{"id":"https://openalex.org/W1990789142","doi":"https://doi.org/10.1158/1538-7445.am10-2789","title":"Abstract 2789: C-reactive protein and risk of lung cancer","display_name":"Abstract 2789: C-reactive protein and risk of lung cancer","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W1990789142","doi":"https://doi.org/10.1158/1538-7445.am10-2789","mag":"1990789142"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am10-2789","doi":"https://doi.org/10.1158/1538-7445.am10-2789","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-2789","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019860962","display_name":"Anil K. Chaturvedi","orcid":"https://orcid.org/0000-0003-2696-8899","observed_orcids":["https://orcid.org/0000-0003-2696-8899"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anil Chaturvedi","raw_affiliation_strings":["1National Cancer Institute, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Institute, Rockville, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019329822","display_name":"Neil E. Caporaso","orcid":"https://orcid.org/0000-0001-7562-4609","observed_orcids":["https://orcid.org/0000-0001-7562-4609"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil Caporaso","raw_affiliation_strings":["1National Cancer Institute, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Institute, Rockville, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009110617","display_name":"Hormuzd A. Katki","orcid":"https://orcid.org/0000-0003-2002-0095","observed_orcids":["https://orcid.org/0000-0003-2002-0095"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hormuzd Katki","raw_affiliation_strings":["1National Cancer Institute, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Institute, Rockville, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063845988","display_name":"Hui\u2010Lee Wong","orcid":"https://orcid.org/0000-0002-4825-0426","observed_orcids":["https://orcid.org/0000-0002-4825-0426"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui-Lee Wong","raw_affiliation_strings":["1National Cancer Institute, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Institute, Rockville, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015067632","display_name":"Nilanjan Chatterjee","orcid":"https://orcid.org/0000-0002-9060-008X","observed_orcids":["https://orcid.org/0000-0002-9060-008X","https://orcid.org/0000-0003-3213-3839","https://orcid.org/0000-0002-7932-0191"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nilanjan Chatterjee","raw_affiliation_strings":["1National Cancer Institute, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Institute, Rockville, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008765740","display_name":"Sharon R. Pine","orcid":"https://orcid.org/0000-0001-5318-0277","observed_orcids":["https://orcid.org/0000-0001-5318-0277"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon Pine","raw_affiliation_strings":["1National Cancer Institute, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Institute, Rockville, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091653870","display_name":"Stephen Jacob Chanock","orcid":"https://orcid.org/0000-0002-2324-3393","observed_orcids":["https://orcid.org/0000-0002-2324-3393"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Chanock","raw_affiliation_strings":["1National Cancer Institute, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Institute, Rockville, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085788179","display_name":"James J. Goedert","orcid":"https://orcid.org/0000-0001-6134-1472","observed_orcids":["https://orcid.org/0000-0001-6134-1472"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Goedert","raw_affiliation_strings":["1National Cancer Institute, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Institute, Rockville, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035778053","display_name":"Eric A. Engels","orcid":"https://orcid.org/0000-0003-0203-6958","observed_orcids":["https://orcid.org/0000-0003-0203-6958"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Engels","raw_affiliation_strings":["1National Cancer Institute, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Institute, Rockville, MD","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210140884"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"70","issue":"8_Supplement","first_page":"2789","last_page":"2789"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.47850000858306885,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.47850000858306885,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.33009999990463257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.06340000033378601,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9620000123977661},{"id":"https://openalex.org/keywords/high-sensitivity-crp","display_name":"high-sensitivity CRP","score":0.8539999723434448},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/lung-carcinogenesis","display_name":"lung carcinogenesis","score":0.5870000123977661},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.7570000290870667},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.574999988079071},{"id":"https://openalex.org/keywords/haplotypes","display_name":"haplotypes","score":0.8320000171661377},{"id":"https://openalex.org/keywords/lung-cancer-risk-prediction","display_name":"lung cancer risk prediction","score":0.7590000033378601},{"id":"https://openalex.org/keywords/lung-cancer-screening","display_name":"lung cancer screening","score":0.7139999866485596},{"id":"https://openalex.org/keywords/prostate-lung-colorectal-and-ovarian-cancer-screening-trial","display_name":"Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial","score":0.9319999814033508},{"id":"https://openalex.org/keywords/pre-diagnostic-biomarkers","display_name":"pre-diagnostic biomarkers","score":0.6499999761581421},{"id":"https://openalex.org/keywords/tobacco-smoke","display_name":"tobacco smoke","score":0.3869999945163727}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8046039342880249},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7535420656204224},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7258217334747314},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6111029982566833},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5826148986816406},{"id":"https://openalex.org/C2781195455","wikidata":"https://www.wikidata.org/wiki/Q422766","display_name":"C-reactive protein","level":3,"score":0.5193037390708923},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4957195520401001},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4772722125053406},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4732311964035034},{"id":"https://openalex.org/C68443243","wikidata":"https://www.wikidata.org/wiki/Q2786686","display_name":"Quartile","level":3,"score":0.47221308946609497},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.46405211091041565},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.45410382747650146},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4466868042945862},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.4175006151199341},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.23356512188911438},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.19972333312034607},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.11370089650154114},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07108786702156067},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am10-2789","doi":"https://doi.org/10.1158/1538-7445.am10-2789","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-2789","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2135820395","https://openalex.org/W1996302441","https://openalex.org/W2479642693","https://openalex.org/W1576429616","https://openalex.org/W4288058019","https://openalex.org/W2908386505","https://openalex.org/W2104657191","https://openalex.org/W2483220589","https://openalex.org/W2096979913","https://openalex.org/W3194896863"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Chronic":[2],"inflammation":[3,269],"could":[4],"act":[5],"as":[6],"a":[7,52,158],"co-factor":[8],"to":[9,94],"tobacco":[10],"smoke":[11],"in":[12,116,142,151,179,212,260,270,275,298],"increasing":[13,161],"lung":[14,22,47,58,134,184,220,228,257,271,276,299],"cancer":[15,23,135,185,221,229,258,277,300],"risk,":[16,259],"underscoring":[17],"the":[18,29,77,81,143,180,293,312,317],"potential":[19],"for":[20,140,160,172,266,292,320],"both":[21,237],"prevention":[24],"and":[25,37,60,67,70,85,103,108,120,190,196,205,242,286],"screening.":[26],"We":[27,50,112],"investigated":[28],"association":[30,168],"of":[31,46,56,80,227,262,295,311,316],"circulating":[32,281],"high-sensitivity":[33],"C-reactive":[34],"protein":[35],"(CRP)":[36],"CRP":[38,114,124,128,164,203,213,234,250,282,296],"single":[39],"nucleotide":[40],"polymorphisms":[41],"(SNPs)":[42],"with":[43,63,73,132,157,209,219,232,254],"prospective":[44],"risk":[45,136,162,301],"cancer.":[48],"Methods:":[49],"conducted":[51],"nested":[53],"case-control":[54],"study":[55],"592":[57],"cancers":[59],"670":[61],"controls":[62,72],"available":[64,74],"pre-diagnostic":[65],"serum":[66,118],"378":[68],"cases":[69,95],"447":[71],"DNA":[75],"within":[76],"screening":[78],"arm":[79],"Prostate,":[82],"Lung,":[83],"Colorectal,":[84],"Ovarian":[86],"Cancer":[87,321,331],"Screening":[88],"Trial":[89],"(N=77,464).":[90],"Controls":[91],"were":[92,130,207,216,230],"matched":[93],"on":[96],"age,":[97],"sex,":[98],"entry":[99],"year,":[100],"follow-up":[101],"time,":[102],"smoking":[104],"status":[105],"(cumulative":[106],"amount":[107],"time":[109],"since":[110],"quitting).":[111],"measured":[113],"levels":[115,129,251,283],"baseline":[117],"samples":[119],"genotyped":[121],"5":[122],"common":[123],"SNPs.":[125],"Results:":[126],"Elevated":[127,249],"associated":[131,208,218,253],"increased":[133,256],"(odds":[137],"ratio":[138],"[OR]":[139],"individuals":[141],"fourth":[144],"quartile":[145],"(Q4,":[146],"\u22655.6":[147],"mg/L)":[148],"vs.":[149,240,246],"those":[150],"Q1":[152],"(<1.0":[153],"mg/L)=1.98;":[154],"95%":[155,177,188,194,200],"CI=1.35-2.89),":[156],"trend":[159],"across":[163,280],"quartiles":[165],"(p-trend<0.001).":[166],"This":[167],"was":[169],"most":[170],"apparent":[171],"squamous":[173],"cell":[174],"carcinomas":[175],"(OR=2.92;":[176],"CI=1.30-6.54),":[178],"2-5":[181],"years":[182],"before":[183],"diagnosis":[186],"(OR=2.33;":[187],"CI=1.24-4.39),":[189],"among":[191,236,284],"former":[192,238,285],"(OR=2.48;":[193],"CI=1.53-4.03)":[195],"current":[197,243,287],"smokers":[198,244,288],"(OR=1.90;":[199],"CI=1.06-3.41).":[201],"Although":[202],"SNPs":[204],"haplotypes":[206],"significant":[210],"differences":[211],"levels,":[214,235],"they":[215],"not":[217],"risk.":[222],"Ten-year":[223],"standardized":[224],"absolute":[225,278],"risks":[226,279],"higher":[231],"elevated":[233],"(Q4=2.55%":[239],"Q1=1.39%)":[241],"(Q4=7.37%":[245],"Q1=4.03%).":[247],"Conclusions:":[248],"are":[252],"subsequently":[255],"support":[261],"an":[263],"etiologic":[264],"role":[265],"chronic":[267],"pulmonary":[268],"carcinogenesis.":[272],"The":[273],"separation":[274],"provides":[289],"preliminary":[290],"evidence":[291],"utility":[294],"measurements":[297],"stratification.":[302],"Citation":[303],"Format:":[304],"{Authors}.":[305],"{Abstract":[306],"title}":[307],"[abstract].":[308],"In:":[309],"Proceedings":[310],"101st":[313],"Annual":[314],"Meeting":[315],"American":[318],"Association":[319],"Research;":[322],"2010":[323],"Apr":[324],"17-21;":[325],"Washington,":[326],"DC.":[327],"Philadelphia":[328],"(PA):":[329],"AACR;":[330],"Res":[332],"2010;70(8":[333],"Suppl):Abstract":[334],"nr":[335],"2789.":[336]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}