{"id":"https://openalex.org/W1990499122","doi":"https://doi.org/10.1172/jci36435","title":"Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium","display_name":"Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium","publication_year":2009,"publication_date":"2009-08-13","ids":{"openalex":"https://openalex.org/W1990499122","doi":"https://doi.org/10.1172/jci36435","mag":"1990499122","pmid":"https://pubmed.ncbi.nlm.nih.gov/19690388","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2735918"},"language":"en","primary_location":{"id":"doi:10.1172/jci36435","doi":"https://doi.org/10.1172/jci36435","is_oa":false,"landing_page_url":"https://doi.org/10.1172/jci36435","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2735918","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066377823","display_name":"Daekee Lee","orcid":"https://orcid.org/0000-0001-8130-2059","observed_orcids":["https://orcid.org/0000-0001-8130-2059"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daekee Lee","raw_affiliation_strings":["Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA. daekee@ewha.ac.kr","Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA. daekee@ewha.ac.kr","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031067040","display_name":"Ming Yu","orcid":"https://orcid.org/0000-0001-8692-6135","observed_orcids":["https://orcid.org/0000-0001-8692-6135"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming Yu","raw_affiliation_strings":["University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100398838","display_name":"Eunjung Lee","orcid":"https://orcid.org/0000-0002-8287-6131","observed_orcids":["https://orcid.org/0000-0002-8287-6131"]},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eunjung Lee","raw_affiliation_strings":["Ewha Womans University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ewha Womans University","institution_ids":["https://openalex.org/I138925566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089222191","display_name":"Hyunok Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyunok Kim","raw_affiliation_strings":["Ewha Womans University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ewha Womans University","institution_ids":["https://openalex.org/I138925566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100636314","display_name":"Yanan Yang","orcid":"https://orcid.org/0009-0000-2717-7453","observed_orcids":["https://orcid.org/0009-0000-2717-7453","https://orcid.org/0009-0008-6190-8094"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanan Yang","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100334920","display_name":"Kyoungmi Kim","orcid":"https://orcid.org/0000-0003-0941-806X","observed_orcids":["https://orcid.org/0000-0003-0941-806X"]},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyoungmi Kim","raw_affiliation_strings":["Ewha Womans University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ewha Womans University","institution_ids":["https://openalex.org/I138925566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024547629","display_name":"Christina Pannicia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Pannicia","raw_affiliation_strings":["University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111845730","display_name":"Jonathan M. Kurie","orcid":"https://orcid.org/0000-0002-1472-8719","observed_orcids":["https://orcid.org/0000-0002-1472-8719"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan M. Kurie","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025298255","display_name":"David W. Threadgill","orcid":"https://orcid.org/0000-0003-3538-1635","observed_orcids":["https://orcid.org/0000-0003-3538-1635"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David W. Threadgill","raw_affiliation_strings":["North Carolina State University","University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North Carolina State University","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5066377823"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":3.8255,"has_fulltext":false,"cited_by_count":91,"citation_normalized_percentile":{"value":0.93613917,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"119","issue":"9","first_page":"2702","last_page":"2713"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her3","display_name":"HER3","score":0.9819999933242798},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9010000228881836},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.7839999794960022},{"id":"https://openalex.org/keywords/intestinal-epithelium","display_name":"intestinal epithelium","score":0.859000027179718},{"id":"https://openalex.org/keywords/erbb4","display_name":"ErbB4","score":0.8029999732971191},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8040000200271606},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8669999837875366},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/apcmin-mice","display_name":"ApcMin/+ mice","score":0.7450000047683716},{"id":"https://openalex.org/keywords/egfr-inhibitor-resistance","display_name":"EGFR inhibitor resistance","score":0.6499999761581421},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.5320000052452087},{"id":"https://openalex.org/keywords/receptor-heterodimerization","display_name":"receptor heterodimerization","score":0.6150000095367432},{"id":"https://openalex.org/keywords/targeted-cancer-therapy","display_name":"targeted cancer therapy","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.6314374208450317},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.592643141746521},{"id":"https://openalex.org/C2781077229","wikidata":"https://www.wikidata.org/wiki/Q509615","display_name":"Intestinal epithelium","level":3,"score":0.5920655727386475},{"id":"https://openalex.org/C115456853","wikidata":"https://www.wikidata.org/wiki/Q17917132","display_name":"ERBB3","level":4,"score":0.5602077841758728},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4778047204017639},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46289435029029846},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4401014745235443},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.43151330947875977},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4040106534957886},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29833680391311646},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17615270614624023},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.07843494415283203}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017491","descriptor_name":"Genes, APC","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018815","descriptor_name":"Genes, erbB","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020893","descriptor_name":"Receptor, ErbB-3","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020893","descriptor_name":"Receptor, ErbB-3","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D020893","descriptor_name":"Receptor, ErbB-3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066247","descriptor_name":"Receptor, ErbB-4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1172/jci36435","doi":"https://doi.org/10.1172/jci36435","is_oa":false,"landing_page_url":"https://doi.org/10.1172/jci36435","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1503157","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2735918","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2735918","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2735918","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:19690388","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19690388","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:jw827k48b","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.17615/wy24-qs07","pdf_url":null,"source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical Investigation, 119(9)","raw_type":"Article"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/218793","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/218793","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"doi:10.17615/wy24-qs07","doi":"https://doi.org/10.17615/wy24-qs07","is_oa":true,"landing_page_url":"https://doi.org/10.17615/wy24-qs07","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1503157","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2735918","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1085565077","display_name":null,"funder_award_id":"P30CA016086","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2687674258","display_name":null,"funder_award_id":"R15-2006-020","funder_id":"https://openalex.org/F4320322348","funder_display_name":"Korea Science and Engineering Foundation"},{"id":"https://openalex.org/G3951587671","display_name":"The ErbB Receptor Tyrosine Kinases: A Model for Receptor    Interaction and Specificity","funder_award_id":"9729645","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5415847141","display_name":null,"funder_award_id":"CA-092479","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5685585280","display_name":"SPORE in Gastrointestinal Cancer","funder_award_id":"P50CA106991","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7362607528","display_name":"ERBB receptors in normal and cancerous colon biology","funder_award_id":"R01CA092479","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000174629","display_name":null,"funder_award_id":"CA106991","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000868127","display_name":"Center for Gastrointestinal Biology and Disease","funder_award_id":"P30DK034987","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000913976","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016086","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G970245308","display_name":null,"funder_award_id":"CA106991","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320322348","display_name":"Korea Science and Engineering Foundation","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320338389","display_name":"Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina at Chapel Hill","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W136642420","https://openalex.org/W279429461","https://openalex.org/W1484163259","https://openalex.org/W1591151241","https://openalex.org/W1665419471","https://openalex.org/W1964321121","https://openalex.org/W1973557583","https://openalex.org/W1974024530","https://openalex.org/W1981585290","https://openalex.org/W1988588903","https://openalex.org/W1989220658","https://openalex.org/W1992160099","https://openalex.org/W1998971866","https://openalex.org/W2002796256","https://openalex.org/W2010538668","https://openalex.org/W2010662888","https://openalex.org/W2011910303","https://openalex.org/W2013204970","https://openalex.org/W2014111401","https://openalex.org/W2017982166","https://openalex.org/W2026199302","https://openalex.org/W2041063937","https://openalex.org/W2042103473","https://openalex.org/W2042400521","https://openalex.org/W2043605105","https://openalex.org/W2056464773","https://openalex.org/W2062909560","https://openalex.org/W2069526613","https://openalex.org/W2070732456","https://openalex.org/W2075279572","https://openalex.org/W2077366285","https://openalex.org/W2087861588","https://openalex.org/W2100976544","https://openalex.org/W2107427447","https://openalex.org/W2108246579","https://openalex.org/W2109303707","https://openalex.org/W2132349680","https://openalex.org/W2159121906","https://openalex.org/W2160180902","https://openalex.org/W2166207015","https://openalex.org/W2166770565","https://openalex.org/W2216718464","https://openalex.org/W2247329814","https://openalex.org/W2254360823","https://openalex.org/W7039498750"],"related_works":["https://openalex.org/W2988106977","https://openalex.org/W2488199836","https://openalex.org/W3215295260","https://openalex.org/W2164055165","https://openalex.org/W60746763","https://openalex.org/W4282940254","https://openalex.org/W3168895807","https://openalex.org/W4254752626","https://openalex.org/W7096958663","https://openalex.org/W4221032572"],"abstract_inverted_index":{"Pharmacologic":[0],"blockade":[1],"of":[2,22,27,62,68,78,80,97,105,125,152,167,173,182,210],"EGFR":[3,36],"or":[4,176],"the":[5,17,20,28,59,101,136,188,208],"closely":[6],"related":[7],"receptor":[8],"ERBB2":[9],"has":[10,191],"modest":[11],"efficacy":[12],"against":[13],"colorectal":[14,211],"cancers":[15],"in":[16,39,44,93,100,131,154,179,194],"clinic.":[18],"Although":[19],"upregulation":[21],"ERBB3,":[23,112],"a":[24,128,155,204],"pseudo-kinase":[25,190],"member":[26],"EGFR/ERBB":[29],"family,":[30],"is":[31],"known":[32],"to":[33,35,84,123,145],"contribute":[34,144],"inhibitor":[37],"resistance":[38],"other":[40],"cancers,":[41],"its":[42],"functions":[43],"normal":[45],"and":[46,82,170,198],"malignant":[47],"intestinal":[48,60,85,98,113,196],"epithelium":[49,61,110],"have":[50,55],"not":[51],"been":[52],"defined.":[53],"We":[54],"shown":[56],"here":[57],"that":[58,141,187,200],"mice":[63],"with":[64,135,165],"intestine-specific":[65,89],"genetic":[66],"ablation":[67,91],"Erbb3":[69,90],"exhibits":[70],"no":[71],"cytological":[72],"abnormalities":[73],"but":[74],"does":[75],"exhibit":[76],"loss":[77,151,166],"expression":[79],"ERBB4":[81,168,177],"sensitivity":[83],"damage.":[86],"By":[87],"contrast,":[88],"resulted":[92,178],"almost":[94],"complete":[95],"absence":[96],"tumors":[99,114],"ApcMin":[102],"mouse":[103,137],"model":[104],"colon":[106,146,159],"cancer.":[107],"Unlike":[108],"nontransformed":[109],"lacking":[111,115],"ERBB3":[116,153,175,189,201],"had":[117],"reduced":[118],"PI3K/AKT":[119],"signaling,":[120],"which":[121,139],"led":[122],"attenuation":[124],"tumorigenesis":[126,197],"via":[127],"tumor-specific":[129],"increase":[130],"caspase-3-mediated":[132],"apoptosis.":[133,183],"Consistent":[134],"data,":[138],"suggest":[140,199],"ERBB3-ERBB4":[142],"heterodimers":[143],"cancer":[147,160],"survival,":[148],"experimentally":[149],"induced":[150],"KRAS":[156],"mutant":[157],"human":[158],"cell":[161],"line":[162],"was":[163],"associated":[164],"expression,":[169],"siRNA":[171],"knockdown":[172],"either":[174],"elevated":[180],"levels":[181],"These":[184],"results":[185],"indicate":[186],"essential":[192],"roles":[193],"supporting":[195],"may":[202],"be":[203],"promising":[205],"target":[206],"for":[207],"treatment":[209],"cancers.":[212]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
