{"id":"https://openalex.org/W1991153500","doi":"https://doi.org/10.1016/s0304-3959(99)00148-7","title":"Implications of recent advances in the understanding of pain pathophysiology for the assessment of pain in patients","display_name":"Implications of recent advances in the understanding of pain pathophysiology for the assessment of pain in patients","publication_year":1999,"publication_date":"1999-08-01","ids":{"openalex":"https://openalex.org/W1991153500","doi":"https://doi.org/10.1016/s0304-3959(99)00148-7","mag":"1991153500","pmid":"https://pubmed.ncbi.nlm.nih.gov/10491983"},"language":"en","primary_location":{"id":"doi:10.1016/s0304-3959(99)00148-7","doi":"https://doi.org/10.1016/s0304-3959(99)00148-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0304-3959(99)00148-7","pdf_url":null,"source":{"id":"https://openalex.org/S140848990","display_name":"Pain","issn_l":"0304-3959","issn":["0304-3959","1872-6623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017534594","display_name":"Clifford J. Woolf","orcid":"https://orcid.org/0000-0002-6636-3897","observed_orcids":["https://orcid.org/0000-0002-6636-3897","https://orcid.org/0000-0001-9840-596X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Clifford J. Woolf","raw_affiliation_strings":["Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Massachusetts General Hospital East, Charlestown, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Massachusetts General Hospital East, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030131585","display_name":"Isabelle D\u00e9costerd","orcid":"https://orcid.org/0000-0002-4820-5289","observed_orcids":["https://orcid.org/0000-0002-4820-5289"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Isabelle Decosterd","raw_affiliation_strings":["Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Massachusetts General Hospital East, Charlestown, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Massachusetts General Hospital East, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017534594"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":1.5148,"has_fulltext":false,"cited_by_count":178,"citation_normalized_percentile":{"value":0.81073446,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"82","issue":"Supplement 1","first_page":"S141","last_page":"S147"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.8877000212669373,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.8877000212669373,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10084","display_name":"Musculoskeletal pain and rehabilitation","score":0.04749999940395355,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.03319999948143959,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pathophysiology-of-pain","display_name":"pain pathophysiology","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pain-assessment","display_name":"pain assessment","score":0.8199999928474426},{"id":"https://openalex.org/keywords/clinical-pain-management","display_name":"clinical pain management","score":0.8140000104904175},{"id":"https://openalex.org/keywords/pain-mechanisms","display_name":"pain mechanisms","score":0.6359999775886536},{"id":"https://openalex.org/keywords/pain-diagnosis","display_name":"pain diagnosis","score":0.640999972820282},{"id":"https://openalex.org/keywords/outcome-measures","display_name":"outcome measures","score":0.6060000061988831},{"id":"https://openalex.org/keywords/treatment-efficacy-evaluation","display_name":"treatment efficacy assessment","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6131768226623535},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5796667337417603},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5784639716148376},{"id":"https://openalex.org/C2781118164","wikidata":"https://www.wikidata.org/wiki/Q1088113","display_name":"Chronic pain","level":2,"score":0.4930844008922577},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.44606178998947144},{"id":"https://openalex.org/C2993997175","wikidata":"https://www.wikidata.org/wiki/Q81938","display_name":"Acute pain","level":2,"score":0.4261396825313568},{"id":"https://openalex.org/C2983098980","wikidata":"https://www.wikidata.org/wiki/Q621261","display_name":"Pain management","level":2,"score":0.4240194857120514},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3611711263656616},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3450556993484497},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11807012557983398},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.06821435689926147},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.059557437896728516},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1016/s0304-3959(99)00148-7","doi":"https://doi.org/10.1016/s0304-3959(99)00148-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0304-3959(99)00148-7","pdf_url":null,"source":{"id":"https://openalex.org/S140848990","display_name":"Pain","issn_l":"0304-3959","issn":["0304-3959","1872-6623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"journal-article"},{"id":"pmid:10491983","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10491983","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.617.8742","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.617.8742","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.againstpain.org/fr/pdf/isarevuepain.pdf","raw_type":"text"},{"id":"pmh:oai:iris.unil.ch:iris/150418","doi":null,"is_oa":false,"landing_page_url":"https://iris.unil.ch/handle/iris/150418","pdf_url":null,"source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"review article"},{"id":"pmh:oai:serval.unil.ch:BIB_855CCBBE186C","doi":null,"is_oa":false,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_855CCBBE186C","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pain, vol. Suppl 6, pp. S141-7","raw_type":"info:eu-repo/semantics/review"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W18184263","https://openalex.org/W36710632","https://openalex.org/W1608662179","https://openalex.org/W1617355594","https://openalex.org/W1744651828","https://openalex.org/W1822822588","https://openalex.org/W1835398160","https://openalex.org/W1871284454","https://openalex.org/W1965866432","https://openalex.org/W1974642350","https://openalex.org/W1976256963","https://openalex.org/W1978174847","https://openalex.org/W1978939719","https://openalex.org/W1982266887","https://openalex.org/W1991550485","https://openalex.org/W1994618304","https://openalex.org/W2012810767","https://openalex.org/W2015303667","https://openalex.org/W2033980432","https://openalex.org/W2037490409","https://openalex.org/W2038075430","https://openalex.org/W2046593983","https://openalex.org/W2051746492","https://openalex.org/W2052273708","https://openalex.org/W2054119130","https://openalex.org/W2058020736","https://openalex.org/W2067825805","https://openalex.org/W2080211618","https://openalex.org/W2084701217","https://openalex.org/W2091167834","https://openalex.org/W2091746433","https://openalex.org/W2097331976","https://openalex.org/W2107705149","https://openalex.org/W2132829674","https://openalex.org/W2161702050","https://openalex.org/W2302271595","https://openalex.org/W2500157777","https://openalex.org/W2595437246","https://openalex.org/W4285719527","https://openalex.org/W6671382464"],"related_works":["https://openalex.org/W88256422","https://openalex.org/W7030041375","https://openalex.org/W2004621676","https://openalex.org/W2516111248","https://openalex.org/W2895684641","https://openalex.org/W2002931026","https://openalex.org/W3039512862","https://openalex.org/W2515214979","https://openalex.org/W2048741711","https://openalex.org/W2135901257"],"abstract_inverted_index":{"As":[0],"we":[1,10,83],"approach":[2,145],"the":[3,13,48,53,81,103,115,198,203,206],"new":[4,144,209],"millennium,":[5],"it":[6],"is":[7,59],"clear":[8],"that":[9,32,40],"are":[11,24,73,126,184],"on":[12,92,150],"brink":[14],"of":[15,47,55,71,108,153,168,205,208],"a":[16,29,98,143],"major":[17,78],"change":[18],"in":[19,52,80,114,121],"clinical":[20,191],"pain":[21,61,109,130,164,169,214],"management.":[22],"We":[23,139],"poised":[25],"to":[26,38,97,119,132,162,173,176],"move":[27],"from":[28,44],"treatment":[30,62,107,134],"paradigm":[31],"has":[33,89],"been":[34,90],"almost":[35],"entirely":[36],"empirical":[37],"one":[39],"will":[41,63,76,110,117],"be":[42,66,118,160,174],"derived":[43],"an":[45,151],"understanding":[46],"actual":[49],"mechanisms":[50,125],"involved":[51],"pathogenesis":[54],"pain.":[56],"When":[57],"this":[58,72,158],"achieved,":[60],"at":[64,136,212],"last":[65],"rationally":[67],"based.":[68],"The":[69,112],"implications":[70],"immense":[74],"and":[75,95,106,131,155,190],"necessitate":[77],"changes":[79],"way":[82],"classify":[84],"pain,":[85,148],"which":[86,171],"until":[87],"now":[88],"based":[91,149],"disease,":[93],"duration":[94],"anatomy,":[96],"mechanism-based":[99],"classification.":[100],"In":[101],"addition,":[102],"assessment,":[104,170],"diagnosis":[105],"change.":[111],"aim":[113],"future":[116],"identify":[120],"individual":[122],"patients":[123],"what":[124],"responsible":[127],"for":[128,141,146,186,196,202],"their":[129],"target":[133],"specifically":[135],"those":[137],"mechanisms.":[138,215],"present":[140],"discussion,":[142],"classifying":[147],"analysis":[152],"mechanisms,":[154,183],"show":[156],"how":[157],"could":[159],"used":[161],"assess":[163],"clinically.":[165],"Such":[166],"kinds":[167],"need":[172],"designed":[175],"reveal":[177],"as":[178,180,193,195],"much":[179],"possible":[181],"about":[182],"necessary":[185,201],"more":[187],"sophisticated":[188],"epidemiology":[189],"research":[192],"well":[194],"providing":[197],"outcome":[199],"measures":[200],"evaluation":[204],"efficacy":[207],"treatments":[210],"targeted":[211],"particular":[213]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
