{"id":"https://openalex.org/W1990899009","doi":"https://doi.org/10.1016/0006-2952(94)90452-9","title":"Role of thiol homeostasis and adenine nucleotide metabolism in the protective effects of fructose in quinone-induced cytotoxicity in rat hepatocytes","display_name":"Role of thiol homeostasis and adenine nucleotide metabolism in the protective effects of fructose in quinone-induced cytotoxicity in rat hepatocytes","publication_year":1994,"publication_date":"1994-11-01","ids":{"openalex":"https://openalex.org/W1990899009","doi":"https://doi.org/10.1016/0006-2952(94)90452-9","mag":"1990899009","pmid":"https://pubmed.ncbi.nlm.nih.gov/7980636"},"language":"en","primary_location":{"id":"doi:10.1016/0006-2952(94)90452-9","doi":"https://doi.org/10.1016/0006-2952(94)90452-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-2952(94)90452-9","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056108651","display_name":"Corike Toxopeus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Corike Toxopeus","raw_affiliation_strings":["Research Institute of Toxicology (RITOX), Utrecht University, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Toxicology (RITOX), Utrecht University, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083721213","display_name":"Ineke van Holsteijn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ineke van Holsteijn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049641098","display_name":"Menno P.J. de Winther","orcid":"https://orcid.org/0000-0002-4038-6636","observed_orcids":["https://orcid.org/0000-0002-4038-6636"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Menno P.J. de Winther","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066489599","display_name":"Diels van den Dobbelsteen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diels Van Den Dobbelsteen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007867404","display_name":"G. Jean Horbach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G.J.M. Jean Horbach","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006145213","display_name":"Bas J. Blaauboer","orcid":"https://orcid.org/0000-0002-0108-2402","observed_orcids":["https://orcid.org/0000-0002-0108-2402"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bas J. Blaauboer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5065928316","display_name":"Jan Noordhoek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jan Noordhoek","raw_affiliation_strings":["Dept of Toxicology, University of Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands","Research Institute of Toxicology (RITOX), Utrecht University, PO Box 80.176, 3508 TD Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Toxicology, University of Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427"]},{"raw_affiliation_string":"Research Institute of Toxicology (RITOX), Utrecht University, PO Box 80.176, 3508 TD Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5056108651"],"corresponding_institution_ids":["https://openalex.org/I193662353"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":2.2908,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.84794696,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":"9","first_page":"1683","last_page":"1692"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.586899995803833,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.586899995803833,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.24320000410079956,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.1143999993801117,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fructose","display_name":"fructose","score":0.8949999809265137},{"id":"https://openalex.org/keywords/quinone-toxicity","display_name":"quinone toxicity","score":0.7419999837875366},{"id":"https://openalex.org/keywords/menadione","display_name":"menadione","score":0.9919999837875366},{"id":"https://openalex.org/keywords/1-4-naphthoquinone","display_name":"1,4-naphthoquinone","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.8009999990463257},{"id":"https://openalex.org/keywords/thiol-homeostasis","display_name":"thiol homeostasis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/glutathione-disulfide","display_name":"glutathione disulfide","score":0.9490000009536743},{"id":"https://openalex.org/keywords/adenine-nucleotides","display_name":"adenine nucleotides","score":0.8339999914169312},{"id":"https://openalex.org/keywords/atp","display_name":"ATP","score":0.7400000095367432},{"id":"https://openalex.org/keywords/adenylate-energy-charge","display_name":"energy charge","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.6610000133514404},{"id":"https://openalex.org/keywords/redox-cycling","display_name":"redox cycling","score":0.7860000133514404},{"id":"https://openalex.org/keywords/lactic-acid-production","display_name":"lactic acid production","score":0.5379999876022339},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.3149999976158142}],"concepts":[{"id":"https://openalex.org/C2781095387","wikidata":"https://www.wikidata.org/wiki/Q192471","display_name":"Menadione","level":3,"score":0.9439268112182617},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.7546599507331848},{"id":"https://openalex.org/C3075310","wikidata":"https://www.wikidata.org/wiki/Q356718","display_name":"Energy charge","level":4,"score":0.7461814284324646},{"id":"https://openalex.org/C2776970464","wikidata":"https://www.wikidata.org/wiki/Q122043","display_name":"Fructose","level":2,"score":0.666039764881134},{"id":"https://openalex.org/C2994266630","wikidata":"https://www.wikidata.org/wiki/Q424021","display_name":"Adenine nucleotide","level":4,"score":0.6179114580154419},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.565363883972168},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5315040946006775},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.5145818591117859},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5036632418632507},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.4042012691497803},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.3175390958786011},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08891364932060242},{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.06543800234794617},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.05603468418121338},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000227","descriptor_name":"Adenine Nucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005632","descriptor_name":"Fructose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009285","descriptor_name":"Naphthoquinones","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D013438","descriptor_name":"Sulfhydryl Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014812","descriptor_name":"Vitamin K","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/0006-2952(94)90452-9","doi":"https://doi.org/10.1016/0006-2952(94)90452-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-2952(94)90452-9","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},{"id":"pmid:7980636","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7980636","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical pharmacology","raw_type":"Journal Article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/91cfbcee-bbce-4f48-a7e6-780a7a348fc1","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/role-of-thiol-homeostasis-and-adenine-nucleotide-metabolism-in-the-protective-effects-of-fructose-in-quinoneinduced-cytotoxicity-in-rat-hepatocytes(91cfbcee-bbce-4f48-a7e6-780a7a348fc1).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biochemical pharmacology, 48(9), 1682 - 1692. Elsevier Inc.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/5e41337c-f2e1-4388-9902-b7ed9dbc022f","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/5e41337c-f2e1-4388-9902-b7ed9dbc022f","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Toxopeus, C, van Holsteijn, I, de Winther, M P, van den Dobbelsteen, D, Horbach, G J, Blaauboer, B J & Noordhoek, J 1994, 'Role of thiol homeostasis and adenine nucleotide metabolism in the protective effects of fructose in quinone-induced cytotoxicity in rat hepatocytes', Biochemical pharmacology, vol. 48, no. 9, pp. 1682-1692. https://doi.org/10.1016/0006-2952(94)90452-9","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W138310767","https://openalex.org/W150246076","https://openalex.org/W175713055","https://openalex.org/W248833920","https://openalex.org/W591690468","https://openalex.org/W1490154674","https://openalex.org/W1533084749","https://openalex.org/W1537037928","https://openalex.org/W1548077438","https://openalex.org/W1566830427","https://openalex.org/W1593547522","https://openalex.org/W1599255220","https://openalex.org/W1775749144","https://openalex.org/W1839383719","https://openalex.org/W1921034080","https://openalex.org/W1972909321","https://openalex.org/W1984806653","https://openalex.org/W1988426946","https://openalex.org/W1988951065","https://openalex.org/W1989890429","https://openalex.org/W1991532823","https://openalex.org/W1993295697","https://openalex.org/W2006370393","https://openalex.org/W2010977373","https://openalex.org/W2023461311","https://openalex.org/W2025793174","https://openalex.org/W2028479043","https://openalex.org/W2037776985","https://openalex.org/W2048894296","https://openalex.org/W2049453944","https://openalex.org/W2062602696","https://openalex.org/W2063576996","https://openalex.org/W2070360049","https://openalex.org/W2070368181","https://openalex.org/W2072573383","https://openalex.org/W2085605190","https://openalex.org/W2155174050","https://openalex.org/W2160487932","https://openalex.org/W2162193265","https://openalex.org/W2176711926","https://openalex.org/W2260383328","https://openalex.org/W2297084781","https://openalex.org/W2330578975","https://openalex.org/W2434842666","https://openalex.org/W2500975048","https://openalex.org/W2520555365","https://openalex.org/W3215619572","https://openalex.org/W4240329821","https://openalex.org/W4285719527","https://openalex.org/W6727019548","https://openalex.org/W7073994143"],"related_works":["https://openalex.org/W2070368181","https://openalex.org/W2072573383","https://openalex.org/W1595656597","https://openalex.org/W1996229994","https://openalex.org/W2080212977","https://openalex.org/W2067238258","https://openalex.org/W2038039620","https://openalex.org/W1998431913","https://openalex.org/W1973830078","https://openalex.org/W2155174050"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}