{"id":"https://openalex.org/W1991053809","doi":"https://doi.org/10.1002/ijc.24001","title":"Prognostic marker profile to assess risk in stage I\u2013III hormone receptor\u2010positive breast cancer patients","display_name":"Prognostic marker profile to assess risk in stage I\u2013III hormone receptor\u2010positive breast cancer patients","publication_year":2008,"publication_date":"2008-09-15","ids":{"openalex":"https://openalex.org/W1991053809","doi":"https://doi.org/10.1002/ijc.24001","mag":"1991053809","pmid":"https://pubmed.ncbi.nlm.nih.gov/19035452"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.24001","doi":"https://doi.org/10.1002/ijc.24001","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.24001","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.24001","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.24001","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034230229","display_name":"Troy M. Bremer","orcid":"https://orcid.org/0000-0001-6100-605X","observed_orcids":["https://orcid.org/0000-0001-6100-605X"]},"institutions":[{"id":"https://openalex.org/I4210108016","display_name":"Prediction Sciences (United States)","ror":"https://ror.org/0114c6692","country_code":"US","type":"company","lineage":["https://openalex.org/I4210108016"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Troy M. Bremer","raw_affiliation_strings":["Prediction Sciences, La Jolla, CA 92037-1354, USA","Prediction Sciences, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prediction Sciences, La Jolla, CA 92037-1354, USA","institution_ids":["https://openalex.org/I4210108016"]},{"raw_affiliation_string":"Prediction Sciences, La Jolla, CA","institution_ids":["https://openalex.org/I4210108016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088324209","display_name":"Jocelyne D. Jacquemier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210144608","display_name":"Centre de Recherche en Canc\u00e9rologie de Marseille","ror":"https://ror.org/0494jpz02","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]},{"id":"https://openalex.org/I4210150365","display_name":"Institut Paoli-Calmettes","ror":"https://ror.org/04s3t1g37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210150365"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jocelyne Jacquemier","raw_affiliation_strings":["Centre de Recherche en Cance\u0301rologie de Marseille, De\u0301partement d'Oncologie Mole\u0301culaire, UMR891 INSERM/Institut Paoli-Calmettes, Marseille, France","Centre de Recherche en Cance\u0301rologie de Marseille, De\u0301partement de BioPathologie, UMR891 INSERM/Institut Paoli-Calmettes, Marseilles, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche en Cance\u0301rologie de Marseille, De\u0301partement d'Oncologie Mole\u0301culaire, UMR891 INSERM/Institut Paoli-Calmettes, Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]},{"raw_affiliation_string":"Centre de Recherche en Cance\u0301rologie de Marseille, De\u0301partement de BioPathologie, UMR891 INSERM/Institut Paoli-Calmettes, Marseilles, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011917700","display_name":"Emmanuelle Charafe\u2010Jauffret","orcid":"https://orcid.org/0000-0002-0286-1299","observed_orcids":["https://orcid.org/0000-0002-0286-1299"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210144608","display_name":"Centre de Recherche en Canc\u00e9rologie de Marseille","ror":"https://ror.org/0494jpz02","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]},{"id":"https://openalex.org/I4210150365","display_name":"Institut Paoli-Calmettes","ror":"https://ror.org/04s3t1g37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210150365"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Emmanuelle Charafe\u2010Jauffret","raw_affiliation_strings":["Centre de Recherche en Cance\u0301rologie de Marseille, De\u0301partement d'Oncologie Mole\u0301culaire, UMR891 INSERM/Institut Paoli-Calmettes, Marseille, France","Centre de Recherche en Cance\u0301rologie de Marseille, De\u0301partement de BioPathologie, UMR891 INSERM/Institut Paoli-Calmettes, Marseilles, France","Universite\u0301 de la Me\u0301diterrane\u0301e, UFR de Me\u0301decine, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche en Cance\u0301rologie de Marseille, De\u0301partement d'Oncologie Mole\u0301culaire, UMR891 INSERM/Institut Paoli-Calmettes, Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]},{"raw_affiliation_string":"Centre de Recherche en Cance\u0301rologie de Marseille, De\u0301partement de BioPathologie, UMR891 INSERM/Institut Paoli-Calmettes, Marseilles, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]},{"raw_affiliation_string":"Universite\u0301 de la Me\u0301diterrane\u0301e, UFR de Me\u0301decine, Marseille, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009364522","display_name":"Patrice Viens","orcid":"https://orcid.org/0000-0003-1511-1048","observed_orcids":["https://orcid.org/0000-0003-1511-1048"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210150365","display_name":"Institut Paoli-Calmettes","ror":"https://ror.org/04s3t1g37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210150365"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Patrice Viens","raw_affiliation_strings":["De\u0301partement d'Oncologie Me\u0301dicale, UMR891 INSERM/Institut Paoli-Calmettes, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"De\u0301partement d'Oncologie Me\u0301dicale, UMR891 INSERM/Institut Paoli-Calmettes, Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210150365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033716671","display_name":"Daniel Birnbaum","orcid":"https://orcid.org/0000-0001-7920-9883","observed_orcids":["https://orcid.org/0000-0001-7920-9883"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210144608","display_name":"Centre de Recherche en Canc\u00e9rologie de Marseille","ror":"https://ror.org/0494jpz02","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]},{"id":"https://openalex.org/I4210150365","display_name":"Institut Paoli-Calmettes","ror":"https://ror.org/04s3t1g37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210150365"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Daniel Birnbaum","raw_affiliation_strings":["Centre de Recherche en Cance\u0301rologie de Marseille, De\u0301partement d'Oncologie Mole\u0301culaire, UMR891 INSERM/Institut Paoli-Calmettes, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche en Cance\u0301rologie de Marseille, De\u0301partement d'Oncologie Mole\u0301culaire, UMR891 INSERM/Institut Paoli-Calmettes, Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009371859","display_name":"Steven P. Linke","orcid":"https://orcid.org/0000-0001-8584-4947","observed_orcids":["https://orcid.org/0000-0001-8584-4947"]},"institutions":[{"id":"https://openalex.org/I4210108016","display_name":"Prediction Sciences (United States)","ror":"https://ror.org/0114c6692","country_code":"US","type":"company","lineage":["https://openalex.org/I4210108016"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven P. Linke","raw_affiliation_strings":["","Prediction Sciences, La Jolla, CA","Fax: +858-777-3614"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Prediction Sciences, La Jolla, CA","institution_ids":["https://openalex.org/I4210108016"]},{"raw_affiliation_string":"Fax: +858-777-3614","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5009371859"],"corresponding_institution_ids":["https://openalex.org/I4210108016"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":0.6826,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.71506721,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"124","issue":"4","first_page":"896","last_page":"904"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hormone-receptor-positive-breast-cancer","display_name":"hormone receptor-positive breast cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.6069999933242798},{"id":"https://openalex.org/keywords/adjuvant-therapy-decision-making","display_name":"adjuvant therapy decision-making","score":0.6909999847412109},{"id":"https://openalex.org/keywords/er","display_name":"Er","score":0.4659999907016754},{"id":"https://openalex.org/keywords/pgr","display_name":"PGR","score":0.9459999799728394},{"id":"https://openalex.org/keywords/erbb2","display_name":"ERBB2","score":0.9800000190734863},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tp53","display_name":"TP53","score":0.9980000257492065},{"id":"https://openalex.org/keywords/distant-metastasis","display_name":"distant metastasis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/disease-specific-survival","display_name":"disease-specific survival","score":0.9160000085830688},{"id":"https://openalex.org/keywords/node-negative-patients","display_name":"node-negative patients","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.7460262775421143},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.7114524245262146},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6967253684997559},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6896566152572632},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6855266690254211},{"id":"https://openalex.org/C2780275930","wikidata":"https://www.wikidata.org/wiki/Q1628266","display_name":"Hormone therapy","level":4,"score":0.5444108843803406},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.543430507183075},{"id":"https://openalex.org/C2780182762","wikidata":"https://www.wikidata.org/wiki/Q1630279","display_name":"Guideline","level":2,"score":0.4792380630970001},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4687982201576233},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4339365065097809},{"id":"https://openalex.org/C2777982462","wikidata":"https://www.wikidata.org/wiki/Q2481887","display_name":"Adjuvant therapy","level":3,"score":0.431113064289093},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42454665899276733},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.41994017362594604},{"id":"https://openalex.org/C23589133","wikidata":"https://www.wikidata.org/wiki/Q412005","display_name":"Hormone receptor","level":4,"score":0.41048234701156616},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21037444472312927},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11131665110588074},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018931","descriptor_name":"Antineoplastic Agents, Hormonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ijc.24001","doi":"https://doi.org/10.1002/ijc.24001","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.24001","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.24001","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:19035452","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19035452","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/ijc.24001","doi":"https://doi.org/10.1002/ijc.24001","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.24001","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.24001","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7799999713897705,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G4107464296","display_name":"SBIR Phase I: Multi-Marker Prognostic Test for Breast Cancer Outcome","funder_award_id":"0611297","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320323807","display_name":"Institut National Du Cancer","ror":"https://ror.org/03m8vkq32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1991053809.pdf","grobid_xml":"https://content.openalex.org/works/W1991053809.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W196157878","https://openalex.org/W1575982426","https://openalex.org/W1589403420","https://openalex.org/W1930298597","https://openalex.org/W1967252809","https://openalex.org/W1990500611","https://openalex.org/W1992177331","https://openalex.org/W1992316503","https://openalex.org/W1996624321","https://openalex.org/W1999919514","https://openalex.org/W2010871781","https://openalex.org/W2043235003","https://openalex.org/W2087810003","https://openalex.org/W2099630695","https://openalex.org/W2105882193","https://openalex.org/W2107333022","https://openalex.org/W2107413762","https://openalex.org/W2109103446","https://openalex.org/W2123129045","https://openalex.org/W2128985829","https://openalex.org/W2130588419","https://openalex.org/W2131994307","https://openalex.org/W2143336748","https://openalex.org/W2153933760","https://openalex.org/W2156273110","https://openalex.org/W2156604663","https://openalex.org/W2156711378","https://openalex.org/W2162817699","https://openalex.org/W2163563958"],"related_works":["https://openalex.org/W2049550987","https://openalex.org/W2004728641","https://openalex.org/W2321004702","https://openalex.org/W2324154615","https://openalex.org/W126289092","https://openalex.org/W2885867072","https://openalex.org/W2137740564","https://openalex.org/W1981069173","https://openalex.org/W2156579044","https://openalex.org/W3000117924"],"abstract_inverted_index":{"Single":[0],"markers":[1,66],"are":[2],"insufficient":[3],"to":[4,138,201,242,248],"accurately":[5,216],"assess":[6],"risk":[7,81,104,191,199],"of":[8,25,50,124,150,194,220,253],"relapse":[9],"for":[10,110,136,164],"adjuvant":[11,254],"therapy":[12],"guidance":[13],"in":[14,92,131,160],"operable":[15],"breast":[16,245],"cancer":[17,246],"patients.":[18,113],"In":[19,114,167,228],"addition,":[20],"the":[21,46,118,142,178,181,186,202,230,249],"accuracy":[22],"and":[23,37,48,61,63,75,163,174,238],"interpretability":[24],"current":[26],"multi-marker":[27],"tests":[28],"is":[29],"generally":[30],"limited":[31],"by":[32],"their":[33,38],"simply":[34],"additive":[35],"algorithms":[36],"overlap":[39],"with":[40,67,100,141,170],"clinicopathologic":[41,69,240],"risks.":[42],"Here,":[43],"we":[44],"report":[45],"development":[47],"validation":[49],"a":[51,79,121,146,218,224],"nonlinear":[52],"algorithm":[53,85],"that":[54],"combines":[55,233],"protein":[56],"(ER,":[57],"PGR,":[58],"ERBB2,":[59],"BCL2":[60],"TP53)":[62],"genomic":[64],"(MYC/8q24)":[65],"standard":[68,171],"features":[70],"(tumor":[71],"size,":[72],"tumor":[73],"grade":[74],"nodal":[76],"status)":[77],"into":[78],"global":[80],"assessment":[82],"profile.":[83],"The":[84],"was":[86,180],"trained":[87],"using":[88],"statistical":[89],"pattern":[90],"recognition":[91],"200":[93],"stage":[94],"I-III":[95],"hormone":[96,101,115],"receptor-positive":[97],"patients":[98,162,196,209,222,247],"treated":[99],"therapy.":[102,255],"Continuous":[103],"scores":[105],"(0-10+)":[106],"were":[107,158],"then":[108],"generated":[109],"232":[111],"independent":[112],"therapy-treated":[116],"patients,":[117],"profile":[119,179,187,231],"achieved":[120,159],"hazard":[122],"ratio":[123],"6.2":[125],"(95%":[126,153],"confidence":[127],"interval":[128],"[CI],":[129],"1.8-20)":[130],"high-":[132],"vs.":[133],"low-risk":[134,143,226],"groups":[135],"time":[137],"distant":[139],"metastasis":[140,148],"group":[144,219],"having":[145],"10-year":[147],"rate":[149],"just":[151],"4%":[152],"CI,":[154],"0-8%).":[155],"Similar":[156],"results":[157],"untreated":[161],"disease-specific":[165],"survival.":[166],"multivariate":[168],"analyses":[169],"prognostic":[172],"factors":[173],"clinical":[175],"practice":[176],"guidelines,":[177,203],"only":[182],"significant":[183],"variable.":[184],"Furthermore,":[185],"reclassified":[188],"as":[189],"low":[190],"over":[192],"half":[193],"node-negative":[195],"at":[197],"elevated":[198],"according":[200],"which":[204],"could":[205],"have":[206],"spared":[207],"such":[208],"from":[210],"unnecessary":[211],"cytotoxic":[212],"chemotherapy.":[213],"It":[214],"also":[215],"identified":[217],"high-risk":[221],"within":[223],"guideline":[225],"group.":[227],"summary,":[229],"intelligently":[232],"biologically":[234],"relevant":[235],"marker":[236],"pathways":[237],"established":[239],"risks":[241],"help":[243],"guide":[244],"most":[250],"appropriate":[251],"level":[252]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}