{"id":"https://openalex.org/W1990908331","doi":"https://doi.org/10.1517/14728222.2013.733699","title":"Therapeutic opportunities for targeting the ubiquitous cell surface receptor CD47","display_name":"Therapeutic opportunities for targeting the ubiquitous cell surface receptor CD47","publication_year":2012,"publication_date":"2012-10-27","ids":{"openalex":"https://openalex.org/W1990908331","doi":"https://doi.org/10.1517/14728222.2013.733699","mag":"1990908331","pmid":"https://pubmed.ncbi.nlm.nih.gov/23101472","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3564224"},"language":"en","primary_location":{"id":"doi:10.1517/14728222.2013.733699","doi":"https://doi.org/10.1517/14728222.2013.733699","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14728222.2013.733699","pdf_url":null,"source":{"id":"https://openalex.org/S149756942","display_name":"Expert Opinion on Therapeutic Targets","issn_l":"1472-8222","issn":["1472-8222","1744-7631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Therapeutic Targets","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3564224","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027276690","display_name":"David R. Soto\u2010Pantoja","orcid":"https://orcid.org/0000-0003-0107-7678","observed_orcids":["https://orcid.org/0000-0003-0107-7678"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David R Soto-Pantoja","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health, Center for Cancer Research, Laboratory of Pathology, Bethesda, MD 20892-1500, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health, Center for Cancer Research, Laboratory of Pathology, Bethesda, MD 20892-1500, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059265805","display_name":"Erica V. Stein","orcid":"https://orcid.org/0000-0001-8778-8846","observed_orcids":["https://orcid.org/0000-0001-8778-8846"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erica V Stein","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health, Center for Cancer Research, Laboratory of Pathology, Bethesda, MD 20892-1500, USA; George Washington University, Microbiology and Immunology Program of the Institute for Biomedical Sciences, Departments of Microbiology, Immunology and Tropical Medicine, 2300 Eye Street, NW, Ross Hall, Washington, DC, 20037, USA","George Washington University, Microbiology and Immunology Program of the Institute for Biomedical Sciences, Departments of Microbiology, Immunology and Tropical Medicine,\n2300 Eye Street, NW, Ross Hall, Washington, DC, 20037, USA","National Cancer Institute, National Institutes of Health, Center for Cancer Research, Laboratory of Pathology,\nBethesda, MD 20892-1500, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health, Center for Cancer Research, Laboratory of Pathology, Bethesda, MD 20892-1500, USA; George Washington University, Microbiology and Immunology Program of the Institute for Biomedical Sciences, Departments of Microbiology, Immunology and Tropical Medicine, 2300 Eye Street, NW, Ross Hall, Washington, DC, 20037, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I193531525","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"George Washington University, Microbiology and Immunology Program of the Institute for Biomedical Sciences, Departments of Microbiology, Immunology and Tropical Medicine,\n2300 Eye Street, NW, Ross Hall, Washington, DC, 20037, USA","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health, Center for Cancer Research, Laboratory of Pathology,\nBethesda, MD 20892-1500, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063847581","display_name":"Natasha M. Rogers","orcid":"https://orcid.org/0000-0003-2456-9544","observed_orcids":["https://orcid.org/0000-0003-2456-9544"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natasha M Rogers","raw_affiliation_strings":["University of Pittsburgh School of Medicine, Vascular Medicine Institute, Division of Pulmonary Allergy and Critical Care Medicine, E1240 Biomedical Science Tower, Room E1200, 200 Lothrop Street, Pittsburgh, PA 15261, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh School of Medicine, Vascular Medicine Institute, Division of Pulmonary Allergy and Critical Care Medicine, E1240 Biomedical Science Tower, Room E1200, 200 Lothrop Street, Pittsburgh, PA 15261, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018560319","display_name":"Maryam Sharifi\u2010Sanjani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maryam Sharifi-Sanjani","raw_affiliation_strings":["University of Pittsburgh School of Medicine, Vascular Medicine Institute, Division of Pulmonary Allergy and Critical Care Medicine, E1240 Biomedical Science Tower, Room E1200, 200 Lothrop Street, Pittsburgh, PA 15261, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh School of Medicine, Vascular Medicine Institute, Division of Pulmonary Allergy and Critical Care Medicine, E1240 Biomedical Science Tower, Room E1200, 200 Lothrop Street, Pittsburgh, PA 15261, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029263699","display_name":"Jeffrey Scott Isenberg","orcid":"https://orcid.org/0000-0002-4221-1688","observed_orcids":["https://orcid.org/0000-0002-4221-1688"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey S Isenberg","raw_affiliation_strings":["University of Pittsburgh School of Medicine, Vascular Medicine Institute, Division of Pulmonary Allergy and Critical Care Medicine, E1240 Biomedical Science Tower, Room E1258, 200 Lothrop Street, Pittsburgh, PA 15261, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh School of Medicine, Vascular Medicine Institute, Division of Pulmonary Allergy and Critical Care Medicine, E1240 Biomedical Science Tower, Room E1258, 200 Lothrop Street, Pittsburgh, PA 15261, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031078822","display_name":"David D. Roberts","orcid":"https://orcid.org/0000-0002-2481-2981","observed_orcids":["https://orcid.org/0000-0002-2481-2981"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David D Roberts","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health, Center for Cancer Research, Laboratory of Pathology, Building 10 Room 2A33, Bethesda, MD 20892-1500, USA +301 594 5256; +301 402 0043; droberts@helix.nih.gov","+301 402 0043","National Cancer Institute, National Institutes of Health, Center for Cancer Research, Laboratory of Pathology,\nBuilding 10 Room 2A33, Bethesda, MD 20892-1500, USA +301 594 5256"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health, Center for Cancer Research, Laboratory of Pathology, Building 10 Room 2A33, Bethesda, MD 20892-1500, USA +301 594 5256; +301 402 0043; droberts@helix.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"+301 402 0043","institution_ids":[]},{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health, Center for Cancer Research, Laboratory of Pathology,\nBuilding 10 Room 2A33, Bethesda, MD 20892-1500, USA +301 594 5256","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3839,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.34109002,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"17","issue":"1","first_page":"89","last_page":"103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd47","display_name":"CD47","score":1.0},{"id":"https://openalex.org/keywords/sirpalpha","display_name":"SIRP\u03b1","score":0.953000009059906},{"id":"https://openalex.org/keywords/thrombospondin-1","display_name":"thrombospondin-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cell-surface-receptor-signaling","display_name":"cell surface receptor signaling","score":0.5979999899864197},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.5},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.7609999775886536},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.949999988079071},{"id":"https://openalex.org/keywords/organ-transplantation","display_name":"organ transplantation","score":0.9649999737739563},{"id":"https://openalex.org/keywords/pulmonary-hypertension","display_name":"pulmonary hypertension","score":0.9900000095367432},{"id":"https://openalex.org/keywords/radiation-protection","display_name":"radiation protection","score":0.953000009059906},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"tissue engineering","score":0.47200000286102295},{"id":"https://openalex.org/keywords/vascular-disease","display_name":"vascular disease","score":0.47600001096725464},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.5210000276565552},{"id":"https://openalex.org/keywords/inflammatory-diseases","display_name":"inflammatory diseases","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C2780104668","wikidata":"https://www.wikidata.org/wiki/Q21108354","display_name":"CD47","level":3,"score":0.7064359188079834},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5129587054252625},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.46012377738952637},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43631452322006226},{"id":"https://openalex.org/C197462201","wikidata":"https://www.wikidata.org/wiki/Q2476074","display_name":"Cell surface receptor","level":3,"score":0.41336894035339355},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3787700831890106},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3699381649494171},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33681148290634155},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3044997453689575},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1658743917942047},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14782491326332092}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002320","descriptor_name":"Cardiovascular Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051928","descriptor_name":"CD47 Antigen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1517/14728222.2013.733699","doi":"https://doi.org/10.1517/14728222.2013.733699","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14728222.2013.733699","pdf_url":null,"source":{"id":"https://openalex.org/S149756942","display_name":"Expert Opinion on Therapeutic Targets","issn_l":"1472-8222","issn":["1472-8222","1744-7631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Therapeutic Targets","raw_type":"journal-article"},{"id":"pmid:23101472","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23101472","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on therapeutic targets","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3564224","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3564224","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Expert Opin Ther Targets","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3564224","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3564224","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Expert Opin Ther Targets","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8399999737739563}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1660195859","display_name":"Roles of CD47 Signaling in Tumor Immunology","funder_award_id":"ZIASC009174","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G237465954","display_name":"Biodegradable Synthetic Vascular Graft","funder_award_id":"R01HL089658","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3610883892","display_name":"TSP1-CD47 in Promotion of PAH-Associated Vasoconstriction and Vascular Overgrowth","funder_award_id":"5r01hl108954-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4762513988","display_name":"Therapeutic Targeting of Vascular Subphenotypes of Lung Disease","funder_award_id":"P01HL103455","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7380604859","display_name":"TSP-1 and ROS: CD47 and SIRP-alpha as Mediators of Vascular Dysfunction","funder_award_id":"R01HL112914","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7659836770","display_name":null,"funder_award_id":"R01HL1089542","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8206519137","display_name":"Cellular Interactions with Thrombospondin","funder_award_id":"ZIASC009172","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G832719042","display_name":null,"funder_award_id":"R01HL-108954","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":139,"referenced_works":["https://openalex.org/W1481997113","https://openalex.org/W1496549373","https://openalex.org/W1497770306","https://openalex.org/W1550850348","https://openalex.org/W1577297332","https://openalex.org/W1577635103","https://openalex.org/W1592843561","https://openalex.org/W1631519520","https://openalex.org/W1647337374","https://openalex.org/W1782687244","https://openalex.org/W1943184809","https://openalex.org/W1964757399","https://openalex.org/W1964791394","https://openalex.org/W1966217032","https://openalex.org/W1971063170","https://openalex.org/W1971670260","https://openalex.org/W1972477461","https://openalex.org/W1973457181","https://openalex.org/W1974252083","https://openalex.org/W1974992164","https://openalex.org/W1975327241","https://openalex.org/W1978379971","https://openalex.org/W1978445662","https://openalex.org/W1979970110","https://openalex.org/W1981739316","https://openalex.org/W1983256461","https://openalex.org/W1986544634","https://openalex.org/W1994418185","https://openalex.org/W1995355177","https://openalex.org/W1996406153","https://openalex.org/W1997023449","https://openalex.org/W1999532278","https://openalex.org/W1999967194","https://openalex.org/W2001570963","https://openalex.org/W2004458273","https://openalex.org/W2004936937","https://openalex.org/W2006595691","https://openalex.org/W2007981025","https://openalex.org/W2009523688","https://openalex.org/W2010850700","https://openalex.org/W2011674492","https://openalex.org/W2012228368","https://openalex.org/W2013292757","https://openalex.org/W2013778759","https://openalex.org/W2015101923","https://openalex.org/W2016902922","https://openalex.org/W2017022268","https://openalex.org/W2019453934","https://openalex.org/W2019905662","https://openalex.org/W2023659339","https://openalex.org/W2026809196","https://openalex.org/W2035067948","https://openalex.org/W2035831225","https://openalex.org/W2036524028","https://openalex.org/W2036735258","https://openalex.org/W2037009561","https://openalex.org/W2037697953","https://openalex.org/W2037846718","https://openalex.org/W2038996373","https://openalex.org/W2039949492","https://openalex.org/W2040062469","https://openalex.org/W2040261887","https://openalex.org/W2040698128","https://openalex.org/W2042436980","https://openalex.org/W2043249881","https://openalex.org/W2044062220","https://openalex.org/W2044441834","https://openalex.org/W2045570844","https://openalex.org/W2052998574","https://openalex.org/W2054189988","https://openalex.org/W2054385312","https://openalex.org/W2057274775","https://openalex.org/W2059313294","https://openalex.org/W2062390638","https://openalex.org/W2062926614","https://openalex.org/W2069023227","https://openalex.org/W2073439809","https://openalex.org/W2074858207","https://openalex.org/W2081209804","https://openalex.org/W2082861282","https://openalex.org/W2083891497","https://openalex.org/W2087929503","https://openalex.org/W2088777095","https://openalex.org/W2090564308","https://openalex.org/W2091133773","https://openalex.org/W2091934608","https://openalex.org/W2091947258","https://openalex.org/W2092246736","https://openalex.org/W2092473926","https://openalex.org/W2092705900","https://openalex.org/W2094227293","https://openalex.org/W2094502174","https://openalex.org/W2096916633","https://openalex.org/W2097126393","https://openalex.org/W2097504458","https://openalex.org/W2100202350","https://openalex.org/W2100577875","https://openalex.org/W2101635856","https://openalex.org/W2101682437","https://openalex.org/W2102598871","https://openalex.org/W2103746815","https://openalex.org/W2106545303","https://openalex.org/W2106764575","https://openalex.org/W2109878500","https://openalex.org/W2110882632","https://openalex.org/W2110899236","https://openalex.org/W2113017194","https://openalex.org/W2114782912","https://openalex.org/W2119670049","https://openalex.org/W2124067042","https://openalex.org/W2124576850","https://openalex.org/W2124578279","https://openalex.org/W2125457182","https://openalex.org/W2128519451","https://openalex.org/W2129645310","https://openalex.org/W2130869560","https://openalex.org/W2131484344","https://openalex.org/W2133725847","https://openalex.org/W2135231064","https://openalex.org/W2140933978","https://openalex.org/W2142541925","https://openalex.org/W2142610113","https://openalex.org/W2144267004","https://openalex.org/W2144945558","https://openalex.org/W2146999774","https://openalex.org/W2150066073","https://openalex.org/W2153948972","https://openalex.org/W2154192697","https://openalex.org/W2154672378","https://openalex.org/W2156024443","https://openalex.org/W2157085976","https://openalex.org/W2157830017","https://openalex.org/W2163042186","https://openalex.org/W2166151208","https://openalex.org/W2167798168","https://openalex.org/W2168324886","https://openalex.org/W2211700888","https://openalex.org/W2313373597","https://openalex.org/W4313422310"],"related_works":["https://openalex.org/W4229916684","https://openalex.org/W3210629434","https://openalex.org/W4413865991","https://openalex.org/W4292560305","https://openalex.org/W2070268146","https://openalex.org/W2110899236","https://openalex.org/W4389117587","https://openalex.org/W4289444289","https://openalex.org/W3026660164","https://openalex.org/W2299543276"],"abstract_inverted_index":{"INTRODUCTION:":[0],"CD47":[1,26,52,59,94,126,154],"is":[2],"a":[3,12,64,122],"ubiquitously":[4],"expressed":[5],"cell":[6,36,136],"surface":[7],"receptor":[8,33],"that":[9,73,134],"serves":[10],"as":[11,29,63],"counter-receptor":[13],"for":[14,34,90,127],"SIRP\u03b1":[15,160],"in":[16,53,101],"recognition":[17],"of":[18,51,82,98,104,125,145,169],"self":[19],"by":[20],"the":[21,44,54,131],"innate":[22],"immune":[23,57],"system.":[24],"Independently,":[25],"also":[27],"functions":[28,50],"an":[30],"important":[31],"signaling":[32,95],"regulating":[35],"responses":[37],"to":[38,77,142],"stress.":[39,146],"AREAS":[40],"COVERED:":[41],"We":[42,85],"review":[43],"expression,":[45],"molecular":[46],"interactions,":[47],"and":[48,56,68,80,96,106,114,137,159,171,183],"pathophysiological":[49],"cardiovascular":[55],"systems.":[58],"was":[60],"first":[61],"identified":[62],"potential":[65],"tumor":[66],"marker,":[67],"we":[69],"examine":[70],"recent":[71],"evidence":[72],"its":[74,156],"dysregulation":[75],"contributes":[76],"cancer":[78],"progression":[79],"evasion":[81],"anti-tumor":[83],"immunity.":[84],"further":[86],"discuss":[87],"therapeutic":[88],"strategies":[89],"enhancing":[91],"or":[92,155],"inhibiting":[93],"applications":[97,164],"such":[99],"agents":[100],"preclinical":[102],"models":[103],"ischemia":[105],"ischemia/reperfusion":[107],"injuries,":[108,180],"organ":[109,177],"transplantation,":[110,178],"pulmonary":[111],"hypertension,":[112],"radioprotection,":[113],"cancer.":[115,184],"EXPERT":[116],"OPINION:":[117],"Ongoing":[118],"studies":[119],"are":[120],"revealing":[121],"central":[123],"role":[124],"conveying":[128],"signals":[129],"from":[130],"extracellular":[132],"microenvironment":[133],"limit":[135],"tissue":[138],"survival":[139],"upon":[140],"exposure":[141],"various":[143],"types":[144],"Based":[147],"on":[148],"this":[149],"key":[150],"function,":[151],"therapeutics":[152],"targeting":[153],"ligands":[157],"thrombospondin-1":[158],"could":[161],"have":[162],"broad":[163],"spanning":[165],"reconstructive":[166],"surgery,":[167],"engineering":[168],"tissues":[170],"biocompatible":[172],"surfaces,":[173],"vascular":[174],"diseases,":[175,182],"diabetes,":[176],"radiation":[179],"inflammatory":[181]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}