{"id":"https://openalex.org/W1990683148","doi":"https://doi.org/10.1007/s40263-014-0148-4","title":"The Evidence for a Beneficial Role of Vitamin A in Multiple Sclerosis","display_name":"The Evidence for a Beneficial Role of Vitamin A in Multiple Sclerosis","publication_year":2014,"publication_date":"2014-02-20","ids":{"openalex":"https://openalex.org/W1990683148","doi":"https://doi.org/10.1007/s40263-014-0148-4","mag":"1990683148","pmid":"https://pubmed.ncbi.nlm.nih.gov/24557746"},"language":"en","primary_location":{"id":"doi:10.1007/s40263-014-0148-4","doi":"https://doi.org/10.1007/s40263-014-0148-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s40263-014-0148-4","pdf_url":null,"source":{"id":"https://openalex.org/S153913659","display_name":"CNS Drugs","issn_l":"1172-7047","issn":["1172-7047","1179-1934"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Drugs","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020111272","display_name":"Y\u00e1ra Dadalti Fragoso","orcid":"https://orcid.org/0000-0001-8726-089X","observed_orcids":["https://orcid.org/0000-0001-8726-089X"]},"institutions":[{"id":"https://openalex.org/I4210140372","display_name":"Universidade Metropolitana de Santos","ror":"https://ror.org/035mpnm25","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210140372"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Yara Dadalti Fragoso","raw_affiliation_strings":["Department of Neurology, MS Reference Center, Medical School, Universidade Metropolitana de Santos, Rua da Constituicao 374, Santos, SP, CEP 11015-470, Brazil, yara@bsnet.com.br","Department of Neurology, MS Reference Center, Medical School, Universidade Metropolitana de Santos, Rua da Constituicao 374, Santos, SP, CEP 11015-470, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, MS Reference Center, Medical School, Universidade Metropolitana de Santos, Rua da Constituicao 374, Santos, SP, CEP 11015-470, Brazil, yara@bsnet.com.br","institution_ids":["https://openalex.org/I4210140372"]},{"raw_affiliation_string":"Department of Neurology, MS Reference Center, Medical School, Universidade Metropolitana de Santos, Rua da Constituicao 374, Santos, SP, CEP 11015-470, Brazil","institution_ids":["https://openalex.org/I4210140372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072965524","display_name":"Patrick N. Stoney","orcid":"https://orcid.org/0000-0003-0383-9496","observed_orcids":["https://orcid.org/0000-0003-0383-9496"]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Patrick N. Stoney","raw_affiliation_strings":["Institute of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, UK","institution_ids":["https://openalex.org/I195460627"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037680649","display_name":"Peter J. A. McCaffery","orcid":"https://orcid.org/0000-0002-5956-3997","observed_orcids":["https://orcid.org/0000-0002-5956-3997"]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter J. McCaffery","raw_affiliation_strings":["Institute of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, UK","institution_ids":["https://openalex.org/I195460627"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5020111272"],"corresponding_institution_ids":["https://openalex.org/I4210140372"],"apc_list":{"value":5090,"currency":"USD","value_usd":5090},"apc_paid":null,"fwci":0.896,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.64510386,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"28","issue":"4","first_page":"291","last_page":"299"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-a","display_name":"vitamin A","score":0.9819999933242798},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.8529999852180481},{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":1.0},{"id":"https://openalex.org/keywords/neuroimmunology","display_name":"neuroimmunology","score":0.8730000257492065},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.6330000162124634},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5149999856948853},{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.5690000057220459},{"id":"https://openalex.org/keywords/vitamin-supplementation","display_name":"vitamin supplementation","score":0.7139999866485596},{"id":"https://openalex.org/keywords/brain-protection","display_name":"cerebral protection","score":0.7200000286102295},{"id":"https://openalex.org/keywords/nuclear-receptor-signaling","display_name":"nuclear receptor signaling","score":0.6060000061988831},{"id":"https://openalex.org/keywords/immune-tolerance","display_name":"immune tolerance","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.7727465629577637},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.7373002171516418},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7073476314544678},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.6581162810325623},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48705628514289856},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48119789361953735},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.47979146242141724},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.47839391231536865},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.4581858217716217},{"id":"https://openalex.org/C2777621572","wikidata":"https://www.wikidata.org/wiki/Q139200","display_name":"Ergocalciferol","level":4,"score":0.43905341625213623},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3481348752975464},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3441457152366638},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28480732440948486},{"id":"https://openalex.org/C2780106736","wikidata":"https://www.wikidata.org/wiki/Q139347","display_name":"Cholecalciferol","level":3,"score":0.2773231267929077},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2481391727924347},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22851154208183289},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014801","descriptor_name":"Vitamin A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014801","descriptor_name":"Vitamin A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014801","descriptor_name":"Vitamin A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014801","descriptor_name":"Vitamin A","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014801","descriptor_name":"Vitamin A","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014801","descriptor_name":"Vitamin A","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s40263-014-0148-4","doi":"https://doi.org/10.1007/s40263-014-0148-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s40263-014-0148-4","pdf_url":null,"source":{"id":"https://openalex.org/S153913659","display_name":"CNS Drugs","issn_l":"1172-7047","issn":["1172-7047","1179-1934"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Drugs","raw_type":"journal-article"},{"id":"pmid:24557746","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24557746","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS drugs","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.4099999964237213,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2299889168","display_name":"Retinoic acid signalling within the hypothalamus is essential to the photoperiodic neuroendocrine response","funder_award_id":"BB/G014272/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G3112609764","display_name":null,"funder_award_id":"BB/G014272/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G3702213380","display_name":"Inflammatory signals regulate neuroendocrine control of growth and energy balance through re-modelling of mammalian hypothalamus","funder_award_id":"BB/K001043/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G7434789568","display_name":null,"funder_award_id":"BB/K001043/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320336557","display_name":"Ci\u00eancia sem Fronteiras","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":99,"referenced_works":["https://openalex.org/W1498255299","https://openalex.org/W1506579269","https://openalex.org/W1526228971","https://openalex.org/W1557149681","https://openalex.org/W1608126464","https://openalex.org/W1637566857","https://openalex.org/W1911105016","https://openalex.org/W1965422165","https://openalex.org/W1966316797","https://openalex.org/W1969035181","https://openalex.org/W1969416680","https://openalex.org/W1971156017","https://openalex.org/W1971562865","https://openalex.org/W1971788432","https://openalex.org/W1975605578","https://openalex.org/W1977336803","https://openalex.org/W1978628739","https://openalex.org/W1978780433","https://openalex.org/W1979154501","https://openalex.org/W1980888912","https://openalex.org/W1983263013","https://openalex.org/W1984648075","https://openalex.org/W1986766905","https://openalex.org/W1987617253","https://openalex.org/W1992173180","https://openalex.org/W1992851412","https://openalex.org/W1993607604","https://openalex.org/W1993921528","https://openalex.org/W1995635160","https://openalex.org/W1999170657","https://openalex.org/W2001801508","https://openalex.org/W2003481369","https://openalex.org/W2005166009","https://openalex.org/W2006492215","https://openalex.org/W2007600985","https://openalex.org/W2007629498","https://openalex.org/W2008713912","https://openalex.org/W2010171083","https://openalex.org/W2018081040","https://openalex.org/W2018938924","https://openalex.org/W2019316370","https://openalex.org/W2021041444","https://openalex.org/W2022283661","https://openalex.org/W2024464574","https://openalex.org/W2024490058","https://openalex.org/W2025011598","https://openalex.org/W2027575557","https://openalex.org/W2034013050","https://openalex.org/W2034671678","https://openalex.org/W2034959869","https://openalex.org/W2035452932","https://openalex.org/W2037259928","https://openalex.org/W2043135658","https://openalex.org/W2044523394","https://openalex.org/W2046780372","https://openalex.org/W2048652649","https://openalex.org/W2049983202","https://openalex.org/W2057339543","https://openalex.org/W2062636762","https://openalex.org/W2065234112","https://openalex.org/W2065809881","https://openalex.org/W2071822405","https://openalex.org/W2078575275","https://openalex.org/W2080683349","https://openalex.org/W2081865759","https://openalex.org/W2083151217","https://openalex.org/W2085623509","https://openalex.org/W2088445542","https://openalex.org/W2089938835","https://openalex.org/W2100202927","https://openalex.org/W2100770448","https://openalex.org/W2103213691","https://openalex.org/W2107129088","https://openalex.org/W2107631420","https://openalex.org/W2108838859","https://openalex.org/W2113561458","https://openalex.org/W2114080475","https://openalex.org/W2119490376","https://openalex.org/W2121940170","https://openalex.org/W2122946745","https://openalex.org/W2127379971","https://openalex.org/W2128111531","https://openalex.org/W2128746061","https://openalex.org/W2130471591","https://openalex.org/W2130924672","https://openalex.org/W2133197725","https://openalex.org/W2133300604","https://openalex.org/W2145016172","https://openalex.org/W2146529109","https://openalex.org/W2148573039","https://openalex.org/W2151047905","https://openalex.org/W2155779547","https://openalex.org/W2158863995","https://openalex.org/W2170235819","https://openalex.org/W2170860777","https://openalex.org/W2299122378","https://openalex.org/W2471371292","https://openalex.org/W2776663677","https://openalex.org/W4254794817"],"related_works":["https://openalex.org/W4324274076","https://openalex.org/W2474521649","https://openalex.org/W2065809881","https://openalex.org/W4313545413","https://openalex.org/W2132191168","https://openalex.org/W2122946745","https://openalex.org/W1894517614","https://openalex.org/W2085623509","https://openalex.org/W862509735","https://openalex.org/W1783048998"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}
