{"id":"https://openalex.org/W1990804137","doi":"https://doi.org/10.3109/15513818809041571","title":"Eosinophilic Granulomatous Lymphadenopathy: Association with Hyper-IgE and Eosinophilia","display_name":"Eosinophilic Granulomatous Lymphadenopathy: Association with Hyper-IgE and Eosinophilia","publication_year":1988,"publication_date":"1988-01-01","ids":{"openalex":"https://openalex.org/W1990804137","doi":"https://doi.org/10.3109/15513818809041571","mag":"1990804137","pmid":"https://pubmed.ncbi.nlm.nih.gov/3211808"},"language":"en","primary_location":{"id":"doi:10.3109/15513818809041571","doi":"https://doi.org/10.3109/15513818809041571","is_oa":false,"landing_page_url":"https://doi.org/10.3109/15513818809041571","pdf_url":null,"source":{"id":"https://openalex.org/S4210187405","display_name":"Pediatric Pathology","issn_l":"0277-0938","issn":["0277-0938"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026725319","display_name":"Chaim Kaplinsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Chaim Kaplinsky","raw_affiliation_strings":["Sambur Center for Pediatric Hematology and Oncology, Petah Tikva, Israel","The Sambur Center for Pediatric Hematology and Oncology and the Department of Pathology, Sackler School of Medicine, Tel Aviv University, Beilinson Medical Center, Petah Tikva, 49 100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sambur Center for Pediatric Hematology and Oncology, Petah Tikva, Israel","institution_ids":[]},{"raw_affiliation_string":"The Sambur Center for Pediatric Hematology and Oncology and the Department of Pathology, Sackler School of Medicine, Tel Aviv University, Beilinson Medical Center, Petah Tikva, 49 100, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110076942","display_name":"Celia Mor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Celia Mor","raw_affiliation_strings":["The Sambur Center for Pediatric Hematology and Oncology and the Department of Pathology, Sackler School of Medicine, Tel Aviv University, Beilinson Medical Center, Petah Tikva, 49 100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Sambur Center for Pediatric Hematology and Oncology and the Department of Pathology, Sackler School of Medicine, Tel Aviv University, Beilinson Medical Center, Petah Tikva, 49 100, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108419274","display_name":"Ian J. Cohen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ian J. Cohen","raw_affiliation_strings":["The Sambur Center for Pediatric Hematology and Oncology and the Department of Pathology, Sackler School of Medicine, Tel Aviv University, Beilinson Medical Center, Petah Tikva, 49 100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Sambur Center for Pediatric Hematology and Oncology and the Department of Pathology, Sackler School of Medicine, Tel Aviv University, Beilinson Medical Center, Petah Tikva, 49 100, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108771066","display_name":"Yaacov Goshen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yaacov Goshen","raw_affiliation_strings":["The Sambur Center for Pediatric Hematology and Oncology and the Department of Pathology, Sackler School of Medicine, Tel Aviv University, Beilinson Medical Center, Petah Tikva, 49 100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Sambur Center for Pediatric Hematology and Oncology and the Department of Pathology, Sackler School of Medicine, Tel Aviv University, Beilinson Medical Center, Petah Tikva, 49 100, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110020436","display_name":"Rina Zaizov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Rina Zaizov","raw_affiliation_strings":["The Sambur Center for Pediatric Hematology and Oncology and the Department of Pathology, Sackler School of Medicine, Tel Aviv University, Beilinson Medical Center, Petah Tikva, 49 100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Sambur Center for Pediatric Hematology and Oncology and the Department of Pathology, Sackler School of Medicine, Tel Aviv University, Beilinson Medical Center, Petah Tikva, 49 100, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076907379","display_name":"Dina Atias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113309","display_name":"Bnai Zion Medical Center","ror":"https://ror.org/01yvj7247","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I4210113309"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Dina Atias","raw_affiliation_strings":["Department of Pediatrics, Rothschild University Hospital, The Abba Khoushy School of Medicine, Haifa, 31048, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Rothschild University Hospital, The Abba Khoushy School of Medicine, Haifa, 31048, Israel","institution_ids":["https://openalex.org/I4210113309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.08677494,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"4","first_page":"377","last_page":"384"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":0.39500001072883606,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":0.39500001072883606,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11909","display_name":"Histiocytic Disorders and Treatments","score":0.24390000104904175,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.17000000178813934,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyper-ige-syndrome","display_name":"hyper-IgE syndrome","score":0.8930000066757202},{"id":"https://openalex.org/keywords/eosinophilia","display_name":"eosinophilia","score":0.9670000076293945},{"id":"https://openalex.org/keywords/cervical-lymphadenopathy","display_name":"cervical lymphadenopathy","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pediatric-lymphadenopathy","display_name":"pediatric lymphadenopathy","score":0.8130000233650208},{"id":"https://openalex.org/keywords/eosinophils","display_name":"eosinophils","score":0.8429999947547913},{"id":"https://openalex.org/keywords/lymph-node-pathology","display_name":"lymph node histopathology","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C2777129736","wikidata":"https://www.wikidata.org/wiki/Q505142","display_name":"Eosinophilia","level":2,"score":0.8216570615768433},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7388430237770081},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.7030079364776611},{"id":"https://openalex.org/C2779655305","wikidata":"https://www.wikidata.org/wiki/Q5065339","display_name":"Cervical lymphadenopathy","level":3,"score":0.6803572177886963},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6372964382171631},{"id":"https://openalex.org/C2779758542","wikidata":"https://www.wikidata.org/wiki/Q2106364","display_name":"Eosinophilic","level":2,"score":0.6038722991943359},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.546816349029541},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.5027954578399658},{"id":"https://openalex.org/C2778549279","wikidata":"https://www.wikidata.org/wiki/Q962200","display_name":"Cervical lymph nodes","level":4,"score":0.5016088485717773},{"id":"https://openalex.org/C2777697326","wikidata":"https://www.wikidata.org/wiki/Q757678","display_name":"Atopy","level":3,"score":0.45327484607696533},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.4147779941558838},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35102009773254395},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.2881244719028473},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2636057138442993},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.1739744246006012},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06641563773155212},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004802","descriptor_name":"Eosinophilia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D004802","descriptor_name":"Eosinophilia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D004802","descriptor_name":"Eosinophilia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004802","descriptor_name":"Eosinophilia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004803","descriptor_name":"Eosinophilic Granuloma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D004803","descriptor_name":"Eosinophilic Granuloma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D004803","descriptor_name":"Eosinophilic Granuloma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004803","descriptor_name":"Eosinophilic Granuloma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006942","descriptor_name":"Hypergammaglobulinemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008206","descriptor_name":"Lymphatic Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008206","descriptor_name":"Lymphatic Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008206","descriptor_name":"Lymphatic Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008206","descriptor_name":"Lymphatic Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009333","descriptor_name":"Neck","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/15513818809041571","doi":"https://doi.org/10.3109/15513818809041571","is_oa":false,"landing_page_url":"https://doi.org/10.3109/15513818809041571","pdf_url":null,"source":{"id":"https://openalex.org/S4210187405","display_name":"Pediatric Pathology","issn_l":"0277-0938","issn":["0277-0938"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Pathology","raw_type":"journal-article"},{"id":"pmid:3211808","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3211808","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric pathology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7400000095367432}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W102911073","https://openalex.org/W1528782884","https://openalex.org/W1971115863","https://openalex.org/W1972031015","https://openalex.org/W2017963581","https://openalex.org/W2036503735","https://openalex.org/W2054372914","https://openalex.org/W2069642139","https://openalex.org/W2075461200","https://openalex.org/W2099123147","https://openalex.org/W2163977389","https://openalex.org/W2336448658","https://openalex.org/W2396104359","https://openalex.org/W2408699294","https://openalex.org/W2468148138","https://openalex.org/W2764465688","https://openalex.org/W3119870843","https://openalex.org/W3121840360","https://openalex.org/W4205894350"],"related_works":["https://openalex.org/W7202073810","https://openalex.org/W2281634856","https://openalex.org/W2099160052","https://openalex.org/W2061176253","https://openalex.org/W2326975417","https://openalex.org/W4388734785","https://openalex.org/W2412034357","https://openalex.org/W2520559360","https://openalex.org/W2413118947","https://openalex.org/W2405304957"],"abstract_inverted_index":{"Cervical":[0],"lymph":[1,84],"node":[2],"enlargement":[3],"is":[4],"probably":[5],"the":[6,27,42,50,63,76,79,83],"most":[7],"frequently":[8],"detected":[9],"childhood":[10],"lymphadenopathy.":[11],"We":[12,45],"report":[13],"2":[14],"cases":[15],"of":[16,29,52,66,82],"cervical":[17],"lymphadenopathy":[18],"in":[19,78],"children":[20],"associated":[21],"with":[22],"hyper-IgE":[23],"and":[24,35,54,70],"eosinophilia,":[25],"displaying":[26],"features":[28],"necrotizing":[30,67],"eosinophilic":[31,68],"granulomatosis.":[32],"Immunohistochemical":[33],"analysis":[34],"a":[36,73],"serological":[37],"work-up":[38],"failed":[39],"to":[40,48,56],"elucidate":[41],"underlying":[43],"etiology.":[44],"would":[46],"like":[47],"call":[49],"attention":[51],"physicians":[53],"pathologists":[55],"this":[57],"unusual":[58],"clinical":[59],"picture,":[60],"different":[61],"from":[62],"fatal":[64],"form":[65],"granulomatosis,":[69],"we":[71],"suggest":[72],"role":[74],"for":[75],"eosinophils":[77],"pathologic":[80],"appearance":[81],"nodes.":[85]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}