{"id":"https://openalex.org/W1990904097","doi":"https://doi.org/10.1371/journal.pone.0032227","title":"Coupled Analysis of In Vitro and Histology Tissue Samples to Quantify Structure-Function Relationship","display_name":"Coupled Analysis of In Vitro and Histology Tissue Samples to Quantify Structure-Function Relationship","publication_year":2012,"publication_date":"2012-03-30","ids":{"openalex":"https://openalex.org/W1990904097","doi":"https://doi.org/10.1371/journal.pone.0032227","mag":"1990904097","pmid":"https://pubmed.ncbi.nlm.nih.gov/22479315","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3316529"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0032227","doi":"https://doi.org/10.1371/journal.pone.0032227","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0032227","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0032227&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0032227&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046236337","display_name":"Evrim Acar","orcid":"https://orcid.org/0000-0002-3737-292X","observed_orcids":["https://orcid.org/0000-0002-3737-292X"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Evrim Acar","raw_affiliation_strings":["Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, Denmark","Faculty of Life Sciences, Univ. of Copenhagen, Frederiksberg C, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Faculty of Life Sciences, Univ. of Copenhagen, Frederiksberg C, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015163321","display_name":"George E. Plopper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George E. Plopper","raw_affiliation_strings":["Department of Biology, Rensselaer Polytechnic Institute, Troy, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Rensselaer Polytechnic Institute, Troy, New York, United States of America","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073676361","display_name":"B\u00fclent Yener","orcid":"https://orcid.org/0000-0003-3989-6097","observed_orcids":["https://orcid.org/0000-0003-3989-6097"]},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"B\u00fclent Yener","raw_affiliation_strings":["Department of Computer Science, Rensselaer Polytechnic Institute, Troy, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Rensselaer Polytechnic Institute, Troy, New York, United States of America","institution_ids":["https://openalex.org/I165799507"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5073676361"],"corresponding_institution_ids":["https://openalex.org/I165799507"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.7535,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.86484286,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"7","issue":"3","first_page":"e32227","last_page":"e32227"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.6621000170707703,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.6621000170707703,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.10499999672174454,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12536","display_name":"Topological and Geometric Data Analysis","score":0.08619999885559082,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/structure-function-relationship","display_name":"structure-function relationship","score":0.9570000171661377},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"tissue engineering","score":0.531000018119812},{"id":"https://openalex.org/keywords/in-vitro-cell-culture-model","display_name":"in vitro cell culture model","score":0.8180000185966492},{"id":"https://openalex.org/keywords/histology","display_name":"histology","score":0.8140000104904175},{"id":"https://openalex.org/keywords/fluorescence-imaging","display_name":"fluorescence imaging","score":0.6850000023841858},{"id":"https://openalex.org/keywords/graph-theory","display_name":"graph theory","score":0.828000009059906},{"id":"https://openalex.org/keywords/matrix-factorization","display_name":"matrix factorization","score":0.7570000290870667},{"id":"https://openalex.org/keywords/tensor-decomposition","display_name":"tensor decomposition","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cancer-detection","display_name":"cancer detection","score":0.7770000100135803},{"id":"https://openalex.org/keywords/brain-tissue","display_name":"brain tissue","score":0.9449999928474426},{"id":"https://openalex.org/keywords/breast-tissue","display_name":"breast tissue","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bone","display_name":"bone","score":0.9929999709129333}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.568087100982666},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5342791080474854},{"id":"https://openalex.org/C2983453321","wikidata":"https://www.wikidata.org/wiki/Q40397","display_name":"Biological tissue","level":2,"score":0.48952993750572205},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.47770312428474426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42192861437797546},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4198800027370453},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.41520076990127563},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38345372676849365},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3684607446193695},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3515847325325012},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.2468232810497284},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.22363343834877014},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20520904660224915},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13824522495269775},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12445992231369019},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008953","descriptor_name":"Models, Anatomic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0032227","doi":"https://doi.org/10.1371/journal.pone.0032227","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0032227","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0032227&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2327228","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3316529","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3316529","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3316529","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:22479315","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22479315","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire/754f9851-078d-447f-9bf4-b944ac6ce267","doi":null,"is_oa":true,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/754f9851-078d-447f-9bf4-b944ac6ce267","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evrim, A A, Plopper, G E & Yener, B 2012, 'Coupled analysis of in vitro and histology tissue samples to quantify structure-function relationship', P L o S One, vol. 7, no. 3. https://doi.org/10.1371/journal.pone.0032227","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:873b3078fcab41099b8c2a4663e44296","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/873b3078fcab41099b8c2a4663e44296","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 3, p e32227 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0032227","doi":"https://doi.org/10.1371/journal.pone.0032227","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0032227","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0032227&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5095367927","display_name":"A Computational Approach To Closing The Gap Between Tissue Structure And Function","funder_award_id":"R01EB008016","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320310490","display_name":"Villum Fonden","ror":"https://ror.org/007ww2d15"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990904097.pdf","grobid_xml":"https://content.openalex.org/works/W1990904097.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1568769222","https://openalex.org/W1580960713","https://openalex.org/W1632866817","https://openalex.org/W1979614424","https://openalex.org/W1983922466","https://openalex.org/W1990478471","https://openalex.org/W1994219736","https://openalex.org/W2000215628","https://openalex.org/W2007147765","https://openalex.org/W2018337293","https://openalex.org/W2020763802","https://openalex.org/W2024165284","https://openalex.org/W2024632790","https://openalex.org/W2027123781","https://openalex.org/W2033234872","https://openalex.org/W2057343036","https://openalex.org/W2065281378","https://openalex.org/W2084705412","https://openalex.org/W2091410499","https://openalex.org/W2094786692","https://openalex.org/W2103243046","https://openalex.org/W2111324774","https://openalex.org/W2112737775","https://openalex.org/W2121739212","https://openalex.org/W2124833098","https://openalex.org/W2126563020","https://openalex.org/W2132048066","https://openalex.org/W2134772683","https://openalex.org/W2140862024","https://openalex.org/W2144012133","https://openalex.org/W2144349513","https://openalex.org/W2144705783","https://openalex.org/W2150430828","https://openalex.org/W2153547712","https://openalex.org/W2161627936","https://openalex.org/W2161634498","https://openalex.org/W2293933553","https://openalex.org/W2406134447","https://openalex.org/W6993175652"],"related_works":["https://openalex.org/W2274507790","https://openalex.org/W2018337293","https://openalex.org/W1659390021","https://openalex.org/W2083862851","https://openalex.org/W7116835001","https://openalex.org/W3212300666","https://openalex.org/W2571028265","https://openalex.org/W4282932161","https://openalex.org/W4392307021","https://openalex.org/W6912653210"],"abstract_inverted_index":{"The":[0],"structure/function":[1,41],"relationship":[2],"is":[3,138],"fundamental":[4],"to":[5,94,117],"our":[6,135,201],"understanding":[7],"of":[8,32,48,102,109,112,121,134,146,159,170,184,191,209],"biological":[9,33,52,72,97],"systems":[10],"at":[11,28,54],"all":[12],"levels,":[13],"and":[14,24,57,106,148,162,172,177,188,194,212],"drives":[15],"most,":[16],"if":[17],"not":[18],"all,":[19],"techniques":[20,202],"for":[21],"detecting,":[22],"diagnosing,":[23],"treating":[25],"disease.":[26],"However,":[27],"the":[29,40,55,69,119,132,163,168,206],"tissue":[30,92,104,160],"level":[31],"complexity":[34],"we":[35,60,83],"encounter":[36],"a":[37,65,143,182],"gap":[38,82],"in":[39,64,122,149,167,215],"relationship:":[42],"having":[43],"accumulated":[44],"an":[45],"extraordinary":[46],"amount":[47],"detailed":[49],"information":[50,81],"about":[51],"tissues":[53,211],"cellular":[56],"subcellular":[58],"level,":[59],"cannot":[61],"assemble":[62],"it":[63],"way":[66],"that":[67,90,200],"explains":[68],"correspondingly":[70],"complex":[71],"functions":[73],"these":[74],"structures":[75,161],"perform.":[76],"To":[77,131],"help":[78],"close":[79],"this":[80],"define":[84],"here":[85],"several":[86],"quantitative":[87,144],"temperospatial":[88],"features":[89],"link":[91],"structure":[93],"its":[95],"corresponding":[96,128,214],"function.":[98],"Both":[99],"histological":[100],"images":[101,108],"human":[103,113,129],"samples":[105],"fluorescence":[107],"three-dimensional":[110],"cultures":[111],"cells":[114],"are":[115,153,165],"used":[116],"compare":[118],"accuracy":[120],"vitro":[123,150,216],"culture":[124,219],"models":[125],"with":[126,181],"their":[127,213],"tissues.":[130,196],"best":[133],"knowledge,":[136],"there":[137],"no":[139],"prior":[140],"work":[141],"on":[142],"comparison":[145],"histology":[147],"samples.":[151],"Features":[152],"calculated":[154],"from":[155],"graph":[156],"theoretical":[157],"representations":[158],"data":[164],"analyzed":[166],"form":[169],"matrices":[171],"higher-order":[173],"tensors":[174],"using":[175],"matrix":[176],"tensor":[178],"factorization":[179],"methods,":[180],"goal":[183],"differentiating":[185],"between":[186,205],"cancerous":[187],"healthy":[189],"states":[190],"brain,":[192],"breast,":[193],"bone":[195],"We":[197],"also":[198],"show":[199],"can":[203],"differentiate":[204],"structural":[207],"organization":[208],"native":[210],"engineered":[217],"cell":[218],"models.":[220]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
