{"id":"https://openalex.org/W1990649329","doi":"https://doi.org/10.1111/ene.12514","title":"The impact of oxaliplatin\u2010based chemotherapy for colorectal cancer on the autonomous nervous system","display_name":"The impact of oxaliplatin\u2010based chemotherapy for colorectal cancer on the autonomous nervous system","publication_year":2014,"publication_date":"2014-07-17","ids":{"openalex":"https://openalex.org/W1990649329","doi":"https://doi.org/10.1111/ene.12514","mag":"1990649329","pmid":"https://pubmed.ncbi.nlm.nih.gov/25041285"},"language":"en","primary_location":{"id":"doi:10.1111/ene.12514","doi":"https://doi.org/10.1111/ene.12514","is_oa":false,"landing_page_url":"https://doi.org/10.1111/ene.12514","pdf_url":null,"source":{"id":"https://openalex.org/S162635963","display_name":"European Journal of Neurology","issn_l":"1351-5101","issn":["1351-5101","1468-1331"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078782512","display_name":"Emmanouil V. Dermitzakis","orcid":"https://orcid.org/0000-0001-9275-0076","observed_orcids":["https://orcid.org/0000-0001-9275-0076"]},"institutions":[{"id":"https://openalex.org/I4210104108","display_name":"Papageorgiou General Hospital","ror":"https://ror.org/01663qy58","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210104108"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"E. V. Dermitzakis","raw_affiliation_strings":["Laboratory of Clinical Neurophysiology, Department of Neurology, Papageorgiou Hospital, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Neurophysiology, Department of Neurology, Papageorgiou Hospital, Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210104108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083019131","display_name":"Vasilios \u039a. Kimiskidis","orcid":"https://orcid.org/0000-0002-3335-3019","observed_orcids":["https://orcid.org/0000-0002-3335-3019"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"V. K. Kimiskidis","raw_affiliation_strings":["Laboratory of Clinical Neurophysiology, Aristotle University of Thessaloniki, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Neurophysiology, Aristotle University of Thessaloniki, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078271543","display_name":"Anastasia G Eleftheraki","orcid":"https://orcid.org/0000-0003-1826-4699","observed_orcids":["https://orcid.org/0000-0003-1826-4699"]},"institutions":[{"id":"https://openalex.org/I4210115932","display_name":"Hellenic Cooperative Oncology Group","ror":"https://ror.org/02bxsvn11","country_code":"GR","type":"company","lineage":["https://openalex.org/I4210115932"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"A. Eleftheraki","raw_affiliation_strings":["Section of Biostatistics; Hellenic Cooperative Oncology Group; Athens Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Biostatistics; Hellenic Cooperative Oncology Group; Athens Greece","institution_ids":["https://openalex.org/I4210115932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063290792","display_name":"George Lazaridis","orcid":"https://orcid.org/0000-0002-7476-2513","observed_orcids":["https://orcid.org/0000-0002-7476-2513"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I4210104108","display_name":"Papageorgiou General Hospital","ror":"https://ror.org/01663qy58","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210104108"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"G. Lazaridis","raw_affiliation_strings":["Department of Medical Oncology \u201cPapageorgiou\u201d Hospital Aristotle University of Thessaloniki School of Medicine Thessaloniki Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology \u201cPapageorgiou\u201d Hospital Aristotle University of Thessaloniki School of Medicine Thessaloniki Greece","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I4210104108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052643310","display_name":"Apostolos Konstantis","orcid":"https://orcid.org/0000-0003-2277-5264","observed_orcids":["https://orcid.org/0000-0003-2277-5264"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I4210104108","display_name":"Papageorgiou General Hospital","ror":"https://ror.org/01663qy58","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210104108"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"A. Konstantis","raw_affiliation_strings":["Department of Medical Oncology \u201cPapageorgiou\u201d Hospital Aristotle University of Thessaloniki School of Medicine Thessaloniki Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology \u201cPapageorgiou\u201d Hospital Aristotle University of Thessaloniki School of Medicine Thessaloniki Greece","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I4210104108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110214532","display_name":"Georgios Basdanis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I2800980381","display_name":"AHEPA University Hospital","ror":"https://ror.org/01q1jaw52","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2800980381"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"G. Basdanis","raw_affiliation_strings":["First Propaedeutic Department of Surgery, AHEPA Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Propaedeutic Department of Surgery, AHEPA Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I2800980381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028521246","display_name":"Iakovos Tsiptsios","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104108","display_name":"Papageorgiou General Hospital","ror":"https://ror.org/01663qy58","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210104108"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"I. Tsiptsios","raw_affiliation_strings":["Laboratory of Clinical Neurophysiology, Department of Neurology, Papageorgiou Hospital, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Neurophysiology, Department of Neurology, Papageorgiou Hospital, Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210104108"]}]},{"author_position":"middle","author":{"id":null,"display_name":"G. Georgiadis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165841","display_name":"Hippocration General Hospital","ror":"https://ror.org/05v5wwy67","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210165841"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"G. Georgiadis","raw_affiliation_strings":["Neurological Department \u201cHippocration\u201d General Hospital Thessaloniki Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurological Department \u201cHippocration\u201d General Hospital Thessaloniki Greece","institution_ids":["https://openalex.org/I4210165841"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041575636","display_name":"George Fountzilas","orcid":"https://orcid.org/0000-0001-8045-2186","observed_orcids":["https://orcid.org/0000-0001-8045-2186"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I4210104108","display_name":"Papageorgiou General Hospital","ror":"https://ror.org/01663qy58","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210104108"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"G. Fountzilas","raw_affiliation_strings":["Department of Medical Oncology \u201cPapageorgiou\u201d Hospital Aristotle University of Thessaloniki School of Medicine Thessaloniki Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology \u201cPapageorgiou\u201d Hospital Aristotle University of Thessaloniki School of Medicine Thessaloniki Greece","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I4210104108"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5078782512"],"corresponding_institution_ids":["https://openalex.org/I4210104108"],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":0.4914,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.65600501,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"21","issue":"12","first_page":"1471","last_page":"1477"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.021299999207258224,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxaliplatin","display_name":"oxaliplatin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8840000033378601},{"id":"https://openalex.org/keywords/chemotherapy-induced-peripheral-neuropathy","display_name":"chemotherapy-induced peripheral neuropathy","score":0.6990000009536743},{"id":"https://openalex.org/keywords/autonomic-nervous-system","display_name":"autonomic nervous system","score":0.7710000276565552},{"id":"https://openalex.org/keywords/orthostatic-hypotension","display_name":"orthostatic hypotension","score":0.9829999804496765},{"id":"https://openalex.org/keywords/sympathetic-skin-response","display_name":"sympathetic skin response","score":0.906000018119812},{"id":"https://openalex.org/keywords/mfolfox6","display_name":"mFOLFOX6","score":0.8389999866485596},{"id":"https://openalex.org/keywords/xelox","display_name":"XELOX","score":0.9909999966621399},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.8119999766349792},{"id":"https://openalex.org/keywords/autonomic-dysfunction","display_name":"autonomic dysfunction","score":0.7409999966621399}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9438213109970093},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.9052757024765015},{"id":"https://openalex.org/C2778260052","wikidata":"https://www.wikidata.org/wiki/Q117636","display_name":"FOLFOX","level":5,"score":0.8721619844436646},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5976945757865906},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5747048258781433},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.552019476890564},{"id":"https://openalex.org/C2777909004","wikidata":"https://www.wikidata.org/wiki/Q420207","display_name":"Capecitabine","level":4,"score":0.513102650642395},{"id":"https://openalex.org/C2777372248","wikidata":"https://www.wikidata.org/wiki/Q171064","display_name":"Autonomic nervous system","level":4,"score":0.5058019161224365},{"id":"https://openalex.org/C73787029","wikidata":"https://www.wikidata.org/wiki/Q7104929","display_name":"Orthostatic vital signs","level":3,"score":0.49586495757102966},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44995856285095215},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.42582112550735474},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.3827595114707947},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2573813796043396}],"mesh":[{"descriptor_ui":"D000069287","descriptor_name":"Capecitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001341","descriptor_name":"Autonomic Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D010071","descriptor_name":"Oxaloacetates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/ene.12514","doi":"https://doi.org/10.1111/ene.12514","is_oa":false,"landing_page_url":"https://doi.org/10.1111/ene.12514","pdf_url":null,"source":{"id":"https://openalex.org/S162635963","display_name":"European Journal of Neurology","issn_l":"1351-5101","issn":["1351-5101","1468-1331"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neurology","raw_type":"journal-article"},{"id":"pmid:25041285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25041285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1963597340","https://openalex.org/W1965967022","https://openalex.org/W1979437488","https://openalex.org/W1991245788","https://openalex.org/W1993213432","https://openalex.org/W1998910446","https://openalex.org/W2011665876","https://openalex.org/W2014004239","https://openalex.org/W2036868596","https://openalex.org/W2039258063","https://openalex.org/W2044309123","https://openalex.org/W2053636957","https://openalex.org/W2067155036","https://openalex.org/W2079378158","https://openalex.org/W2081302357","https://openalex.org/W2087591540","https://openalex.org/W2113919377","https://openalex.org/W2119881391","https://openalex.org/W2134977275","https://openalex.org/W2152841954","https://openalex.org/W2164906123","https://openalex.org/W2281598789","https://openalex.org/W2466489130","https://openalex.org/W2589453797","https://openalex.org/W4233598440","https://openalex.org/W4298160471"],"related_works":["https://openalex.org/W2525406182","https://openalex.org/W2024892541","https://openalex.org/W6977712540","https://openalex.org/W2475006353","https://openalex.org/W2542003453","https://openalex.org/W2136984368","https://openalex.org/W4400418461","https://openalex.org/W2163024772","https://openalex.org/W2344341270","https://openalex.org/W2164400199"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,109,159],"oxaliplatin":[2],"(\u039f\u03a7\u0391)-based":[3],"regimens":[4],"FOLFOX":[5],"and":[6,54,68,79,103,190,207],"XELOX":[7,52],"can":[8],"cause":[9],"peripheral":[10],"neuropathy.":[11],"It":[12],"is":[13,197],"unknown":[14],"if":[15],"\u039f\u03a7\u0391,":[16],"alone":[17],"or":[18,51],"in":[19,164],"combination":[20],"regimens,":[21],"affects":[22],"the":[23,31,37,59,83,92,112,119,143,165,168,180,203,208],"Autonomous":[24],"Nervous":[25],"System":[26],"(ANS).":[27],"Accordingly,":[28],"we":[29],"evaluated":[30],"impact":[32,170],"of":[33,61,91,111,161,171],"\u039f\u03a7\u0391-based":[34],"chemotherapy":[35,85,196],"on":[36,202],"ANS.":[38],"METHODS:":[39],"We":[40],"enrolled":[41],"36":[42],"patients":[43,136],"with":[44,48,199],"colorectal":[45],"cancer,":[46],"treated":[47],"adjuvant":[49],"mFOLFOX6":[50],"chemotherapy,":[53],"22":[55],"healthy":[56],"volunteers.":[57],"For":[58],"assessment":[60,90],"ANS":[62,87,175],"function,":[63],"participants":[64],"completed":[65],"a":[66],"questionnaire":[67,166],"underwent":[69],"neurophysiological":[70],"examination":[71],"at":[72,118,142,179],"three":[73],"time":[74,121,182],"points":[75,183],"(baseline,":[76],"3-4":[77],"months":[78,81],"6-8":[80,144],"after":[82],"first":[84],"cycle).":[86],"testing":[88],"included":[89],"adrenergic":[93,204],"cardiovascular":[94,205],"function":[95],"(orthostatic":[96],"hypotension-OH),":[97],"parasympathetic":[98,209],"heart":[99,210],"innervation":[100],"(ratio":[101],"30/15)":[102],"Sympathetic":[104],"Skin":[105],"Response":[106],"(SSR).":[107],"RESULTS:":[108],"values":[110],"30/15":[113],"ratio":[114],"were":[115],"significantly":[116],"reduced":[117],"two":[120,181],"point":[122],"assessments":[123],"compared":[124,147,184],"to":[125,148,174,185],"baseline":[126,149,186],"(Wilcoxon":[127],"signed":[128],"ranks":[129],"test,":[130],"both":[131],"P":[132,191],"<":[133],"0.001),":[134],"while":[135],"had":[137],"more":[138],"often":[139],"diastolic":[140],"OH":[141],"month":[145],"evaluation":[146],"(P":[150,187],"=":[151,188,192],"0.039).":[152],"In":[153],"contrast,":[154],"SSR":[155,213],"was":[156,177],"not":[157],"affected.":[158],"incidence":[160],"positive":[162],"responses":[163],"assessing":[167],"subjective":[169],"symptoms":[172],"attributable":[173],"dysfunction":[176],"higher":[178],"0.036":[189],"0.020).":[193],"CONCLUSIONS:":[194],"Oxaliplatin-based":[195],"associated":[198],"significant":[200],"effects":[201],"reaction":[206],"innervation,":[211],"whereas":[212],"remains":[214],"untouched.":[215]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
