raw_affiliation_strings":["The Institute of Animal Health Neuropathogenesis Unit, Edinburgh EH9 3JF, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Animal Health Neuropathogenesis Unit, Edinburgh EH9 3JF, UK","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108527936","display_name":"\u0421. \u041c\u0430\u0440\u0442\u0438\u043d","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174729306","display_name":"Animal and Plant Health Agency","ror":"https://ror.org/0378g3743","country_code":"GB","type":"government","lineage":["https://openalex.org/I1326803253","https://openalex.org/I174729306","https://openalex.org/I2802373619"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. Martin","raw_affiliation_strings":["Veterinary Laboratories Agency (VLA-Lasswade), Pentlands Science Park, Bush Loan, Midlothian EH26 0PZ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary Laboratories Agency (VLA-Lasswade), Pentlands Science Park, Bush Loan, Midlothian EH26 0PZ, UK","institution_ids":["https://openalex.org/I174729306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3520,"currency":"USD","value_usd":3520},"apc_paid":null,"fwci":2.3843,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.87887787,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"134","issue":"1","first_page":"17","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scrapie","display_name":"scrapie","score":0.8700000047683716},{"id":"https://openalex.org/keywords/bovine-spongiform-encephalopathy","display_name":"bovine spongiform encephalopathy","score":0.9800000190734863},{"id":"https://openalex.org/keywords/prion-disease","display_name":"prion disease","score":0.9490000009536743},{"id":"https://openalex.org/keywords/prion-protein","display_name":"prion protein","score":0.9179999828338623},{"id":"https://openalex.org/keywords/peptide-mapping","display_name":"peptide mapping","score":0.7540000081062317},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.7990000247955322},{"id":"https://openalex.org/keywords/strain-differentiation","display_name":"strain differentiation","score":0.5419999957084656},{"id":"https://openalex.org/keywords/sheep","display_name":"sheep","score":0.6029999852180481},{"id":"https://openalex.org/keywords/western-blot","display_name":"Western blot","score":0.4350000023841858},{"id":"https://openalex.org/keywords/prp-genotype","display_name":"PrP genotype","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C2776735649","wikidata":"https://www.wikidata.org/wiki/Q170102","display_name":"Scrapie","level":4,"score":0.9582509994506836},{"id":"https://openalex.org/C2781131914","wikidata":"https://www.wikidata.org/wiki/Q154666","display_name":"Bovine spongiform encephalopathy","level":4,"score":0.9313031435012817},{"id":"https://openalex.org/C2776797465","wikidata":"https://www.wikidata.org/wiki/Q703961","display_name":"Transmissible spongiform encephalopathy","level":5,"score":0.8777740001678467},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.7379238605499268},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.644906759262085},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5743541717529297},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5444350242614746},{"id":"https://openalex.org/C3019804061","wikidata":"https://www.wikidata.org/wiki/Q14881255","display_name":"Prion protein","level":3,"score":0.5383665561676025},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5056154727935791},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.5026676654815674},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3644371032714844},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1983826458454132},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.15714257955551147},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15529665350914001},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1257784068584442},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10163617134094238}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D008221","descriptor_name":"Lymphoid Tissue","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010449","descriptor_name":"Peptide Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011328","descriptor_name":"Prions","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012608","descriptor_name":"Scrapie","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012757","descriptor_name":"Sheep Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D012757","descriptor_name":"Sheep Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016643","descriptor_name":"Encephalopathy, Bovine Spongiform","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D016643","descriptor_name":"Encephalopathy, Bovine Spongiform","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016643","descriptor_name":"Encephalopathy, Bovine Spongiform","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jcpa.2005.06.005","doi":"https://doi.org/10.1016/j.jcpa.2005.06.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jcpa.2005.06.005","pdf_url":null,"source":{"id":"https://openalex.org/S177502829","display_name":"Journal of Comparative Pathology","issn_l":"0021-9975","issn":["0021-9975","1532-3129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Comparative Pathology","raw_type":"journal-article"},{"id":"pmid:16324707","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16324707","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of comparative pathology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319995","display_name":"Department for Environment, Food and Rural Affairs, UK Government","ror":"https://ror.org/00tnppw48"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W53055727","https://openalex.org/W310556292","https://openalex.org/W398235022","https://openalex.org/W1500847022","https://openalex.org/W1534728973","https://openalex.org/W1540278447","https://openalex.org/W1557724928","https://openalex.org/W1784563469","https://openalex.org/W1866802343","https://openalex.org/W1987526595","https://openalex.org/W2018407130","https://openalex.org/W2021034011","https://openalex.org/W2029323775","https://openalex.org/W2029904589","https://openalex.org/W2052317760","https://openalex.org/W2064722614","https://openalex.org/W2069460222","https://openalex.org/W2072077683","https://openalex.org/W2074400407","https://openalex.org/W2076133781","https://openalex.org/W2078034208","https://openalex.org/W2078290196","https://openalex.org/W2083578508","https://openalex.org/W2110420813","https://openalex.org/W2110458251","https://openalex.org/W2113156058","https://openalex.org/W2124985576","https://openalex.org/W2126655133","https://openalex.org/W2133118132","https://openalex.org/W2142880647","https://openalex.org/W2154763071","https://openalex.org/W2158138061","https://openalex.org/W2158386265","https://openalex.org/W2163749649","https://openalex.org/W2165902759","https://openalex.org/W4251167651"],"related_works":["https://openalex.org/W1987526595","https://openalex.org/W2147589584","https://openalex.org/W2069548140","https://openalex.org/W2051537685","https://openalex.org/W2143358380","https://openalex.org/W2002067670","https://openalex.org/W2029323775","https://openalex.org/W2149246722","https://openalex.org/W2092466305","https://openalex.org/W2320713307"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}