{"id":"https://openalex.org/W1990871468","doi":"https://doi.org/10.1111/exd.12139","title":"Expansion of epidermal progenitors with high p63 phosphorylation during wound healing of mouse epidermis","display_name":"Expansion of epidermal progenitors with high p63 phosphorylation during wound healing of mouse epidermis","publication_year":2013,"publication_date":"2013-03-20","ids":{"openalex":"https://openalex.org/W1990871468","doi":"https://doi.org/10.1111/exd.12139","mag":"1990871468","pmid":"https://pubmed.ncbi.nlm.nih.gov/23614751","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4437578"},"language":"en","primary_location":{"id":"doi:10.1111/exd.12139","doi":"https://doi.org/10.1111/exd.12139","is_oa":true,"landing_page_url":"https://doi.org/10.1111/exd.12139","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/exd.12139","source":{"id":"https://openalex.org/S158010168","display_name":"Experimental Dermatology","issn_l":"0906-6705","issn":["0906-6705","1600-0625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/exd.12139","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Daisuke Suzuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daisuke Suzuki","raw_affiliation_strings":["Department of Animal Biology Institute for Regenerative Medicine University of Pennsylvania School of Veterinary Medicine Philadelphia PA USA","University of Pennsylvania School of Veterinary Medicine Department of Animal Biology Institute for Regenerative Medicine Philadelphia PA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Biology Institute for Regenerative Medicine University of Pennsylvania School of Veterinary Medicine Philadelphia PA USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"University of Pennsylvania School of Veterinary Medicine Department of Animal Biology Institute for Regenerative Medicine Philadelphia PA USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046953707","display_name":"Makoto Senoo","orcid":"https://orcid.org/0000-0002-0155-0683","observed_orcids":["https://orcid.org/0000-0002-0155-0683"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Makoto Senoo","raw_affiliation_strings":["Department of Animal Biology Institute for Regenerative Medicine University of Pennsylvania School of Veterinary Medicine Philadelphia PA USA","University of Pennsylvania School of Veterinary Medicine Department of Animal Biology Institute for Regenerative Medicine Philadelphia PA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Biology Institute for Regenerative Medicine University of Pennsylvania School of Veterinary Medicine Philadelphia PA USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"University of Pennsylvania School of Veterinary Medicine Department of Animal Biology Institute for Regenerative Medicine Philadelphia PA USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5046953707"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":2.8196,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.87967575,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"22","issue":"5","first_page":"374","last_page":"376"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.7544000148773193,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.7544000148773193,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.14900000393390656,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.0697999969124794,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermal-progenitors","display_name":"epidermal progenitors","score":0.9599999785423279},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.8560000061988831},{"id":"https://openalex.org/keywords/epidermal-stem-cells","display_name":"epidermal stem cells","score":0.9629999995231628},{"id":"https://openalex.org/keywords/stem-cell-differentiation","display_name":"stem cell differentiation","score":0.828000009059906},{"id":"https://openalex.org/keywords/transit-amplifying-cells","display_name":"transit amplifying cells","score":0.8820000290870667},{"id":"https://openalex.org/keywords/epidermal-regeneration","display_name":"epidermal regeneration","score":0.7179999947547913},{"id":"https://openalex.org/keywords/full-thickness-wounds","display_name":"full-thickness wounds","score":0.7609999775886536},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5809999704360962},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.7679600119590759},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7400147318840027},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7172977924346924},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6906326413154602},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.6437889337539673},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6269614100456238},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5902817845344543},{"id":"https://openalex.org/C190567982","wikidata":"https://www.wikidata.org/wiki/Q7535422","display_name":"Skin repair","level":3,"score":0.4306778311729431},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.42352068424224854},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.41375887393951416},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3828412890434265},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.30156731605529785},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.15005555748939514},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.1138177216053009},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07757976651191711},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.040667176246643066},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000078404","descriptor_name":"Epidermal Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":true},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/exd.12139","doi":"https://doi.org/10.1111/exd.12139","is_oa":true,"landing_page_url":"https://doi.org/10.1111/exd.12139","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/exd.12139","source":{"id":"https://openalex.org/S158010168","display_name":"Experimental Dermatology","issn_l":"0906-6705","issn":["0906-6705","1600-0625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Dermatology","raw_type":"journal-article"},{"id":"pmid:23614751","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23614751","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental dermatology","raw_type":"Letter"},{"id":"pmh:oai:pubmedcentral.nih.gov:4437578","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4437578","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Exp Dermatol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/exd.12139","doi":"https://doi.org/10.1111/exd.12139","is_oa":true,"landing_page_url":"https://doi.org/10.1111/exd.12139","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/exd.12139","source":{"id":"https://openalex.org/S158010168","display_name":"Experimental Dermatology","issn_l":"0906-6705","issn":["0906-6705","1600-0625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Dermatology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8386551050","display_name":"Core Center","funder_award_id":"P30AR057217","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320308109","display_name":"Pennsylvania Department of Health","ror":"https://ror.org/00ra1fg11"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990871468.pdf","grobid_xml":"https://content.openalex.org/works/W1990871468.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1495963743","https://openalex.org/W1497205269","https://openalex.org/W1973697421","https://openalex.org/W1997832474","https://openalex.org/W2010807493","https://openalex.org/W2039896571","https://openalex.org/W2054127220","https://openalex.org/W2059694060","https://openalex.org/W2069466607","https://openalex.org/W2071308813","https://openalex.org/W2077446787","https://openalex.org/W2077693542","https://openalex.org/W2083881575","https://openalex.org/W2133632488","https://openalex.org/W2323343779"],"related_works":["https://openalex.org/W2952967374","https://openalex.org/W1536007208","https://openalex.org/W1986711033","https://openalex.org/W2173623840","https://openalex.org/W2593620662","https://openalex.org/W4366182202","https://openalex.org/W7020504813","https://openalex.org/W7046580978","https://openalex.org/W4385515377","https://openalex.org/W1418100287"],"abstract_inverted_index":{"The":[0],"transcription":[1],"factor":[2],"p63":[3,27,44,73,89,107,118],"plays":[4],"an":[5],"essential":[6],"role":[7],"in":[8,39,68,93,97],"maintaining":[9],"the":[10,30,48,112,128],"proliferative":[11,113],"potential":[12,114],"of":[13,26,33,115,130],"epidermal":[14,61,85,116],"stem":[15,34,78],"cells.":[16],"We":[17],"have":[18],"shown":[19],"recently":[20],"that":[21,63,84],"under":[22],"homoeostatic":[23],"conditions,":[24],"phosphorylation":[25,45,90,119],"increases":[28],"during":[29,51,134],"early":[31],"transition":[32],"cells":[35,38,62,133],"to":[36,47,65,95,126],"transit-amplifying":[37],"human":[40],"epidermis.":[41],"However,":[42],"how":[43],"relates":[46],"regenerative":[49,132],"processes":[50],"wound":[52,66,100,135],"healing":[53],"remains":[54],"unknown.":[55],"In":[56],"this":[57],"study,":[58],"we":[59],"characterize":[60],"contribute":[64],"repair":[67],"mouse":[69],"models":[70],"using":[71],"phosphorylated":[72,106],"as":[74,122],"a":[75,123],"marker":[76],"for":[77],"cell":[79],"differentiation.":[80],"Our":[81],"studies":[82],"reveal":[83],"progenitors":[86],"with":[87,111],"high":[88],"preferentially":[91],"expand":[92],"response":[94],"wounding":[96],"both":[98],"full-thickness":[99],"and":[101],"surface":[102],"injury":[103],"models.":[104],"As":[105],"levels":[108],"inversely":[109],"correlate":[110],"progenitors,":[117],"may":[120],"serve":[121],"therapeutic":[124],"target":[125],"modulate":[127],"function":[129],"these":[131],"healing.":[136]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}