{"id":"https://openalex.org/W1990959166","doi":"https://doi.org/10.1210/jcem-15-1-22","title":"THE CONCENTRATION OF RELAXIN IN THE BLOOD SERUM AND OTHER TISSUES OF WOMEN DURING PREGNANCY*","display_name":"THE CONCENTRATION OF RELAXIN IN THE BLOOD SERUM AND OTHER TISSUES OF WOMEN DURING PREGNANCY*","publication_year":1955,"publication_date":"1955-01-01","ids":{"openalex":"https://openalex.org/W1990959166","doi":"https://doi.org/10.1210/jcem-15-1-22","mag":"1990959166","pmid":"https://pubmed.ncbi.nlm.nih.gov/13221624"},"language":"en","primary_location":{"id":"doi:10.1210/jcem-15-1-22","doi":"https://doi.org/10.1210/jcem-15-1-22","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-15-1-22","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035834414","display_name":"MEYER X. ZARROW","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. X. ZARROW","raw_affiliation_strings":["The Department of Biological Sciences, Purdue University Lafayette, Indiana; Department of Obstetrics and Gynecology, University of Utah School of Medicine Salt Lake City, Utah","Department of Obstetrics and Gynecology, University of Utah School of Medicine Salt Lake City, Utah","The Department of Biological Sciences, Purdue University Lafayette, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Biological Sciences, Purdue University Lafayette, Indiana; Department of Obstetrics and Gynecology, University of Utah School of Medicine Salt Lake City, Utah","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Utah School of Medicine Salt Lake City, Utah","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"The Department of Biological Sciences, Purdue University Lafayette, Indiana","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070388698","display_name":"Emil G. Holmstrom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. G. HOLMSTROM","raw_affiliation_strings":["The Department of Biological Sciences, Purdue University Lafayette, Indiana; Department of Obstetrics and Gynecology, University of Utah School of Medicine Salt Lake City, Utah","Department of Obstetrics and Gynecology, University of Utah School of Medicine Salt Lake City, Utah","The Department of Biological Sciences, Purdue University Lafayette, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Biological Sciences, Purdue University Lafayette, Indiana; Department of Obstetrics and Gynecology, University of Utah School of Medicine Salt Lake City, Utah","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Utah School of Medicine Salt Lake City, Utah","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"The Department of Biological Sciences, Purdue University Lafayette, Indiana","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059421223","display_name":"Hilton A. Salhanick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. A. SALHANICK","raw_affiliation_strings":["The Department of Biological Sciences, Purdue University Lafayette, Indiana; Department of Obstetrics and Gynecology, University of Utah School of Medicine Salt Lake City, Utah","Department of Obstetrics and Gynecology, University of Utah School of Medicine Salt Lake City, Utah","The Department of Biological Sciences, Purdue University Lafayette, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Biological Sciences, Purdue University Lafayette, Indiana; Department of Obstetrics and Gynecology, University of Utah School of Medicine Salt Lake City, Utah","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Utah School of Medicine Salt Lake City, Utah","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"The Department of Biological Sciences, Purdue University Lafayette, Indiana","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I223532165"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":19.6403,"has_fulltext":false,"cited_by_count":80,"citation_normalized_percentile":{"value":0.99343976,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"15","issue":"1","first_page":"22","last_page":"27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12715","display_name":"Pregnancy-related medical research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12715","display_name":"Pregnancy-related medical research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/relaxin","display_name":"relaxin","score":1.0},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.921999990940094},{"id":"https://openalex.org/keywords/childbirth","display_name":"childbirth","score":0.9589999914169312},{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":0.9359999895095825},{"id":"https://openalex.org/keywords/diabetes-in-pregnancy","display_name":"diabetes in pregnancy","score":0.7630000114440918},{"id":"https://openalex.org/keywords/pregnancy-hormones","display_name":"pregnancy hormones","score":0.49799999594688416},{"id":"https://openalex.org/keywords/human-pregnancy","display_name":"human pregnancy","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C2777121736","wikidata":"https://www.wikidata.org/wiki/Q24773888","display_name":"Relaxin","level":3,"score":0.9852749109268188},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.8394104242324829},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.7211825847625732},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5514904856681824},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5219204425811768},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4871666133403778},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4460785388946533},{"id":"https://openalex.org/C2994136372","wikidata":"https://www.wikidata.org/wiki/Q110084","display_name":"Blood serum","level":2,"score":0.413574755191803},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4092864990234375},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.375093549489975},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.270449161529541},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001769","descriptor_name":"Blood","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012065","descriptor_name":"Relaxin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D044967","descriptor_name":"Serum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1210/jcem-15-1-22","doi":"https://doi.org/10.1210/jcem-15-1-22","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-15-1-22","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},{"id":"pmid:13221624","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13221624","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1015143126","https://openalex.org/W1166905297","https://openalex.org/W1498870602","https://openalex.org/W1555611632","https://openalex.org/W1998157358","https://openalex.org/W2034723427","https://openalex.org/W2043194840","https://openalex.org/W2044572072","https://openalex.org/W2049798120","https://openalex.org/W2059606721","https://openalex.org/W2109499991","https://openalex.org/W2121946322","https://openalex.org/W2152188213","https://openalex.org/W2317848883","https://openalex.org/W2321048056","https://openalex.org/W2321984629","https://openalex.org/W2324882944","https://openalex.org/W2325157381","https://openalex.org/W2416632697"],"related_works":["https://openalex.org/W2121946322","https://openalex.org/W2321984629","https://openalex.org/W2008587465","https://openalex.org/W1984467148","https://openalex.org/W2395072354","https://openalex.org/W2399335320","https://openalex.org/W2419419304","https://openalex.org/W2107449144","https://openalex.org/W1989377155","https://openalex.org/W2149170291"],"abstract_inverted_index":{"INVESTIGATIONS":[0],"on":[1,28],"the":[2,29,35,47,50,54,60,63,82,91,99,110,118,133,144],"physiology":[3],"of":[4,13,31,44,49,62,94,112,115,121,130,148],"relaxin":[5,45,86,114,149],"would":[6],"indicate":[7],"that":[8],"it":[9],"is":[10,73],"a":[11,71,107,124],"hormone":[12,33],"pregnancy":[14,69,95,122,153],"(1,":[15],"2).":[16],"Additional":[17],"evidence":[18],"for":[19],"this":[20,32],"concept":[21],"may":[22],"be":[23],"obtained":[24],"also":[25],"from":[26],"studies":[27],"presence":[30],"in":[34,46,59,90,98,109,117,150],"blood":[36,48,145],"and":[37,53,58,75,123,154,164],"other":[38],"tissues":[39],"during":[40,68],"gestation.":[41],"The":[42,136],"concentration":[43],"rabbit":[51],"(3)":[52],"guinea":[55],"pig":[56],"(4)":[57],"ovary":[61],"pregnant":[64],"sow":[65],"increases":[66],"progressively":[67],"until":[70],"plateau":[72],"reached,":[74],"then":[76],"drops":[77],"precipitously":[78],"at":[79,155],"parturition.":[80,156],"In":[81,157],"human":[83],"being,":[84],"however,":[85],"has":[87],"been":[88],"detected":[89],"first":[92],"part":[93],"but":[96],"not":[97],"last":[100],"trimester":[101],"(5,":[102],"6).":[103],"Pommerenke":[104],"(6)":[105],"reported":[106],"drop":[108],"level":[111],"serum":[113,146],"women":[116,151],"fifth":[119],"month":[120],"total":[125],"absence":[126],"(at":[127],"5\u20136":[128],"ml.":[129],"serum)":[131],"by":[132,162],"eighth":[134],"month.":[135],"present":[137],"investigation":[138],"was":[139],"undertaken":[140],"to":[141],"determine":[142],"quantitatively":[143],"levels":[147],"throughout":[152],"addition,":[158],"several":[159],"pregnancies":[160],"complicated":[161],"pre-eclampsia":[163],"diabetes":[165],"were":[166],"studied.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}