{"id":"https://openalex.org/W1990976056","doi":"https://doi.org/10.1002/(sici)1099-1263(200001/02)20:1<35::aid-jat633>3.0.co;2-8","title":"The peripubertal male rat assay as an alternative to the Hershberger castrated male rat assay for the detection of anti-androgens, oestrogens and metabolic modulators","display_name":"The peripubertal male rat assay as an alternative to the Hershberger castrated male rat assay for the detection of anti-androgens, oestrogens and metabolic modulators","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W1990976056","doi":"https://doi.org/10.1002/(sici)1099-1263(200001/02)20:1<35::aid-jat633>3.0.co;2-8","mag":"1990976056","pmid":"https://pubmed.ncbi.nlm.nih.gov/10641015"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1099-1263(200001/02)20:1<35::aid-jat633>3.0.co;2-8","doi":"https://doi.org/10.1002/(sici)1099-1263(200001/02)20:1<35::aid-jat633>3.0.co;2-8","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1099-1263(200001/02)20:1<35::aid-jat633>3.0.co;2-8","pdf_url":null,"source":{"id":"https://openalex.org/S81851855","display_name":"Journal of Applied Toxicology","issn_l":"0260-437X","issn":["0260-437X","1099-1263"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113714844","display_name":"John Ashby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"J. Ashby","raw_affiliation_strings":["AstraZeneca Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK. John.Ashby@CTL.AstraZeneca.com","AstraZeneca Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK. John.Ashby@CTL.AstraZeneca.com","institution_ids":["https://openalex.org/I105036370"]},{"raw_affiliation_string":"AstraZeneca Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111645797","display_name":"P.A. Lefevre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. A. Lefevre","raw_affiliation_strings":["AstraZeneca Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK","institution_ids":["https://openalex.org/I105036370"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113714844"],"corresponding_institution_ids":["https://openalex.org/I105036370"],"apc_list":{"value":3940,"currency":"USD","value_usd":3940},"apc_paid":null,"fwci":12.6403,"has_fulltext":false,"cited_by_count":129,"citation_normalized_percentile":{"value":0.99410086,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"20","issue":"1","first_page":"35","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endocrine-disruptors","display_name":"endocrine disruptors","score":0.8989999890327454},{"id":"https://openalex.org/keywords/androgen-receptor-antagonists","display_name":"androgen receptor antagonists","score":0.9850000143051147},{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.9959999918937683},{"id":"https://openalex.org/keywords/metabolic-regulators","display_name":"metabolic modulators","score":0.9850000143051147},{"id":"https://openalex.org/keywords/vinclozolin","display_name":"vinclozolin","score":0.777999997138977},{"id":"https://openalex.org/keywords/cyproterone-acetate","display_name":"cyproterone acetate","score":0.9459999799728394},{"id":"https://openalex.org/keywords/flutamide","display_name":"flutamide","score":0.9620000123977661},{"id":"https://openalex.org/keywords/dde","display_name":"DDE","score":0.8799999952316284},{"id":"https://openalex.org/keywords/anastrozole","display_name":"anastrozole","score":0.8460000157356262},{"id":"https://openalex.org/keywords/finasteride","display_name":"finasteride","score":0.9829999804496765},{"id":"https://openalex.org/keywords/ketoconazole","display_name":"ketoconazole","score":0.9980000257492065},{"id":"https://openalex.org/keywords/butyl-benzyl-phthalate","display_name":"butyl benzyl phthalate","score":0.9700000286102295},{"id":"https://openalex.org/keywords/bisphenol-a","display_name":"bisphenol A","score":0.9929999709129333},{"id":"https://openalex.org/keywords/diethylstilbestrol","display_name":"diethylstilbestrol","score":0.9879999756813049},{"id":"https://openalex.org/keywords/dibutyl-phthalate","display_name":"dibutyl phthalate","score":0.9959999918937683},{"id":"https://openalex.org/keywords/fenitrothion","display_name":"fenitrothion","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C2778313021","wikidata":"https://www.wikidata.org/wiki/Q418669","display_name":"Flutamide","level":5,"score":0.8581215739250183},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7302363514900208},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.702368974685669},{"id":"https://openalex.org/C2779322244","wikidata":"https://www.wikidata.org/wiki/Q574820","display_name":"Antiandrogen","level":4,"score":0.6915626525878906},{"id":"https://openalex.org/C2776977304","wikidata":"https://www.wikidata.org/wiki/Q412907","display_name":"Vinclozolin","level":3,"score":0.657883882522583},{"id":"https://openalex.org/C2779643248","wikidata":"https://www.wikidata.org/wiki/Q415612","display_name":"Dibutyl phthalate","level":2,"score":0.6245080232620239},{"id":"https://openalex.org/C2777155358","wikidata":"https://www.wikidata.org/wiki/Q426185","display_name":"Cyproterone acetate","level":4,"score":0.5548782348632812},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.5509778261184692},{"id":"https://openalex.org/C2780862370","wikidata":"https://www.wikidata.org/wiki/Q1138899","display_name":"Endocrine disruptor","level":4,"score":0.5432151556015015},{"id":"https://openalex.org/C2780509179","wikidata":"https://www.wikidata.org/wiki/Q411958","display_name":"Methoxychlor","level":3,"score":0.535487949848175},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.4372536540031433},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.43183690309524536},{"id":"https://openalex.org/C2777956591","wikidata":"https://www.wikidata.org/wiki/Q415563","display_name":"Ethinylestradiol","level":4,"score":0.42607298493385315},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41468751430511475},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3748946189880371},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2668614983558655},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21693643927574158},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.10247761011123657},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.09941869974136353},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.08268550038337708},{"id":"https://openalex.org/C161176658","wikidata":"https://www.wikidata.org/wiki/Q131656","display_name":"Pesticide","level":2,"score":0.0},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C74600772","wikidata":"https://www.wikidata.org/wiki/Q193237","display_name":"Fungicide","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C2986817661","wikidata":"https://www.wikidata.org/wiki/Q185698","display_name":"Research methodology","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077384","descriptor_name":"Anastrozole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000726","descriptor_name":"Androgen Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000726","descriptor_name":"Androgen Antagonists","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000726","descriptor_name":"Androgen Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004968","descriptor_name":"Estrogens, Non-Steroidal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004968","descriptor_name":"Estrogens, Non-Steroidal","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004968","descriptor_name":"Estrogens, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005278","descriptor_name":"Fenitrothion","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005837","descriptor_name":"Genitalia, Male","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005837","descriptor_name":"Genitalia, Male","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007654","descriptor_name":"Ketoconazole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009919","descriptor_name":"Orchiectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011627","descriptor_name":"Puberty","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012741","descriptor_name":"Sexual Maturation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018120","descriptor_name":"Finasteride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/(sici)1099-1263(200001/02)20:1<35::aid-jat633>3.0.co;2-8","doi":"https://doi.org/10.1002/(sici)1099-1263(200001/02)20:1<35::aid-jat633>3.0.co;2-8","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1099-1263(200001/02)20:1<35::aid-jat633>3.0.co;2-8","pdf_url":null,"source":{"id":"https://openalex.org/S81851855","display_name":"Journal of Applied Toxicology","issn_l":"0260-437X","issn":["0260-437X","1099-1263"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Toxicology","raw_type":"journal-article"},{"id":"pmid:10641015","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10641015","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied toxicology : JAT","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1978082040","https://openalex.org/W1980532326","https://openalex.org/W1984445735","https://openalex.org/W1986310133","https://openalex.org/W1991090048","https://openalex.org/W2006261800","https://openalex.org/W2009040345","https://openalex.org/W2011868725","https://openalex.org/W2018130591","https://openalex.org/W2022373675","https://openalex.org/W2025885384","https://openalex.org/W2033903065","https://openalex.org/W2036235027","https://openalex.org/W2038445778","https://openalex.org/W2051137386","https://openalex.org/W2053594689","https://openalex.org/W2069724569","https://openalex.org/W2079594367","https://openalex.org/W2087836560","https://openalex.org/W2108241608","https://openalex.org/W2118359480","https://openalex.org/W2122285171","https://openalex.org/W2127993619","https://openalex.org/W2128922640","https://openalex.org/W2131007321","https://openalex.org/W2140056942","https://openalex.org/W2141634370","https://openalex.org/W2168538509","https://openalex.org/W2326357482","https://openalex.org/W2327758174"],"related_works":["https://openalex.org/W1631234379","https://openalex.org/W2135631082","https://openalex.org/W1984074440","https://openalex.org/W2078038493","https://openalex.org/W1986168736","https://openalex.org/W2074662906","https://openalex.org/W2158120784","https://openalex.org/W2032990368","https://openalex.org/W2066321889","https://openalex.org/W2036235027"],"abstract_inverted_index":{"A":[0,51,205],"range":[1,261],"of":[2,7,91,105,120,142,149,158,171,175,182,208,211,216,222,239,262,278,284,288,293,311,331,336,349,359,364,379,398],"chemicals":[3,27,154],"with":[4,76,155,301,388],"various":[5],"levels":[6,164],"activity":[8,19,150],"as":[9,270],"actual":[10],"or":[11,81],"potential":[12],"endocrine":[13,381,393],"disrupters":[14,382],"have":[15,166,256],"been":[16,167],"evaluated":[17],"for":[18,151,160,373],"in":[20,88,99,117,133,139,236,241,252,280,286],"the":[21,55,62,89,103,106,118,135,140,152,156,172,183,201,209,214,219,223,237,253,272,309,312,322,334,347,350,357],"peripubertal":[22,254,351],"male":[23,255,315,324,352],"rat":[24,316,325,353],"assay.":[25],"The":[26,83,303],"studied":[28,85],"included":[29],"anti-androgens":[30],"(vinclozolin),":[31],"cyproterone":[32],"acetate,":[33],"flutamide,":[34],"2,":[35],"2-bis(4-chlorophenyl)-1,1-dichloroethylene":[36],"(DDE),":[37],"metabolic":[38],"modulators":[39],"(anastrazole,":[40],"finasteride,":[41],"ketoconazole)":[42],"and":[43,61,74,96,102,108,129,187,193,218,228,266,268,321,383,396],"oestrogens":[44,265],"(butyl":[45],"benzyl":[46],"phthalate":[47,59],"(BBP),":[48],"methoxychlor,":[49],"bisphenol":[50],"(BPA),":[52],"diethylstilboestrol":[53],"(DES)),":[54],"suspected":[56],"anti-androgen":[57],"dibutyl":[58],"(DBP)":[60],"non-oestrogen":[63],"fenitrothion.":[64],"Dosing":[65],"extended":[66],"over":[67,200],"postnatal":[68],"days":[69,295],"(pnd)":[70],"22-35,":[71,75],"36-50,":[72],"36-55":[73],"recovery":[77],"to":[78,179,188,259,299,390],"pnd":[79,203],"55":[80],"22-55.":[82,204],"endpoints":[84],"were":[86,110,124,131,177],"changes":[87,116,251],"weights":[90,104],"testes,":[92],"epididymides,":[93],"seminal":[94],"vesicles":[95],"prostate.":[97],"Changes":[98,138],"body":[100,220,242],"weight":[101,141,221,250],"liver":[107],"kidney":[109],"also":[111,125],"monitored.":[112],"In":[113],"some":[114],"experiments":[115],"day":[119,210],"prepuce":[121],"separation":[122],"(PPS)":[123],"determined.":[126],"Only":[127],"BBP":[128],"BPA":[130],"inactive":[132],"all":[134,181],"assays":[136,395],"conducted.":[137],"reproductive":[143,248],"tissues":[144],"provided":[145],"a":[146,189,260,344,377],"sensitive":[147],"indicator":[148],"remaining":[153],"exception":[157],"DDE,":[159,194],"which":[161,332,389],"higher":[162],"dose":[163,386],"could":[165],"used.":[168],"However,":[169],"none":[170],"curtailed":[173],"periods":[174],"exposure":[176,198,217],"able":[178],"detect":[180],"agents.":[184],"Diethyl":[185],"stilboestrol,":[186],"lesser":[190],"extent":[191],"DBP":[192],"delayed":[195],"PPS":[196,212,281],"when":[197,232],"occurred":[199],"period":[202,215],"complex":[206],"dependence":[207],"on":[213,346,362,376],"test":[224],"animals":[225],"was":[226],"observed,":[227],"caution":[229],"is":[230,245,341,369],"recommended":[231],"assessing":[233],"this":[234],"endpoint":[235],"presence":[238],"reductions":[240],"weight.":[243],"It":[244,340],"concluded":[246,342],"that":[247,269,343],"tissue":[249],"shown":[257],"sensitivity":[258],"biochemical":[263],"modulators,":[264],"anti-androgens,":[267],"such":[271],"assay":[273,317,326,354],"warrants":[274],"further":[275,360],"evaluation.":[276],"Measurement":[277],"delays":[279,292],"may":[282],"be":[283,297],"value":[285],"cases":[287],"large":[289],"delays,":[290],"but":[291],"1-2":[294],"will":[296],"difficult":[298],"interpret":[300],"confidence.":[302],"present":[304],"results":[305],"are":[306,333],"discussed":[307],"within":[308],"context":[310],"sexually":[313],"mature":[314],"described":[318,327],"by":[319,328],"O'Connor":[320],"castrated":[323],"Hershberger,":[329],"both":[330],"subject":[335],"current":[337],"international":[338,374],"study.":[339],"decision":[345],"usefulness":[348],"must":[355],"await":[356],"generation":[358],"data":[361],"each":[363],"these":[365],"three":[366],"assays.":[367,399],"There":[368],"an":[370],"urgent":[371],"need":[372],"agreement":[375],"list":[378],"reference":[380],"their":[384],"active":[385],"levels,":[387],"validate":[391],"individual":[392],"disruption":[394],"batteries":[397]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}