{"id":"https://openalex.org/W1990769918","doi":"https://doi.org/10.1523/jneurosci.5080-05.2006","title":"A Hot-Sensing Cold Receptor: C-Terminal Domain Determines Thermosensation in Transient Receptor Potential Channels","display_name":"A Hot-Sensing Cold Receptor: C-Terminal Domain Determines Thermosensation in Transient Receptor Potential Channels","publication_year":2006,"publication_date":"2006-05-03","ids":{"openalex":"https://openalex.org/W1990769918","doi":"https://doi.org/10.1523/jneurosci.5080-05.2006","mag":"1990769918","pmid":"https://pubmed.ncbi.nlm.nih.gov/16672657","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6674176"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.5080-05.2006","doi":"https://doi.org/10.1523/jneurosci.5080-05.2006","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.5080-05.2006","pdf_url":"https://www.jneurosci.org/content/jneuro/26/18/4835.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1990769918"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/26/18/4835.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029670158","display_name":"Sebasti\u00e1n Brauchi","orcid":"https://orcid.org/0000-0002-8494-9912","observed_orcids":["https://orcid.org/0000-0002-8494-9912"]},"institutions":[{"id":"https://openalex.org/I16465266","display_name":"Austral University of Chile","ror":"https://ror.org/029ycp228","country_code":"CL","type":"education","lineage":["https://openalex.org/I16465266"]},{"id":"https://openalex.org/I89106005","display_name":"Centro de Estudios Cient\u00edficos","ror":"https://ror.org/00t8xfq63","country_code":"CL","type":"nonprofit","lineage":["https://openalex.org/I89106005"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Sebastian Brauchi","raw_affiliation_strings":["Laboratory of Biophysics and Molecular Physiology, Centro de Estudios Cientificos and Universidad Austral de Chile, Valdivia, 905-9100, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biophysics and Molecular Physiology, Centro de Estudios Cientificos and Universidad Austral de Chile, Valdivia, 905-9100, Chile","institution_ids":["https://openalex.org/I16465266","https://openalex.org/I89106005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113493289","display_name":"Gerardo Orta","orcid":"https://orcid.org/0000-0002-6817-6673","observed_orcids":["https://orcid.org/0000-0002-6817-6673"]},"institutions":[{"id":"https://openalex.org/I89106005","display_name":"Centro de Estudios Cient\u00edficos","ror":"https://ror.org/00t8xfq63","country_code":"CL","type":"nonprofit","lineage":["https://openalex.org/I89106005"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Gerardo Orta","raw_affiliation_strings":["Laboratory of Biophysics and Molecular Physiology, Centro de Estudios Cientificos and","Laboratory of Biophysics and Molecular Physiology , Centro de Estudios Cient\u0131 \u00b4ficos , Avenida Arturo Prat 514 , Valdivia , Chile 905-9100"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biophysics and Molecular Physiology, Centro de Estudios Cientificos and","institution_ids":["https://openalex.org/I89106005"]},{"raw_affiliation_string":"Laboratory of Biophysics and Molecular Physiology , Centro de Estudios Cient\u0131 \u00b4ficos , Avenida Arturo Prat 514 , Valdivia , Chile 905-9100","institution_ids":["https://openalex.org/I89106005"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Marcelo Salazar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89106005","display_name":"Centro de Estudios Cient\u00edficos","ror":"https://ror.org/00t8xfq63","country_code":"CL","type":"nonprofit","lineage":["https://openalex.org/I89106005"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Marcelo Salazar","raw_affiliation_strings":["Laboratory of Biophysics and Molecular Physiology, Centro de Estudios Cientificos and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biophysics and Molecular Physiology, Centro de Estudios Cientificos and","institution_ids":["https://openalex.org/I89106005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109029827","display_name":"Eduardo Rosenmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89106005","display_name":"Centro de Estudios Cient\u00edficos","ror":"https://ror.org/00t8xfq63","country_code":"CL","type":"nonprofit","lineage":["https://openalex.org/I89106005"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Eduardo Rosenmann","raw_affiliation_strings":["Laboratory of Biophysics and Molecular Physiology, Centro de Estudios Cientificos and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biophysics and Molecular Physiology, Centro de Estudios Cientificos and","institution_ids":["https://openalex.org/I89106005"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039029363","display_name":"Ram\u00f3n Latorre","orcid":"https://orcid.org/0000-0002-6044-5795","observed_orcids":["https://orcid.org/0000-0002-6044-5795"]},"institutions":[{"id":"https://openalex.org/I89106005","display_name":"Centro de Estudios Cient\u00edficos","ror":"https://ror.org/00t8xfq63","country_code":"CL","type":"nonprofit","lineage":["https://openalex.org/I89106005"]}],"countries":["CL"],"is_corresponding":true,"raw_author_name":"Ramon Latorre","raw_affiliation_strings":["Laboratory of Biophysics and Molecular Physiology, Centro de Estudios Cientificos and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biophysics and Molecular Physiology, Centro de Estudios Cientificos and","institution_ids":["https://openalex.org/I89106005"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039029363"],"corresponding_institution_ids":["https://openalex.org/I89106005"],"apc_list":null,"apc_paid":null,"fwci":7.0924,"has_fulltext":true,"cited_by_count":311,"citation_normalized_percentile":{"value":0.98388465,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"26","issue":"18","first_page":"4835","last_page":"4840"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trpm8","display_name":"TRPM8","score":0.7379999756813049},{"id":"https://openalex.org/keywords/trpv1","display_name":"TRPV1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/c-terminal-domain","display_name":"C-terminal domain","score":0.8669999837875366},{"id":"https://openalex.org/keywords/temperature-sensing","display_name":"temperature sensing","score":0.6370000243186951},{"id":"https://openalex.org/keywords/cold-receptors","display_name":"cold receptors","score":0.5149999856948853},{"id":"https://openalex.org/keywords/heat-receptors","display_name":"heat receptors","score":0.8740000128746033},{"id":"https://openalex.org/keywords/chimeric-channels","display_name":"chimeric channels","score":0.7770000100135803},{"id":"https://openalex.org/keywords/ion-channel-gating-kinetics","display_name":"channel gating kinetics","score":0.7490000128746033},{"id":"https://openalex.org/keywords/dorsal-root-ganglion-neurons","display_name":"dorsal root ganglion neurons","score":0.8619999885559082}],"concepts":[{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.9352314472198486},{"id":"https://openalex.org/C163146387","wikidata":"https://www.wikidata.org/wiki/Q15324395","display_name":"TRPM8","level":5,"score":0.8544290065765381},{"id":"https://openalex.org/C2780118905","wikidata":"https://www.wikidata.org/wiki/Q16949811","display_name":"Cold sensitivity","level":4,"score":0.6722602248191833},{"id":"https://openalex.org/C160145004","wikidata":"https://www.wikidata.org/wiki/Q413209","display_name":"TRPV1","level":4,"score":0.6624017953872681},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.656809389591217},{"id":"https://openalex.org/C194544171","wikidata":"https://www.wikidata.org/wiki/Q21105679","display_name":"Gating","level":2,"score":0.524756669998169},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5239410996437073},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.519258975982666},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45892173051834106},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.44438838958740234},{"id":"https://openalex.org/C167007842","wikidata":"https://www.wikidata.org/wiki/Q15322678","display_name":"TRPC1","level":4,"score":0.4363604784011841},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32496342062950134},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29472815990448},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.14059466123580933},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0679808259010315}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002211","descriptor_name":"Capsaicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003952","descriptor_name":"Diagnostic Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004307","descriptor_name":"Dose-Response Relationship, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D008610","descriptor_name":"Menthol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013697","descriptor_name":"Thermosensing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013823","descriptor_name":"Thermoreceptors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019269","descriptor_name":"Phosphatidylinositol 4,5-Diphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D050051","descriptor_name":"Transient Receptor Potential Channels","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D050051","descriptor_name":"Transient Receptor Potential Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D050051","descriptor_name":"Transient Receptor Potential Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050053","descriptor_name":"TRPM Cation Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050053","descriptor_name":"TRPM Cation Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1523/jneurosci.5080-05.2006","doi":"https://doi.org/10.1523/jneurosci.5080-05.2006","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.5080-05.2006","pdf_url":"https://www.jneurosci.org/content/jneuro/26/18/4835.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmid:16672657","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16672657","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:6674176","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6674176/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmh:oai:americanae.aecid.es:3230157","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3230157","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JOURNAL OF NEUROSCIENCE","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:localhost:10533/177270","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10533/177270","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JOURNAL OF NEUROSCIENCE","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.5080-05.2006","doi":"https://doi.org/10.1523/jneurosci.5080-05.2006","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.5080-05.2006","pdf_url":"https://www.jneurosci.org/content/jneuro/26/18/4835.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308888","display_name":"Tinker Foundation","ror":"https://ror.org/01sv5w039"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990769918.pdf","grobid_xml":"https://content.openalex.org/works/W1990769918.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1495409864","https://openalex.org/W1511198581","https://openalex.org/W1601947680","https://openalex.org/W1981328110","https://openalex.org/W1983519301","https://openalex.org/W1995330222","https://openalex.org/W1996196738","https://openalex.org/W2022293360","https://openalex.org/W2029993965","https://openalex.org/W2040664792","https://openalex.org/W2041322673","https://openalex.org/W2053120786","https://openalex.org/W2057709157","https://openalex.org/W2059742450","https://openalex.org/W2066098715","https://openalex.org/W2090617423","https://openalex.org/W2094955398","https://openalex.org/W2100241249","https://openalex.org/W2100713606","https://openalex.org/W2103120820","https://openalex.org/W2107057154","https://openalex.org/W2113839545","https://openalex.org/W2120229762","https://openalex.org/W2120961946","https://openalex.org/W2129220462","https://openalex.org/W2135567029","https://openalex.org/W2154166729","https://openalex.org/W2167957790","https://openalex.org/W2765425259","https://openalex.org/W3196492948"],"related_works":["https://openalex.org/W2166903664","https://openalex.org/W3130769019","https://openalex.org/W6889992450","https://openalex.org/W3047260684","https://openalex.org/W2046260128","https://openalex.org/W2018022754","https://openalex.org/W97033274","https://openalex.org/W1861203810","https://openalex.org/W2090617423","https://openalex.org/W3202410037"],"abstract_inverted_index":{"Temperature":[0],"transduction":[1],"in":[2,20,89,105],"mammals":[3],"is":[4,120],"possible":[5],"because":[6],"of":[7,10,13,58,61,80,84],"the":[8,59,64,78,81,96,101,107,117,124,147],"presence":[9],"a":[11],"set":[12],"temperature-dependent":[14],"transient":[15],"receptor":[16,98,103],"potential":[17],"(TRP)":[18],"channels":[19,139],"dorsal":[21],"root":[22],"ganglia":[23],"neurons":[24],"and":[25,51,86,100,122,133],"skin":[26],"cells.":[27],"Six":[28],"thermo-TRP":[29,138],"channels,":[30],"all":[31],"characterized":[32],"by":[33,55,69,92],"their":[34],"unusually":[35],"high":[36],"temperature":[37,70,128,155],"sensitivity":[38],"(Q10":[39],">":[40],"10),":[41],"have":[42],"been":[43],"cloned:":[44],"TRPV1-4":[45],"are":[46,53],"heat":[47,97],"activated,":[48],"whereas":[49],"TRPM8":[50],"TRPA1":[52],"activated":[54],"cold.":[56],"Because":[57],"lack":[60],"structural":[62],"information,":[63],"molecular":[65],"basis":[66],"for":[67],"regulation":[68],"remains":[71],"unknown.":[72],"In":[73],"this":[74],"study,":[75],"we":[76,114],"assessed":[77],"role":[79],"C-terminal":[82,109,118],"domain":[83,110,119],"thermo-TRPs":[85],"its":[87],"involvement":[88],"thermal":[90],"activation":[91],"using":[93],"chimeras":[94],"between":[95],"TRPV1":[99],"cold":[102],"TRPM8,":[104],"which":[106,150],"entire":[108],"was":[111],"switched.":[112],"Here,":[113],"demonstrate":[115],"that":[116],"modular":[121],"confers":[123],"channel":[125,130],"phenotype":[126],"regarding":[127],"sensitivity,":[129],"gating":[131],"kinetics,":[132],"PIP2":[134],"(phosphatidylinositol-4,5-bisphophate)":[135],"modulation.":[136],"Thus,":[137],"contain":[140],"an":[141],"interchangeable":[142],"specific":[143],"region,":[144],"different":[145],"from":[146],"voltage":[148],"sensor,":[149],"allows":[151],"them":[152],"to":[153],"sense":[154],"stimuli.":[156]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":21},{"year":2015,"cited_by_count":23},{"year":2014,"cited_by_count":32},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":19}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
