{"id":"https://openalex.org/W1990705137","doi":"https://doi.org/10.1016/s0272-6386(12)80429-x","title":"Reversible Activation Defect of the Platelet Glycoprotein IIb-IIIa Complex in Patients With Uremia","display_name":"Reversible Activation Defect of the Platelet Glycoprotein IIb-IIIa Complex in Patients With Uremia","publication_year":1993,"publication_date":"1993-11-01","ids":{"openalex":"https://openalex.org/W1990705137","doi":"https://doi.org/10.1016/s0272-6386(12)80429-x","mag":"1990705137","pmid":"https://pubmed.ncbi.nlm.nih.gov/8238012"},"language":"en","primary_location":{"id":"doi:10.1016/s0272-6386(12)80429-x","doi":"https://doi.org/10.1016/s0272-6386(12)80429-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0272-6386(12)80429-x","pdf_url":null,"source":{"id":"https://openalex.org/S18197459","display_name":"American Journal of Kidney Diseases","issn_l":"0272-6386","issn":["0272-6386","1523-6838"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Kidney Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090115261","display_name":"Ariela Benigni","orcid":"https://orcid.org/0000-0002-4721-5485","observed_orcids":["https://orcid.org/0000-0002-4721-5485"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210128630","display_name":"Centro di Riferimento Oncologico","ror":"https://ror.org/03ks1vk59","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210128630","https://openalex.org/I4210153126"]}],"countries":["ES","IT","US"],"is_corresponding":false,"raw_author_name":"Ariela Benigni","raw_affiliation_strings":["Mario Negri Institute for Pharmacological Research, Laboratori Negri Bergamo, Italy","From the Mario Negri Institute for Pharmacological Research, Laboratori Negri Bergamo, Bergamo, Italy","the Division of Nephrology, Ospedali Riuniti di Bergamo, Bergamo, Italy","the Roon Research Center, Division of Experimental Thrombosis and Hemostasis, Department of Molecular and Experimental Medicine and Committee on Vascular Biology, The Scripps Research Institute, La Jolla, CA","the Service of Hemotherapy and Hemostasis, Hospital Clinic i Provincial, Barcelona, Spain","the Servizio Immunotrasfusionale e Divisione di Patologia Clinica, Centro di Riferimento Oncologico, Aviano (Pordenone), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mario Negri Institute for Pharmacological Research, Laboratori Negri Bergamo, Italy","institution_ids":["https://openalex.org/I19630809"]},{"raw_affiliation_string":"From the Mario Negri Institute for Pharmacological Research, Laboratori Negri Bergamo, Bergamo, Italy","institution_ids":["https://openalex.org/I19630809"]},{"raw_affiliation_string":"the Division of Nephrology, Ospedali Riuniti di Bergamo, Bergamo, Italy","institution_ids":[]},{"raw_affiliation_string":"the Roon Research Center, Division of Experimental Thrombosis and Hemostasis, Department of Molecular and Experimental Medicine and Committee on Vascular Biology, The Scripps Research Institute, La Jolla, CA","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"the Service of Hemotherapy and Hemostasis, Hospital Clinic i Provincial, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]},{"raw_affiliation_string":"the Servizio Immunotrasfusionale e Divisione di Patologia Clinica, Centro di Riferimento Oncologico, Aviano (Pordenone), Italy","institution_ids":["https://openalex.org/I4210128630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010373098","display_name":"Paola Boccardo","orcid":"https://orcid.org/0000-0003-4969-6187","observed_orcids":["https://orcid.org/0000-0003-4969-6187"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210128630","display_name":"Centro di Riferimento Oncologico","ror":"https://ror.org/03ks1vk59","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210128630","https://openalex.org/I4210153126"]}],"countries":["ES","IT","US"],"is_corresponding":false,"raw_author_name":"Paola Boccardo","raw_affiliation_strings":["From the Mario Negri Institute for Pharmacological Research, Laboratori Negri Bergamo, Bergamo, Italy","the Division of Nephrology, Ospedali Riuniti di Bergamo, Bergamo, Italy","the Roon Research Center, Division of Experimental Thrombosis and Hemostasis, Department of Molecular and Experimental Medicine and Committee on Vascular Biology, The Scripps Research Institute, La Jolla, CA","the Service of Hemotherapy and Hemostasis, Hospital Clinic i Provincial, Barcelona, Spain","the Servizio Immunotrasfusionale e Divisione di Patologia Clinica, Centro di Riferimento Oncologico, Aviano (Pordenone), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Mario Negri Institute for Pharmacological Research, Laboratori Negri Bergamo, Bergamo, Italy","institution_ids":["https://openalex.org/I19630809"]},{"raw_affiliation_string":"the Division of Nephrology, Ospedali Riuniti di Bergamo, Bergamo, Italy","institution_ids":[]},{"raw_affiliation_string":"the Roon Research Center, Division of Experimental Thrombosis and Hemostasis, Department of Molecular and Experimental Medicine and Committee on Vascular Biology, The Scripps Research Institute, La Jolla, CA","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"the Service of Hemotherapy and Hemostasis, Hospital Clinic i Provincial, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]},{"raw_affiliation_string":"the Servizio Immunotrasfusionale e Divisione di Patologia Clinica, Centro di Riferimento Oncologico, Aviano (Pordenone), Italy","institution_ids":["https://openalex.org/I4210128630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040397073","display_name":"Miriam Galbusera","orcid":"https://orcid.org/0000-0003-2434-7343","observed_orcids":["https://orcid.org/0000-0003-2434-7343"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210128630","display_name":"Centro di Riferimento Oncologico","ror":"https://ror.org/03ks1vk59","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210128630","https://openalex.org/I4210153126"]}],"countries":["ES","IT","US"],"is_corresponding":false,"raw_author_name":"Miriam Galbusera","raw_affiliation_strings":["From the Mario Negri Institute for Pharmacological Research, Laboratori Negri Bergamo, Bergamo, Italy","the Division of Nephrology, Ospedali Riuniti di Bergamo, Bergamo, Italy","the Roon Research Center, Division of Experimental Thrombosis and Hemostasis, Department of Molecular and Experimental Medicine and Committee on Vascular Biology, The Scripps Research Institute, La Jolla, CA","the Service of Hemotherapy and Hemostasis, Hospital Clinic i Provincial, Barcelona, Spain","the Servizio Immunotrasfusionale e Divisione di Patologia Clinica, Centro di Riferimento Oncologico, Aviano (Pordenone), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Mario Negri Institute for Pharmacological Research, Laboratori Negri Bergamo, Bergamo, Italy","institution_ids":["https://openalex.org/I19630809"]},{"raw_affiliation_string":"the Division of Nephrology, Ospedali Riuniti di Bergamo, Bergamo, Italy","institution_ids":[]},{"raw_affiliation_string":"the Roon Research Center, Division of Experimental Thrombosis and Hemostasis, Department of Molecular and Experimental Medicine and Committee on Vascular Biology, The Scripps Research Institute, La Jolla, CA","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"the Service of Hemotherapy and Hemostasis, Hospital Clinic i Provincial, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]},{"raw_affiliation_string":"the Servizio Immunotrasfusionale e Divisione di Patologia Clinica, Centro di Riferimento Oncologico, Aviano (Pordenone), Italy","institution_ids":["https://openalex.org/I4210128630"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Juan Monteagudo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210128630","display_name":"Centro di Riferimento Oncologico","ror":"https://ror.org/03ks1vk59","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210128630","https://openalex.org/I4210153126"]}],"countries":["ES","IT","US"],"is_corresponding":false,"raw_author_name":"Juan Monteagudo","raw_affiliation_strings":["From the Mario Negri Institute for Pharmacological Research, Laboratori Negri Bergamo, Bergamo, Italy; the Service of Hemotherapy and Hemostasis, Hospital Clinic i Provincial, Barcelona, Spain; the Servizio Immunotrasfusionale e Divisione di Patologia Clinica, Centro di Riferimento Oncologico, Aviano (Pordenone), Italy; the Division of Nephrology, Ospedali Riuniti di Bergamo, Bergamo, Italy; and the Roon Research Center, Division of Experimental Thrombosis and Hemostasis, Department of Molecular and Experimental Medicine and Committee on Vascular Biology, The Scripps Research Institute, La Jolla, CA","From the Mario Negri Institute for Pharmacological Research, Laboratori Negri Bergamo, Bergamo, Italy","the Division of Nephrology, Ospedali Riuniti di Bergamo, Bergamo, Italy","the Roon Research Center, Division of Experimental Thrombosis and Hemostasis, Department of Molecular and Experimental Medicine and Committee on Vascular Biology, The Scripps Research Institute, La Jolla, CA","the Service of Hemotherapy and Hemostasis, Hospital Clinic i Provincial, Barcelona, Spain","the Servizio Immunotrasfusionale e Divisione di Patologia Clinica, Centro di Riferimento Oncologico, Aviano (Pordenone), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Mario Negri Institute for Pharmacological Research, Laboratori Negri Bergamo, Bergamo, Italy; the Service of Hemotherapy and Hemostasis, Hospital Clinic i Provincial, Barcelona, Spain; the Servizio Immunotrasfusionale e Divisione di Patologia Clinica, Centro di Riferimento Oncologico, Aviano (Pordenone), Italy; the Division of Nephrology, Ospedali Riuniti di Bergamo, Bergamo, Italy; and the Roon Research Center, Division of Experimental Thrombosis and Hemostasis, Department of Molecular and Experimental Medicine and Committee on Vascular Biology, The Scripps Research Institute, La Jolla, CA","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I19630809","https://openalex.org/I4210128630"]},{"raw_affiliation_string":"From the Mario Negri Institute for Pharmacological Research, Laboratori Negri Bergamo, Bergamo, Italy","institution_ids":["https://openalex.org/I19630809"]},{"raw_affiliation_string":"the Division of Nephrology, Ospedali Riuniti di Bergamo, Bergamo, Italy","institution_ids":[]},{"raw_affiliation_string":"the Roon Research Center, Division of Experimental Thrombosis and Hemostasis, Department of Molecular and Experimental Medicine and Committee on Vascular Biology, The Scripps Research Institute, La Jolla, CA","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"the Service of Hemotherapy and Hemostasis, Hospital Clinic i Provincial, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]},{"raw_affiliation_string":"the Servizio Immunotrasfusionale e Divisione di Patologia Clinica, Centro di Riferimento Oncologico, Aviano (Pordenone), Italy","institution_ids":["https://openalex.org/I4210128630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108087156","display_name":"Luigi De Marco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210128630","display_name":"Centro di Riferimento Oncologico","ror":"https://ror.org/03ks1vk59","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210128630","https://openalex.org/I4210153126"]}],"countries":["ES","IT","US"],"is_corresponding":false,"raw_author_name":"Luigi De Marco","raw_affiliation_strings":["From the Mario Negri Institute for Pharmacological Research, Laboratori Negri Bergamo, Bergamo, Italy; the Service of Hemotherapy and Hemostasis, Hospital Clinic i Provincial, Barcelona, Spain; the Servizio Immunotrasfusionale e Divisione di Patologia Clinica, Centro di Riferimento Oncologico, Aviano (Pordenone), Italy; the Division of Nephrology, Ospedali Riuniti di Bergamo, Bergamo, Italy; and the Roon Research Center, Division of Experimental Thrombosis and Hemostasis, Department of Molecular and Experimental Medicine and Committee on Vascular Biology, The Scripps Research Institute, La Jolla, CA","From the Mario Negri Institute for Pharmacological Research, Laboratori Negri Bergamo, Bergamo, Italy","the Division of Nephrology, Ospedali Riuniti di Bergamo, Bergamo, Italy","the Roon Research Center, Division of Experimental Thrombosis and Hemostasis, Department of Molecular and Experimental Medicine and Committee on Vascular Biology, The Scripps Research Institute, La Jolla, CA","the Service of Hemotherapy and Hemostasis, Hospital Clinic i Provincial, Barcelona, Spain","the Servizio Immunotrasfusionale e Divisione di Patologia Clinica, Centro di Riferimento Oncologico, Aviano (Pordenone), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Mario Negri Institute for Pharmacological Research, Laboratori Negri Bergamo, Bergamo, Italy; the Service of Hemotherapy and Hemostasis, Hospital Clinic i Provincial, Barcelona, Spain; the Servizio Immunotrasfusionale e Divisione di Patologia Clinica, Centro di Riferimento Oncologico, Aviano (Pordenone), Italy; the Division of Nephrology, Ospedali Riuniti di Bergamo, Bergamo, Italy; and the Roon Research Center, Division of Experimental Thrombosis and Hemostasis, Department of Molecular and Experimental Medicine and Committee on Vascular Biology, The Scripps Research Institute, La Jolla, CA","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I19630809","https://openalex.org/I4210128630"]},{"raw_affiliation_string":"From the Mario Negri Institute for Pharmacological Research, Laboratori Negri Bergamo, Bergamo, Italy","institution_ids":["https://openalex.org/I19630809"]},{"raw_affiliation_string":"the Division of Nephrology, Ospedali Riuniti di Bergamo, Bergamo, Italy","institution_ids":[]},{"raw_affiliation_string":"the Roon Research Center, Division of Experimental Thrombosis and Hemostasis, Department of Molecular and Experimental Medicine and Committee on Vascular Biology, The Scripps Research Institute, La Jolla, CA","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"the Service of Hemotherapy and Hemostasis, Hospital Clinic i Provincial, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]},{"raw_affiliation_string":"the Servizio Immunotrasfusionale e Divisione di Patologia Clinica, Centro di Riferimento Oncologico, Aviano (Pordenone), Italy","institution_ids":["https://openalex.org/I4210128630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023556434","display_name":"Giuseppe Remuzzi","orcid":"https://orcid.org/0000-0002-6194-3446","observed_orcids":["https://orcid.org/0000-0002-6194-3446"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210128630","display_name":"Centro di Riferimento Oncologico","ror":"https://ror.org/03ks1vk59","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210128630","https://openalex.org/I4210153126"]}],"countries":["ES","IT","US"],"is_corresponding":true,"raw_author_name":"Giuseppe Remuzzi","raw_affiliation_strings":["From the Mario Negri Institute for Pharmacological Research, Laboratori Negri Bergamo, Bergamo, Italy; the Service of Hemotherapy and Hemostasis, Hospital Clinic i Provincial, Barcelona, Spain; the Servizio Immunotrasfusionale e Divisione di Patologia Clinica, Centro di Riferimento Oncologico, Aviano (Pordenone), Italy; the Division of Nephrology, Ospedali Riuniti di Bergamo, Bergamo, Italy; and the Roon Research Center, Division of Experimental Thrombosis and Hemostasis, Department of Molecular and Experimental Medicine and Committee on Vascular Biology, The Scripps Research Institute, La Jolla, CA","From the Mario Negri Institute for Pharmacological Research, Laboratori Negri Bergamo, Bergamo, Italy","the Division of Nephrology, Ospedali Riuniti di Bergamo, Bergamo, Italy","the Roon Research Center, Division of Experimental Thrombosis and Hemostasis, Department of Molecular and Experimental Medicine and Committee on Vascular Biology, The Scripps Research Institute, La Jolla, CA","the Service of Hemotherapy and Hemostasis, Hospital Clinic i Provincial, Barcelona, Spain","the Servizio Immunotrasfusionale e Divisione di Patologia Clinica, Centro di Riferimento Oncologico, Aviano (Pordenone), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Mario Negri Institute for Pharmacological Research, Laboratori Negri Bergamo, Bergamo, Italy; the Service of Hemotherapy and Hemostasis, Hospital Clinic i Provincial, Barcelona, Spain; the Servizio Immunotrasfusionale e Divisione di Patologia Clinica, Centro di Riferimento Oncologico, Aviano (Pordenone), Italy; the Division of Nephrology, Ospedali Riuniti di Bergamo, Bergamo, Italy; and the Roon Research Center, Division of Experimental Thrombosis and Hemostasis, Department of Molecular and Experimental Medicine and Committee on Vascular Biology, The Scripps Research Institute, La Jolla, CA","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I19630809","https://openalex.org/I4210128630"]},{"raw_affiliation_string":"From the Mario Negri Institute for Pharmacological Research, Laboratori Negri Bergamo, Bergamo, Italy","institution_ids":["https://openalex.org/I19630809"]},{"raw_affiliation_string":"the Division of Nephrology, Ospedali Riuniti di Bergamo, Bergamo, Italy","institution_ids":[]},{"raw_affiliation_string":"the Roon Research Center, Division of Experimental Thrombosis and Hemostasis, Department of Molecular and Experimental Medicine and Committee on Vascular Biology, The Scripps Research Institute, La Jolla, CA","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"the Service of Hemotherapy and Hemostasis, Hospital Clinic i Provincial, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]},{"raw_affiliation_string":"the Servizio Immunotrasfusionale e Divisione di Patologia Clinica, Centro di Riferimento Oncologico, Aviano (Pordenone), Italy","institution_ids":["https://openalex.org/I4210128630"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110092925","display_name":"Zaverio M. Ruggeri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210128630","display_name":"Centro di Riferimento Oncologico","ror":"https://ror.org/03ks1vk59","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210128630","https://openalex.org/I4210153126"]}],"countries":["ES","IT","US"],"is_corresponding":false,"raw_author_name":"Zaverio M. Ruggeri","raw_affiliation_strings":["From the Mario Negri Institute for Pharmacological Research, Laboratori Negri Bergamo, Bergamo, Italy; the Service of Hemotherapy and Hemostasis, Hospital Clinic i Provincial, Barcelona, Spain; the Servizio Immunotrasfusionale e Divisione di Patologia Clinica, Centro di Riferimento Oncologico, Aviano (Pordenone), Italy; the Division of Nephrology, Ospedali Riuniti di Bergamo, Bergamo, Italy; and the Roon Research Center, Division of Experimental Thrombosis and Hemostasis, Department of Molecular and Experimental Medicine and Committee on Vascular Biology, The Scripps Research Institute, La Jolla, CA","From the Mario Negri Institute for Pharmacological Research, Laboratori Negri Bergamo, Bergamo, Italy","the Division of Nephrology, Ospedali Riuniti di Bergamo, Bergamo, Italy","the Roon Research Center, Division of Experimental Thrombosis and Hemostasis, Department of Molecular and Experimental Medicine and Committee on Vascular Biology, The Scripps Research Institute, La Jolla, CA","the Service of Hemotherapy and Hemostasis, Hospital Clinic i Provincial, Barcelona, Spain","the Servizio Immunotrasfusionale e Divisione di Patologia Clinica, Centro di Riferimento Oncologico, Aviano (Pordenone), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Mario Negri Institute for Pharmacological Research, Laboratori Negri Bergamo, Bergamo, Italy; the Service of Hemotherapy and Hemostasis, Hospital Clinic i Provincial, Barcelona, Spain; the Servizio Immunotrasfusionale e Divisione di Patologia Clinica, Centro di Riferimento Oncologico, Aviano (Pordenone), Italy; the Division of Nephrology, Ospedali Riuniti di Bergamo, Bergamo, Italy; and the Roon Research Center, Division of Experimental Thrombosis and Hemostasis, Department of Molecular and Experimental Medicine and Committee on Vascular Biology, The Scripps Research Institute, La Jolla, CA","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I19630809","https://openalex.org/I4210128630"]},{"raw_affiliation_string":"From the Mario Negri Institute for Pharmacological Research, Laboratori Negri Bergamo, Bergamo, Italy","institution_ids":["https://openalex.org/I19630809"]},{"raw_affiliation_string":"the Division of Nephrology, Ospedali Riuniti di Bergamo, Bergamo, Italy","institution_ids":[]},{"raw_affiliation_string":"the Roon Research Center, Division of Experimental Thrombosis and Hemostasis, Department of Molecular and Experimental Medicine and Committee on Vascular Biology, The Scripps Research Institute, La Jolla, CA","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"the Service of Hemotherapy and Hemostasis, Hospital Clinic i Provincial, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]},{"raw_affiliation_string":"the Servizio Immunotrasfusionale e Divisione di Patologia Clinica, Centro di Riferimento Oncologico, Aviano (Pordenone), Italy","institution_ids":["https://openalex.org/I4210128630"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5023556434"],"corresponding_institution_ids":["https://openalex.org/I123431417","https://openalex.org/I19630809","https://openalex.org/I4210115097","https://openalex.org/I4210128630"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":null,"fwci":1.3614,"has_fulltext":false,"cited_by_count":99,"citation_normalized_percentile":{"value":0.79795918,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"22","issue":"5","first_page":"668","last_page":"676"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uremia","display_name":"uremia","score":0.8289999961853027},{"id":"https://openalex.org/keywords/glycoprotein-iib-iiia","display_name":"integrin \u03b1IIb\u03b23","score":0.8059999942779541},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.8619999885559082},{"id":"https://openalex.org/keywords/uremic-bleeding","display_name":"uremic bleeding","score":0.7889999747276306},{"id":"https://openalex.org/keywords/von-willebrand-factor-binding","display_name":"von Willebrand factor binding","score":0.8859999775886536},{"id":"https://openalex.org/keywords/fibrinogen-binding","display_name":"fibrinogen binding","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hemodialysis","display_name":"hemodialysis","score":0.9259999990463257},{"id":"https://openalex.org/keywords/platelet-function","display_name":"platelet function","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.800445020198822},{"id":"https://openalex.org/C2776635150","wikidata":"https://www.wikidata.org/wiki/Q13365776","display_name":"Uremia","level":2,"score":0.7377460598945618},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6660870909690857},{"id":"https://openalex.org/C26828662","wikidata":"https://www.wikidata.org/wiki/Q7202248","display_name":"Platelet membrane glycoprotein","level":3,"score":0.638580858707428},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.6368331909179688},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6241767406463623},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5859313011169434},{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.5478888750076294},{"id":"https://openalex.org/C2910542480","wikidata":"https://www.wikidata.org/wiki/Q2335787","display_name":"Platelet Glycoprotein GPIIb-IIIa Complex","level":4,"score":0.46788686513900757},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.46214115619659424},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4247116148471832},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33305227756500244}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006435","descriptor_name":"Renal Dialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010980","descriptor_name":"Platelet Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014511","descriptor_name":"Uremia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014511","descriptor_name":"Uremia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0272-6386(12)80429-x","doi":"https://doi.org/10.1016/s0272-6386(12)80429-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0272-6386(12)80429-x","pdf_url":null,"source":{"id":"https://openalex.org/S18197459","display_name":"American Journal of Kidney Diseases","issn_l":"0272-6386","issn":["0272-6386","1523-6838"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Kidney Diseases","raw_type":"journal-article"},{"id":"pmid:8238012","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8238012","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of kidney diseases : the official journal of the National Kidney Foundation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G391231601","display_name":null,"funder_award_id":"HL 42846","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W97079667","https://openalex.org/W153675611","https://openalex.org/W421286179","https://openalex.org/W957480215","https://openalex.org/W1490933001","https://openalex.org/W1493308665","https://openalex.org/W1504674459","https://openalex.org/W1542285348","https://openalex.org/W1555561206","https://openalex.org/W1601529928","https://openalex.org/W1758388002","https://openalex.org/W1924175076","https://openalex.org/W1964027757","https://openalex.org/W1966201969","https://openalex.org/W1969877791","https://openalex.org/W1972225863","https://openalex.org/W1976876483","https://openalex.org/W1987281329","https://openalex.org/W1988165262","https://openalex.org/W1992646081","https://openalex.org/W1992799429","https://openalex.org/W1995200468","https://openalex.org/W2015695912","https://openalex.org/W2021331922","https://openalex.org/W2027199532","https://openalex.org/W2045175248","https://openalex.org/W2059894934","https://openalex.org/W2059933593","https://openalex.org/W2080580789","https://openalex.org/W2086779380","https://openalex.org/W2087754560","https://openalex.org/W2119064142","https://openalex.org/W2165207329","https://openalex.org/W2169030528","https://openalex.org/W2171721261","https://openalex.org/W2275456352","https://openalex.org/W2315613377","https://openalex.org/W2336841031","https://openalex.org/W2401738599","https://openalex.org/W2410315730","https://openalex.org/W2411155409","https://openalex.org/W2413799853","https://openalex.org/W2415773430","https://openalex.org/W2441030593","https://openalex.org/W2599064878","https://openalex.org/W4205168545","https://openalex.org/W4290462119"],"related_works":["https://openalex.org/W1894514973","https://openalex.org/W2053075118","https://openalex.org/W2500056499","https://openalex.org/W2411155409","https://openalex.org/W28408655","https://openalex.org/W2035413059","https://openalex.org/W2029742711","https://openalex.org/W2401481504","https://openalex.org/W2187801978","https://openalex.org/W4243692563"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}