{"id":"https://openalex.org/W1990746420","doi":"https://doi.org/10.1210/en.2008-0994","title":"Membrane Estrogen Receptor-\u03b1 Interacts with Metabotropic Glutamate Receptor Type 1a to Mobilize Intracellular Calcium in Hypothalamic Astrocytes","display_name":"Membrane Estrogen Receptor-\u03b1 Interacts with Metabotropic Glutamate Receptor Type 1a to Mobilize Intracellular Calcium in Hypothalamic Astrocytes","publication_year":2008,"publication_date":"2008-10-23","ids":{"openalex":"https://openalex.org/W1990746420","doi":"https://doi.org/10.1210/en.2008-0994","mag":"1990746420","pmid":"https://pubmed.ncbi.nlm.nih.gov/18948402","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2654734"},"language":"en","primary_location":{"id":"doi:10.1210/en.2008-0994","doi":"https://doi.org/10.1210/en.2008-0994","is_oa":true,"landing_page_url":"https://doi.org/10.1210/en.2008-0994","pdf_url":"https://academic.oup.com/endo/article-pdf/150/3/1369/9004501/endo1369.pdf","source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/endo/article-pdf/150/3/1369/9004501/endo1369.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"John Kuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Kuo","raw_affiliation_strings":["Department of Neurobiology (J.K., O.R.H., G.B., J.O., P.M.), David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California 90095","Laboratory of Neuroendocrinology and Brain Research Institute, and Department of Obstetrics and Gynecology (J.K.), David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology (J.K., O.R.H., G.B., J.O., P.M.), David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California 90095","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Laboratory of Neuroendocrinology and Brain Research Institute, and Department of Obstetrics and Gynecology (J.K.), David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California 90095","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073990784","display_name":"Omid R. Hariri","orcid":"https://orcid.org/0000-0003-3203-3424","observed_orcids":["https://orcid.org/0000-0003-3203-3424"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Omid R. Hariri","raw_affiliation_strings":["Department of Neurobiology (J.K., O.R.H., G.B., J.O., P.M.), David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology (J.K., O.R.H., G.B., J.O., P.M.), David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California 90095","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061204824","display_name":"Galyna Bondar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Galyna Bondar","raw_affiliation_strings":["Department of Neurobiology (J.K., O.R.H., G.B., J.O., P.M.), David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology (J.K., O.R.H., G.B., J.O., P.M.), David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California 90095","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007523210","display_name":"Julie Ogi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie Ogi","raw_affiliation_strings":["Department of Neurobiology (J.K., O.R.H., G.B., J.O., P.M.), David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology (J.K., O.R.H., G.B., J.O., P.M.), David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California 90095","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029348051","display_name":"Paul E. Micevych","orcid":"https://orcid.org/0000-0002-9577-5874","observed_orcids":["https://orcid.org/0000-0002-9577-5874"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paul Micevych","raw_affiliation_strings":["Department of Neurobiology (J.K., O.R.H., G.B., J.O., P.M.), David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology (J.K., O.R.H., G.B., J.O., P.M.), David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California 90095","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5029348051"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":4.9424,"has_fulltext":true,"cited_by_count":85,"citation_normalized_percentile":{"value":0.95765172,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"150","issue":"3","first_page":"1369","last_page":"1376"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/membrane-estrogen-receptor-alpha","display_name":"membrane estrogen receptor alpha","score":0.8610000014305115},{"id":"https://openalex.org/keywords/estradiol-signaling","display_name":"estradiol signaling","score":0.8159999847412109},{"id":"https://openalex.org/keywords/calcium-mobilization","display_name":"calcium mobilization","score":0.9330000281333923},{"id":"https://openalex.org/keywords/hypothalamic-astrocytes","display_name":"hypothalamic astrocytes","score":0.9800000190734863},{"id":"https://openalex.org/keywords/receptor-interaction","display_name":"receptor interaction","score":0.578000009059906},{"id":"https://openalex.org/keywords/progesterone-synthesis","display_name":"progesterone secretion","score":0.9010000228881836},{"id":"https://openalex.org/keywords/fulvestrant","display_name":"fulvestrant","score":0.8859999775886536},{"id":"https://openalex.org/keywords/dhpg","display_name":"DHPG","score":0.7440000176429749},{"id":"https://openalex.org/keywords/antiestrogens","display_name":"antiestrogens","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C41653306","wikidata":"https://www.wikidata.org/wiki/Q6589190","display_name":"Metabotropic glutamate receptor 5","level":5,"score":0.6573551893234253},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6406567096710205},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6390545964241028},{"id":"https://openalex.org/C200385062","wikidata":"https://www.wikidata.org/wiki/Q6594119","display_name":"Metabotropic glutamate receptor 3","level":5,"score":0.5850048065185547},{"id":"https://openalex.org/C49051014","wikidata":"https://www.wikidata.org/wiki/Q2033959","display_name":"Metabotropic glutamate receptor","level":4,"score":0.5598646998405457},{"id":"https://openalex.org/C207951395","wikidata":"https://www.wikidata.org/wiki/Q288431","display_name":"Metabotropic glutamate receptor 1","level":5,"score":0.5332773327827454},{"id":"https://openalex.org/C56940625","wikidata":"https://www.wikidata.org/wiki/Q6589868","display_name":"Metabotropic glutamate receptor 6","level":5,"score":0.5125939249992371},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5043727159500122},{"id":"https://openalex.org/C87247309","wikidata":"https://www.wikidata.org/wiki/Q6590338","display_name":"Metabotropic glutamate receptor 7","level":5,"score":0.4884401857852936},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46912360191345215},{"id":"https://openalex.org/C26702167","wikidata":"https://www.wikidata.org/wiki/Q901988","display_name":"Metabotropic receptor","level":4,"score":0.4577106833457947},{"id":"https://openalex.org/C116592611","wikidata":"https://www.wikidata.org/wiki/Q21113349","display_name":"Metabotropic glutamate receptor 4","level":5,"score":0.45261743664741516},{"id":"https://openalex.org/C2129178","wikidata":"https://www.wikidata.org/wiki/Q6590408","display_name":"Metabotropic glutamate receptor 8","level":5,"score":0.45020902156829834},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.34285488724708557},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.34018245339393616},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3259761333465576},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25219714641571045},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020318","descriptor_name":"Rats, Long-Evans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/en.2008-0994","doi":"https://doi.org/10.1210/en.2008-0994","is_oa":true,"landing_page_url":"https://doi.org/10.1210/en.2008-0994","pdf_url":"https://academic.oup.com/endo/article-pdf/150/3/1369/9004501/endo1369.pdf","source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2654734","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2654734","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Text"},{"id":"pmid:18948402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18948402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1210/en.2008-0994","doi":"https://doi.org/10.1210/en.2008-0994","is_oa":true,"landing_page_url":"https://doi.org/10.1210/en.2008-0994","pdf_url":"https://academic.oup.com/endo/article-pdf/150/3/1369/9004501/endo1369.pdf","source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3667970594","display_name":"UCLA Women's Reproductive Health Research Center","funder_award_id":"K12HD001281","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G3773250293","display_name":"Physiology of hypothalamic neurosteroidal progesterone","funder_award_id":"R01HD042635","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332502","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"},{"id":"https://openalex.org/F4320337666","display_name":"David Geffen School of Medicine, University of California, Los Angeles","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990746420.pdf","grobid_xml":"https://content.openalex.org/works/W1990746420.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W783873688","https://openalex.org/W1564409279","https://openalex.org/W1572171312","https://openalex.org/W1948716141","https://openalex.org/W1954468845","https://openalex.org/W1954747488","https://openalex.org/W1966066124","https://openalex.org/W1968998907","https://openalex.org/W1969461328","https://openalex.org/W1980941288","https://openalex.org/W1981467972","https://openalex.org/W1982710339","https://openalex.org/W1987559410","https://openalex.org/W2001788344","https://openalex.org/W2004126266","https://openalex.org/W2005766913","https://openalex.org/W2006173437","https://openalex.org/W2008871773","https://openalex.org/W2013481652","https://openalex.org/W2014754503","https://openalex.org/W2017864239","https://openalex.org/W2018154007","https://openalex.org/W2020338570","https://openalex.org/W2031518606","https://openalex.org/W2037790468","https://openalex.org/W2044744723","https://openalex.org/W2048105028","https://openalex.org/W2052889947","https://openalex.org/W2053526588","https://openalex.org/W2054459050","https://openalex.org/W2058409428","https://openalex.org/W2059994807","https://openalex.org/W2060090078","https://openalex.org/W2063780120","https://openalex.org/W2068400560","https://openalex.org/W2070293233","https://openalex.org/W2070955684","https://openalex.org/W2075564085","https://openalex.org/W2077274654","https://openalex.org/W2078517822","https://openalex.org/W2079681298","https://openalex.org/W2085405074","https://openalex.org/W2090191477","https://openalex.org/W2101774453","https://openalex.org/W2104089674","https://openalex.org/W2106042714","https://openalex.org/W2108242014","https://openalex.org/W2108538173","https://openalex.org/W2110560495","https://openalex.org/W2122015809","https://openalex.org/W2122860707","https://openalex.org/W2124658196","https://openalex.org/W2125256810","https://openalex.org/W2126836250","https://openalex.org/W2128296469","https://openalex.org/W2128635872","https://openalex.org/W2137272726","https://openalex.org/W2142133036","https://openalex.org/W2146853018","https://openalex.org/W2153830242","https://openalex.org/W2169788816","https://openalex.org/W4236458467"],"related_works":["https://openalex.org/W2284434807","https://openalex.org/W2110560495","https://openalex.org/W2004065307","https://openalex.org/W2157308235","https://openalex.org/W1971369867","https://openalex.org/W4237104046","https://openalex.org/W1977813273","https://openalex.org/W1970231474","https://openalex.org/W1970846921","https://openalex.org/W2107554331"],"abstract_inverted_index":{"Estradiol,":[0],"acting":[1],"on":[2],"a":[3,63,72,80,105,170,206],"membrane-associated":[4],"estrogen":[5,125],"receptor-alpha":[6],"(mERalpha),":[7],"induces":[8],"an":[9,31],"increase":[10,74,108],"in":[11,21,43,53,75,82,214,245],"free":[12],"cytoplasmic":[13],"calcium":[14,49],"concentration":[15],"([Ca(2+)](i))":[16],"needed":[17],"for":[18],"progesterone":[19],"synthesis":[20],"hypothalamic":[22,59,219],"astrocytes.":[23,60,220,246],"To":[24],"determine":[25],"whether":[26],"rapid":[27,114],"estradiol":[28,103,181,234],"signaling":[29,244],"involves":[30],"interaction":[32,209],"of":[33,56,65,102,123,180,218],"mERalpha":[34,211,225],"with":[35,47,120,197],"metabotropic":[36],"glutamate":[37],"receptor":[38,126,163],"type":[39],"1a":[40],"(mGluR1a),":[41],"changes":[42],"[Ca(2+)](i)":[44,76,107,116,172,190],"were":[45],"monitored":[46],"the":[48,124,144,161,189,215,233],"indicator,":[50],"Fluo-4":[51],"AM,":[52],"primary":[54],"cultures":[55],"female":[57],"postpubertal":[58],"17beta-Estradiol":[61],"over":[62],"range":[64],"1":[66,121],"nm":[67,70,101],"to":[68,91],"100":[69],"induced":[71],"maximal":[73],"flux":[77,117,173],"measured":[78],"as":[79],"change":[81],"relative":[83,95],"fluorescence":[84],"[DeltaF":[85],"Ca(2+)":[86],"=":[87],"615":[88],"+/-":[89,93,110,131,135,150,154,175,193],"36":[90],"641":[92],"47":[94],"fluorescent":[96],"units":[97],"(RFU)],":[98],"whereas":[99],"0.1":[100],"stimulated":[104,169],"moderate":[106],"(275":[109],"16":[111],"RFU).":[112],"The":[113],"estradiol-induced":[115,242],"was":[118],"blocked":[119],"microm":[122],"antagonist":[127,146],"ICI":[128],"182,780":[129],"(635":[130],"24":[132],"vs.":[133,152],"102":[134],"11":[136],"RFU,":[137,156],"P":[138,157],"<":[139,158,202],"0.001)":[140],"and":[141,212,229],"20":[142,155],"nmof":[143],"mGluR1a":[145,162,213,230],"LY":[147],"367385":[148],"(617":[149],"35":[151],"133":[153],"0.001).":[159,203],"Whereas":[160],"agonist":[164],"(RS)-3,5-dihydroxyphenyl-glycine":[165,185],"(50":[166,186],"microm)":[167,187],"also":[168],"robust":[171],"(626":[174],"23":[176],"RFU),":[177],"combined":[178],"treatment":[179],"(1":[182],"nm)":[183],"plus":[184],"augmented":[188],"response":[191],"(762":[192],"17":[194],"RFU)":[195],"compared":[196],"either":[198],"compound":[199],"alone":[200],"(P":[201],"Coimmunoprecipitation":[204],"demonstrated":[205],"direct":[207],"physical":[208],"between":[210],"plasma":[216],"membrane":[217,243],"These":[221],"results":[222],"indicate":[223],"that":[224,237],"acts":[226],"through":[227],"mGluR1a,":[228],"activation":[231],"facilitates":[232],"response,":[235],"suggesting":[236],"neural":[238],"activity":[239],"can":[240],"modify":[241]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
