{"id":"https://openalex.org/W1990591095","doi":"https://doi.org/10.1021/bi0022285","title":"cis- and trans-Diamminedichloroplatinum(II) Interstrand Cross-Linking of a Defined Sequence Nucleosomal Core Particle,","display_name":"cis- and trans-Diamminedichloroplatinum(II) Interstrand Cross-Linking of a Defined Sequence Nucleosomal Core Particle,","publication_year":2000,"publication_date":"2000-11-29","ids":{"openalex":"https://openalex.org/W1990591095","doi":"https://doi.org/10.1021/bi0022285","mag":"1990591095","pmid":"https://pubmed.ncbi.nlm.nih.gov/11123932"},"language":"en","primary_location":{"id":"doi:10.1021/bi0022285","doi":"https://doi.org/10.1021/bi0022285","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi0022285","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041998517","display_name":"Julie T. Millard","orcid":"https://orcid.org/0000-0001-6825-0207","observed_orcids":["https://orcid.org/0000-0001-6825-0207"]},"institutions":[{"id":"https://openalex.org/I27504731","display_name":"Colby College","ror":"https://ror.org/00fvyjk73","country_code":"US","type":"education","lineage":["https://openalex.org/I27504731"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie T. Millard","raw_affiliation_strings":["Department of Chemistry, Colby College, Waterville, Maine 04901","Department of Chemistry, Colby College, Waterville, Maine 04901, USA. jtmillar@colby.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Colby College, Waterville, Maine 04901","institution_ids":["https://openalex.org/I27504731"]},{"raw_affiliation_string":"Department of Chemistry, Colby College, Waterville, Maine 04901, USA. jtmillar@colby.edu","institution_ids":["https://openalex.org/I27504731"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015377625","display_name":"Erin E. Wilkes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27504731","display_name":"Colby College","ror":"https://ror.org/00fvyjk73","country_code":"US","type":"education","lineage":["https://openalex.org/I27504731"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin E. Wilkes","raw_affiliation_strings":["Department of Chemistry, Colby College, Waterville, Maine 04901"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Colby College, Waterville, Maine 04901","institution_ids":["https://openalex.org/I27504731"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27504731"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.44,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.63181173,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"39","issue":"51","first_page":"16046","last_page":"16055"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13105","display_name":"Synthesis and pharmacology of benzodiazepine derivatives","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9629999995231628},{"id":"https://openalex.org/keywords/transplatin","display_name":"transplatin","score":0.9599999785423279},{"id":"https://openalex.org/keywords/interstrand-cross-linking","display_name":"interstrand cross-linking","score":0.8619999885559082},{"id":"https://openalex.org/keywords/nucleosome","display_name":"nucleosome","score":0.6000000238418579},{"id":"https://openalex.org/keywords/5s-rdna","display_name":"5S rDNA","score":0.859000027179718},{"id":"https://openalex.org/keywords/xenopus-borealis","display_name":"Xenopus borealis","score":0.925000011920929},{"id":"https://openalex.org/keywords/nucleosome-reconstitution","display_name":"nucleosome reconstitution","score":0.7710000276565552},{"id":"https://openalex.org/keywords/dna-platination","display_name":"DNA platination","score":0.5979999899864197},{"id":"https://openalex.org/keywords/site-specific-cross-linking","display_name":"site-specific cross-linking","score":0.6940000057220459},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.6499999761581421},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.43700000643730164}],"concepts":[{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.7219134569168091},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.7095593214035034},{"id":"https://openalex.org/C84772758","wikidata":"https://www.wikidata.org/wiki/Q271794","display_name":"Nucleosome","level":4,"score":0.566718339920044},{"id":"https://openalex.org/C173681060","wikidata":"https://www.wikidata.org/wiki/Q5773169","display_name":"Histone octamer","level":5,"score":0.5656434297561646},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5278176069259644},{"id":"https://openalex.org/C40250595","wikidata":"https://www.wikidata.org/wiki/Q185098","display_name":"Electrophoresis","level":2,"score":0.5236065983772278},{"id":"https://openalex.org/C116084860","wikidata":"https://www.wikidata.org/wiki/Q48255","display_name":"Gel electrophoresis","level":2,"score":0.5148848295211792},{"id":"https://openalex.org/C101660505","wikidata":"https://www.wikidata.org/wiki/Q898301","display_name":"Polyacrylamide gel electrophoresis","level":3,"score":0.45191556215286255},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40992650389671326},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3735559582710266},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31329789757728577},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21025466918945312}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004275","descriptor_name":"DNA, Ribosomal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009707","descriptor_name":"Nucleosomes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009707","descriptor_name":"Nucleosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009707","descriptor_name":"Nucleosomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012341","descriptor_name":"RNA, Ribosomal, 5S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012341","descriptor_name":"RNA, Ribosomal, 5S","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014981","descriptor_name":"Xenopus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017665","descriptor_name":"Hydroxyl Radical","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi0022285","doi":"https://doi.org/10.1021/bi0022285","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi0022285","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:11123932","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11123932","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7099999785423279}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1293452886","display_name":"Diepoxide Cross-Linking of DNA","funder_award_id":"R15CA077748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3333927734","display_name":null,"funder_award_id":"1R15CA77748-01","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320310094","display_name":"University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320311883","display_name":"Colby College","ror":"https://ror.org/00fvyjk73"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W60390590","https://openalex.org/W107832641","https://openalex.org/W1541581440","https://openalex.org/W1566237035","https://openalex.org/W1592023228","https://openalex.org/W1775562748","https://openalex.org/W1947282333","https://openalex.org/W1964794107","https://openalex.org/W1964798092","https://openalex.org/W1965257259","https://openalex.org/W1966878726","https://openalex.org/W1969737828","https://openalex.org/W1975324887","https://openalex.org/W1979629335","https://openalex.org/W1983762073","https://openalex.org/W1991362133","https://openalex.org/W2001652098","https://openalex.org/W2002962545","https://openalex.org/W2003435166","https://openalex.org/W2005110328","https://openalex.org/W2006475699","https://openalex.org/W2010048885","https://openalex.org/W2013368026","https://openalex.org/W2031168662","https://openalex.org/W2033776031","https://openalex.org/W2034742750","https://openalex.org/W2036680211","https://openalex.org/W2038655805","https://openalex.org/W2043610941","https://openalex.org/W2051261725","https://openalex.org/W2051632678","https://openalex.org/W2055167460","https://openalex.org/W2059678562","https://openalex.org/W2065367918","https://openalex.org/W2065619687","https://openalex.org/W2066323178","https://openalex.org/W2070663406","https://openalex.org/W2075668056","https://openalex.org/W2079797742","https://openalex.org/W2083999236","https://openalex.org/W2090628009","https://openalex.org/W2093272255","https://openalex.org/W2129314778","https://openalex.org/W2160571470","https://openalex.org/W2163448787","https://openalex.org/W2170562450","https://openalex.org/W2314225431","https://openalex.org/W2415503185","https://openalex.org/W2507203008","https://openalex.org/W3025417354","https://openalex.org/W4247418383"],"related_works":["https://openalex.org/W2051261725","https://openalex.org/W1546508695","https://openalex.org/W2492095109","https://openalex.org/W1986925509","https://openalex.org/W2031168662","https://openalex.org/W2002226039","https://openalex.org/W2075942243","https://openalex.org/W2076423562","https://openalex.org/W2071094711","https://openalex.org/W2047382597"],"abstract_inverted_index":{"Interstrand":[0],"cross-linking":[1,119,139,167],"studies":[2],"with":[3,75],"the":[4,20,28,54,76,84,141,165],"antitumor":[5],"drug":[6,85,150],"cis-diamminedichloroplatinum(II)":[7,138],"and":[8,30,127,135,156,170],"its":[9],"clinically":[10],"inactive":[11],"isomer,":[12],"trans-diamminedichloroplatinum(II),":[13],"were":[14,35,71,80,111,120,153],"performed":[15],"on":[16],"a":[17],"fragment":[18],"of":[19,24,56,100,104,117,137,168],"5S":[21,33],"rRNA":[22],"gene":[23],"Xenopus":[25],"borealis":[26],"in":[27,140,164],"free":[29,105,146,169],"nucleosomal":[31,142,171],"state.":[32],"nucleosomes":[34],"formed":[36],"via":[37],"histone":[38],"octamer":[39],"exchange":[40],"from":[41],"chicken":[42],"erythrocyte":[43],"core":[44,62,93,109],"particles.":[45,63,94],"Native":[46],"polyacrylamide":[47,124],"gel":[48,125],"electrophoresis":[49,126],"was":[50,89],"used":[51],"to":[52,59,145],"probe":[53],"ability":[55],"platinated":[57,87],"DNA":[58,88,147],"reconstitute":[60],"into":[61,92],"Both":[64],"isomers":[65],"negatively":[66],"impacted":[67],"reconstitution":[68,103],"when":[69],"histones":[70,79,101],"present":[72,82],"during":[73,83],"incubation":[74],"drug.":[77],"When":[78],"not":[81,112],"treatment,":[86],"successfully":[90],"reconstituted":[91],"These":[95],"results":[96],"suggest":[97],"that":[98,152],"platination":[99],"impedes":[102],"DNA.":[106],"However,":[107],"already-formed":[108],"particles":[110],"disrupted":[113],"upon":[114],"platination.":[115],"Sites":[116],"interstrand":[118,166],"probed":[121],"through":[122],"denaturing":[123],"quantitative":[128],"phosphorimagery.":[129],"We":[130],"found":[131],"both":[132,149],"site-specific":[133],"enhancement":[134],"depression":[136],"samples":[143],"relative":[144],"at":[148],"concentrations":[151],"tested":[154],"(0.01":[155],"0.0025":[157],"mM).":[158],"trans-Diamminedichloroplatinum(II)":[159],"exhibited":[160],"no":[161],"detectable":[162],"differences":[163],"samples.":[172]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
