{"id":"https://openalex.org/W1991007374","doi":"https://doi.org/10.1080/07328319908044843","title":"Increased Cytotoxicity and Decreased In Vivo Toxicity of FdUMP[10] Relative to 5-FU","display_name":"Increased Cytotoxicity and Decreased In Vivo Toxicity of FdUMP[10] Relative to 5-FU","publication_year":1999,"publication_date":"1999-08-01","ids":{"openalex":"https://openalex.org/W1991007374","doi":"https://doi.org/10.1080/07328319908044843","mag":"1991007374","pmid":"https://pubmed.ncbi.nlm.nih.gov/10478484"},"language":"en","primary_location":{"id":"doi:10.1080/07328319908044843","doi":"https://doi.org/10.1080/07328319908044843","is_oa":false,"landing_page_url":"https://doi.org/10.1080/07328319908044843","pdf_url":null,"source":{"id":"https://openalex.org/S4210177795","display_name":"Nucleosides and Nucleotides","issn_l":"0732-8311","issn":["0732-8311","2332-3892"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleosides and Nucleotides","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005645688","display_name":"Jinqian Liu","orcid":"https://orcid.org/0000-0002-8141-9588","observed_orcids":["https://orcid.org/0000-0002-8141-9588"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinqian Liu","raw_affiliation_strings":["University of Nebraska Medical Center","Eppley Institute, University of Nebraska Medical Center, Omaha 68198-6805, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"Eppley Institute, University of Nebraska Medical Center, Omaha 68198-6805, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059388858","display_name":"Alan Skradis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Skradis","raw_affiliation_strings":["University of Nebraska Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083606423","display_name":"Carol Kolar","orcid":"https://orcid.org/0000-0003-1716-467X","observed_orcids":["https://orcid.org/0000-0003-1716-467X"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol Kolar","raw_affiliation_strings":["University of Nebraska Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086247738","display_name":"Jeff Kolath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeff Kolath","raw_affiliation_strings":["University of Nebraska Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111665592","display_name":"James Anderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Anderson","raw_affiliation_strings":["University of Nebraska Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012357049","display_name":"Terrence A. Lawson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terrence Lawson","raw_affiliation_strings":["University of Nebraska Medical Center","Eppley Institute for Cancer Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"Eppley Institute for Cancer Research","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089092786","display_name":"James E. Talmadge","orcid":"https://orcid.org/0000-0002-6328-6056","observed_orcids":["https://orcid.org/0000-0002-6328-6056"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Talmadge","raw_affiliation_strings":["University of Nebraska Medical Center","Pathology & Microbiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"Pathology & Microbiology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024922312","display_name":"William H. Gmeiner","orcid":"https://orcid.org/0000-0003-1883-3791","observed_orcids":["https://orcid.org/0000-0003-1883-3791"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William H. Gmeiner","raw_affiliation_strings":["University of Nebraska Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center","institution_ids":["https://openalex.org/I59130452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I59130452"],"apc_list":null,"apc_paid":null,"fwci":0.1916,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.37955956,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"18","issue":"8","first_page":"1789","last_page":"1802"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.3278999924659729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.3278999924659729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.20900000631809235,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.10750000178813934,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9760000109672546},{"id":"https://openalex.org/keywords/prodrugs","display_name":"prodrugs","score":0.6029999852180481},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8389999866485596},{"id":"https://openalex.org/keywords/in-vivo-toxicity","display_name":"in vivo toxicity","score":0.6819999814033508},{"id":"https://openalex.org/keywords/thymidylate-synthase","display_name":"thymidylate synthase","score":0.8100000023841858},{"id":"https://openalex.org/keywords/thymidine-kinase","display_name":"thymidine kinase","score":0.652999997138977},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.9589999914169312},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.7350000143051147}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.80467689037323},{"id":"https://openalex.org/C123321153","wikidata":"https://www.wikidata.org/wiki/Q22676802","display_name":"Thymidylate synthase","level":4,"score":0.7984941601753235},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.7176347374916077},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5915442109107971},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.557987630367279},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5356457233428955},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4065669775009155},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38782912492752075},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3829895853996277},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35230037569999695},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.3009893298149109},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.15359529852867126},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.06872379779815674},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.047793298959732056},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005468","descriptor_name":"Fluorodeoxyuridylate","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D005468","descriptor_name":"Fluorodeoxyuridylate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005468","descriptor_name":"Fluorodeoxyuridylate","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007928","descriptor_name":"Lethal Dose 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009962","descriptor_name":"Orotate Phosphoribosyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D013937","descriptor_name":"Thymidine Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013940","descriptor_name":"Thymidylate Synthase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/07328319908044843","doi":"https://doi.org/10.1080/07328319908044843","is_oa":false,"landing_page_url":"https://doi.org/10.1080/07328319908044843","pdf_url":null,"source":{"id":"https://openalex.org/S4210177795","display_name":"Nucleosides and Nucleotides","issn_l":"0732-8311","issn":["0732-8311","2332-3892"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleosides and Nucleotides","raw_type":"journal-article"},{"id":"pmid:10478484","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10478484","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleosides & nucleotides","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1522525722","display_name":"IMPACT OF 5FU ON THE STRUCTURE OF THE U4/U6 COMPLEX","funder_award_id":"R01CA060612","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2741700846","display_name":null,"funder_award_id":"NCI-36727","funder_id":"https://openalex.org/F4320332162","funder_display_name":"Centers for Disease Control and Prevention"}],"funders":[{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1574900767","https://openalex.org/W1605234039","https://openalex.org/W1962875322","https://openalex.org/W1977715167","https://openalex.org/W1979984946","https://openalex.org/W1982236081","https://openalex.org/W2004708243","https://openalex.org/W2004972769","https://openalex.org/W2014063382","https://openalex.org/W2016791396","https://openalex.org/W2062370426","https://openalex.org/W2065915399","https://openalex.org/W2074659347","https://openalex.org/W2074825788","https://openalex.org/W2110083695","https://openalex.org/W2154126059","https://openalex.org/W2157422354","https://openalex.org/W2159848047","https://openalex.org/W2170431369","https://openalex.org/W2313857605","https://openalex.org/W2951527143"],"related_works":["https://openalex.org/W1992012760","https://openalex.org/W4416128328","https://openalex.org/W2312829717","https://openalex.org/W2088558066","https://openalex.org/W2062102779","https://openalex.org/W2070090812","https://openalex.org/W1134520384","https://openalex.org/W7122656990","https://openalex.org/W2079090575","https://openalex.org/W2070652485"],"abstract_inverted_index":{"The":[0,171],"efficacy":[1],"of":[2,31,38,40,55,61,118,169,184],"treatment":[3],"with":[4,51,98,207],"5-Fluorouracil":[5],"(5-FU)":[6],"is":[7,33,45,76,144,158,192],"limited,":[8],"in":[9,47,96,176,205],"part,":[10],"by":[11],"its":[12],"inefficient":[13],"conversion":[14],"to":[15,107,113,131,138,161,181,187],"5-Fluoro-2'-deoxyuridine-5'-O-monophosphate":[16],"(FdUMP).":[17],"We":[18],"present":[19],"data":[20],"indicating":[21],"that":[22,152,164],"FdUMP[10],":[23,185],"designed":[24],"as":[25,35,59,100,102,195,200],"a":[26,36,67,114,201],"pro-drug":[27],"for":[28,121],"intracellular":[29],"release":[30],"FdUMP,":[32],"cytotoxic":[34,82,147],"consequence":[37],"uptake":[39],"the":[41,56,124,166],"multimeric":[42,190],"form.":[43],"FdUMP[10]":[44,75,91,127,157],"stable":[46],"cell":[48],"culture":[49],"medium,":[50],"more":[52,77,81,146],"than":[53,78,83,148],"one-half":[54],"material":[57],"persisting":[58],"multimers":[60],"at":[62,71],"least":[63],"six":[64],"nucleotides":[65],"after":[66],"48":[68],"h":[69],"incubation":[70],"37":[72],"degrees":[73],"C.":[74],"400":[79],"times":[80],"5-FU":[84,122,139,149],"towards":[85,150],"human":[86],"colorectal":[87],"tumor":[88],"cells":[89,151],"(H630).":[90],"also":[92],"has":[93],"decreased":[94,174],"toxicity":[95,175],"vivo,":[97,177],"doses":[99],"high":[101],"200":[103],"mg/kg/day":[104,120],"(qdx3)":[105],"administered":[106],"Balb/c":[108],"mice":[109],"without":[110],"morbidity,":[111],"compared":[112],"maximum":[115],"tolerated":[116],"dose":[117],"45":[119],"using":[123],"same":[125],"protocol.":[126],"shows":[128],"reduced":[129,179],"sensitivity":[130,180],"OPRTase-":[132],"and":[133,140,143,178],"TK-mediated":[134],"drug":[135,182],"resistance,":[136],"relative":[137,186],"FdU,":[141],"respectively,":[142],"much":[145],"overexpress":[153],"thymidylate":[154],"synthase.":[155],"Thus,":[156],"less":[159],"susceptible":[160],"resistance":[162,183],"mechanisms":[163],"limit":[165],"clinical":[167],"utility":[168],"5-FU.":[170,208],"increased":[172],"cytotoxicity,":[173],"5-FU,":[188],"indicates":[189],"FdUMP":[191],"potentially":[193],"valuable":[194],"an":[196],"anti-neoplastic":[197],"agent,":[198,203],"either":[199],"single":[202],"or":[204],"combination":[206]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
