{"id":"https://openalex.org/W1990717633","doi":"https://doi.org/10.1016/j.febslet.2012.11.026","title":"PDT\u2010induced HSP70 externalization up\u2010regulates NO production via TLR2 signal pathway in macrophages","display_name":"PDT\u2010induced HSP70 externalization up\u2010regulates NO production via TLR2 signal pathway in macrophages","publication_year":2012,"publication_date":"2012-12-13","ids":{"openalex":"https://openalex.org/W1990717633","doi":"https://doi.org/10.1016/j.febslet.2012.11.026","mag":"1990717633","pmid":"https://pubmed.ncbi.nlm.nih.gov/23247210"},"language":"en","primary_location":{"id":"doi:10.1016/j.febslet.2012.11.026","doi":"https://doi.org/10.1016/j.febslet.2012.11.026","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.febslet.2012.11.026","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2012.11.026","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2012.11.026","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014709751","display_name":"Sheng Song","orcid":"https://orcid.org/0000-0001-5676-0533","observed_orcids":["https://orcid.org/0000-0001-5676-0533"]},"institutions":[{"id":"https://openalex.org/I187400657","display_name":"South China Normal University","ror":"https://ror.org/01kq0pv72","country_code":"CN","type":"education","lineage":["https://openalex.org/I187400657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sheng Song","raw_affiliation_strings":["MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China","MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631 (China)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China","institution_ids":["https://openalex.org/I187400657"]},{"raw_affiliation_string":"MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631 (China)","institution_ids":["https://openalex.org/I187400657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021081534","display_name":"Feifan Zhou","orcid":"https://orcid.org/0000-0001-8213-507X","observed_orcids":["https://orcid.org/0000-0001-8213-507X"]},"institutions":[{"id":"https://openalex.org/I187400657","display_name":"South China Normal University","ror":"https://ror.org/01kq0pv72","country_code":"CN","type":"education","lineage":["https://openalex.org/I187400657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feifan Zhou","raw_affiliation_strings":["MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China","MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631 (China)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China","institution_ids":["https://openalex.org/I187400657"]},{"raw_affiliation_string":"MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631 (China)","institution_ids":["https://openalex.org/I187400657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001447073","display_name":"Wei R. Chen","orcid":"https://orcid.org/0000-0002-7133-5794","observed_orcids":["https://orcid.org/0000-0002-7133-5794"]},"institutions":[{"id":"https://openalex.org/I139325414","display_name":"University of Central Oklahoma","ror":"https://ror.org/02n455404","country_code":"US","type":"education","lineage":["https://openalex.org/I139325414"]},{"id":"https://openalex.org/I187400657","display_name":"South China Normal University","ror":"https://ror.org/01kq0pv72","country_code":"CN","type":"education","lineage":["https://openalex.org/I187400657"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Wei R. Chen","raw_affiliation_strings":["Biomedical Engineering Program, Department of Engineering and Physics, University of Central Oklahoma, Edmond, Oklahoma 73034, USA","MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Program, Department of Engineering and Physics, University of Central Oklahoma, Edmond, Oklahoma 73034, USA","institution_ids":["https://openalex.org/I139325414"]},{"raw_affiliation_string":"MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China","institution_ids":["https://openalex.org/I187400657"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110877689","display_name":"Da Xing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187400657","display_name":"South China Normal University","ror":"https://ror.org/01kq0pv72","country_code":"CN","type":"education","lineage":["https://openalex.org/I187400657"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Da Xing","raw_affiliation_strings":["MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China","MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631 (China)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China","institution_ids":["https://openalex.org/I187400657"]},{"raw_affiliation_string":"MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631 (China)","institution_ids":["https://openalex.org/I187400657"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110877689"],"corresponding_institution_ids":["https://openalex.org/I187400657"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":1.81,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.83419769,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"587","issue":"2","first_page":"128","last_page":"135"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.8676999807357788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.8676999807357788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.07900000363588333,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.9440000057220459},{"id":"https://openalex.org/keywords/nitric-oxide-production","display_name":"nitric oxide production","score":0.843999981880188},{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.8690000176429749},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.9200000166893005},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.7929999828338623},{"id":"https://openalex.org/keywords/pi3k-signaling","display_name":"PI3K signaling","score":0.7329999804496765},{"id":"https://openalex.org/keywords/myd88","display_name":"MyD88","score":0.9700000286102295},{"id":"https://openalex.org/keywords/apoptotic-cells","display_name":"apoptotic cells","score":0.6520000100135803},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.8690000176429749}],"concepts":[{"id":"https://openalex.org/C2779379281","wikidata":"https://www.wikidata.org/wiki/Q61895854","display_name":"Externalization","level":2,"score":0.786125659942627},{"id":"https://openalex.org/C2781236682","wikidata":"https://www.wikidata.org/wiki/Q410015","display_name":"TLR2","level":4,"score":0.7116900682449341},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5787030458450317},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5338839888572693},{"id":"https://openalex.org/C68991219","wikidata":"https://www.wikidata.org/wiki/Q419102","display_name":"Hsp70","level":4,"score":0.4945337474346161},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.32347214221954346},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21739187836647034},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2095727026462555},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.09607723355293274},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08633160591125488},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.06807392835617065},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.05598342418670654},{"id":"https://openalex.org/C11171543","wikidata":"https://www.wikidata.org/wiki/Q41630","display_name":"Psychoanalysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053594","descriptor_name":"Myeloid Differentiation Factor 88","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.febslet.2012.11.026","doi":"https://doi.org/10.1016/j.febslet.2012.11.026","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.febslet.2012.11.026","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2012.11.026","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:23247210","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23247210","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.febslet.2012.11.026","doi":"https://doi.org/10.1016/j.febslet.2012.11.026","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.febslet.2012.11.026","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2012.11.026","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990717633.pdf","grobid_xml":"https://content.openalex.org/works/W1990717633.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W175906499","https://openalex.org/W196395934","https://openalex.org/W1558643874","https://openalex.org/W1942176190","https://openalex.org/W1978802620","https://openalex.org/W1981406623","https://openalex.org/W1989984065","https://openalex.org/W1998585620","https://openalex.org/W2004465286","https://openalex.org/W2009887653","https://openalex.org/W2012552289","https://openalex.org/W2034394701","https://openalex.org/W2037592581","https://openalex.org/W2060420887","https://openalex.org/W2066627683","https://openalex.org/W2070732456","https://openalex.org/W2071563028","https://openalex.org/W2081349312","https://openalex.org/W2089900609","https://openalex.org/W2094899662","https://openalex.org/W2098842077","https://openalex.org/W2108157005","https://openalex.org/W2133288737","https://openalex.org/W2140716860","https://openalex.org/W2143781587","https://openalex.org/W2151734986","https://openalex.org/W2153928437","https://openalex.org/W2160100841","https://openalex.org/W2166151208","https://openalex.org/W2407744954","https://openalex.org/W2412540639","https://openalex.org/W4249528279","https://openalex.org/W4313379129"],"related_works":["https://openalex.org/W2071563028","https://openalex.org/W2056457009","https://openalex.org/W2081785241","https://openalex.org/W2045151809","https://openalex.org/W1974709405","https://openalex.org/W2044617686","https://openalex.org/W2011199179","https://openalex.org/W2365608836","https://openalex.org/W2006098000","https://openalex.org/W2149375213"],"abstract_inverted_index":{"We":[0,14],"studied":[1],"the":[2,25,56],"molecular":[3],"mechanism":[4],"underlying":[5],"PDT-induced":[6,86],"apoptosis-dependent":[7],"macrophage":[8,34,93],"activation,":[9],"particularly":[10],"through":[11,42],"NO":[12,17],"production.":[13],"demonstrate":[15],"that":[16,39,85],"production":[18],"is":[19,30],"initially":[20],"induced":[21],"by":[22,33],"HSP70":[23,76],"on":[24],"apoptotic":[26,40,71],"cell":[27],"surface,":[28],"and":[29,47,73],"further":[31],"enhanced":[32],"phagocytosis.":[35],"Additionally,":[36],"we":[37],"found":[38],"cells,":[41],"TLR2,":[43],"could":[44,49],"activate":[45],"PI3K,":[46],"this":[48],"be":[50],"either":[51],"dependent":[52],"or":[53],"independent":[54],"of":[55,58],"activation":[57],"MyD88.":[59],"These":[60],"results":[61],"reveal":[62],"a":[63],"novel":[64],"pathway":[65],"linking":[66],"innate":[67,94],"immune":[68],"signalling":[69],"to":[70],"cells":[72],"point":[74],"at":[75],"as":[77],"an":[78,89],"important":[79,90],"antitumor":[80],"immunostimulant.":[81],"They":[82],"also":[83],"indicate":[84],"apoptosis":[87],"has":[88],"role":[91],"in":[92],"immunity.":[95]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
