{"id":"https://openalex.org/W1990651940","doi":"https://doi.org/10.1097/00008571-199512001-00014","title":"Lung Cancer and CYP2D6 (the debrisoquine polymorphism): sources of heterogeneity in the proposed association","display_name":"Lung Cancer and CYP2D6 (the debrisoquine polymorphism): sources of heterogeneity in the proposed association","publication_year":1995,"publication_date":"1995-12-01","ids":{"openalex":"https://openalex.org/W1990651940","doi":"https://doi.org/10.1097/00008571-199512001-00014","mag":"1990651940","pmid":"https://pubmed.ncbi.nlm.nih.gov/7581482"},"language":"en","primary_location":{"id":"doi:10.1097/00008571-199512001-00014","doi":"https://doi.org/10.1097/00008571-199512001-00014","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00008571-199512001-00014","pdf_url":null,"source":{"id":"https://openalex.org/S196130971","display_name":"Pharmacogenetics","issn_l":"0960-314X","issn":["0960-314X","1473-561X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019329822","display_name":"Neil E. Caporaso","orcid":"https://orcid.org/0000-0001-7562-4609","observed_orcids":["https://orcid.org/0000-0001-7562-4609"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4391012607","display_name":"Division of Cancer Epidemiology and Genetics","ror":"https://ror.org/00vkwep27","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil Caporaso","raw_affiliation_strings":["Genetic Epidemiology Branch,National Cancer Institute, Rockville, MD 20892, USA","Genetic Epidemiology Branch, National Cancer Institute, Executive Plaza North 439, 6130 Executive Blvd. Rockville MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Epidemiology Branch,National Cancer Institute, Rockville, MD 20892, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4391012607"]},{"raw_affiliation_string":"Genetic Epidemiology Branch, National Cancer Institute, Executive Plaza North 439, 6130 Executive Blvd. Rockville MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047418153","display_name":"Michael Rutledge DeBaun","orcid":"https://orcid.org/0000-0002-0574-1604","observed_orcids":["https://orcid.org/0000-0002-0574-1604"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4391012607","display_name":"Division of Cancer Epidemiology and Genetics","ror":"https://ror.org/00vkwep27","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R. DeBaun","raw_affiliation_strings":["Genetic Epidemiology Branch, National Cancer Institute, Executive Plaza North 439, 6130 Executive Blvd. Rockville MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Epidemiology Branch, National Cancer Institute, Executive Plaza North 439, 6130 Executive Blvd. Rockville MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091859226","display_name":"Nathaniel Rothman","orcid":"https://orcid.org/0000-0001-6924-0895","observed_orcids":["https://orcid.org/0000-0001-6924-0895","https://orcid.org/0000-0002-0866-9943"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathaniel Rothman","raw_affiliation_strings":["Environmental Epidemiology Branch, Epidemiology and Biostatistics Program, National Cancer Institute, Executive Plaza North 439, 6130 Executive Blvd. Rockville MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental Epidemiology Branch, Epidemiology and Biostatistics Program, National Cancer Institute, Executive Plaza North 439, 6130 Executive Blvd. Rockville MD 20892, USA","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.5773,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.96843824,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"5","issue":"Special Issue","first_page":"S129","last_page":"S134"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cyp2d6","display_name":"CYP2D6","score":0.9959999918937683},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.9700000286102295},{"id":"https://openalex.org/keywords/study-heterogeneity","display_name":"study heterogeneity","score":0.777999997138977},{"id":"https://openalex.org/keywords/selection-bias","display_name":"selection bias","score":0.8510000109672546},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9610000252723694},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.6629999876022339},{"id":"https://openalex.org/keywords/effect-modification","display_name":"effect modification","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cyp1a1","display_name":"CYP1A1","score":0.8209999799728394},{"id":"https://openalex.org/keywords/gstm1","display_name":"GSTM1","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C2777600422","wikidata":"https://www.wikidata.org/wiki/Q3704421","display_name":"Debrisoquine","level":5,"score":0.8885904550552368},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7442169189453125},{"id":"https://openalex.org/C33664856","wikidata":"https://www.wikidata.org/wiki/Q3271142","display_name":"CYP2D6","level":4,"score":0.7178767919540405},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6118255257606506},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.5423581600189209},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5393732190132141},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.5268486738204956},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5162999033927917},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.49925947189331055},{"id":"https://openalex.org/C2779372377","wikidata":"https://www.wikidata.org/wiki/Q17147792","display_name":"Lung cancer susceptibility","level":5,"score":0.4421975016593933},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41198229789733887},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.3757143020629883},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.3546164035797119},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.30304330587387085},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28621718287467957},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19982308149337769}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010551","descriptor_name":"Personality","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D015983","descriptor_name":"Selection Bias","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019389","descriptor_name":"Cytochrome P-450 CYP2D6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00008571-199512001-00014","doi":"https://doi.org/10.1097/00008571-199512001-00014","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00008571-199512001-00014","pdf_url":null,"source":{"id":"https://openalex.org/S196130971","display_name":"Pharmacogenetics","issn_l":"0960-314X","issn":["0960-314X","1473-561X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenetics","raw_type":"journal-article"},{"id":"pmid:7581482","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7581482","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.979200005531311,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2188181641","https://openalex.org/W2075658187","https://openalex.org/W2091091699","https://openalex.org/W2021133564","https://openalex.org/W1998746257","https://openalex.org/W2306577156","https://openalex.org/W2034179809","https://openalex.org/W1982602465","https://openalex.org/W7098484019","https://openalex.org/W2061944305"],"abstract_inverted_index":{"Lung":[0],"cancer":[1,29,96],"association":[2],"studies":[3,26,88,150,170],"have":[4,76],"yielded":[5],"suggestive":[6],"but":[7],"not":[8,102],"definitive":[9],"results":[10],"for":[11,46,130,135,153],"a":[12],"few":[13],"genes:":[14],"CYP1A1":[15],"(in":[16],"Japanese),":[17],"GSTM1":[18],"and":[19,30,41,80,155],"CYP2D6.":[20,109],"We":[21,160],"focus":[22],"on":[23,147],"variability":[24],"in":[25,55,70,139,171],"of":[27,53,113,158],"lung":[28,95,136],"the":[31,50,71,84,94,111,164,168],"CYP2D6":[32,67],"gene":[33],"(debrisoquine":[34],"metabolic":[35,74],"phenotype)":[36],"as":[37],"an":[38],"instructive":[39],"case":[40],"we":[42],"propose":[43],"some":[44],"sources":[45,52,157],"this":[47],"heterogeneity.":[48],"Beyond":[49],"general":[51],"bias":[54],"all":[56],"field":[57],"studies,":[58],"three":[59],"specific":[60],"concerns":[61],"are":[62,161],"relevant.":[63],"First,":[64],"evidence":[65],"that":[66,151],"is":[68,83,115,143],"expressed":[69],"brain.":[72],"The":[73],"phenotypes":[75],"distinct":[77],"psychological":[78],"profiles":[79],"therefore":[81],"there":[82],"potential":[85],"to":[86,108,117,120,145,173],"distort":[87],"through":[89],"selection":[90],"bias.":[91,159],"Second,":[92],"among":[93],"histologic":[97],"types,":[98],"adenocarcinoma":[99],"likely":[100,116,144],"does":[101],"share":[103],"increased":[104],"genetic":[105,121,133,141],"susceptibility":[106,142],"due":[107],"Third,":[110],"degree":[112],"smoking":[114,126],"be":[118,128],"related":[119],"susceptibility.":[122],"Effect":[123],"modification":[124],"by":[125],"should":[127],"sought":[129],"any":[131],"putative":[132],"marker":[134],"cancer.":[137],"Progress":[138],"understanding":[140],"depend":[146],"future":[148],"well-designed":[149],"adjust":[152],"these":[154,176],"other":[156],"currently":[162],"reanalyzing":[163],"original":[165],"data":[166],"from":[167],"published":[169],"order":[172],"further":[174],"explore":[175],"issues.":[177]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}