{"id":"https://openalex.org/W1991172822","doi":"https://doi.org/10.1177/0269881114565143","title":"Vintage treatments for PTSD: A reconsideration of tricyclic drugs","display_name":"Vintage treatments for PTSD: A reconsideration of tricyclic drugs","publication_year":2015,"publication_date":"2015-01-13","ids":{"openalex":"https://openalex.org/W1991172822","doi":"https://doi.org/10.1177/0269881114565143","mag":"1991172822","pmid":"https://pubmed.ncbi.nlm.nih.gov/25586404"},"language":"en","primary_location":{"id":"doi:10.1177/0269881114565143","doi":"https://doi.org/10.1177/0269881114565143","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0269881114565143","pdf_url":null,"source":{"id":"https://openalex.org/S136368880","display_name":"Journal of Psychopharmacology","issn_l":"0269-8811","issn":["0269-8811","1461-7285"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Psychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101864584","display_name":"Jonathan R. T. Davidson","orcid":"https://orcid.org/0000-0002-8387-8913","observed_orcids":["https://orcid.org/0000-0002-8387-8913"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jonathan Davidson","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA","institution_ids":["https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101864584"],"corresponding_institution_ids":["https://openalex.org/I4210126298"],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":4.5567,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.93618229,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"29","issue":"3","first_page":"264","last_page":"269"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10242","display_name":"Posttraumatic Stress Disorder Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10242","display_name":"Posttraumatic Stress Disorder Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11132","display_name":"Psychoanalysis and Psychopathology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/posttraumatic-stress-disorder","display_name":"post-traumatic stress disorder","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tricyclic-antidepressants","display_name":"tricyclic antidepressants","score":0.9980000257492065},{"id":"https://openalex.org/keywords/desipramine","display_name":"desipramine","score":0.8309999704360962},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.9100000262260437},{"id":"https://openalex.org/keywords/serotonin-norepinephrine-reuptake-inhibitors","display_name":"serotonin-norepinephrine reuptake inhibitors","score":0.9869999885559082},{"id":"https://openalex.org/keywords/neurotransmitter-systems","display_name":"neurotransmitter systems","score":0.5569999814033508},{"id":"https://openalex.org/keywords/risk-benefit-assessment","display_name":"risk-benefit assessment","score":0.777999997138977},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C2781081902","wikidata":"https://www.wikidata.org/wiki/Q3539074","display_name":"Tricyclic","level":2,"score":0.9151419997215271},{"id":"https://openalex.org/C2780250439","wikidata":"https://www.wikidata.org/wiki/Q423288","display_name":"Desipramine","level":4,"score":0.8901777267456055},{"id":"https://openalex.org/C2779657639","wikidata":"https://www.wikidata.org/wiki/Q908843","display_name":"Tricyclic antidepressant","level":4,"score":0.6604294776916504},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5337793231010437},{"id":"https://openalex.org/C31487548","wikidata":"https://www.wikidata.org/wiki/Q4859664","display_name":"Reuptake inhibitor","level":4,"score":0.48056748509407043},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4769012928009033},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.437640905380249},{"id":"https://openalex.org/C2910584757","wikidata":"https://www.wikidata.org/wiki/Q334477","display_name":"Serotonin Uptake Inhibitors","level":5,"score":0.4361336827278137},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.4279049038887024},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3924543857574463},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.3308570384979248},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.31720542907714844},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3162921369075775},{"id":"https://openalex.org/C2776134451","wikidata":"https://www.wikidata.org/wiki/Q422244","display_name":"Fluoxetine","level":4,"score":0.2893536686897278},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15197360515594482},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.12954169511795044},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.12232816219329834},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.07352188229560852},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000929","descriptor_name":"Antidepressive Agents, Tricyclic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000929","descriptor_name":"Antidepressive Agents, Tricyclic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000929","descriptor_name":"Antidepressive Agents, Tricyclic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003891","descriptor_name":"Desipramine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003891","descriptor_name":"Desipramine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013313","descriptor_name":"Stress Disorders, Post-Traumatic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013313","descriptor_name":"Stress Disorders, Post-Traumatic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017831","descriptor_name":"Diagnosis, Dual (Psychiatry)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018759","descriptor_name":"Adrenergic Uptake Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/0269881114565143","doi":"https://doi.org/10.1177/0269881114565143","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0269881114565143","pdf_url":null,"source":{"id":"https://openalex.org/S136368880","display_name":"Journal of Psychopharmacology","issn_l":"0269-8811","issn":["0269-8811","1461-7285"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Psychopharmacology","raw_type":"journal-article"},{"id":"pmid:25586404","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25586404","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of psychopharmacology (Oxford, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W1530873853","https://openalex.org/W1933096424","https://openalex.org/W1963112881","https://openalex.org/W1972850166","https://openalex.org/W1981149786","https://openalex.org/W1982271015","https://openalex.org/W1989944680","https://openalex.org/W1997932250","https://openalex.org/W2003662114","https://openalex.org/W2004968176","https://openalex.org/W2013932263","https://openalex.org/W2024130431","https://openalex.org/W2024770800","https://openalex.org/W2026609678","https://openalex.org/W2026995360","https://openalex.org/W2046858241","https://openalex.org/W2049546836","https://openalex.org/W2049627162","https://openalex.org/W2053043565","https://openalex.org/W2057344941","https://openalex.org/W2059468663","https://openalex.org/W2060883373","https://openalex.org/W2061896629","https://openalex.org/W2066358721","https://openalex.org/W2070605348","https://openalex.org/W2081328314","https://openalex.org/W2082270426","https://openalex.org/W2085936773","https://openalex.org/W2087841303","https://openalex.org/W2091351148","https://openalex.org/W2093927095","https://openalex.org/W2098234705","https://openalex.org/W2102454290","https://openalex.org/W2107489190","https://openalex.org/W2110667871","https://openalex.org/W2119723109","https://openalex.org/W2128960262","https://openalex.org/W2129585993","https://openalex.org/W2131830842","https://openalex.org/W2136772270","https://openalex.org/W2137598844","https://openalex.org/W2140107414","https://openalex.org/W2146373381","https://openalex.org/W2150463235","https://openalex.org/W2166256285","https://openalex.org/W2175550673","https://openalex.org/W2320836949","https://openalex.org/W2330001440","https://openalex.org/W2336226391","https://openalex.org/W2405096185","https://openalex.org/W2410743862","https://openalex.org/W2415737661","https://openalex.org/W2468480304","https://openalex.org/W2494453857","https://openalex.org/W2917243324","https://openalex.org/W3210183659","https://openalex.org/W4240263741","https://openalex.org/W4251581354","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2419333281","https://openalex.org/W2894609956","https://openalex.org/W2415970041","https://openalex.org/W2013691718","https://openalex.org/W2094769813","https://openalex.org/W1924606161","https://openalex.org/W204189666","https://openalex.org/W2413095856","https://openalex.org/W2074529452","https://openalex.org/W2008142966"],"abstract_inverted_index":{"Serotonin":[0],"(SSRI)":[1,7],"and":[2,27,106],"serotonin-norepinephrine":[3],"(SNRI)":[4],"reuptake":[5],"inhibitors":[6],"are":[8,66],"the":[9,41,62,115],"first-line":[10],"recommended":[11],"drug":[12],"treatments":[13],"for":[14,39,103],"post-traumatic":[15],"stress":[16],"disorder":[17],"(PTSD);":[18],"but":[19],"despite":[20],"their":[21,56,124],"benefits,":[22],"much":[23],"residual":[24],"pathology":[25],"remains":[26],"no":[28],"new":[29],"drugs":[30,49],"have":[31],"yet":[32],"emerged":[33],"with":[34,97,117],"a":[35,51,85,93],"clearly":[36],"demonstrated":[37],"benefit":[38],"treating":[40,131],"disorder.":[42],"A":[43,121],"case":[44],"is":[45],"made":[46],"that":[47,65],"tricyclic":[48,109],"deserve":[50],"closer":[52],"look,":[53],"based":[54],"on":[55],"ability":[57],"to":[58,68],"affect":[59],"several":[60],"of":[61,88,123],"main":[63],"neurotransmitters":[64],"relevant":[67],"PTSD.":[69,132],"Their":[70],"promising":[71],"efficacy,":[72],"which":[73],"was":[74],"shown":[75],"30":[76],"years":[77],"ago,":[78],"had":[79],"not":[80],"been":[81],"followed":[82],"up,":[83],"until":[84],"recent":[86],"trial":[87],"desipramine":[89],"found":[90],"advantages":[91],"over":[92],"SSRI":[94],"in":[95,128],"PTSD":[96],"comorbid":[98],"alcohol":[99],"dependence.":[100],"Opportunities":[101],"exist":[102],"studying":[104],"newer":[105],"purportedly":[107],"safer":[108],"formulations,":[110],"as":[111,113],"well":[112],"further":[114],"work":[116],"older,":[118],"established":[119],"compounds.":[120],"reappraisal":[122],"risk:benefit":[125],"ratio":[126],"seems":[127],"order,":[129],"when":[130]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}