{"id":"https://openalex.org/W1990704535","doi":"https://doi.org/10.1177/0885328214527776","title":"The design of contact lens based ocular drug delivery systems for single-day use: Part (I) Structural factors, surrogate ophthalmic dyes and passive diffusion studies","display_name":"The design of contact lens based ocular drug delivery systems for single-day use: Part (I) Structural factors, surrogate ophthalmic dyes and passive diffusion studies","publication_year":2014,"publication_date":"2014-03-24","ids":{"openalex":"https://openalex.org/W1990704535","doi":"https://doi.org/10.1177/0885328214527776","mag":"1990704535","pmid":"https://pubmed.ncbi.nlm.nih.gov/24663443"},"language":"en","primary_location":{"id":"doi:10.1177/0885328214527776","doi":"https://doi.org/10.1177/0885328214527776","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0885328214527776","pdf_url":null,"source":{"id":"https://openalex.org/S89326922","display_name":"Journal of Biomaterials Applications","issn_l":"0885-3282","issn":["0885-3282","1530-8022"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomaterials Applications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://publications.aston.ac.uk/id/eprint/40010/1/Design_of_contact_lens_based_ocular_drug_delivery_systems_for_single_day_use.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063072296","display_name":"Anisa Mahomed","orcid":"https://orcid.org/0000-0002-3719-7543","observed_orcids":["https://orcid.org/0000-0002-3719-7543"]},"institutions":[{"id":"https://openalex.org/I169199633","display_name":"Aston University","ror":"https://ror.org/05j0ve876","country_code":"GB","type":"education","lineage":["https://openalex.org/I169199633"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anisa Mahomed","raw_affiliation_strings":["Biomaterials Research Unit, School of Engineering and Applied Chemistry, Aston University, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomaterials Research Unit, School of Engineering and Applied Chemistry, Aston University, Birmingham, UK","institution_ids":["https://openalex.org/I169199633"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053574607","display_name":"Brian J. Tighe","orcid":"https://orcid.org/0000-0001-9601-8501","observed_orcids":["https://orcid.org/0000-0001-9601-8501"]},"institutions":[{"id":"https://openalex.org/I169199633","display_name":"Aston University","ror":"https://ror.org/05j0ve876","country_code":"GB","type":"education","lineage":["https://openalex.org/I169199633"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Brian J Tighe","raw_affiliation_strings":["Biomaterials Research Unit, School of Engineering and Applied Chemistry, Aston University, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomaterials Research Unit, School of Engineering and Applied Chemistry, Aston University, Birmingham, UK","institution_ids":["https://openalex.org/I169199633"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I169199633"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.8621,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.66483937,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"29","issue":"3","first_page":"341","last_page":"353"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/contact-lens-drug-delivery","display_name":"contact lens drug delivery","score":0.9160000085830688},{"id":"https://openalex.org/keywords/ocular-drug-delivery","display_name":"ocular drug delivery","score":0.8989999890327454},{"id":"https://openalex.org/keywords/daily-disposable-contact-lenses","display_name":"daily disposable contact lenses","score":0.9509999752044678},{"id":"https://openalex.org/keywords/passive-diffusion","display_name":"passive diffusion","score":0.6840000152587891},{"id":"https://openalex.org/keywords/hydrophobic-interactions","display_name":"hydrophobic interactions","score":0.625},{"id":"https://openalex.org/keywords/molecular-weight","display_name":"molecular weight","score":0.4440000057220459},{"id":"https://openalex.org/keywords/partition-coefficient","display_name":"partition coefficient","score":0.593999981880188},{"id":"https://openalex.org/keywords/moisture-content","display_name":"moisture content","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6344906687736511},{"id":"https://openalex.org/C2986805488","wikidata":"https://www.wikidata.org/wiki/Q23797","display_name":"Contact lens","level":2,"score":0.5774341821670532},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.43703216314315796},{"id":"https://openalex.org/C15336307","wikidata":"https://www.wikidata.org/wiki/Q1766051","display_name":"Lens (geology)","level":2,"score":0.43688246607780457},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.41359880566596985},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3988982141017914},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.38103896379470825},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34515270590782166},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23160627484321594},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.21315735578536987},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.18732523918151855},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.12046626210212708},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003261","descriptor_name":"Contact Lenses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004396","descriptor_name":"Coloring Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060433","descriptor_name":"Administration, Ophthalmic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1177/0885328214527776","doi":"https://doi.org/10.1177/0885328214527776","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0885328214527776","pdf_url":null,"source":{"id":"https://openalex.org/S89326922","display_name":"Journal of Biomaterials Applications","issn_l":"0885-3282","issn":["0885-3282","1530-8022"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomaterials Applications","raw_type":"journal-article"},{"id":"pmid:24663443","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24663443","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomaterials applications","raw_type":"Journal Article"},{"id":"pmh:oai:publications.aston.ac.uk:25763","doi":null,"is_oa":false,"landing_page_url":"https://publications.aston.ac.uk/id/eprint/25763/1/Design_of_contact_lens_based_ocular_drug_delivery_systems_for_single_day_use.pdf","pdf_url":"https://publications.aston.ac.uk/id/eprint/25763/1/Design_of_contact_lens_based_ocular_drug_delivery_systems_for_single_day_use.pdf","source":{"id":"https://openalex.org/S4306400483","display_name":"Aston Publications Explorer (Aston University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169199633","host_organization_name":"Aston University","host_organization_lineage":["https://openalex.org/I169199633"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:publications.aston.ac.uk:40010","doi":null,"is_oa":true,"landing_page_url":"https://publications.aston.ac.uk/view/author/cde3b1ba186958fbd3fadd0530dcb542.html>","pdf_url":"https://publications.aston.ac.uk/id/eprint/40010/1/Design_of_contact_lens_based_ocular_drug_delivery_systems_for_single_day_use.pdf","source":{"id":"https://openalex.org/S4306400483","display_name":"Aston Publications Explorer (Aston University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169199633","host_organization_name":"Aston University","host_organization_lineage":["https://openalex.org/I169199633"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:publications.aston.ac.uk:40010","doi":null,"is_oa":true,"landing_page_url":"https://publications.aston.ac.uk/view/author/cde3b1ba186958fbd3fadd0530dcb542.html>","pdf_url":"https://publications.aston.ac.uk/id/eprint/40010/1/Design_of_contact_lens_based_ocular_drug_delivery_systems_for_single_day_use.pdf","source":{"id":"https://openalex.org/S4306400483","display_name":"Aston Publications Explorer (Aston University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169199633","host_organization_name":"Aston University","host_organization_lineage":["https://openalex.org/I169199633"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990704535.pdf","grobid_xml":"https://content.openalex.org/works/W1990704535.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W210395626","https://openalex.org/W334539524","https://openalex.org/W1232225731","https://openalex.org/W1559467950","https://openalex.org/W1916373532","https://openalex.org/W1969373623","https://openalex.org/W1971972063","https://openalex.org/W1978285976","https://openalex.org/W1981537050","https://openalex.org/W1982349692","https://openalex.org/W1982809657","https://openalex.org/W1985372972","https://openalex.org/W1985900321","https://openalex.org/W1986180285","https://openalex.org/W1993763188","https://openalex.org/W1995488266","https://openalex.org/W1997008209","https://openalex.org/W2004165733","https://openalex.org/W2004184387","https://openalex.org/W2004272132","https://openalex.org/W2007067975","https://openalex.org/W2009528099","https://openalex.org/W2014312979","https://openalex.org/W2015073280","https://openalex.org/W2016202764","https://openalex.org/W2018378283","https://openalex.org/W2045522408","https://openalex.org/W2049870156","https://openalex.org/W2050266747","https://openalex.org/W2061214720","https://openalex.org/W2061722633","https://openalex.org/W2068671849","https://openalex.org/W2073617358","https://openalex.org/W2074208432","https://openalex.org/W2077300098","https://openalex.org/W2079288041","https://openalex.org/W2086619735","https://openalex.org/W2094822768","https://openalex.org/W2115305419","https://openalex.org/W2126691225","https://openalex.org/W2127765589","https://openalex.org/W2128349680","https://openalex.org/W2129631682","https://openalex.org/W2133918524","https://openalex.org/W2139013472","https://openalex.org/W2145496621","https://openalex.org/W2161377632","https://openalex.org/W2317574010","https://openalex.org/W2466565147","https://openalex.org/W2469483474","https://openalex.org/W2903568130","https://openalex.org/W3148661650"],"related_works":["https://openalex.org/W2190075210","https://openalex.org/W2691995931","https://openalex.org/W2804981439","https://openalex.org/W4387107514","https://openalex.org/W2115242666","https://openalex.org/W2600583683","https://openalex.org/W2225948026","https://openalex.org/W4247059642","https://openalex.org/W2560750944","https://openalex.org/W4379093921"],"abstract_inverted_index":{"The":[0,20,239,261],"poor":[1],"retention":[2,38],"and":[3,33,57,82,135,151,168,233,243,248],"efficacy":[4],"of":[5,11,23,29,36,46,60,71,94,100,106,119,132,190,201,204,217,229,263],"instilled":[6],"drops":[7],"as":[8,26,139],"a":[9,27,47,88,97,116,195,286],"means":[10,28],"delivering":[12],"drugs":[13,108],"to":[14,43,86,128,163,179,198,223,257,270],"the":[15,44,54,66,69,91,101,104,110,133,157,169,199,202,205,227,230,264,272,282],"ophthalmic":[16,30,283],"environment":[17,207],"is":[18,39,113,126,253],"well-recognised.":[19],"potential":[21,120],"value":[22],"contact":[24,63,215],"lenses":[25,64,216],"drug":[31,75,147],"delivery,":[32],"consequent":[34],"improvement":[35],"pre-corneal":[37],"one":[40],"obvious":[41],"route":[42],"development":[45,70],"more":[48],"effective":[49,92,181],"ocular":[50,206],"delivery":[51,76],"system.":[52],"Furthermore,":[53],"increasing":[55],"availability":[56],"clinical":[58],"use":[59,74],"daily":[61],"disposable":[62],"provides":[65],"platform":[67],"for":[68,90,184],"viable":[72],"single-day":[73],"devices":[77],"based":[78,155],"on":[79,156,276],"existing":[80],"materials":[81],"lenses.":[83],"In":[84],"order":[85],"provide":[87],"basis":[89],"design":[93,180],"such":[95],"devices,":[96],"systematic":[98],"understanding":[99],"factors":[102,167,225],"affecting":[103,226],"interaction":[105,240,280],"individual":[107],"with":[109,281],"lens":[111,244],"matrix":[112,266],"required.":[114],"Because":[115],"large":[117],"number":[118],"structural":[121,219],"variables":[122],"are":[123],"involved,":[124],"it":[125],"necessary":[127,196],"achieve":[129],"some":[130],"rationalisation":[131],"parameters":[134],"physicochemical":[136],"properties":[137],"(such":[138],"molecular":[140],"weight,":[141],"charge,":[142],"partition":[143],"coefficients)":[144],"that":[145,208],"influence":[146,275],"interactions.":[148],"Ophthalmic":[149],"dyes":[150],"structurally":[152,185],"related":[153,256],"compounds":[154],"same":[158],"core":[159],"structure":[160,250,262],"were":[161,221],"used":[162,176,222],"investigate":[164],"these":[165],"various":[166],"way":[170],"in":[171,177],"which":[172,252],"they":[173],"can":[174],"be":[175],"concert":[178],"release":[182,193,235],"systems":[183],"different":[186],"drugs.":[187],"Initial":[188],"studies":[189],"passive":[191],"diffusional":[192],"form":[194],"precursor":[197],"investigation":[200],"features":[203],"over-ride":[209],"this":[210],"simple":[211],"behaviour.":[212],"Commercially":[213],"available":[214],"differing":[218],"classifications":[220],"study":[224],"uptake":[228],"surrogate":[231],"actives":[232],"their":[234],"under":[236],"'passive'":[237],"conditions.":[238],"between":[241],"active":[242,277],"material":[245],"shows":[246],"considerable":[247],"complex":[249],"dependence,":[251],"not":[254],"simply":[255],"equilibrium":[258],"water":[259],"content.":[260],"polymer":[265],"itself":[267],"was":[268],"found":[269],"have":[271],"dominant":[273],"controlling":[274],"uptake;":[278],"hydrophobic":[279],"dye":[284],"playing":[285],"major":[287],"role.":[288]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}