{"id":"https://openalex.org/W1990765611","doi":"https://doi.org/10.1039/c0cc03078c","title":"Tetrazine\u2013trans-cyclooctene ligation for the rapid construction of 18F labeled probes","display_name":"Tetrazine\u2013trans-cyclooctene ligation for the rapid construction of 18F labeled probes","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W1990765611","doi":"https://doi.org/10.1039/c0cc03078c","mag":"1990765611","pmid":"https://pubmed.ncbi.nlm.nih.gov/20862423","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3230320"},"language":"en","primary_location":{"id":"doi:10.1039/c0cc03078c","doi":"https://doi.org/10.1039/c0cc03078c","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c0cc03078c","pdf_url":null,"source":{"id":"https://openalex.org/S152760256","display_name":"Chemical Communications","issn_l":"1359-7345","issn":["1359-7345","1364-548X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","ki-jl-1","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3230320","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100675106","display_name":"Zibo Li","orcid":"https://orcid.org/0000-0002-1063-0298","observed_orcids":["https://orcid.org/0000-0002-1063-0298","https://orcid.org/0000-0002-5095-3761"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zibo Li","raw_affiliation_strings":["Molecular Imaging Center, Department of Radiology, University of Southern California, Los Angeles 90033, USA. ziboli@usc.edu","Molecular Imaging Center, Department of Radiology, University of Southern California,Los Angeles 90033,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Imaging Center, Department of Radiology, University of Southern California, Los Angeles 90033, USA. ziboli@usc.edu","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Molecular Imaging Center, Department of Radiology, University of Southern California,Los Angeles 90033,USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101390224","display_name":"Hancheng Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hancheng Cai","raw_affiliation_strings":["Molecular Imaging Center, Department of Radiology, University of Southern California, Los Angeles 90033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Imaging Center, Department of Radiology, University of Southern California, Los Angeles 90033, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021991271","display_name":"Matthew Hassink","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Hassink","raw_affiliation_strings":["Brown Laboratories, Department of Chemistry and Biochemistry, University of Delaware, Newark, USA","University of Delaware"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brown Laboratories, Department of Chemistry and Biochemistry, University of Delaware, Newark, USA","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"University of Delaware","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091047943","display_name":"Melissa L. Blackman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa L. Blackman","raw_affiliation_strings":["Brown Laboratories, Department of Chemistry and Biochemistry, University of Delaware, Newark, USA","University of Delaware"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brown Laboratories, Department of Chemistry and Biochemistry, University of Delaware, Newark, USA","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"University of Delaware","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061493169","display_name":"Richard C. D. Brown","orcid":"https://orcid.org/0000-0003-0156-7087","observed_orcids":["https://orcid.org/0000-0003-0156-7087"]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard C. D. Brown","raw_affiliation_strings":["School of Chemistry, University of Southampton, Highfield, Southampton, UK","University of Southampton"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry, University of Southampton, Highfield, Southampton, UK","institution_ids":["https://openalex.org/I43439940"]},{"raw_affiliation_string":"University of Southampton","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111367606","display_name":"Peter S. Conti","orcid":"https://orcid.org/0000-0002-8898-8468","observed_orcids":["https://orcid.org/0000-0002-8898-8468"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter S. Conti","raw_affiliation_strings":["Molecular Imaging Center, Department of Radiology, University of Southern California, Los Angeles 90033, USA","University of Southern California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Imaging Center, Department of Radiology, University of Southern California, Los Angeles 90033, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"University of Southern California","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034235550","display_name":"Joseph M. Fox","orcid":"https://orcid.org/0000-0002-8258-1640","observed_orcids":["https://orcid.org/0000-0002-8258-1640"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph M. Fox","raw_affiliation_strings":["Brown Laboratories, Department of Chemistry and Biochemistry, University of Delaware, Newark, USA","University of Delaware"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brown Laboratories, Department of Chemistry and Biochemistry, University of Delaware, Newark, USA","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"University of Delaware","institution_ids":["https://openalex.org/I86501945"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5034235550","https://openalex.org/A5100675106"],"corresponding_institution_ids":["https://openalex.org/I1174212","https://openalex.org/I86501945"],"apc_list":null,"apc_paid":null,"fwci":11.216,"has_fulltext":false,"cited_by_count":192,"citation_normalized_percentile":{"value":0.99016646,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"46","issue":"42","first_page":"8043","last_page":"8043"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.8339999914169312,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.8339999914169312,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.14219999313354492,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13561","display_name":"Chemical Reactions and Isotopes","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diels-alder-reaction","display_name":"Diels-Alder reaction","score":0.9120000004768372},{"id":"https://openalex.org/keywords/fluorine-18-radiolabeling","display_name":"fluorine-18 radiolabeling","score":0.8289999961853027},{"id":"https://openalex.org/keywords/bioconjugation","display_name":"bioconjugation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/trans-cyclooctene","display_name":"trans-cyclooctene","score":0.8820000290870667}],"concepts":[{"id":"https://openalex.org/C2781436684","wikidata":"https://www.wikidata.org/wiki/Q41295522","display_name":"Cyclooctene","level":3,"score":0.9711752533912659},{"id":"https://openalex.org/C23963754","wikidata":"https://www.wikidata.org/wiki/Q4914729","display_name":"Bioconjugation","level":2,"score":0.9535965919494629},{"id":"https://openalex.org/C2778754187","wikidata":"https://www.wikidata.org/wiki/Q417549","display_name":"Tetrazine","level":2,"score":0.9340059757232666},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.778372049331665},{"id":"https://openalex.org/C179437574","wikidata":"https://www.wikidata.org/wiki/Q15089798","display_name":"Ligation","level":2,"score":0.5399430394172668},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.47319909930229187},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.230348140001297},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1735391914844513},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.06405201554298401},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005462","descriptor_name":"Fluorine Radioisotopes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011874","descriptor_name":"Radiometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034242","descriptor_name":"Cyclooctanes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1039/c0cc03078c","doi":"https://doi.org/10.1039/c0cc03078c","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c0cc03078c","pdf_url":null,"source":{"id":"https://openalex.org/S152760256","display_name":"Chemical Communications","issn_l":"1359-7345","issn":["1359-7345","1364-548X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","ki-jl-1","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Communications","raw_type":"journal-article"},{"id":"pmid:20862423","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20862423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical communications (Cambridge, England)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2239140","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3230320","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3230320","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3230320","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Chem Commun (Camb)","raw_type":"Text"},{"id":"pmh:oai:eprints.soton.ac.uk:180733","doi":null,"is_oa":false,"landing_page_url":"https://eprints.soton.ac.uk/180733/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2239140","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3230320","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4389218539","display_name":"Molecular Design of Advanced Biomaterials","funder_award_id":"P20RR017716","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1980232662","https://openalex.org/W1985129208","https://openalex.org/W1993314947","https://openalex.org/W2002774887","https://openalex.org/W2005598974","https://openalex.org/W2007736465","https://openalex.org/W2019292847","https://openalex.org/W2062524026","https://openalex.org/W2068867550","https://openalex.org/W2081576789","https://openalex.org/W2084857126","https://openalex.org/W2086221737","https://openalex.org/W2111733899","https://openalex.org/W2111789849","https://openalex.org/W2113007722","https://openalex.org/W2134194795","https://openalex.org/W2136277835","https://openalex.org/W2151709132","https://openalex.org/W2155827990","https://openalex.org/W4386873727"],"related_works":["https://openalex.org/W2950055799","https://openalex.org/W2061777714","https://openalex.org/W2170388188","https://openalex.org/W2079393040","https://openalex.org/W2344885917","https://openalex.org/W1959251555","https://openalex.org/W2282630611","https://openalex.org/W80016613","https://openalex.org/W4416070573","https://openalex.org/W2148938466"],"abstract_inverted_index":{"A":[0],"radiolabeling":[1],"method":[2,30],"for":[3],"bioconjugation":[4],"based":[5],"on":[6],"the":[7],"Diels-Alder":[8],"reaction":[9,19],"between":[10],"3,6-diaryl-s-tetrazines":[11],"and":[12],"an":[13,27],"(18)F-labeled":[14],"trans-cyclooctene":[15],"is":[16],"described.":[17],"The":[18],"proceeds":[20],"with":[21],"exceptionally":[22],"fast":[23],"rates,":[24],"making":[25],"it":[26],"effective":[28],"conjugation":[29],"within":[31],"seconds":[32],"at":[33],"low":[34],"micromolar":[35],"concentrations.":[36]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}