{"id":"https://openalex.org/W1990976372","doi":"https://doi.org/10.1111/j.1752-8062.2011.00261.x","title":"Clinical Translational Science 2020: Disruptive Innovation Redefines the Discovery\u2010Application Enterprise","display_name":"Clinical Translational Science 2020: Disruptive Innovation Redefines the Discovery\u2010Application Enterprise","publication_year":2011,"publication_date":"2011-02-01","ids":{"openalex":"https://openalex.org/W1990976372","doi":"https://doi.org/10.1111/j.1752-8062.2011.00261.x","mag":"1990976372","pmid":"https://pubmed.ncbi.nlm.nih.gov/21348959","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5439842"},"language":"en","primary_location":{"id":"doi:10.1111/j.1752-8062.2011.00261.x","doi":"https://doi.org/10.1111/j.1752-8062.2011.00261.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1752-8062.2011.00261.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1752-8062.2011.00261.x","source":{"id":"https://openalex.org/S106654227","display_name":"Clinical and Translational Science","issn_l":"1752-8054","issn":["1752-8054","1752-8062"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1752-8062.2011.00261.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062664304","display_name":"Scott Arthur Waldman","orcid":"https://orcid.org/0000-0001-6619-175X","observed_orcids":["https://orcid.org/0000-0001-6619-175X"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott A. Waldman","raw_affiliation_strings":["Department of Pharmacology and Experimental Therapeutics, Division of Clinical Pharmacology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA. scott.waldman@jefferson.edu","Department of Pharmacology and Experimental Therapeutics, Division of Clinical Pharmacology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Therapeutics, Division of Clinical Pharmacology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA. scott.waldman@jefferson.edu","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Department of Pharmacology and Experimental Therapeutics, Division of Clinical Pharmacology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047902810","display_name":"Andr\u00e9 Terzic","orcid":"https://orcid.org/0000-0001-9210-009X","observed_orcids":["https://orcid.org/0000-0001-9210-009X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andre Terzic","raw_affiliation_strings":["Divisions of Cardiovascular Diseases and Clinical Pharmacology, Departments of Medicine, Molecular Pharmacology, and Experimental Therapeutics and Medical Genetics, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Cardiovascular Diseases and Clinical Pharmacology, Departments of Medicine, Molecular Pharmacology, and Experimental Therapeutics and Medical Genetics, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":null,"fwci":2.9652,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.89808822,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"4","issue":"1","first_page":"69","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12168","display_name":"Health and Medical Research Impacts","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12168","display_name":"Health and Medical Research Impacts","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13656","display_name":"Science, Research, and Medicine","score":0.04390000179409981,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12766","display_name":"Interdisciplinary Research and Collaboration","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/1802","display_name":"Information Systems and Management"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clinical-and-translational-research","display_name":"clinical and translational research","score":0.7459999918937683},{"id":"https://openalex.org/keywords/disruptive-innovation","display_name":"disruptive innovation","score":0.6029999852180481},{"id":"https://openalex.org/keywords/translational-capacity","display_name":"translational capacity","score":0.49300000071525574},{"id":"https://openalex.org/keywords/drug-development-failure","display_name":"drug development failure","score":0.39399999380111694},{"id":"https://openalex.org/keywords/molecular-targets","display_name":"molecular targets","score":0.42399999499320984},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"personalized medicine","score":0.7789999842643738},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.4959999918937683},{"id":"https://openalex.org/keywords/research-collaboration","display_name":"research collaboration","score":0.5960000157356262},{"id":"https://openalex.org/keywords/research-capacity-gaps","display_name":"research capacity gaps","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C2778757428","wikidata":"https://www.wikidata.org/wiki/Q1250464","display_name":"Realm","level":2,"score":0.6366714835166931},{"id":"https://openalex.org/C162264550","wikidata":"https://www.wikidata.org/wiki/Q17112037","display_name":"Translational medicine","level":2,"score":0.4929490089416504},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.46652042865753174},{"id":"https://openalex.org/C207267971","wikidata":"https://www.wikidata.org/wiki/Q120208","display_name":"Emerging technologies","level":2,"score":0.4564291834831238},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.4492746591567993},{"id":"https://openalex.org/C2778137410","wikidata":"https://www.wikidata.org/wiki/Q2732820","display_name":"Government (linguistics)","level":2,"score":0.44887685775756836},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.4382634460926056},{"id":"https://openalex.org/C55587333","wikidata":"https://www.wikidata.org/wiki/Q1133029","display_name":"Engineering ethics","level":1,"score":0.4365866184234619},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.42653900384902954},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.39430004358291626},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36606574058532715},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.28966084122657776},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2466297447681427},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2075149118900299},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1881432831287384},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1848074495792389},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12655267119407654},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D009316","descriptor_name":"National Institutes of Health (U.S.)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009936","descriptor_name":"Organizational Innovation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000331","qualifier_name":"legislation & jurisprudence","is_major_topic":true},{"descriptor_ui":"D057170","descriptor_name":"Translational Research, Biomedical","qualifier_ui":"Q000331","qualifier_name":"legislation & jurisprudence","is_major_topic":false},{"descriptor_ui":"D057170","descriptor_name":"Translational Research, Biomedical","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1111/j.1752-8062.2011.00261.x","doi":"https://doi.org/10.1111/j.1752-8062.2011.00261.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1752-8062.2011.00261.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1752-8062.2011.00261.x","source":{"id":"https://openalex.org/S106654227","display_name":"Clinical and Translational Science","issn_l":"1752-8054","issn":["1752-8054","1752-8062"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Science","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4290013","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5439842","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5439842","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5439842","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Transl Sci","raw_type":"Text"},{"id":"pmid:21348959","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21348959","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and translational science","raw_type":"Journal Article"},{"id":"pmh:oai:jdc.jefferson.edu:petfp-1009","doi":null,"is_oa":false,"landing_page_url":"https://jdc.jefferson.edu/petfp/9","pdf_url":null,"source":{"id":"https://openalex.org/S4210178181","display_name":"The Medicine Forum","issn_l":"2325-2863","issn":["2325-2863"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Pharmacology and Experimental Therapeutics Faculty Papers","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1111/j.1752-8062.2011.00261.x","doi":"https://doi.org/10.1111/j.1752-8062.2011.00261.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1752-8062.2011.00261.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1752-8062.2011.00261.x","source":{"id":"https://openalex.org/S106654227","display_name":"Clinical and Translational Science","issn_l":"1752-8054","issn":["1752-8054","1752-8062"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"},{"score":0.428600013256073,"display_name":"Industry, innovation and infrastructure","id":"https://metadata.un.org/sdg/9"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306143","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990976372.pdf","grobid_xml":"https://content.openalex.org/works/W1990976372.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1968055343","https://openalex.org/W1981090471","https://openalex.org/W1993450023","https://openalex.org/W1998062343","https://openalex.org/W2020092280","https://openalex.org/W2050689508","https://openalex.org/W2064991695","https://openalex.org/W2075432689","https://openalex.org/W2093065590","https://openalex.org/W2094856950","https://openalex.org/W2101716521","https://openalex.org/W2108662045","https://openalex.org/W2114269304","https://openalex.org/W2117669462","https://openalex.org/W2146252218","https://openalex.org/W2150764597","https://openalex.org/W2153298670","https://openalex.org/W2165961284","https://openalex.org/W2290946523","https://openalex.org/W2410395484"],"related_works":["https://openalex.org/W7124469577","https://openalex.org/W2055236938","https://openalex.org/W2040320922","https://openalex.org/W4210439073","https://openalex.org/W4282553957","https://openalex.org/W177850491","https://openalex.org/W4416931273","https://openalex.org/W1993450023","https://openalex.org/W7143337756","https://openalex.org/W2200295520"],"abstract_inverted_index":{"Vaccines,":[0],"analgesia,":[1],"and":[2,37,40,46,74,84,90,93,98,116,126,149,173,181,188,206,211,236,252,268,275,299,322,369,372,381,388],"antibiotics":[3],"embody":[4],"some":[5],"of":[6,20,25,35,54,82,109,124,155,169,190,209,227,248,270,272,290,341,355],"the":[7,23,33,52,110,122,132,153,166,170,179,186,191,203,225,237,246,266,323,337,349,398],"most":[8],"enduring":[9],"therapeutic":[10,97,300],"breakthroughs":[11],"that":[12,59,278,295,339,374],"have":[13,101,284,375],"transformed":[14],"medicine.Building":[15],"on":[16,64],"such":[17],"fine":[18],"paradigms":[19,263],"biomedical":[21],"innovation,":[22],"evolution":[24],"technologies":[26,235],"has":[27,76,113,244],"increasingly":[28],"sparked":[29],"spectacular":[30],"advances":[31,136],"across":[32],"continuum":[34],"wellness":[36],"disease-spanning":[38],"medical":[39,60],"surgical":[41],"specialties.Discovery":[42],"science-fueled":[43],"by":[44],"government":[45],"private":[47,117,350],"sector":[48,118,351],"resources-has":[49],"systematically":[50],"instituted":[51],"principles":[53],"modern":[55],"healthcare":[56,157,332],"delivery":[57],"ensuring":[58],"practice":[61],"is":[62,129,198,336,364],"based":[63],"up-to-date":[65],"scientifi":[66,250],"c":[67,251],"evidence.Th":[68],"e":[69,107],"harmony":[70],"between":[71],"science,":[72],"technology,":[73],"resources":[75],"culminated":[77],"in":[78,137,145,201,224,233,319,348,357,378],"a":[79,194,311,316],"golden":[80],"age":[81],"discovery":[83,125],"translation,":[85],"eradicating":[86],"infections,":[87],"curing":[88],"cancers,":[89],"palliating":[91],"endocrine":[92],"metabolic":[94],"diseases.Indeed,":[95],"proven":[96],"preventive":[99],"approaches":[100],"progressively":[102],"moved":[103],"into":[104,240,261,330,345],"everyday":[105],"practice.Th":[106],"success":[108],"science-medicine":[111],"union":[112],"spurred":[114],"public":[115],"investments,":[119],"further":[120],"fueling":[121],"engine":[123],"enabling":[127,135,234],"technology.Th":[128],"integration":[130],"produced":[131,285],"new":[133,221,262,291,331,385],"biology,":[134],"technology":[138],"platforms":[139],"to":[140,164,174,215,255,264,366,383],"off":[141,160],"er":[142],"unprecedented":[143],"opportunities":[144,163,212],"disease":[146,304],"prediction,":[147],"prevention,":[148],"even":[150],"cure":[151],"beyond":[152],"reach":[154],"traditional":[156],"solutions.Modern":[158],"science":[159],"ers":[161],"outstanding":[162],"probe":[165],"innermost":[167],"workings":[168],"human":[171],"body,":[172],"understand":[175],"how":[176],"events":[177],"at":[178],"subcellular":[180],"molecular":[182,293],"levels":[183],"infl":[184],"uence":[185],"functioning":[187],"integrity":[189],"individual":[192],"as":[193],"whole.1,2":[195],"Remarkable":[196],"progress":[197],"being":[199],"made":[200],"understanding":[202],"molecular,":[204],"genetic,":[205],"cellular":[207],"origins":[208],"disease,":[210],"now":[213],"exist":[214],"uncover":[216],"practical":[217],"uses":[218],"for":[219,302,327],"this":[220],"knowledge,":[222],"particularly":[223],"realm":[226],"personalized":[228],"medicine.3,4":[229],"Unexpectedly,":[230],"however,":[231],"acceleration":[232],"resultant":[238],"insights":[239],"basic":[241,379],"pathophysiological":[242],"mechanisms":[243],"outstripped":[245],"capacity":[247,318],"current":[249],"clinical":[253,346,386],"structures":[254],"effi":[256,358],"ciently":[257],"manage":[258],"their":[259,307,328],"translation":[260],"improve":[265],"health":[267],"quality":[269],"life":[271],"individuals,":[273],"communities,":[274],"populations.5":[276],"In":[277],"context,":[279],"federally":[280],"funded":[281],"research":[282,363],"programs":[283],"hundreds,":[286],"if":[287],"not":[288],"thousands,":[289],"disease-related":[292],"targets":[294,301,371],"represent":[296],"potential":[297],"diagnostic":[298],"tailored":[303],"management.6":[305],"Unfortunately,":[306],"applications":[308,387],"remain":[309],"only":[310],"distant":[312],"promise,":[313],"refl":[314],"ecting":[315],"limited":[317],"structures,":[320],"resources,":[321],"specialized":[324],"workforces":[325],"required":[326],"translations":[329],"paradigms.Compounding":[333],"these":[334],"challenges":[335],"reality":[338],"95%":[340],"promising":[342],"therapies":[343],"brought":[344],"development":[347],"ultimately":[352],"fail":[353],"because":[354],"limitations":[356],"cacy":[359],"or":[360],"unacceptable":[361],"toxicities.Further":[362],"needed":[365],"identify,":[367],"measure,":[368],"validate":[370],"pathways":[373],"been":[376],"detected":[377],"studies,":[380],"then":[382],"develop":[384],"rigorously":[389],"Clinical":[390],"Translational":[391],"Science":[392],"2020:":[393],"Disruptive":[394],"Innovation":[395],"Redefi":[396],"nes":[397],"Discovery-Application":[399],"Enterprise":[400]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}