{"id":"https://openalex.org/W1990498887","doi":"https://doi.org/10.1371/journal.pcbi.1003045","title":"Human Germline Antibody Gene Segments Encode Polyspecific Antibodies","display_name":"Human Germline Antibody Gene Segments Encode Polyspecific Antibodies","publication_year":2013,"publication_date":"2013-04-25","ids":{"openalex":"https://openalex.org/W1990498887","doi":"https://doi.org/10.1371/journal.pcbi.1003045","mag":"1990498887","pmid":"https://pubmed.ncbi.nlm.nih.gov/23637590","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3636087"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003045","doi":"https://doi.org/10.1371/journal.pcbi.1003045","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003045","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003045&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","ccf-b","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003045&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019038548","display_name":"Jordan R. Willis","orcid":"https://orcid.org/0000-0002-0135-5263","observed_orcids":["https://orcid.org/0000-0002-0135-5263"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan R. Willis","raw_affiliation_strings":["Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, USA","Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America","Department of Chemistry, Vanderbilt University, Nashville, Tennessee, United States of America","Institute for Chemical Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Chemistry, Vanderbilt University, Nashville, Tennessee, United States of America","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Institute for Chemical Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067720514","display_name":"Bryan S. Briney","orcid":"https://orcid.org/0000-0001-9535-2866","observed_orcids":["https://orcid.org/0000-0001-9535-2866"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryan S. Briney","raw_affiliation_strings":["Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085996308","display_name":"Samuel DeLuca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel L. DeLuca","raw_affiliation_strings":["Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America","Department of Chemistry, Vanderbilt University, Nashville, Tennessee, United States of America","Institute for Chemical Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Chemistry, Vanderbilt University, Nashville, Tennessee, United States of America","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Institute for Chemical Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046971682","display_name":"James E. Crowe","orcid":"https://orcid.org/0000-0002-0049-1079","observed_orcids":["https://orcid.org/0000-0002-0049-1079"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James E. Crowe","raw_affiliation_strings":["Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America","Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025842562","display_name":"Jens Meiler","orcid":"https://orcid.org/0000-0001-8945-193X","observed_orcids":["https://orcid.org/0000-0001-8945-193X"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jens Meiler","raw_affiliation_strings":["Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America","Department of Chemistry, Vanderbilt University, Nashville, Tennessee, United States of America","Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America","Institute for Chemical Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Chemistry, Vanderbilt University, Nashville, Tennessee, United States of America","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Institute for Chemical Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America","institution_ids":["https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5025842562","https://openalex.org/A5046971682"],"corresponding_institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":7.3552,"has_fulltext":true,"cited_by_count":88,"citation_normalized_percentile":{"value":0.97776407,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"9","issue":"4","first_page":"e1003045","last_page":"e1003045"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8384000062942505,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8384000062942505,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.09910000115633011,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.03539999946951866,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyspecific-antibodies","display_name":"polyspecific antibodies","score":0.7570000290870667},{"id":"https://openalex.org/keywords/variable-heavy-chain","display_name":"variable heavy chain","score":0.6010000109672546},{"id":"https://openalex.org/keywords/cdr1","display_name":"CDR1","score":0.6729999780654907},{"id":"https://openalex.org/keywords/cdr2","display_name":"CDR2","score":1.0},{"id":"https://openalex.org/keywords/antibody-design","display_name":"antibody design","score":0.5339999794960022},{"id":"https://openalex.org/keywords/antibody-maturation","display_name":"antibody maturation","score":0.6660000085830688},{"id":"https://openalex.org/keywords/somatic-hypermutation","display_name":"somatic hypermutation","score":0.9129999876022339},{"id":"https://openalex.org/keywords/antigen-antibody-recognition","display_name":"antibody-antigen recognition","score":0.746999979019165},{"id":"https://openalex.org/keywords/epitope-binding","display_name":"epitope binding","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6690977811813354},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6685237884521484},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6501263380050659},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.6427115201950073},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.6047892570495605},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5659908652305603},{"id":"https://openalex.org/C2781377902","wikidata":"https://www.wikidata.org/wiki/Q21418769","display_name":"Affinity maturation","level":3,"score":0.559302031993866},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5014879703521729},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4981107711791992},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39836621284484863}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000936","descriptor_name":"Antigen-Antibody Complex","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005803","descriptor_name":"Genes, Immunoglobulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011381","descriptor_name":"Programming Languages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1003045","doi":"https://doi.org/10.1371/journal.pcbi.1003045","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003045","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003045&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","ccf-b","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2640648","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3636087","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3636087","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3636087","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmid:23637590","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23637590","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.720.4373","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.720.4373","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.meilerlab.org/index.php/publications/showPublication/pub_id/146/","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1003045","doi":null,"is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003045","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:d1144f8b135244d290964927cdbc7e3e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d1144f8b135244d290964927cdbc7e3e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 9, Iss 4, p e1003045 (2013)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/691566","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Human_Germline_Antibody_Gene_Segments_Encode_Polyspecific_Antibodies_/691566","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003045","doi":"https://doi.org/10.1371/journal.pcbi.1003045","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003045","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003045&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","ccf-b","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3479296141","display_name":null,"funder_award_id":"HHSN272200900047C","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5286034964","display_name":"MOLECULAR AND STRUCTURAL BASIS FOR FINE SPECIFICITY OF ANTIVIRAL ANTIBODIES","funder_award_id":"HDTRA11010067","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G6646543412","display_name":"Clonal Analysis of the Human B Cell Response to HIV","funder_award_id":"U01AI078407","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G804605078","display_name":null,"funder_award_id":"HHSN272200900047C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990498887.pdf","grobid_xml":"https://content.openalex.org/works/W1990498887.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1517617266","https://openalex.org/W1551909090","https://openalex.org/W1570991491","https://openalex.org/W1964126053","https://openalex.org/W1967772277","https://openalex.org/W1969644422","https://openalex.org/W1974596630","https://openalex.org/W1975142943","https://openalex.org/W1979882766","https://openalex.org/W1992743196","https://openalex.org/W1993174731","https://openalex.org/W1995380127","https://openalex.org/W1995875735","https://openalex.org/W2005109042","https://openalex.org/W2008708467","https://openalex.org/W2015712944","https://openalex.org/W2022231632","https://openalex.org/W2027102035","https://openalex.org/W2032515169","https://openalex.org/W2032564126","https://openalex.org/W2036808217","https://openalex.org/W2041404167","https://openalex.org/W2041877620","https://openalex.org/W2050909253","https://openalex.org/W2054467356","https://openalex.org/W2071739012","https://openalex.org/W2081926288","https://openalex.org/W2082660881","https://openalex.org/W2083445427","https://openalex.org/W2083663804","https://openalex.org/W2088563323","https://openalex.org/W2092927147","https://openalex.org/W2094225605","https://openalex.org/W2097985410","https://openalex.org/W2099672409","https://openalex.org/W2106531843","https://openalex.org/W2109834179","https://openalex.org/W2113118666","https://openalex.org/W2119333315","https://openalex.org/W2132164302","https://openalex.org/W2135815512","https://openalex.org/W2137015675","https://openalex.org/W2140234717","https://openalex.org/W2141920824","https://openalex.org/W2144685448","https://openalex.org/W2151130483","https://openalex.org/W2156063815","https://openalex.org/W2162681417","https://openalex.org/W2578150941","https://openalex.org/W2765633603"],"related_works":["https://openalex.org/W7098652109","https://openalex.org/W2081926288","https://openalex.org/W2905370614","https://openalex.org/W2067001279","https://openalex.org/W1872459230","https://openalex.org/W4415929062","https://openalex.org/W7202197622","https://openalex.org/W3109731210","https://openalex.org/W2928725995","https://openalex.org/W2953176058"],"abstract_inverted_index":{"Structural":[0],"flexibility":[1],"in":[2,29,155,183,217,234],"germline":[3,39,120,235],"gene-encoded":[4,40],"antibodies":[5,41,56,67,86,161,240,252],"allows":[6],"promiscuous":[7],"binding":[8,13,76,140,243],"to":[9,77,84,123,136,162,170],"diverse":[10,53,257],"antigens.":[11],"The":[12,94,115,149],"affinity":[14],"and":[15,112,224],"specificity":[16,209],"for":[17,44,50,102,232,256],"a":[18,70,78,124,146,164,167],"particular":[19],"epitope":[20,258],"typically":[21],"increase":[22],"as":[23],"antibody":[24,100,153,175,181],"genes":[25],"acquire":[26],"somatic":[27],"mutations":[28],"antigen-stimulated":[30],"B":[31],"cells.":[32],"In":[33,157],"this":[34],"work,":[35],"we":[36,213],"investigated":[37],"whether":[38],"are":[42,134,229],"optimal":[43],"polyspecificity":[45,233,255],"by":[46,55,58,69,128],"determining":[47],"the":[48,103,119,131,173,188,200,208,218,225,248],"basis":[49],"recognition":[51],"of":[52,64,141,172,196,207,210,239,242,251],"antigens":[54,91,144,245],"encoded":[57,68],"three":[59],"VH":[60,72,219],"gene":[61,121,220],"segments.":[62],"Panels":[63],"somatically":[65],"mutated":[66],"common":[71,147],"gene,":[73],"but":[74],"each":[75],"different":[79],"antigen,":[80,166],"were":[81],"computationally":[82],"redesigned":[83],"predict":[85],"that":[87,133,171,187,228,253],"could":[88],"engage":[89],"multiple":[90,244],"at":[92],"once.":[93],"Rosetta":[95,189],"multi-state":[96],"design":[97,130,191,238,250],"process":[98,150],"predicted":[99,116,135],"sequences":[101,117,122],"entire":[104],"heavy":[105],"chain":[106],"variable":[107],"region,":[108],"including":[109],"framework,":[110],"CDR1,":[111,222],"CDR2":[113],"mutations.":[114],"matched":[118],"remarkable":[125],"degree,":[126],"revealing":[127],"computational":[129,190],"residues":[132],"enable":[137],"polyspecificity,":[138],"i.e.,":[139],"many":[142],"unrelated":[143],"with":[145],"sequence.":[148],"thereby":[151],"reverses":[152],"maturation":[154,182],"silico.":[156,184],"contrast,":[158],"when":[159],"designing":[160],"bind":[163],"single":[165],"sequence":[168,176],"similar":[169],"mature":[174,211],"was":[177],"returned,":[178],"mimicking":[179],"natural":[180],"We":[185],"demonstrated":[186],"algorithm":[192],"captures":[193],"important":[194],"aspects":[195],"antibody/antigen":[197],"recognition.":[198],"While":[199],"hypervariable":[201],"region":[202],"CDR3":[203],"often":[204],"mediates":[205],"much":[206],"antibodies,":[212],"identified":[214],"key":[215],"positions":[216],"encoding":[221],"CDR2,":[223],"immunoglobulin":[226],"framework":[227],"critical":[230],"contributors":[231],"antibodies.":[236],"Computational":[237],"capable":[241],"may":[246],"allow":[247],"rational":[249],"retain":[254],"binding.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}