{"id":"https://openalex.org/W1990674452","doi":"https://doi.org/10.4161/onci.20225","title":"The protooncogene Vav1 regulates murine leukemia virus-induced T-cell leukemogenesis","display_name":"The protooncogene Vav1 regulates murine leukemia virus-induced T-cell leukemogenesis","publication_year":2012,"publication_date":"2012-05-15","ids":{"openalex":"https://openalex.org/W1990674452","doi":"https://doi.org/10.4161/onci.20225","mag":"1990674452","pmid":"https://pubmed.ncbi.nlm.nih.gov/22934252","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3429564"},"language":"en","primary_location":{"id":"doi:10.4161/onci.20225","doi":"https://doi.org/10.4161/onci.20225","is_oa":true,"landing_page_url":"https://doi.org/10.4161/onci.20225","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/onci.20225?needAccess=true","source":{"id":"https://openalex.org/S2497914550","display_name":"OncoImmunology","issn_l":"2162-4011","issn":["2162-4011","2162-402X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoImmunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/onci.20225?needAccess=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012700214","display_name":"Sandra Kaminski","orcid":"https://orcid.org/0000-0001-7213-6060","observed_orcids":["https://orcid.org/0000-0001-7213-6060"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210114166","display_name":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier","ror":"https://ror.org/02785qs39","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210114166"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sandra Kaminski","raw_affiliation_strings":["Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier; UMR 5535; CNRS; Montpellier, France","Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier","Montpellier, France","UMR 5535"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier; UMR 5535; CNRS; Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210114166"]},{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier","institution_ids":["https://openalex.org/I4210114166"]},{"raw_affiliation_string":"Montpellier, France","institution_ids":[]},{"raw_affiliation_string":"UMR 5535","institution_ids":["https://openalex.org/I4210114166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061365808","display_name":"Oumeya Adjali","orcid":"https://orcid.org/0000-0001-9693-127X","observed_orcids":["https://orcid.org/0000-0001-9693-127X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210114166","display_name":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier","ror":"https://ror.org/02785qs39","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210114166"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Oumeya Adjali","raw_affiliation_strings":["Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier; UMR 5535; CNRS; Montpellier, France","Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier","Montpellier, France","UMR 5535"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier; UMR 5535; CNRS; Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210114166"]},{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier","institution_ids":["https://openalex.org/I4210114166"]},{"raw_affiliation_string":"Montpellier, France","institution_ids":[]},{"raw_affiliation_string":"UMR 5535","institution_ids":["https://openalex.org/I4210114166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106454516","display_name":"Chantal Jacquet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210114166","display_name":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier","ror":"https://ror.org/02785qs39","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210114166"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Chantal Jacquet","raw_affiliation_strings":["Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier; UMR 5535; CNRS; Montpellier, France","Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier","Montpellier, France","UMR 5535"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier; UMR 5535; CNRS; Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210114166"]},{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier","institution_ids":["https://openalex.org/I4210114166"]},{"raw_affiliation_string":"Montpellier, France","institution_ids":[]},{"raw_affiliation_string":"UMR 5535","institution_ids":["https://openalex.org/I4210114166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047333734","display_name":"Johan Garaude","orcid":"https://orcid.org/0000-0001-7789-7715","observed_orcids":["https://orcid.org/0000-0001-7789-7715"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4387153574","display_name":"Universit\u00e9 Montpellier 1","ror":"https://ror.org/0227fbx80","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307","https://openalex.org/I4387153574"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Johan Garaude","raw_affiliation_strings":["INSERM; U1040; Universit\u00e9 de Montpellier 1; UFR Medecine; Montpellier, France","INSERM","Montpellier, France","U1040","UFR Medecine","Universit\u00e9 de Montpellier 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM; U1040; Universit\u00e9 de Montpellier 1; UFR Medecine; Montpellier, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4387153574"]},{"raw_affiliation_string":"INSERM","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Montpellier, France","institution_ids":[]},{"raw_affiliation_string":"U1040","institution_ids":[]},{"raw_affiliation_string":"UFR Medecine","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 de Montpellier 1","institution_ids":["https://openalex.org/I19894307","https://openalex.org/I4387153574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080036349","display_name":"Anne Keriel","orcid":"https://orcid.org/0000-0003-3340-299X","observed_orcids":["https://orcid.org/0000-0003-3340-299X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210114166","display_name":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier","ror":"https://ror.org/02785qs39","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210114166"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anne Keriel","raw_affiliation_strings":["Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier; UMR 5535; CNRS; Montpellier, France","Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier","Montpellier, France","UMR 5535"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier; UMR 5535; CNRS; Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210114166"]},{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier","institution_ids":["https://openalex.org/I4210114166"]},{"raw_affiliation_string":"Montpellier, France","institution_ids":[]},{"raw_affiliation_string":"UMR 5535","institution_ids":["https://openalex.org/I4210114166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068373275","display_name":"Adeline Lassaux","orcid":"https://orcid.org/0000-0002-7077-4023","observed_orcids":["https://orcid.org/0000-0002-7077-4023"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210114166","display_name":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier","ror":"https://ror.org/02785qs39","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210114166"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Adeline Lassaux","raw_affiliation_strings":["Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier; UMR 5535; CNRS; Montpellier, France","Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier","Montpellier, France","UMR 5535"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier; UMR 5535; CNRS; Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210114166"]},{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier","institution_ids":["https://openalex.org/I4210114166"]},{"raw_affiliation_string":"Montpellier, France","institution_ids":[]},{"raw_affiliation_string":"UMR 5535","institution_ids":["https://openalex.org/I4210114166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087895317","display_name":"Robert A. Hipskind","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210114166","display_name":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier","ror":"https://ror.org/02785qs39","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210114166"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Robert Hipskind","raw_affiliation_strings":["Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier; UMR 5535; CNRS; Montpellier, France","Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier","Montpellier, France","UMR 5535"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier; UMR 5535; CNRS; Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210114166"]},{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier","institution_ids":["https://openalex.org/I4210114166"]},{"raw_affiliation_string":"Montpellier, France","institution_ids":[]},{"raw_affiliation_string":"UMR 5535","institution_ids":["https://openalex.org/I4210114166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031967403","display_name":"Marc Sitbon","orcid":"https://orcid.org/0000-0003-3616-2338","observed_orcids":["https://orcid.org/0000-0003-3616-2338"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210114166","display_name":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier","ror":"https://ror.org/02785qs39","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210114166"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marc Sitbon","raw_affiliation_strings":["Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier; UMR 5535; CNRS; Montpellier, France","Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier","Montpellier, France","UMR 5535"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier; UMR 5535; CNRS; Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210114166"]},{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier","institution_ids":["https://openalex.org/I4210114166"]},{"raw_affiliation_string":"Montpellier, France","institution_ids":[]},{"raw_affiliation_string":"UMR 5535","institution_ids":["https://openalex.org/I4210114166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005174262","display_name":"Naomi N. Taylor","orcid":"https://orcid.org/0000-0002-2459-4558","observed_orcids":["https://orcid.org/0000-0002-2459-4558"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210114166","display_name":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier","ror":"https://ror.org/02785qs39","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210114166"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Naomi Taylor","raw_affiliation_strings":["Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier; UMR 5535; CNRS; Montpellier, France","Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier","Montpellier, France","UMR 5535"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier; UMR 5535; CNRS; Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210114166"]},{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier","institution_ids":["https://openalex.org/I4210114166"]},{"raw_affiliation_string":"Montpellier, France","institution_ids":[]},{"raw_affiliation_string":"UMR 5535","institution_ids":["https://openalex.org/I4210114166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5106124877","display_name":"Mart\u00edn Villalba","orcid":"https://orcid.org/0000-0002-4385-4888","observed_orcids":["https://orcid.org/0000-0002-4385-4888"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4387153574","display_name":"Universit\u00e9 Montpellier 1","ror":"https://ror.org/0227fbx80","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307","https://openalex.org/I4387153574"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Martin Villalba","raw_affiliation_strings":["INSERM; U1040; Universit\u00e9 de Montpellier 1; UFR Medecine; Montpellier, France","INSERM","Montpellier, France","U1040","UFR Medecine","Universit\u00e9 de Montpellier 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM; U1040; Universit\u00e9 de Montpellier 1; UFR Medecine; Montpellier, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4387153574"]},{"raw_affiliation_string":"INSERM","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Montpellier, France","institution_ids":[]},{"raw_affiliation_string":"U1040","institution_ids":[]},{"raw_affiliation_string":"UFR Medecine","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 de Montpellier 1","institution_ids":["https://openalex.org/I19894307","https://openalex.org/I4387153574"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5106124877"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4387153574"],"apc_list":{"value":2375,"currency":"GBP","value_usd":2913},"apc_paid":{"value":2375,"currency":"GBP","value_usd":2913},"fwci":0.3898,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.57472586,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"1","issue":"5","first_page":"600","last_page":"608"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vav1","display_name":"Vav1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/proto-oncogenes","display_name":"proto-oncogenes","score":0.7590000033378601},{"id":"https://openalex.org/keywords/t-cell-leukemia","display_name":"T-cell leukemia","score":0.7160000205039978},{"id":"https://openalex.org/keywords/murine-leukemia-virus","display_name":"murine leukemia virus","score":0.8519999980926514},{"id":"https://openalex.org/keywords/moloney-murine-leukemia-virus","display_name":"Moloney murine leukemia virus","score":0.8510000109672546},{"id":"https://openalex.org/keywords/t-cell-development","display_name":"T cell development","score":0.8550000190734863},{"id":"https://openalex.org/keywords/thymic-hypertrophy","display_name":"thymic hypertrophy","score":0.6190000176429749},{"id":"https://openalex.org/keywords/splenomegaly","display_name":"splenomegaly","score":0.7860000133514404},{"id":"https://openalex.org/keywords/hematocrit","display_name":"hematocrit","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5776952505111694},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5690747499465942},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5640572309494019},{"id":"https://openalex.org/C2779562191","wikidata":"https://www.wikidata.org/wiki/Q673848","display_name":"Murine leukemia virus","level":3,"score":0.5622525215148926},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5595913529396057},{"id":"https://openalex.org/C2778954852","wikidata":"https://www.wikidata.org/wiki/Q7799635","display_name":"Thymocyte","level":4,"score":0.5547757744789124},{"id":"https://openalex.org/C2778431562","wikidata":"https://www.wikidata.org/wiki/Q189308","display_name":"Retrovirus","level":3,"score":0.4946422278881073},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.45707306265830994},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.44770482182502747},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4458155632019043},{"id":"https://openalex.org/C2776913467","wikidata":"https://www.wikidata.org/wiki/Q7667895","display_name":"T-cell leukemia","level":3,"score":0.4455738365650177},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4197666645050049},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.32559090852737427},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.21415022015571594},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.21227380633354187},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.18002402782440186},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.17410853505134583},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.10745137929916382}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.4161/onci.20225","doi":"https://doi.org/10.4161/onci.20225","is_oa":true,"landing_page_url":"https://doi.org/10.4161/onci.20225","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/onci.20225?needAccess=true","source":{"id":"https://openalex.org/S2497914550","display_name":"OncoImmunology","issn_l":"2162-4011","issn":["2162-4011","2162-402X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoImmunology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2429643","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3429564","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22934252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22934252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncoimmunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3429564","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3429564/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncoimmunology","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-02193064v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.archives-ouvertes.fr/hal-02193064","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oncoimmunology","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:inserm-00726759v1","doi":null,"is_oa":true,"landing_page_url":"https://inserm.hal.science/inserm-00726759","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"OncoImmunology, 2012, 1 (5), pp.600-608. ⟨10.4161/onci.20225⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.4161/onci.20225","doi":"https://doi.org/10.4161/onci.20225","is_oa":true,"landing_page_url":"https://doi.org/10.4161/onci.20225","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/onci.20225?needAccess=true","source":{"id":"https://openalex.org/S2497914550","display_name":"OncoImmunology","issn_l":"2162-4011","issn":["2162-4011","2162-402X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoImmunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990674452.pdf","grobid_xml":"https://content.openalex.org/works/W1990674452.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W135518686","https://openalex.org/W1513677920","https://openalex.org/W1535168002","https://openalex.org/W1564968700","https://openalex.org/W1595862591","https://openalex.org/W1598851434","https://openalex.org/W1646181671","https://openalex.org/W1839381104","https://openalex.org/W1857839734","https://openalex.org/W1869465538","https://openalex.org/W1914853352","https://openalex.org/W1967270109","https://openalex.org/W1972185242","https://openalex.org/W1973803951","https://openalex.org/W1975785018","https://openalex.org/W2000058440","https://openalex.org/W2001324898","https://openalex.org/W2021156954","https://openalex.org/W2022702976","https://openalex.org/W2029350186","https://openalex.org/W2039968266","https://openalex.org/W2044356299","https://openalex.org/W2044374752","https://openalex.org/W2045976797","https://openalex.org/W2058299309","https://openalex.org/W2074932405","https://openalex.org/W2084715356","https://openalex.org/W2096432487","https://openalex.org/W2097116931","https://openalex.org/W2103138806","https://openalex.org/W2128037490","https://openalex.org/W2134594325","https://openalex.org/W2135090999","https://openalex.org/W2136628679","https://openalex.org/W2156648441","https://openalex.org/W2161117293","https://openalex.org/W2170211828"],"related_works":["https://openalex.org/W2984800162","https://openalex.org/W2154317853","https://openalex.org/W2130415744","https://openalex.org/W2398170205","https://openalex.org/W1857839734","https://openalex.org/W3090448695","https://openalex.org/W1524570718","https://openalex.org/W4312066610","https://openalex.org/W4385687393","https://openalex.org/W2424443413"],"abstract_inverted_index":{"Vav1":[0,44,73],"is":[1,8,62],"expressed":[2],"exclusively":[3],"in":[4,53,60,74,139],"hematopoietic":[5],"cells":[6],"and":[7,14,33,39,111,162],"required":[9],"for":[10],"T":[11,76,135,144,152,159,163],"cell":[12,77,136,145,153,160,164],"development":[13,28,137,146,161],"activation.":[15],"Vav1-deficient":[16,81,103,115],"mice":[17,82,104,116],"show":[18],"thymic":[19],"hypocellularity":[20],"due":[21],"to":[22,48],"a":[23,50,156],"partial":[24],"block":[25],"during":[26],"thymocyte":[27],"at":[29,130],"the":[30,35,70,84,148],"DN3":[31],"stage":[32,133],"between":[34,158],"double":[36],"positive":[37,41],"(DP)":[38],"single":[40],"(SP)":[42],"transition.":[43],"has":[45],"been":[46],"shown":[47],"play":[49],"significant":[51],"role":[52,59,71],"several":[54],"non-hematopoietic":[55],"tumors":[56],"but":[57],"its":[58],"leukemogenesis":[61],"unknown.":[63],"To":[64],"address":[65],"this":[66],"question,":[67],"we":[68],"investigated":[69],"of":[72,80,87,134,150],"retrovirus-induced":[75,151],"leukemogenesis.":[78,165],"Infection":[79],"with":[83,117,121],"Moloney":[85],"strain":[86],"murine":[88],"leukemia":[89],"virus":[90],"(M-MuLV)":[91],"significantly":[92],"affected":[93],"tumor":[94,98],"phenotype":[95],"without":[96],"modulating":[97],"incidence":[99],"or":[100],"latency.":[101],"M-MuLV-infected":[102],"showed":[105],"reduced":[106],"splenomegaly,":[107],"higher":[108],"hematocrit":[109],"levels":[110],"hypertrophic":[112],"thymi.":[113],"Notably,":[114],"M-MuLV":[118],"leukemias":[119],"presented":[120],"markedly":[122],"lower":[123],"TCR\u03b2/CD3":[124],"levels,":[125],"indicating":[126],"that":[127],"transformation":[128],"occurred":[129],"an":[131],"earlier":[132],"than":[138],"WT":[140],"mice.":[141],"Thus,":[142],"impaired":[143],"modulates":[147],"outcome":[149],"leukemias,":[154],"demonstrating":[155],"link":[157]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}