{"id":"https://openalex.org/W1990956893","doi":"https://doi.org/10.1016/j.bcp.2010.11.005","title":"Stable formyl peptide receptor agonists that activate the neutrophil NADPH-oxidase identified through screening of a compound library","display_name":"Stable formyl peptide receptor agonists that activate the neutrophil NADPH-oxidase identified through screening of a compound library","publication_year":2010,"publication_date":"2010-11-22","ids":{"openalex":"https://openalex.org/W1990956893","doi":"https://doi.org/10.1016/j.bcp.2010.11.005","mag":"1990956893","pmid":"https://pubmed.ncbi.nlm.nih.gov/21095183"},"language":"en","primary_location":{"id":"doi:10.1016/j.bcp.2010.11.005","doi":"https://doi.org/10.1016/j.bcp.2010.11.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bcp.2010.11.005","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hal.science/hal-00654976","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010104292","display_name":"Huamei Fu Forsman","orcid":"https://orcid.org/0000-0002-8781-284X","observed_orcids":["https://orcid.org/0000-0002-8781-284X"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Huamei Forsman","raw_affiliation_strings":["Department of Rheumatology and Inflammation Research, Institute of Medicine, University of G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Inflammation Research, Institute of Medicine, University of G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039438134","display_name":"Christina Kalder\u00e9n","orcid":"https://orcid.org/0000-0001-7004-7048","observed_orcids":["https://orcid.org/0000-0001-7004-7048"]},"institutions":[{"id":"https://openalex.org/I4210137624","display_name":"Swedish Orphan Biovitrum (Sweden)","ror":"https://ror.org/04asvbz37","country_code":"SE","type":"company","lineage":["https://openalex.org/I4210137624"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Christina Kalder\u00e9n","raw_affiliation_strings":["Biovitrum AB, 112 76 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biovitrum AB, 112 76 Stockholm, Sweden","institution_ids":["https://openalex.org/I4210137624"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066320777","display_name":"Anna Nordin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anna Nordin","raw_affiliation_strings":["Department of Rheumatology and Inflammation Research, Institute of Medicine, University of G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Inflammation Research, Institute of Medicine, University of G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021715811","display_name":"Erik Nordling","orcid":"https://orcid.org/0000-0001-9310-7947","observed_orcids":["https://orcid.org/0000-0001-9310-7947"]},"institutions":[{"id":"https://openalex.org/I4210137624","display_name":"Swedish Orphan Biovitrum (Sweden)","ror":"https://ror.org/04asvbz37","country_code":"SE","type":"company","lineage":["https://openalex.org/I4210137624"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Erik Nordling","raw_affiliation_strings":["Biovitrum AB, 112 76 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biovitrum AB, 112 76 Stockholm, Sweden","institution_ids":["https://openalex.org/I4210137624"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037371219","display_name":"Annika Jernmalm Jensen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137624","display_name":"Swedish Orphan Biovitrum (Sweden)","ror":"https://ror.org/04asvbz37","country_code":"SE","type":"company","lineage":["https://openalex.org/I4210137624"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Annika Jernmalm Jensen","raw_affiliation_strings":["Biovitrum AB, 112 76 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biovitrum AB, 112 76 Stockholm, Sweden","institution_ids":["https://openalex.org/I4210137624"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038963650","display_name":"Cl\u00e1es Dahlgren","orcid":"https://orcid.org/0000-0002-8946-5714","observed_orcids":["https://orcid.org/0000-0002-8946-5714"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Claes Dahlgren","raw_affiliation_strings":["Department of Rheumatology and Inflammation Research, Institute of Medicine, University of G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Inflammation Research, Institute of Medicine, University of G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5038963650"],"corresponding_institution_ids":["https://openalex.org/I881427289"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":1.6238,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.83097077,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"81","issue":"3","first_page":"402","last_page":"411"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.5088000297546387,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.5088000297546387,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.2061000019311905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.20190000534057617,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/formyl-peptide-receptor-2","display_name":"formyl peptide receptor 2","score":0.8289999961853027},{"id":"https://openalex.org/keywords/fpr1","display_name":"FPR1","score":0.8420000076293945},{"id":"https://openalex.org/keywords/neutrophil-nadph-oxidase","display_name":"neutrophil NADPH oxidase","score":0.7910000085830688},{"id":"https://openalex.org/keywords/superoxide-release","display_name":"superoxide release","score":0.7570000290870667},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor-agonists","display_name":"G protein-coupled receptor agonists","score":0.8600000143051147},{"id":"https://openalex.org/keywords/intracellular-calcium-response","display_name":"intracellular calcium response","score":0.6269999742507935},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.6890000104904175},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.37700000405311584},{"id":"https://openalex.org/keywords/drug-screening","display_name":"drug screening","score":0.33000001311302185}],"concepts":[{"id":"https://openalex.org/C2776731609","wikidata":"https://www.wikidata.org/wiki/Q24782993","display_name":"Formyl peptide receptor","level":4,"score":0.730437695980072},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.7191954851150513},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.6927536129951477},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6267495155334473},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5915437340736389},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.578510046005249},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.5677481889724731},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5304322242736816},{"id":"https://openalex.org/C2780656570","wikidata":"https://www.wikidata.org/wiki/Q5090627","display_name":"N-Formylmethionine leucyl-phenylalanine","level":4,"score":0.4968269169330597},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3425874412059784},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.33977437019348145},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2541673183441162},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06981170177459717}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020536","descriptor_name":"Enzyme Activators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020536","descriptor_name":"Enzyme Activators","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044042","descriptor_name":"Receptors, Formyl Peptide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044042","descriptor_name":"Receptors, Formyl Peptide","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.bcp.2010.11.005","doi":"https://doi.org/10.1016/j.bcp.2010.11.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bcp.2010.11.005","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},{"id":"pmid:21095183","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21095183","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-00654976v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-00654976","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biochemical Pharmacology, 2010, 81 (3), pp.402. ⟨10.1016/j.bcp.2010.11.005⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:tara.tcd.ie:2262/61437","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2262/61437","pdf_url":null,"source":{"id":"https://openalex.org/S4306400387","display_name":"Trinity's Access to Research Output (TARA) (Trinity College Dublin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205274468","host_organization_name":"Trinity College Dublin","host_organization_lineage":["https://openalex.org/I205274468"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null}],"best_oa_location":{"id":"pmh:oai:HAL:hal-00654976v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-00654976","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biochemical Pharmacology, 2010, 81 (3), pp.402. ⟨10.1016/j.bcp.2010.11.005⟩","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322128","display_name":"Svenska S\u00e4llskapet f\u00f6r Medicinsk Forskning","ror":"https://ror.org/0433fd238"},{"id":"https://openalex.org/F4320322215","display_name":"IngaBritt och Arne Lundbergs Forskningsstiftelse","ror":"https://ror.org/049zxm836"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320324738","display_name":"Stiftelsen Konung Gustaf V:s 80-\u00e5rsfond","ror":"https://ror.org/02szc9j24"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1495468090","https://openalex.org/W1520032219","https://openalex.org/W1534683796","https://openalex.org/W1558468202","https://openalex.org/W1575102738","https://openalex.org/W1576411973","https://openalex.org/W1608128587","https://openalex.org/W1631597983","https://openalex.org/W1968666896","https://openalex.org/W1970426618","https://openalex.org/W1976707334","https://openalex.org/W1981222457","https://openalex.org/W1990163802","https://openalex.org/W1999491936","https://openalex.org/W2002776682","https://openalex.org/W2008243630","https://openalex.org/W2016458751","https://openalex.org/W2025478043","https://openalex.org/W2029023072","https://openalex.org/W2031256148","https://openalex.org/W2045608528","https://openalex.org/W2057318783","https://openalex.org/W2062050180","https://openalex.org/W2069186231","https://openalex.org/W2084988893","https://openalex.org/W2087624900","https://openalex.org/W2091937188","https://openalex.org/W2100607138","https://openalex.org/W2101155229","https://openalex.org/W2101291779","https://openalex.org/W2103372863","https://openalex.org/W2107372340","https://openalex.org/W2108585076","https://openalex.org/W2118676031","https://openalex.org/W2122681773","https://openalex.org/W2125214740","https://openalex.org/W2125577344","https://openalex.org/W2131896212","https://openalex.org/W2132258775","https://openalex.org/W2134219545","https://openalex.org/W2137445290","https://openalex.org/W2142438877","https://openalex.org/W2145541768","https://openalex.org/W2157721575","https://openalex.org/W2158548049","https://openalex.org/W2162885959","https://openalex.org/W2164250471","https://openalex.org/W2172874896","https://openalex.org/W2215268165","https://openalex.org/W2407015583"],"related_works":["https://openalex.org/W1994936100","https://openalex.org/W3091793388","https://openalex.org/W7212378479","https://openalex.org/W1971117764","https://openalex.org/W1993980819","https://openalex.org/W2467279189","https://openalex.org/W3144540681","https://openalex.org/W2103372863","https://openalex.org/W2066871278","https://openalex.org/W2112545983"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}