{"id":"https://openalex.org/W1991162005","doi":"https://doi.org/10.2147/lctt.s45172","title":"Gefitinib frequently induces liver damage in patients with lung adenocarcinoma previously treated by chemotherapy","display_name":"Gefitinib frequently induces liver damage in patients with lung adenocarcinoma previously treated by chemotherapy","publication_year":2013,"publication_date":"2013-06-01","ids":{"openalex":"https://openalex.org/W1991162005","doi":"https://doi.org/10.2147/lctt.s45172","mag":"1991162005","pmid":"https://pubmed.ncbi.nlm.nih.gov/28210130","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5217440"},"language":"en","primary_location":{"id":"doi:10.2147/lctt.s45172","doi":"https://doi.org/10.2147/lctt.s45172","is_oa":true,"landing_page_url":"https://doi.org/10.2147/lctt.s45172","pdf_url":"https://www.dovepress.com/getfile.php?fileID=16356","source":{"id":"https://openalex.org/S4210234644","display_name":"Lung Cancer Targets and Therapy","issn_l":"1179-2728","issn":["1179-2728"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung Cancer: Targets and Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=16356","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088897091","display_name":"Yasoo Sugiura","orcid":"https://orcid.org/0000-0003-3534-1799","observed_orcids":["https://orcid.org/0000-0003-3534-1799"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasoo Sugiura","raw_affiliation_strings":["Department of Pulmonary and Thoracic Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Thoracic Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060611339","display_name":"Etsuo Nemoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Etsuo Nemoto","raw_affiliation_strings":["Department of Pulmonary and Thoracic Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Thoracic Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114046012","display_name":"Yasuyuki Ohkubo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137409","display_name":"National Hospital Organization","ror":"https://ror.org/03ntccx93","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuyuki Ohkubo","raw_affiliation_strings":["Department of Respiratory Medicine, Kanagawa National Hospital, Hadano, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Kanagawa National Hospital, Hadano, Japan","institution_ids":["https://openalex.org/I4210137409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109093195","display_name":"Hisae Fusegawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137409","display_name":"National Hospital Organization","ror":"https://ror.org/03ntccx93","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisae Fusegawa","raw_affiliation_strings":["Department of Respiratory Medicine, Kanagawa National Hospital, Hadano, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Kanagawa National Hospital, Hadano, Japan","institution_ids":["https://openalex.org/I4210137409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069014371","display_name":"Shizuka Kaseda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shizuka Kaseda","raw_affiliation_strings":["Department of Pulmonary and Thoracic Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Thoracic Surgery","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045131030","display_name":"Osamu Kawai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137409","display_name":"National Hospital Organization","ror":"https://ror.org/03ntccx93","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Osamu Kawai","raw_affiliation_strings":["Department of Respiratory Medicine, Kanagawa National Hospital, Hadano, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Kanagawa National Hospital, Hadano, Japan","institution_ids":["https://openalex.org/I4210137409"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2320,"currency":"USD","value_usd":2320},"apc_paid":{"value":2320,"currency":"USD","value_usd":2320},"fwci":0.6901,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.73197106,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"4","issue":null,"first_page":"9","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gefitinib","display_name":"gefitinib","score":1.0},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.6039999723434448},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.8389999866485596},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9610000252723694},{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.906000018119812},{"id":"https://openalex.org/keywords/prior-chemotherapy","display_name":"prior chemotherapy","score":0.7110000252723694},{"id":"https://openalex.org/keywords/alternate-day-dosing","display_name":"alternate-day dosing","score":0.8880000114440918},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.7059999704360962},{"id":"https://openalex.org/keywords/liver-function-monitoring","display_name":"liver function monitoring","score":0.824999988079071},{"id":"https://openalex.org/keywords/asian-patients","display_name":"Asian patients","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.9501806497573853},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9443718791007996},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.7408010959625244},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.6767429709434509},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6205939650535583},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6140674352645874},{"id":"https://openalex.org/C2779563347","wikidata":"https://www.wikidata.org/wiki/Q843799","display_name":"Adenocarcinoma of the lung","level":4,"score":0.5673456192016602},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5268924236297607},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.43478259444236755},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.32718002796173096},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.19926980137825012},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.12335965037345886}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.2147/lctt.s45172","doi":"https://doi.org/10.2147/lctt.s45172","is_oa":true,"landing_page_url":"https://doi.org/10.2147/lctt.s45172","pdf_url":"https://www.dovepress.com/getfile.php?fileID=16356","source":{"id":"https://openalex.org/S4210234644","display_name":"Lung Cancer Targets and Therapy","issn_l":"1179-2728","issn":["1179-2728"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung Cancer: Targets and Therapy","raw_type":"journal-article"},{"id":"pmid:28210130","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28210130","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung Cancer (Auckland, N.Z.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5217440","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5217440/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung Cancer (Auckl)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:78374b2549a942babf80989947c6b5ba","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/78374b2549a942babf80989947c6b5ba","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lung Cancer: Targets and Therapy, Vol 2013, Iss default, Pp 9-14 (2013)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/13302","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/gefitinib-frequently-induces-liver-damage-in-patients-with-lung-adenoc-peer-reviewed-article-LCTT","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/lctt.s45172","doi":"https://doi.org/10.2147/lctt.s45172","is_oa":true,"landing_page_url":"https://doi.org/10.2147/lctt.s45172","pdf_url":"https://www.dovepress.com/getfile.php?fileID=16356","source":{"id":"https://openalex.org/S4210234644","display_name":"Lung Cancer Targets and Therapy","issn_l":"1179-2728","issn":["1179-2728"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung Cancer: Targets and Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1991162005.pdf","grobid_xml":"https://content.openalex.org/works/W1991162005.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W187375057","https://openalex.org/W1964370859","https://openalex.org/W1966268750","https://openalex.org/W1966884769","https://openalex.org/W1981359437","https://openalex.org/W2006804882","https://openalex.org/W2019607817","https://openalex.org/W2023550894","https://openalex.org/W2037581548","https://openalex.org/W2043963246","https://openalex.org/W2070536874","https://openalex.org/W2075549113","https://openalex.org/W2076668534","https://openalex.org/W2077093654","https://openalex.org/W2083064246","https://openalex.org/W2099725888","https://openalex.org/W2104543228","https://openalex.org/W2106602049","https://openalex.org/W2114461323","https://openalex.org/W2118548009","https://openalex.org/W2122553809","https://openalex.org/W2129360604","https://openalex.org/W2132000516","https://openalex.org/W2132157071","https://openalex.org/W2134667653","https://openalex.org/W2139730244","https://openalex.org/W2142464801","https://openalex.org/W2153942353","https://openalex.org/W2156228829","https://openalex.org/W2166084034","https://openalex.org/W2168537144","https://openalex.org/W2171981784","https://openalex.org/W2324892749","https://openalex.org/W2325481887","https://openalex.org/W2330694972","https://openalex.org/W2336792970","https://openalex.org/W4372228097","https://openalex.org/W4376870566"],"related_works":["https://openalex.org/W2466672029","https://openalex.org/W2026600167","https://openalex.org/W2761636277","https://openalex.org/W2083064246","https://openalex.org/W2323011677","https://openalex.org/W2953737499","https://openalex.org/W7098077857","https://openalex.org/W1966723136","https://openalex.org/W2132596236","https://openalex.org/W2059136273"],"abstract_inverted_index":{"Background:":[0],"Gefitinib":[1,229],"is":[2,71],"known":[3],"as":[4],"one":[5],"of":[6,48,81,186,200,258],"the":[7,24,78,164,184],"agents":[8],"for":[9,61,124,135,230,265],"treating":[10],"patients":[11,62,82,99,166,201,233,266],"with":[12,38,86,101,167,203],"both":[13],"advanced":[14,28,231],"lung":[15,30],"cancer":[16,31],"and":[17,45,94,114,132,151,189,208,216,243],"an":[18],"epidermal":[19,25],"growth-factor":[20,26],"receptor":[21],"mutation.":[22],"In":[23],"receptor-mutant":[27],"non-small-cell":[29],"population,":[32],"gefitinib":[33,56,84,104,205,210,259,270],"therapy":[34,271],"has":[35,57],"been":[36],"associated":[37],"increased":[39],"response":[40,198],"rate,":[41],"longer":[42],"progression-free":[43],"survival,":[44],"better":[46],"quality":[47],"life":[49],"compared":[50],"to":[51,58,143,174],"other":[52],"anticancer":[53,176],"drugs.":[54],"However,":[55],"be":[59,240,261],"discontinued":[60],"in":[63,130,267],"whom":[64,268],"adverse":[65],"events":[66],"occur,":[67],"even":[68],"if":[69],"it":[70,249],"still":[72],"effective.":[73],"Here,":[74],"we":[75],"retrospectively":[76,156],"assessed":[77],"clinical":[79,153],"course":[80],"receiving":[83],"therapy,":[85],"a":[87,180,262],"particular":[88],"focus":[89],"on":[90],"liver":[91,119,149,168,187,212,244,253,273,277],"damage.":[92,254,274],"Patients":[93],"methods:":[95],"Of":[96,163],"24":[97],"Asian":[98],"treated":[100,202],"250":[102,206],"mg":[103,207],"daily":[105,204,269],"at":[106],"Kanagawa":[107],"National":[108],"Hospital,":[109],"Japan,":[110],"between":[111,148,183],"January":[112],"2008":[113],"June":[115],"2012,":[116],"grade":[117],"3":[118],"damage":[120,150,188,213],"(Common":[121],"Terminology":[122],"Criteria":[123],"Adverse":[125],"Events,":[126],"version":[127],"4.0)":[128],"occurred":[129],"nine":[131,165],"were":[133,155,214,220],"eligible":[134],"our":[136],"assessment.":[137],"The":[138,146,196,255],"regimen":[139],"was":[140,179],"subsequently":[141],"changed":[142],"alternate-day":[144,209,256,283],"administration.":[145],"relationships":[147],"each":[152],"factor":[154],"examined":[157],"using":[158],"Fisher\u2019s":[159],"exact":[160],"test.":[161],"Results:":[162],"damage,":[169,278],"seven":[170],"had":[171],"previous":[172,190,281],"exposure":[173],"another":[175],"drug.":[177],"There":[178],"significant":[181,252],"relationship":[182],"incidence":[185],"chemotherapy":[191,238],"(":[192,224],"P":[193,225],"=":[194,226],"0.009).":[195],"objective":[197],"rates":[199],"following":[211],"66.7%":[215],"46.7%,":[217],"respectively;":[218],"these":[219],"not":[221],"significantly":[222],"different":[223],"0.597).":[227],"Conclusion:":[228],"adenocarcinoma":[232],"who":[234],"have":[235],"previously":[236],"undergone":[237],"should":[239],"used":[241],"cautiously":[242],"function":[245],"monitored":[246],"closely,":[247],"because":[248],"frequently":[250],"induces":[251,272],"administration":[257,284],"may":[260],"suitable":[263],"option":[264],"Keywords:":[275],"gefitinib,":[276],"adjuvant":[279],"chemotherapy,":[280,282]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
