{"id":"https://openalex.org/W1990637682","doi":"https://doi.org/10.1016/j.nut.2013.12.019","title":"Feeding prepubescent gilts a high-fat diet induces molecular changes in the hypothalamus-pituitary-gonadal axis and predicts early timing of puberty","display_name":"Feeding prepubescent gilts a high-fat diet induces molecular changes in the hypothalamus-pituitary-gonadal axis and predicts early timing of puberty","publication_year":2014,"publication_date":"2014-01-12","ids":{"openalex":"https://openalex.org/W1990637682","doi":"https://doi.org/10.1016/j.nut.2013.12.019","mag":"1990637682","pmid":"https://pubmed.ncbi.nlm.nih.gov/24985008"},"language":"en","primary_location":{"id":"doi:10.1016/j.nut.2013.12.019","doi":"https://doi.org/10.1016/j.nut.2013.12.019","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.nut.2013.12.019","pdf_url":null,"source":{"id":"https://openalex.org/S59739785","display_name":"Nutrition","issn_l":"0899-9007","issn":["0899-9007","1873-1244"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074889378","display_name":"Yong Zhuo","orcid":"https://orcid.org/0000-0002-8348-4199","observed_orcids":["https://orcid.org/0000-0002-8348-4199"]},"institutions":[{"id":"https://openalex.org/I37574244","display_name":"Sichuan Agricultural University","ror":"https://ror.org/0388c3403","country_code":"CN","type":"education","lineage":["https://openalex.org/I37574244"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Zhuo","raw_affiliation_strings":["Institute of Animal Nutrition, and Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Ya'an, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Animal Nutrition, and Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Ya'an, PR China","institution_ids":["https://openalex.org/I37574244"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dongsheng Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37574244","display_name":"Sichuan Agricultural University","ror":"https://ror.org/0388c3403","country_code":"CN","type":"education","lineage":["https://openalex.org/I37574244"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongsheng Zhou","raw_affiliation_strings":["Institute of Animal Nutrition, and Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Ya'an, PR China; Shenzhen Premix Inve Nutrition Co. Ltd, Shenzhen, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Animal Nutrition, and Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Ya'an, PR China; Shenzhen Premix Inve Nutrition Co. Ltd, Shenzhen, PR China","institution_ids":["https://openalex.org/I37574244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058907375","display_name":"Lianqiang Che","orcid":"https://orcid.org/0000-0002-0940-7275","observed_orcids":["https://orcid.org/0000-0002-0940-7275","https://orcid.org/0000-0002-2840-7131","https://orcid.org/0000-0001-6626-922X"]},"institutions":[{"id":"https://openalex.org/I37574244","display_name":"Sichuan Agricultural University","ror":"https://ror.org/0388c3403","country_code":"CN","type":"education","lineage":["https://openalex.org/I37574244"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lianqiang Che","raw_affiliation_strings":["Institute of Animal Nutrition, and Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Ya'an, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Animal Nutrition, and Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Ya'an, PR China","institution_ids":["https://openalex.org/I37574244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060742506","display_name":"Zhengfeng Fang","orcid":"https://orcid.org/0000-0003-1844-194X","observed_orcids":["https://orcid.org/0000-0003-1844-194X","https://orcid.org/0000-0002-6246-392X"]},"institutions":[{"id":"https://openalex.org/I37574244","display_name":"Sichuan Agricultural University","ror":"https://ror.org/0388c3403","country_code":"CN","type":"education","lineage":["https://openalex.org/I37574244"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhengfeng Fang","raw_affiliation_strings":["Institute of Animal Nutrition, and Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Ya'an, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Animal Nutrition, and Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Ya'an, PR China","institution_ids":["https://openalex.org/I37574244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075787108","display_name":"Yan Lin","orcid":"https://orcid.org/0000-0002-0351-3763","observed_orcids":["https://orcid.org/0000-0002-0351-3763"]},"institutions":[{"id":"https://openalex.org/I37574244","display_name":"Sichuan Agricultural University","ror":"https://ror.org/0388c3403","country_code":"CN","type":"education","lineage":["https://openalex.org/I37574244"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Lin","raw_affiliation_strings":["Institute of Animal Nutrition, and Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Ya'an, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Animal Nutrition, and Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Ya'an, PR China","institution_ids":["https://openalex.org/I37574244"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073968554","display_name":"De Wu","orcid":"https://orcid.org/0000-0003-1873-9914","observed_orcids":["https://orcid.org/0000-0003-1873-9914"]},"institutions":[{"id":"https://openalex.org/I37574244","display_name":"Sichuan Agricultural University","ror":"https://ror.org/0388c3403","country_code":"CN","type":"education","lineage":["https://openalex.org/I37574244"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"De Wu","raw_affiliation_strings":["Institute of Animal Nutrition, and Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Ya'an, PR China. Electronic address: Pig2pig@sina.com.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Animal Nutrition, and Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Ya'an, PR China. Electronic address: Pig2pig@sina.com.cn","institution_ids":["https://openalex.org/I37574244"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5073968554"],"corresponding_institution_ids":["https://openalex.org/I37574244"],"apc_list":{"value":3870,"currency":"USD","value_usd":3870},"apc_paid":null,"fwci":2.9726,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.8947116,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"30","issue":"7-8","first_page":"890","last_page":"896"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.8899999856948853},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-gonadal-axis","display_name":"hypothalamic-pituitary-gonadal axis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/kisspeptin","display_name":"kisspeptin","score":0.9769999980926514},{"id":"https://openalex.org/keywords/kisspeptin-receptor","display_name":"kisspeptin receptor","score":0.7919999957084656},{"id":"https://openalex.org/keywords/gonadotropin-releasing-hormone","display_name":"gonadotropin-releasing hormone","score":0.8220000267028809},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.8880000114440918},{"id":"https://openalex.org/keywords/leptin-receptor","display_name":"leptin receptor","score":0.8799999952316284},{"id":"https://openalex.org/keywords/igf-1-receptor","display_name":"IGF-1 receptor","score":0.9319999814033508},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.7760000228881836},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":1.0},{"id":"https://openalex.org/keywords/pig-reproduction","display_name":"swine reproduction","score":0.6449999809265137},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.546999990940094},{"id":"https://openalex.org/keywords/hormone-secretion","display_name":"hormone secretion","score":0.3869999945163727}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8219355344772339},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8114212155342102},{"id":"https://openalex.org/C146819174","wikidata":"https://www.wikidata.org/wiki/Q1703595","display_name":"Hypothalamic\u2013pituitary\u2013gonadal axis","level":4,"score":0.6224481463432312},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6191729307174683},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.5515442490577698},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.5219047665596008},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.49386459589004517},{"id":"https://openalex.org/C2777129507","wikidata":"https://www.wikidata.org/wiki/Q36857","display_name":"Oviduct","level":2,"score":0.4619287848472595},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.45430833101272583},{"id":"https://openalex.org/C2776808119","wikidata":"https://www.wikidata.org/wiki/Q909371","display_name":"Kisspeptin","level":3,"score":0.4384874403476715},{"id":"https://openalex.org/C192536144","wikidata":"https://www.wikidata.org/wiki/Q609370","display_name":"Sexual maturity","level":2,"score":0.4327915608882904},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.42503297328948975},{"id":"https://openalex.org/C2776354409","wikidata":"https://www.wikidata.org/wiki/Q1516012","display_name":"Delayed puberty","level":3,"score":0.4214799702167511},{"id":"https://openalex.org/C1998276","wikidata":"https://www.wikidata.org/wiki/Q388121","display_name":"Estrous cycle","level":2,"score":0.4114904999732971},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.3951120972633362},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.30802416801452637},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.24339506030082703},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1973242163658142}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000824","descriptor_name":"Animal Nutritional Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004041","descriptor_name":"Dietary Fats","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004041","descriptor_name":"Dietary Fats","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007030","descriptor_name":"Hypothalamo-Hypophyseal System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007030","descriptor_name":"Hypothalamo-Hypophyseal System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011627","descriptor_name":"Puberty","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011627","descriptor_name":"Puberty","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011627","descriptor_name":"Puberty","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012741","descriptor_name":"Sexual Maturation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012741","descriptor_name":"Sexual Maturation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014599","descriptor_name":"Uterus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015430","descriptor_name":"Weight Gain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.nut.2013.12.019","doi":"https://doi.org/10.1016/j.nut.2013.12.019","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.nut.2013.12.019","pdf_url":null,"source":{"id":"https://openalex.org/S59739785","display_name":"Nutrition","issn_l":"0899-9007","issn":["0899-9007","1873-1244"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition","raw_type":"journal-article"},{"id":"pmid:24985008","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24985008","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition (Burbank, Los Angeles County, Calif.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.8409000039100647,"id":"https://metadata.un.org/sdg/2"},{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1880891411","https://openalex.org/W1972275518","https://openalex.org/W1975888439","https://openalex.org/W1975890243","https://openalex.org/W1976985571","https://openalex.org/W1979001866","https://openalex.org/W1988718808","https://openalex.org/W2005262731","https://openalex.org/W2014093920","https://openalex.org/W2026474680","https://openalex.org/W2045690475","https://openalex.org/W2048128939","https://openalex.org/W2049850715","https://openalex.org/W2054014326","https://openalex.org/W2069478525","https://openalex.org/W2072083266","https://openalex.org/W2073828263","https://openalex.org/W2091398724","https://openalex.org/W2099189673","https://openalex.org/W2101853789","https://openalex.org/W2108244474","https://openalex.org/W2111338104","https://openalex.org/W2112093149","https://openalex.org/W2115976287","https://openalex.org/W2136971052","https://openalex.org/W2138020309","https://openalex.org/W2142686356","https://openalex.org/W2143506157","https://openalex.org/W2155941020","https://openalex.org/W2156725724","https://openalex.org/W2164194706","https://openalex.org/W2167747681"],"related_works":["https://openalex.org/W2211491691","https://openalex.org/W3110071550","https://openalex.org/W4382890574","https://openalex.org/W2277090424","https://openalex.org/W2184727451","https://openalex.org/W1989060463","https://openalex.org/W2983596012","https://openalex.org/W630341329","https://openalex.org/W1967830289","https://openalex.org/W2018638492"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}