{"id":"https://openalex.org/W1990877618","doi":"https://doi.org/10.1118/1.4852875","title":"Quantitative ultrasound characterization of locally advanced breast cancer by estimation of its scatterer properties","display_name":"Quantitative ultrasound characterization of locally advanced breast cancer by estimation of its scatterer properties","publication_year":2014,"publication_date":"2014-01-02","ids":{"openalex":"https://openalex.org/W1990877618","doi":"https://doi.org/10.1118/1.4852875","mag":"1990877618","pmid":"https://pubmed.ncbi.nlm.nih.gov/24387530"},"language":"en","primary_location":{"id":"doi:10.1118/1.4852875","doi":"https://doi.org/10.1118/1.4852875","is_oa":false,"landing_page_url":"https://doi.org/10.1118/1.4852875","pdf_url":null,"source":{"id":"https://openalex.org/S95522064","display_name":"Medical Physics","issn_l":"0094-2405","issn":["0094-2405","1522-8541","2473-4209"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Physics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044517600","display_name":"Hadi Tadayyon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I4391768120","display_name":"Sunnybrook Research Institute","ror":"https://ror.org/05n0tzs53","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Hadi Tadayyon","raw_affiliation_strings":["Physical Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada and Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario M5G 2M9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physical Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada and Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario M5G 2M9, Canada","institution_ids":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017745259","display_name":"Ali Sadeghi Naini","orcid":"https://orcid.org/0000-0001-5055-339X","observed_orcids":["https://orcid.org/0000-0001-5055-339X"]},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I4210167439","display_name":"Sunnybrook Hospital","ror":"https://ror.org/008kn1a71","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004","https://openalex.org/I4210167439"]},{"id":"https://openalex.org/I4391768120","display_name":"Sunnybrook Research Institute","ror":"https://ror.org/05n0tzs53","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120"]},{"id":"https://openalex.org/I4405271711","display_name":"Odette Cancer Centre","ror":"https://ror.org/02ww1s787","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004","https://openalex.org/I4405271711"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ali Sadeghi-Naini","raw_affiliation_strings":["Physical Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario M5G 2M9, Canada; Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada; and Department of Radiation Oncology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5T 1P5, Canada","Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario M5G 2M9, Canada","Department of Radiation Oncology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5T 1P5, Canada","Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada","Physical Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physical Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario M5G 2M9, Canada; Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada; and Department of Radiation Oncology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5T 1P5, Canada","institution_ids":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120","https://openalex.org/I4405271711"]},{"raw_affiliation_string":"Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario M5G 2M9, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Radiation Oncology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5T 1P5, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada","institution_ids":["https://openalex.org/I1323843004","https://openalex.org/I4210167439","https://openalex.org/I4405271711"]},{"raw_affiliation_string":"Physical Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada","institution_ids":["https://openalex.org/I1323843004","https://openalex.org/I4391768120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070669210","display_name":"Lauren A. Wirtzfeld","orcid":"https://orcid.org/0000-0003-4729-4184","observed_orcids":["https://orcid.org/0000-0003-4729-4184"]},"institutions":[{"id":"https://openalex.org/I530967","display_name":"Toronto Metropolitan University","ror":"https://ror.org/05g13zd79","country_code":"CA","type":"education","lineage":["https://openalex.org/I530967"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lauren Wirtzfeld","raw_affiliation_strings":["Department of Physics, Ryerson University, Toronto, Ontario M5B 2K3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Ryerson University, Toronto, Ontario M5B 2K3, Canada","institution_ids":["https://openalex.org/I530967"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039283573","display_name":"Frances Catriona Wright","orcid":"https://orcid.org/0000-0003-1904-4997","observed_orcids":["https://orcid.org/0000-0003-1904-4997"]},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Frances C. Wright","raw_affiliation_strings":["Division of Surgical Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgical Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada","institution_ids":["https://openalex.org/I1323843004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068273693","display_name":"Gregory Jan Czarnota","orcid":"https://orcid.org/0000-0002-0519-2182","observed_orcids":["https://orcid.org/0000-0002-0519-2182"]},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I4210167439","display_name":"Sunnybrook Hospital","ror":"https://ror.org/008kn1a71","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004","https://openalex.org/I4210167439"]},{"id":"https://openalex.org/I4391768120","display_name":"Sunnybrook Research Institute","ror":"https://ror.org/05n0tzs53","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120"]},{"id":"https://openalex.org/I4405271711","display_name":"Odette Cancer Centre","ror":"https://ror.org/02ww1s787","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004","https://openalex.org/I4405271711"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Gregory Czarnota","raw_affiliation_strings":["Physical Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario M5G 2M9, Canada; Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada; and Department of Radiation Oncology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5T 1P5, Canada","Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario M5G 2M9, Canada","Department of Radiation Oncology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5T 1P5, Canada","Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada","Physical Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physical Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario M5G 2M9, Canada; Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada; and Department of Radiation Oncology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5T 1P5, Canada","institution_ids":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120","https://openalex.org/I4405271711"]},{"raw_affiliation_string":"Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario M5G 2M9, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Radiation Oncology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5T 1P5, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada","institution_ids":["https://openalex.org/I1323843004","https://openalex.org/I4210167439","https://openalex.org/I4405271711"]},{"raw_affiliation_string":"Physical Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada","institution_ids":["https://openalex.org/I1323843004","https://openalex.org/I4391768120"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5068273693"],"corresponding_institution_ids":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4210167439","https://openalex.org/I4391768120","https://openalex.org/I4405271711"],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":null,"fwci":6.6843,"has_fulltext":false,"cited_by_count":79,"citation_normalized_percentile":{"value":0.97362993,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"41","issue":"1","first_page":"012903","last_page":"012903"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10727","display_name":"Ultrasound Imaging and Elastography","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10727","display_name":"Ultrasound Imaging and Elastography","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11739","display_name":"Microwave Imaging and Scattering Analysis","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/locally-advanced-breast-cancer","display_name":"locally advanced breast cancer","score":0.9470000267028809},{"id":"https://openalex.org/keywords/quantitative-ultrasound","display_name":"quantitative ultrasound","score":0.9629999995231628},{"id":"https://openalex.org/keywords/tumor-grading","display_name":"tumor grading","score":0.7139999866485596},{"id":"https://openalex.org/keywords/power-spectrum","display_name":"power spectrum","score":0.5180000066757202},{"id":"https://openalex.org/keywords/effective-scatterer-diameter","display_name":"effective scatterer diameter","score":0.9120000004768372},{"id":"https://openalex.org/keywords/texture-analysis","display_name":"texture analysis","score":0.6200000047683716},{"id":"https://openalex.org/keywords/gray-level-co-occurrence-matrix","display_name":"gray level co-occurrence matrix","score":0.9470000267028809},{"id":"https://openalex.org/keywords/radio-frequency-data","display_name":"radiofrequency data","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.7302256226539612},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6446409225463867},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4476970434188843},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3853225111961365},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.35218507051467896},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2962622344493866},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2899794578552246},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016217","descriptor_name":"Ultrasonography, Mammary","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D060787","descriptor_name":"Neoplasm Grading","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1118/1.4852875","doi":"https://doi.org/10.1118/1.4852875","is_oa":false,"landing_page_url":"https://doi.org/10.1118/1.4852875","pdf_url":null,"source":{"id":"https://openalex.org/S95522064","display_name":"Medical Physics","issn_l":"0094-2405","issn":["0094-2405","1522-8541","2473-4209"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Physics","raw_type":"journal-article"},{"id":"pmid:24387530","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24387530","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical physics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320311055","display_name":"Cancer Care Ontario","ror":"https://ror.org/029n6xw55"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W168125358","https://openalex.org/W267005183","https://openalex.org/W1565508804","https://openalex.org/W1597732836","https://openalex.org/W1970329024","https://openalex.org/W1991232756","https://openalex.org/W1995492257","https://openalex.org/W1999025788","https://openalex.org/W2012126091","https://openalex.org/W2013004258","https://openalex.org/W2015486895","https://openalex.org/W2018834500","https://openalex.org/W2026249247","https://openalex.org/W2027367559","https://openalex.org/W2039298557","https://openalex.org/W2044465660","https://openalex.org/W2047850688","https://openalex.org/W2052266642","https://openalex.org/W2061268828","https://openalex.org/W2077377510","https://openalex.org/W2078671222","https://openalex.org/W2089972139","https://openalex.org/W2090696730","https://openalex.org/W2095420574","https://openalex.org/W2096469096","https://openalex.org/W2097392662","https://openalex.org/W2128824469","https://openalex.org/W2130379066","https://openalex.org/W2130927761","https://openalex.org/W2131199218","https://openalex.org/W2145901183","https://openalex.org/W2147634472","https://openalex.org/W2152483762","https://openalex.org/W2153467118","https://openalex.org/W2157758913","https://openalex.org/W2159610922","https://openalex.org/W2170418136","https://openalex.org/W2727255814","https://openalex.org/W2731927076"],"related_works":["https://openalex.org/W2138655098","https://openalex.org/W2136693088","https://openalex.org/W2564192137","https://openalex.org/W2794587147","https://openalex.org/W2958435669","https://openalex.org/W2947778584","https://openalex.org/W2940661981","https://openalex.org/W2996671462","https://openalex.org/W2911096962","https://openalex.org/W2044878331"],"abstract_inverted_index":{"PURPOSE:":[0],"Tumor":[1],"grading":[2],"is":[3],"an":[4],"important":[5],"part":[6],"of":[7,66,109,127,135,165,193,213,268,278,291,315,323,332],"breast":[8,28,37,53,76,80,171,345,349],"cancer":[9,54],"diagnosis":[10],"and":[11,39,46,58,72,78,91,96,123,151,157,185,197,236,250,347,353],"currently":[12],"requires":[13],"biopsy":[14],"as":[15],"its":[16],"standard.":[17],"Here,":[18],"the":[19,63,67,88,92,103,117,132,136,211,218,228,269,275,279,288,292,299,321,330,337],"authors":[20],"investigate":[21],"quantitative":[22,111,166],"ultrasound":[23,112,167,175],"parameters":[24,168,176,317,340,352],"in":[25,121],"locally":[26,51],"advanced":[27,52,230,316,351],"cancers":[29],"that":[30],"can":[31,318],"potentially":[32],"separate":[33,202],"tumors":[34,77,252,324,346],"from":[35,49,75,87,102,116,144,204,325],"normal":[36,79,124,186,205,305,326,348],"tissue":[38,125,187,206,327],"differentiate":[40],"tumor":[41,122,184,203,270,311,362],"grades.":[42],"METHODS:":[43],"Ultrasound":[44],"images":[45],"radiofrequency":[47,119],"data":[48],"42":[50],"patients":[55],"were":[56,100,114,148,161,177,240,285,307,341,357],"acquired":[57],"analyzed.":[59],"Parameters":[60],"related":[61],"to":[62,131,169,179,217,242,329,359],"linear":[64,156,333,338],"regression":[65,334,339],"power":[68],"spectrum--midband":[69],"fit,":[70],"slope,":[71],"0-MHz-intercept--were":[73],"determined":[74,150],"tissues.":[81,172],"Mean":[82],"scatterer":[83,94,199,215,234,238,257,264,281],"spacing":[84,200],"was":[85],"estimated":[86,101],"spectral":[89],"autocorrelation,":[90],"effective":[93,97,194,214,233,263,280],"diameter":[95,216,235,282],"acoustic":[98,195],"concentration":[99,196],"Gaussian":[104],"form":[105],"factor.":[106],"Parametric":[107],"maps":[108],"each":[110],"parameter":[113],"constructed":[115],"gated":[118],"segments":[120],"regions":[126],"interest.":[128],"In":[129],"addition":[130,212],"mean":[133,198,237,289],"values":[134],"parametric":[137,283],"maps,":[138],"higher":[139],"order":[140],"statistical":[141],"features,":[142],"computed":[143],"gray-level":[145],"co-occurrence":[146],"matrices":[147],"also":[149],"used":[152],"for":[153,256,262,343],"characterization.":[154],"Finally,":[155],"quadratic":[158],"discriminant":[159],"analyses":[160],"performed":[162],"using":[163],"combinations":[164],"classify":[170],"RESULTS:":[173],"Quantitative":[174],"found":[178,241],"be":[180,243],"statistically":[181,244],"different":[182],"between":[183],"(p":[188,253,294],"<":[189],"0.05).":[190],"The":[191,266],"combination":[192,219],"could":[201],"with":[207,287],"82%":[208],"accuracy,":[209],"while":[210],"did":[220],"not":[221],"provide":[222],"significant":[223],"improvement":[224],"(83%":[225],"accuracy).":[226],"Furthermore,":[227],"two":[229],"parameters,":[231],"including":[232],"spacing,":[239,258],"differentiating":[245],"among":[246],"grade":[247,312],"I,":[248],"II,":[249],"III":[251],"=":[254,260,295],"0.014":[255],"p":[259],"0.035":[261],"diameter).":[265],"separation":[267,322],"grades":[271],"further":[272,319],"improved":[273],"when":[274],"textural":[276,355],"features":[277,356],"map":[284,293],"combined":[286],"value":[290],"0.004).":[296],"CONCLUSIONS:":[297],"Overall,":[298],"binary":[300],"classification":[301],"results":[302],"(tumor":[303],"versus":[304],"tissue)":[306],"more":[308],"promising":[309],"than":[310],"assessment.":[313],"Combinations":[314],"improve":[320],"compared":[328],"use":[331],"parameters.":[335],"While":[336],"sufficient":[342],"characterizing":[344],"tissues,":[350],"their":[354],"required":[358],"better":[360],"characterize":[361],"subtypes.":[363]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}