{"id":"https://openalex.org/W1990729227","doi":"https://doi.org/10.2174/138920207783769530","title":"Advances on the Understanding of the Origins of Synaptic Pathology in AD","display_name":"Advances on the Understanding of the Origins of Synaptic Pathology in AD","publication_year":2007,"publication_date":"2007-12-01","ids":{"openalex":"https://openalex.org/W1990729227","doi":"https://doi.org/10.2174/138920207783769530","mag":"1990729227","pmid":"https://pubmed.ncbi.nlm.nih.gov/19415125","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2647163"},"language":"en","primary_location":{"id":"doi:10.2174/138920207783769530","doi":"https://doi.org/10.2174/138920207783769530","is_oa":true,"landing_page_url":"https://doi.org/10.2174/138920207783769530","pdf_url":"http://www.eurekaselect.com/article/11507","source":{"id":"https://openalex.org/S156212020","display_name":"Current Genomics","issn_l":"1389-2029","issn":["1389-2029","1875-5488"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Genomics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.eurekaselect.com/article/11507","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108505001","display_name":"Pascale N. Lacor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pascale Lacor","raw_affiliation_strings":["Department of Neurobiology and Physiology, Northwestern University, Evanston, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Physiology, Northwestern University, Evanston, IL, USA","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108505001"],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":null,"apc_paid":null,"fwci":1.267,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.78033782,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"8","first_page":"486","last_page":"508"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.949999988079071},{"id":"https://openalex.org/keywords/synaptic-pathology","display_name":"synaptic pathology","score":0.7860000133514404},{"id":"https://openalex.org/keywords/synapse-loss","display_name":"synaptic loss","score":0.746999979019165},{"id":"https://openalex.org/keywords/amyloid-hypothesis","display_name":"amyloid hypothesis","score":0.671999990940094},{"id":"https://openalex.org/keywords/soluble-amyloid-beta-oligomers","display_name":"soluble amyloid-beta oligomers","score":0.8190000057220459},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.6010000109672546},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.847000002861023},{"id":"https://openalex.org/keywords/dendritic-spine-loss","display_name":"dendritic spine loss","score":0.9010000228881836},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.6359999775886536},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.7279999852180481},{"id":"https://openalex.org/keywords/synapse-maintenance","display_name":"synapse maintenance","score":0.4350000023841858},{"id":"https://openalex.org/keywords/cell-surface-receptors","display_name":"cell surface receptors","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7265646457672119},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.7184668779373169},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5526406168937683},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.5269171595573425},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.49850988388061523},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.49740317463874817},{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.4671584665775299},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.45623207092285156},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.4431770145893097},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.4279564917087555},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3883185386657715},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3559911251068115},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2647250294685364},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09456980228424072},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.08492910861968994},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07977434992790222},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.2174/138920207783769530","doi":"https://doi.org/10.2174/138920207783769530","is_oa":true,"landing_page_url":"https://doi.org/10.2174/138920207783769530","pdf_url":"http://www.eurekaselect.com/article/11507","source":{"id":"https://openalex.org/S156212020","display_name":"Current Genomics","issn_l":"1389-2029","issn":["1389-2029","1875-5488"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Genomics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1440089","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC2647163","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2647163","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2647163","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Curr Genomics","raw_type":"Text"},{"id":"pmid:19415125","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19415125","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current genomics","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.787.5717","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.787.5717","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/01/38/CG-8-486.PMC2647163.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.2174/138920207783769530","doi":"https://doi.org/10.2174/138920207783769530","is_oa":true,"landing_page_url":"https://doi.org/10.2174/138920207783769530","pdf_url":"http://www.eurekaselect.com/article/11507","source":{"id":"https://openalex.org/S156212020","display_name":"Current Genomics","issn_l":"1389-2029","issn":["1389-2029","1875-5488"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Genomics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9746999740600586,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G775753827","display_name":"ADDLs, synapses & the molecular etiology of Alzheimer's disease","funder_award_id":"R01AG029460","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306229","display_name":"American Health Assistance Foundation","ror":"https://ror.org/03cvfxv40"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990729227.pdf","grobid_xml":"https://content.openalex.org/works/W1990729227.grobid-xml"},"referenced_works_count":355,"referenced_works":["https://openalex.org/W81005182","https://openalex.org/W86686525","https://openalex.org/W99387372","https://openalex.org/W158374110","https://openalex.org/W173047358","https://openalex.org/W187935126","https://openalex.org/W308796606","https://openalex.org/W1476312560","https://openalex.org/W1484094963","https://openalex.org/W1487346158","https://openalex.org/W1500697222","https://openalex.org/W1514559719","https://openalex.org/W1516250632","https://openalex.org/W1544338382","https://openalex.org/W1545362848","https://openalex.org/W1557933310","https://openalex.org/W1567217875","https://openalex.org/W1573292604","https://openalex.org/W1584774790","https://openalex.org/W1584825376","https://openalex.org/W1584834830","https://openalex.org/W1602771322","https://openalex.org/W1611407165","https://openalex.org/W1618236677","https://openalex.org/W1637989849","https://openalex.org/W1640813462","https://openalex.org/W1675105744","https://openalex.org/W1677883125","https://openalex.org/W1681258590","https://openalex.org/W1684991877","https://openalex.org/W1694984064","https://openalex.org/W1705725530","https://openalex.org/W1711248712","https://openalex.org/W1729010372","https://openalex.org/W1796802340","https://openalex.org/W1857351893","https://openalex.org/W1904871314","https://openalex.org/W1948557773","https://openalex.org/W1964049915","https://openalex.org/W1964729801","https://openalex.org/W1964741226","https://openalex.org/W1965670425","https://openalex.org/W1965670935","https://openalex.org/W1965674141","https://openalex.org/W1966181020","https://openalex.org/W1967464880","https://openalex.org/W1967684462","https://openalex.org/W1967917932","https://openalex.org/W1969165181","https://openalex.org/W1970050522","https://openalex.org/W1970164987","https://openalex.org/W1972153963","https://openalex.org/W1972334605","https://openalex.org/W1972456354","https://openalex.org/W1972567838","https://openalex.org/W1972850054","https://openalex.org/W1973514051","https://openalex.org/W1973637060","https://openalex.org/W1974729491","https://openalex.org/W1976476169","https://openalex.org/W1976602187","https://openalex.org/W1976732198","https://openalex.org/W1977002082","https://openalex.org/W1977813572","https://openalex.org/W1979242019","https://openalex.org/W1979369962","https://openalex.org/W1979415323","https://openalex.org/W1979543098","https://openalex.org/W1980750700","https://openalex.org/W1980825524","https://openalex.org/W1980842500","https://openalex.org/W1981288814","https://openalex.org/W1981458288","https://openalex.org/W1981570625","https://openalex.org/W1981919501","https://openalex.org/W1982051443","https://openalex.org/W1982373527","https://openalex.org/W1983288425","https://openalex.org/W1984283611","https://openalex.org/W1984320700","https://openalex.org/W1984924722","https://openalex.org/W1985086842","https://openalex.org/W1985325561","https://openalex.org/W1985397688","https://openalex.org/W1985446830","https://openalex.org/W1986295281","https://openalex.org/W1986559032","https://openalex.org/W1986900475","https://openalex.org/W1987095222","https://openalex.org/W1988424894","https://openalex.org/W1989892416","https://openalex.org/W1990483753","https://openalex.org/W1990752558","https://openalex.org/W1991241547","https://openalex.org/W1991435932","https://openalex.org/W1991763618","https://openalex.org/W1993231594","https://openalex.org/W1993465897","https://openalex.org/W1993759415","https://openalex.org/W1995175521","https://openalex.org/W1995426930","https://openalex.org/W1996189554","https://openalex.org/W1996694656","https://openalex.org/W1996837502","https://openalex.org/W1996917933","https://openalex.org/W1996995902","https://openalex.org/W1997278591","https://openalex.org/W1998659362","https://openalex.org/W1999082266","https://openalex.org/W1999206064","https://openalex.org/W2000706612","https://openalex.org/W2000917982","https://openalex.org/W2001210466","https://openalex.org/W2001900724","https://openalex.org/W2003610815","https://openalex.org/W2004546493","https://openalex.org/W2004646459","https://openalex.org/W2004784342","https://openalex.org/W2004968757","https://openalex.org/W2005797241","https://openalex.org/W2006257247","https://openalex.org/W2008002833","https://openalex.org/W2009174342","https://openalex.org/W2009575166","https://openalex.org/W2011335492","https://openalex.org/W2012921227","https://openalex.org/W2013553668","https://openalex.org/W2014593683","https://openalex.org/W2015508904","https://openalex.org/W2015514982","https://openalex.org/W2015588918","https://openalex.org/W2016436495","https://openalex.org/W2017842407","https://openalex.org/W2019428673","https://openalex.org/W2020486984","https://openalex.org/W2020497815","https://openalex.org/W2020611752","https://openalex.org/W2020951538","https://openalex.org/W2020971197","https://openalex.org/W2022025213","https://openalex.org/W2023500163","https://openalex.org/W2023960956","https://openalex.org/W2023986336","https://openalex.org/W2024262813","https://openalex.org/W2024849224","https://openalex.org/W2024943960","https://openalex.org/W2025018124","https://openalex.org/W2025563134","https://openalex.org/W2026624452","https://openalex.org/W2027190021","https://openalex.org/W2027704676","https://openalex.org/W2028003385","https://openalex.org/W2028061194","https://openalex.org/W2028826941","https://openalex.org/W2029651181","https://openalex.org/W2029918284","https://openalex.org/W2030508474","https://openalex.org/W2032920422","https://openalex.org/W2033847972","https://openalex.org/W2035282018","https://openalex.org/W2036362108","https://openalex.org/W2036745486","https://openalex.org/W2036910361","https://openalex.org/W2037318277","https://openalex.org/W2038072430","https://openalex.org/W2039303134","https://openalex.org/W2039894149","https://openalex.org/W2040721710","https://openalex.org/W2041425500","https://openalex.org/W2041863676","https://openalex.org/W2042794149","https://openalex.org/W2043838674","https://openalex.org/W2044001266","https://openalex.org/W2045035263","https://openalex.org/W2046847750","https://openalex.org/W2047970216","https://openalex.org/W2048027386","https://openalex.org/W2048975745","https://openalex.org/W2049167716","https://openalex.org/W2049747642","https://openalex.org/W2050146983","https://openalex.org/W2050496541","https://openalex.org/W2051261126","https://openalex.org/W2052647401","https://openalex.org/W2052742260","https://openalex.org/W2053116497","https://openalex.org/W2053665966","https://openalex.org/W2054654417","https://openalex.org/W2055361873","https://openalex.org/W2055588023","https://openalex.org/W2056745213","https://openalex.org/W2057714820","https://openalex.org/W2057717465","https://openalex.org/W2058495283","https://openalex.org/W2058581619","https://openalex.org/W2058813140","https://openalex.org/W2058880763","https://openalex.org/W2060431583","https://openalex.org/W2060458492","https://openalex.org/W2060579161","https://openalex.org/W2061346476","https://openalex.org/W2061378782","https://openalex.org/W2061619331","https://openalex.org/W2062214806","https://openalex.org/W2062489139","https://openalex.org/W2063236931","https://openalex.org/W2064579827","https://openalex.org/W2064958479","https://openalex.org/W2064963539","https://openalex.org/W2065327124","https://openalex.org/W2066848236","https://openalex.org/W2070601723","https://openalex.org/W2070881916","https://openalex.org/W2071318481","https://openalex.org/W2071953900","https://openalex.org/W2071982060","https://openalex.org/W2072371192","https://openalex.org/W2072480165","https://openalex.org/W2072554608","https://openalex.org/W2073644281","https://openalex.org/W2074222624","https://openalex.org/W2074697072","https://openalex.org/W2075481535","https://openalex.org/W2078212921","https://openalex.org/W2079213495","https://openalex.org/W2079783388","https://openalex.org/W2080274663","https://openalex.org/W2081095372","https://openalex.org/W2081182167","https://openalex.org/W2081605808","https://openalex.org/W2081768153","https://openalex.org/W2082429191","https://openalex.org/W2082871116","https://openalex.org/W2083480979","https://openalex.org/W2084516940","https://openalex.org/W2084559483","https://openalex.org/W2084979786","https://openalex.org/W2088239473","https://openalex.org/W2088733194","https://openalex.org/W2088997949","https://openalex.org/W2089963291","https://openalex.org/W2090023755","https://openalex.org/W2090496922","https://openalex.org/W2091031840","https://openalex.org/W2091612053","https://openalex.org/W2092217359","https://openalex.org/W2092698227","https://openalex.org/W2093067743","https://openalex.org/W2093419961","https://openalex.org/W2093489701","https://openalex.org/W2094808560","https://openalex.org/W2095456987","https://openalex.org/W2096410114","https://openalex.org/W2096946620","https://openalex.org/W2097965815","https://openalex.org/W2099370040","https://openalex.org/W2100100832","https://openalex.org/W2100295360","https://openalex.org/W2100610042","https://openalex.org/W2100817247","https://openalex.org/W2102973376","https://openalex.org/W2103440561","https://openalex.org/W2103960901","https://openalex.org/W2105704879","https://openalex.org/W2107406217","https://openalex.org/W2108215229","https://openalex.org/W2110582347","https://openalex.org/W2110831253","https://openalex.org/W2110998913","https://openalex.org/W2111920180","https://openalex.org/W2114163624","https://openalex.org/W2114559471","https://openalex.org/W2114729479","https://openalex.org/W2118891894","https://openalex.org/W2119813254","https://openalex.org/W2120435638","https://openalex.org/W2121715365","https://openalex.org/W2121963977","https://openalex.org/W2122065036","https://openalex.org/W2122209646","https://openalex.org/W2122253235","https://openalex.org/W2123619340","https://openalex.org/W2123674262","https://openalex.org/W2125172225","https://openalex.org/W2125420609","https://openalex.org/W2126800086","https://openalex.org/W2126958454","https://openalex.org/W2128111072","https://openalex.org/W2128401893","https://openalex.org/W2128831217","https://openalex.org/W2129354019","https://openalex.org/W2130144581","https://openalex.org/W2131041787","https://openalex.org/W2131303491","https://openalex.org/W2131819352","https://openalex.org/W2131862993","https://openalex.org/W2131897453","https://openalex.org/W2133631618","https://openalex.org/W2134953810","https://openalex.org/W2136747326","https://openalex.org/W2136901555","https://openalex.org/W2137932456","https://openalex.org/W2140542463","https://openalex.org/W2141471665","https://openalex.org/W2144486959","https://openalex.org/W2144620740","https://openalex.org/W2145144183","https://openalex.org/W2146610745","https://openalex.org/W2148568069","https://openalex.org/W2150746478","https://openalex.org/W2150999725","https://openalex.org/W2151025608","https://openalex.org/W2154768876","https://openalex.org/W2157064933","https://openalex.org/W2157069791","https://openalex.org/W2157359173","https://openalex.org/W2158226583","https://openalex.org/W2158766477","https://openalex.org/W2159529587","https://openalex.org/W2160207967","https://openalex.org/W2161227406","https://openalex.org/W2161732570","https://openalex.org/W2162400338","https://openalex.org/W2162807572","https://openalex.org/W2163304386","https://openalex.org/W2163916825","https://openalex.org/W2165021720","https://openalex.org/W2167158605","https://openalex.org/W2167182434","https://openalex.org/W2167423431","https://openalex.org/W2167548313","https://openalex.org/W2167768159","https://openalex.org/W2168025729","https://openalex.org/W2168136532","https://openalex.org/W2168334242","https://openalex.org/W2169152986","https://openalex.org/W2169303217","https://openalex.org/W2170644095","https://openalex.org/W2182295191","https://openalex.org/W2184320181","https://openalex.org/W2218459761","https://openalex.org/W2398670922","https://openalex.org/W2402561972","https://openalex.org/W2404067676","https://openalex.org/W2489606969","https://openalex.org/W2492871322","https://openalex.org/W3145878916","https://openalex.org/W4211107371","https://openalex.org/W4244977089","https://openalex.org/W4252344752","https://openalex.org/W4296154147","https://openalex.org/W4297846234","https://openalex.org/W4300007302","https://openalex.org/W4323238121","https://openalex.org/W6610655590"],"related_works":["https://openalex.org/W7095379268","https://openalex.org/W4224222666","https://openalex.org/W2031346817","https://openalex.org/W2014483271","https://openalex.org/W2963100704","https://openalex.org/W2145331523","https://openalex.org/W1520284233","https://openalex.org/W2099345876","https://openalex.org/W3170071980","https://openalex.org/W2901147556"],"abstract_inverted_index":{"Although":[0],"Alzheimer's":[1],"disease":[2],"(AD)":[3],"was":[4,140],"first":[5,87],"discovered":[6],"a":[7,14,28,38,137],"century":[8],"ago,":[9],"we":[10],"are":[11,24],"still":[12],"facing":[13],"lack":[15],"of":[16,40,65,112,195],"definitive":[17],"diagnosis":[18],"during":[19],"the":[20,32,41,48,66,80,86,108,162,172,186,237],"patient's":[21],"lifetime":[22],"and":[23,47,98,220,227],"unable":[25],"to":[26,50,78,214,232,248],"prescribe":[27],"curative":[29],"treatment.":[30,53],"However,":[31,236],"past":[33],"10":[34],"years":[35],"have":[36],"seen":[37],"\"revamping\"":[39],"main":[42],"hypothesis":[43],"about":[44],"AD":[45,54,92,113,150],"pathogenesis":[46],"hope":[49],"foresee":[51],"possible":[52],"is":[55,240,246],"no":[56,159,180],"longer":[57],"considered":[58],"an":[59],"irreversible":[60],"disease.":[61],"A":[62,100],"major":[63,222],"refinement":[64],"classic":[67],"beta-amyloid":[68,146],"cascade":[69,169],"describing":[70],"amyloid":[71,163,168],"fibrils":[72],"as":[73],"neurotoxins":[74],"has":[75,182],"been":[76,183],"made":[77],"integrate":[79],"key":[81],"scientific":[82],"evidences":[83],"demonstrating":[84],"that":[85,129,206],"pathological":[88,110],"event":[89],"occurring":[90],"in":[91,148,152,161,224],"early":[93],"stages":[94],"affects":[95],"synaptic":[96,130,218],"function":[97],"maintenance.":[99],"concept":[101],"fully":[102,243],"compatible":[103],"with":[104],"synapse":[105,173,225],"loss":[106],"being":[107],"best":[109],"correlate":[111],"rather":[114],"than":[115],"other":[116],"described":[117],"neuropathological":[118],"hallmarks":[119],"(amyloid":[120],"plaques,":[121],"neurofibrillary":[122],"tangles":[123],"or":[124,210],"neuronal":[125],"death).":[126],"The":[127,166],"notion":[128],"alterations":[131],"might":[132],"be":[133],"reverted,":[134],"thus":[135],"offering":[136],"potential":[138],"curability,":[139],"confirmed":[141],"by":[142,176],"immunotherapy":[143],"experiments":[144],"targeting":[145],"protein":[147],"transgenic":[149],"mice":[151],"which":[153,229],"cognitive":[154],"functions":[155],"were":[156],"improved":[157],"despite":[158],"reduction":[160],"plaques":[164],"burden.":[165],"updated":[167],"now":[170],"integrates":[171],"failure":[174],"triggered":[175],"soluble":[177,207],"Abeta-oligomers.":[178],"Still":[179],"consensus":[181],"reached":[184],"on":[185,192,198],"most":[187],"toxic":[188],"Abeta":[189,208],"conformations,":[190],"neither":[191],"their":[193,199,217],"site":[194],"production":[196],"nor":[197],"extra-":[200],"versus":[201],"intra-cellular":[202],"actions.":[203],"Evidence":[204],"shows":[205],"oligomers":[209],"ADDLs":[211],"bind":[212],"selectively":[213],"neurons":[215],"at":[216],"loci,":[219],"trigger":[221],"changes":[223],"composition":[226],"morphology,":[228],"ultimately":[230],"leads":[231],"dendritic":[233],"spine":[234],"loss.":[235],"exact":[238],"mechanism":[239],"not":[241],"yet":[242],"understood":[244],"but":[245],"suspected":[247],"involve":[249],"some":[250],"membrane":[251],"receptor(s).":[252]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}