{"id":"https://openalex.org/W1990485571","doi":"https://doi.org/10.1007/bf02556656","title":"Chemical changes in hydroxyapatite biomaterial underin vivo andin vitro biological conditions","display_name":"Chemical changes in hydroxyapatite biomaterial underin vivo andin vitro biological conditions","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W1990485571","doi":"https://doi.org/10.1007/bf02556656","mag":"1990485571","pmid":"https://pubmed.ncbi.nlm.nih.gov/2504459"},"language":"en","primary_location":{"id":"doi:10.1007/bf02556656","doi":"https://doi.org/10.1007/bf02556656","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf02556656","pdf_url":null,"source":{"id":"https://openalex.org/S197748570","display_name":"Calcified Tissue International","issn_l":"0171-967X","issn":["0171-967X","1432-0827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Calcified Tissue International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003392682","display_name":"Isabelle Orly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"I. Orly","raw_affiliation_strings":["INSERM U.225, UER d'Odontologie, Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U.225, UER d'Odontologie, Nantes, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103149966","display_name":"Marc Gr\u00e9goire","orcid":"https://orcid.org/0000-0003-3868-0198","observed_orcids":["https://orcid.org/0000-0003-3868-0198"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M. Gregoire","raw_affiliation_strings":["INSERM U.225, UER d'Odontologie, Place Alexis Ricordeau, 44042, Nantes, France","INSERM U.225, UER d'Odontologie, Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U.225, UER d'Odontologie, Place Alexis Ricordeau, 44042, Nantes, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"INSERM U.225, UER d'Odontologie, Nantes, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018416621","display_name":"Jean M\u00e9nanteau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J. Menanteau","raw_affiliation_strings":["INSERM U.225, UER d'Odontologie, Place Alexis Ricordeau, 44042, Nantes, France","INSERM U.225, UER d'Odontologie, Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U.225, UER d'Odontologie, Place Alexis Ricordeau, 44042, Nantes, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"INSERM U.225, UER d'Odontologie, Nantes, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012641450","display_name":"Monique Heughebaert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M. Heughebaert","raw_affiliation_strings":["Laboratoire de Physico-Chimie des Solides, U.S. CNRS no 445, Ecole Nationale Superieure de Chimie, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physico-Chimie des Solides, U.S. CNRS no 445, Ecole Nationale Superieure de Chimie, Toulouse, France","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036672522","display_name":"Bertrand Kerebel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B. Kerebel","raw_affiliation_strings":["INSERM U.225, UER d'Odontologie, Place Alexis Ricordeau, 44042, Nantes, France","INSERM U.225, UER d'Odontologie, Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U.225, UER d'Odontologie, Place Alexis Ricordeau, 44042, Nantes, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"INSERM U.225, UER d'Odontologie, Nantes, France","institution_ids":["https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":2.4225,"has_fulltext":false,"cited_by_count":79,"citation_normalized_percentile":{"value":0.89116081,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"45","issue":"1","first_page":"20","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13470","display_name":"Surface Treatment and Coatings","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2210","display_name":"Mechanical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydroxyapatite","display_name":"hydroxyapatite","score":0.9169999957084656},{"id":"https://openalex.org/keywords/calcium-phosphate-biomaterials","display_name":"calcium phosphate biomaterials","score":0.875},{"id":"https://openalex.org/keywords/secondary-nucleation","display_name":"secondary nucleation","score":0.6660000085830688},{"id":"https://openalex.org/keywords/carbonated-apatite","display_name":"carbonated hydroxyapatite","score":0.8889999985694885},{"id":"https://openalex.org/keywords/biomolecule-adsorption","display_name":"biomolecule adsorption","score":0.7129999995231628},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.7409999966621399},{"id":"https://openalex.org/keywords/in-vivo-implantation","display_name":"in vivo implantation","score":0.6759999990463257},{"id":"https://openalex.org/keywords/in-vitro-cell-culture","display_name":"in vitro cell culture","score":0.7829999923706055},{"id":"https://openalex.org/keywords/mineral-precipitation","display_name":"mineral precipitation","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C2778414984","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biomaterial","level":2,"score":0.8466634154319763},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6456983089447021},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6137892007827759},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4408947229385376},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3123423457145691},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2483876347541809},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23975881934165955},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22695794701576233},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.14161068201065063}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005881","descriptor_name":"Gingiva","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005881","descriptor_name":"Gingiva","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006882","descriptor_name":"Hydroxyapatites","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010514","descriptor_name":"Periodontal Pocket","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013055","descriptor_name":"Spectrophotometry, Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019736","descriptor_name":"Prostheses and Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf02556656","doi":"https://doi.org/10.1007/bf02556656","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf02556656","pdf_url":null,"source":{"id":"https://openalex.org/S197748570","display_name":"Calcified Tissue International","issn_l":"0171-967X","issn":["0171-967X","1432-0827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Calcified Tissue International","raw_type":"journal-article"},{"id":"pmid:2504459","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2504459","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Calcified tissue international","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W4858910","https://openalex.org/W13788536","https://openalex.org/W61931198","https://openalex.org/W1963671867","https://openalex.org/W1995906052","https://openalex.org/W1998351418","https://openalex.org/W2008927824","https://openalex.org/W2013228593","https://openalex.org/W2019798142","https://openalex.org/W2027324243","https://openalex.org/W2032113996","https://openalex.org/W2034446076","https://openalex.org/W2040294802","https://openalex.org/W2045078782","https://openalex.org/W2046123480","https://openalex.org/W2046232956","https://openalex.org/W2047366212","https://openalex.org/W2053154124","https://openalex.org/W2054142888","https://openalex.org/W2054195069","https://openalex.org/W2061562389","https://openalex.org/W2063447392","https://openalex.org/W2132044720","https://openalex.org/W2330254009","https://openalex.org/W2495925840","https://openalex.org/W4293772162"],"related_works":["https://openalex.org/W1959891668","https://openalex.org/W435404957","https://openalex.org/W2099692790","https://openalex.org/W2126729829","https://openalex.org/W2058406180","https://openalex.org/W2125625212","https://openalex.org/W2079366403","https://openalex.org/W2132006998","https://openalex.org/W1971381971","https://openalex.org/W1989845364"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}