{"id":"https://openalex.org/W1991145152","doi":"https://doi.org/10.1016/j.jalz.2012.05.1224","title":"P3\u2010006: Endogenous tau contributes to Alzheimer's\u2010like tau pathology in 3xTg mice","display_name":"P3\u2010006: Endogenous tau contributes to Alzheimer's\u2010like tau pathology in 3xTg mice","publication_year":2012,"publication_date":"2012-07-01","ids":{"openalex":"https://openalex.org/W1991145152","doi":"https://doi.org/10.1016/j.jalz.2012.05.1224","mag":"1991145152"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2012.05.1224","doi":"https://doi.org/10.1016/j.jalz.2012.05.1224","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2012.05.1224","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006306026","display_name":"David Baglietto\u2010Vargas","orcid":"https://orcid.org/0000-0003-1441-3175","observed_orcids":["https://orcid.org/0000-0003-1441-3175"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Baglietto\u2010Vargas","raw_affiliation_strings":["University of Irvine, California, Irvine, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Irvine, California, Irvine, California, United States","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065429008","display_name":"Hilda Mart\u00ednez\u2010Coria","orcid":"https://orcid.org/0000-0002-0335-8564","observed_orcids":["https://orcid.org/0000-0002-0335-8564"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hilda Martinez Coria","raw_affiliation_strings":["University of California, Irvine Irvine California United States","University of California, Irvine, Irvine, California, United States#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Irvine Irvine California United States","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"University of California, Irvine, Irvine, California, United States#TAB#","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078725664","display_name":"Carlos J. Rodr\u00edguez\u2010Ortiz","orcid":"https://orcid.org/0000-0003-2688-947X","observed_orcids":["https://orcid.org/0000-0003-2688-947X"]},"institutions":[{"id":"https://openalex.org/I156087764","display_name":"University of California, Merced","ror":"https://ror.org/00d9ah105","country_code":"US","type":"education","lineage":["https://openalex.org/I156087764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos Rodriguez\u2010Ortiz","raw_affiliation_strings":["University of California, Merced, Merced, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Merced, Merced, California, United States","institution_ids":["https://openalex.org/I156087764"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kim Green","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kim Green","raw_affiliation_strings":["University of California, Irvine Irvine California United States","University of California, Irvine, Irvine, California, United States#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Irvine Irvine California United States","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"University of California, Irvine, Irvine, California, United States#TAB#","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037612690","display_name":"Rodrigo Medeiros","orcid":"https://orcid.org/0000-0002-9399-7852","observed_orcids":["https://orcid.org/0000-0002-9399-7852"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rodrigo Medeiros","raw_affiliation_strings":["University of California, Irvine Irvine California United States","University of California, Irvine, Irvine, California, United States#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Irvine Irvine California United States","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"University of California, Irvine, Irvine, California, United States#TAB#","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009317100","display_name":"Masashi Kitazawa","orcid":"https://orcid.org/0000-0003-2165-8197","observed_orcids":["https://orcid.org/0000-0003-2165-8197"]},"institutions":[{"id":"https://openalex.org/I156087764","display_name":"University of California, Merced","ror":"https://ror.org/00d9ah105","country_code":"US","type":"education","lineage":["https://openalex.org/I156087764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masashi Kitazawa","raw_affiliation_strings":["University of California, Merced, Merced, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Merced, Merced, California, United States","institution_ids":["https://openalex.org/I156087764"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026487650","display_name":"Frank M. LaFerla","orcid":"https://orcid.org/0000-0003-2324-6911","observed_orcids":["https://orcid.org/0000-0003-2324-6911"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank LaFerla","raw_affiliation_strings":["University of California, Irvine Irvine California United States","University of California, Irvine, Irvine, California, United States#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Irvine Irvine California United States","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"University of California, Irvine, Irvine, California, United States#TAB#","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.13275968,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"8","issue":"4S_Part_12","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C3017833866","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tau pathology","level":4,"score":0.8480618000030518},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.8133753538131714},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.7289878129959106},{"id":"https://openalex.org/C2777739294","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tauopathy","level":4,"score":0.6355187296867371},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.6266504526138306},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.6243863105773926},{"id":"https://openalex.org/C2778198054","wikidata":"https://www.wikidata.org/wiki/Q15195154","display_name":"Hyperphosphorylation","level":3,"score":0.6235647201538086},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.586192786693573},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5264029502868652},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.4808864891529083},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38614320755004883},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3772381842136383},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35660111904144287},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34822988510131836},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.34595584869384766},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3173580765724182},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.30271729826927185},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24754342436790466},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19909805059432983},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1358107030391693},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2012.05.1224","doi":"https://doi.org/10.1016/j.jalz.2012.05.1224","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2012.05.1224","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2040787372","https://openalex.org/W2912518824","https://openalex.org/W2492923316","https://openalex.org/W2148409203","https://openalex.org/W2038036050","https://openalex.org/W2061808546","https://openalex.org/W2066713907","https://openalex.org/W2022598930","https://openalex.org/W1718169406","https://openalex.org/W2901965232"],"abstract_inverted_index":{"Abnormal":[0],"tau":[1,32,56,74,87,103,154,164,180,188,198],"aggregates,":[2],"also":[3],"known":[4],"as":[5,128,201,203],"neurofibrillary":[6],"tangles":[7],"(NFTs),":[8],"and":[9,63,159,162,183,237],"amyloid-beta":[10],"(A\u03b2)":[11],"plaques":[12],"are":[13],"pathological":[14,35,69,106,141],"hallmarks":[15],"of":[16,29,52,71,93,100,143],"Alzheimer's":[17],"disease":[18,61],"(AD).":[19],"Recent":[20],"studies":[21,82],"have":[22],"shown":[23],"contradictory":[24],"results":[25,176,222],"about":[26],"the":[27,34,49,53,60,64,78,98,105,139,167,233],"role":[28,99,142],"endogenous":[30,54,101],"mouse":[31,86,118,179],"in":[33,38,75,104,110,156,166,189],"events":[36,107],"observed":[37],"AD":[39,111],"models.":[40],"On":[41,77],"one":[42],"hand,":[43,80],"it":[44],"has":[45],"been":[46],"suggested":[47],"that":[48,85,108,149,178],"concomitant":[50],"expression":[51],"murine":[55,102,144],"might":[57],"interfere":[58],"with":[59,123,172,186],"progression":[62],"neurodegenerative":[65],"processes":[66],"by":[67,120],"delaying":[68],"accumulation":[70],"human":[72,187],"mutant":[73],"neurons.":[76],"other":[79,81],"strongly":[83],"indicate":[84,177],"is":[88,181],"a":[89,115,217],"critical":[90],"downstream":[91],"mediator":[92],"A\u03b2":[94,205],"toxicity.":[95],"To":[96],"clarify":[97],"occur":[109],"models,":[112],"we":[113,147],"developed":[114],"novel":[116],"transgenic":[117,194],"model":[119,133],"crossing":[121],"3xTg-AD":[122,173,190],"mtauKO":[124],"mice,":[125],"referred":[126],"to":[127,137,230],"3xTg-AD/mtauKO":[129,150],"mice.":[130,174,191],"This":[131],"new":[132,228],"(3xTg-AD/mtauKO)":[134],"allows":[135],"us":[136],"determine":[138],"specific":[140],"tau.":[145,238],"Here,":[146],"show":[148],"mice":[151],"exhibit":[152],"lower":[153],"loads":[155],"both":[157,193,208],"soluble":[158,168],"insoluble":[160],"fractions":[161],"reduced":[163],"hyperphosphorylation":[165],"fraction":[169],"when":[170,214],"compared":[171],"These":[175,221],"hyperphosphorylated":[182],"significantly":[184],"co-aggregated":[185],"Interestingly,":[192],"models":[195,209,229],"showed":[196],"similar":[197],"kinase":[199],"activity":[200],"well":[202],"comparable":[204],"pathology.":[206],"Furthermore,":[207],"exhibited":[210],"equivalent":[211],"cognitive":[212],"dysfunction":[213],"tested":[215],"on":[216],"spatial":[218],"memory":[219],"task.":[220],"provide":[223],"relevant":[224],"insights":[225],"for":[226],"developing":[227],"better":[231],"understand":[232],"link":[234],"between":[235],"\u03b2-amyloid":[236]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}