{"id":"https://openalex.org/W1990481922","doi":"https://doi.org/10.3389/fncel.2015.00003","title":"Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure","display_name":"Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure","publication_year":2015,"publication_date":"2015-01-28","ids":{"openalex":"https://openalex.org/W1990481922","doi":"https://doi.org/10.3389/fncel.2015.00003","mag":"1990481922","pmid":"https://pubmed.ncbi.nlm.nih.gov/25674052","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4309183"},"language":"en","primary_location":{"id":"doi:10.3389/fncel.2015.00003","doi":"https://doi.org/10.3389/fncel.2015.00003","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncel.2015.00003","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncel.2015.00003/pdf","source":{"id":"https://openalex.org/S36653316","display_name":"Frontiers in Cellular Neuroscience","issn_l":"1662-5102","issn":["1662-5102"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fncel.2015.00003/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080521930","display_name":"Phillip M. Uribe","orcid":"https://orcid.org/0000-0002-7396-8907","observed_orcids":["https://orcid.org/0000-0002-7396-8907"]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phillip M. Uribe","raw_affiliation_strings":["Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014584239","display_name":"Leen H. Kawas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102871","display_name":"Athira Pharma (United States)","ror":"https://ror.org/01e1qb944","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102871"]},{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leen H. Kawas","raw_affiliation_strings":["Department of Integrative Physiology and Neuroscience, Washington State University Pullman, WA, USA ; M3 Biotechnology, Inc. Seattle, WA, USA","Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA","M3 Biotechnology, Inc., Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Physiology and Neuroscience, Washington State University Pullman, WA, USA ; M3 Biotechnology, Inc. Seattle, WA, USA","institution_ids":["https://openalex.org/I4210102871","https://openalex.org/I72951846"]},{"raw_affiliation_string":"Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA","institution_ids":["https://openalex.org/I72951846"]},{"raw_affiliation_string":"M3 Biotechnology, Inc., Seattle, WA, USA","institution_ids":["https://openalex.org/I4210102871"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051401004","display_name":"Joseph W. Harding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102871","display_name":"Athira Pharma (United States)","ror":"https://ror.org/01e1qb944","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102871"]},{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph W. Harding","raw_affiliation_strings":["Department of Integrative Physiology and Neuroscience, Washington State University Pullman, WA, USA ; M3 Biotechnology, Inc. Seattle, WA, USA","Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA","M3 Biotechnology, Inc., Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Physiology and Neuroscience, Washington State University Pullman, WA, USA ; M3 Biotechnology, Inc. Seattle, WA, USA","institution_ids":["https://openalex.org/I4210102871","https://openalex.org/I72951846"]},{"raw_affiliation_string":"Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA","institution_ids":["https://openalex.org/I72951846"]},{"raw_affiliation_string":"M3 Biotechnology, Inc., Seattle, WA, USA","institution_ids":["https://openalex.org/I4210102871"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079662555","display_name":"Allison B. Coffin","orcid":"https://orcid.org/0000-0001-8593-9903","observed_orcids":["https://orcid.org/0000-0001-8593-9903"]},"institutions":[{"id":"https://openalex.org/I137317281","display_name":"Washington State University Vancouver","ror":"https://ror.org/00g2fk805","country_code":"US","type":"education","lineage":["https://openalex.org/I137317281","https://openalex.org/I72951846"]},{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Allison B. Coffin","raw_affiliation_strings":["Department of Integrative Physiology and Neuroscience, Washington State University Pullman, WA, USA ; College of Arts and Sciences, Washington State University Vancouver, WA, USA","College of Arts and Sciences, Washington State University, Vancouver, WA, USA","Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Physiology and Neuroscience, Washington State University Pullman, WA, USA ; College of Arts and Sciences, Washington State University Vancouver, WA, USA","institution_ids":["https://openalex.org/I137317281","https://openalex.org/I72951846"]},{"raw_affiliation_string":"College of Arts and Sciences, Washington State University, Vancouver, WA, USA","institution_ids":["https://openalex.org/I137317281"]},{"raw_affiliation_string":"Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA","institution_ids":["https://openalex.org/I72951846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5079662555"],"corresponding_institution_ids":["https://openalex.org/I137317281","https://openalex.org/I72951846"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":1.5156,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.78159367,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":null,"first_page":"3","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.859000027179718},{"id":"https://openalex.org/keywords/aminoglycoside-ototoxicity","display_name":"aminoglycoside ototoxicity","score":0.9100000262260437},{"id":"https://openalex.org/keywords/hair-cell-protection","display_name":"hair cell protection","score":0.8989999890327454},{"id":"https://openalex.org/keywords/lateral-line","display_name":"lateral line","score":0.7929999828338623},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.7699999809265137},{"id":"https://openalex.org/keywords/gentamicin","display_name":"gentamicin","score":0.8899999856948853},{"id":"https://openalex.org/keywords/neomycin","display_name":"neomycin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hgf-receptor","display_name":"HGF receptor","score":0.6790000200271606},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.7289999723434448},{"id":"https://openalex.org/keywords/tor","display_name":"Tor","score":0.9629999995231628},{"id":"https://openalex.org/keywords/mek","display_name":"MEK","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hearing-loss","display_name":"hearing loss","score":0.5699999928474426},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C2776996007","wikidata":"https://www.wikidata.org/wiki/Q2399112","display_name":"Hepatocyte growth factor","level":3,"score":0.8104339241981506},{"id":"https://openalex.org/C2777787772","wikidata":"https://www.wikidata.org/wiki/Q45355603","display_name":"Aminoglycoside","level":3,"score":0.5624487400054932},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5551151633262634},{"id":"https://openalex.org/C2779841869","wikidata":"https://www.wikidata.org/wiki/Q423098","display_name":"Neomycin","level":3,"score":0.5350412726402283},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5335453152656555},{"id":"https://openalex.org/C2778585322","wikidata":"https://www.wikidata.org/wiki/Q1566641","display_name":"Hair cell","level":3,"score":0.5287541747093201},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5132901072502136},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.49386125802993774},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.43570899963378906},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.41859015822410583},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3048977851867676},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2888360321521759},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.28229182958602905},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23268115520477295},{"id":"https://openalex.org/C2778500370","wikidata":"https://www.wikidata.org/wiki/Q212344","display_name":"Inner ear","level":2,"score":0.1919255554676056},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.17039132118225098},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.09905654191970825},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fncel.2015.00003","doi":"https://doi.org/10.3389/fncel.2015.00003","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncel.2015.00003","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncel.2015.00003/pdf","source":{"id":"https://openalex.org/S36653316","display_name":"Frontiers in Cellular Neuroscience","issn_l":"1662-5102","issn":["1662-5102"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3289677","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4309183","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4309183","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4309183","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Neurosci","raw_type":"Text"},{"id":"pmid:25674052","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25674052","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cellular neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5a260fd38277453d8ee7a6fa963495a0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5a260fd38277453d8ee7a6fa963495a0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cellular Neuroscience, Vol 9 (2015)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fncel.2015.00003","doi":"https://doi.org/10.3389/fncel.2015.00003","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncel.2015.00003","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncel.2015.00003/pdf","source":{"id":"https://openalex.org/S36653316","display_name":"Frontiers in Cellular Neuroscience","issn_l":"1662-5102","issn":["1662-5102"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309913","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990481922.pdf","grobid_xml":"https://content.openalex.org/works/W1990481922.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W53776436","https://openalex.org/W341931602","https://openalex.org/W856065083","https://openalex.org/W1554089468","https://openalex.org/W1556198965","https://openalex.org/W1574887471","https://openalex.org/W1963506121","https://openalex.org/W1965850555","https://openalex.org/W1972896709","https://openalex.org/W1975290731","https://openalex.org/W1975857526","https://openalex.org/W1975949784","https://openalex.org/W1979018311","https://openalex.org/W1981014336","https://openalex.org/W1987114356","https://openalex.org/W1987192848","https://openalex.org/W1987427290","https://openalex.org/W1997470128","https://openalex.org/W2000697304","https://openalex.org/W2003403183","https://openalex.org/W2005775837","https://openalex.org/W2010202334","https://openalex.org/W2020482316","https://openalex.org/W2024306318","https://openalex.org/W2026164154","https://openalex.org/W2033372273","https://openalex.org/W2033409614","https://openalex.org/W2043351945","https://openalex.org/W2056788308","https://openalex.org/W2057995143","https://openalex.org/W2060637142","https://openalex.org/W2061039847","https://openalex.org/W2061379238","https://openalex.org/W2066474908","https://openalex.org/W2072316722","https://openalex.org/W2078806022","https://openalex.org/W2081725744","https://openalex.org/W2082313150","https://openalex.org/W2083740430","https://openalex.org/W2085890965","https://openalex.org/W2087816118","https://openalex.org/W2088883749","https://openalex.org/W2089000332","https://openalex.org/W2091508032","https://openalex.org/W2093168078","https://openalex.org/W2096007562","https://openalex.org/W2104059846","https://openalex.org/W2107459815","https://openalex.org/W2110703406","https://openalex.org/W2111842868","https://openalex.org/W2123541991","https://openalex.org/W2124926343","https://openalex.org/W2129090736","https://openalex.org/W2134138119","https://openalex.org/W2135854785","https://openalex.org/W2137473984","https://openalex.org/W2137701107","https://openalex.org/W2140042422","https://openalex.org/W2147661737","https://openalex.org/W2149515389","https://openalex.org/W2153490249","https://openalex.org/W2168432145","https://openalex.org/W2169776855","https://openalex.org/W2170803730","https://openalex.org/W3147310958","https://openalex.org/W6664622944"],"related_works":["https://openalex.org/W4372328797","https://openalex.org/W7099392795","https://openalex.org/W2147661737","https://openalex.org/W2765579651","https://openalex.org/W2168432145","https://openalex.org/W3046074300","https://openalex.org/W2170803730","https://openalex.org/W2606757140","https://openalex.org/W2129090736","https://openalex.org/W2135854785"],"abstract_inverted_index":{"Loss":[0],"of":[1,29,140,160,203,218,228,235,251,263],"sensory":[2],"hair":[3,45,91,103,112,166,264],"cells":[4,46,104,113,265],"from":[5,47,146],"exposure":[6],"to":[7,76,108,118,232],"certain":[8],"licit":[9],"drugs":[10],"(e.g.,":[11],"aminoglycoside":[12,48,182],"antibiotics,":[13],"platinum-based":[14],"chemotherapy":[15],"agents)":[16],"can":[17,43],"result":[18],"in":[19],"permanent":[20],"hearing":[21],"loss.":[22],"Here":[23],"we":[24,94],"ask":[25],"if":[26],"allosteric":[27],"activation":[28,199],"the":[30,78,96,158,191,204,219,233,239,249],"hepatocyte":[31],"growth":[32],"factor":[33],"(HGF)":[34],"cascade":[35],"via":[36],"Dihexa,":[37],"a":[38,62,68,89,137,201],"small":[39,245],"molecule":[40],"drug":[41],"candidate,":[42],"protect":[44],"toxicity.":[49],"Unlike":[50],"native":[51],"HGF,":[52],"Dihexa":[53,87,124,138,154,236,252,260,272],"is":[54,172,186,200,211],"chemically":[55],"stable":[56],"and":[57,81,114,132,178,225,270],"blood-brain":[58],"barrier":[59],"permeable.":[60],"As":[61],"synthetic":[63],"HGF":[64,75,79,192,198,221],"mimetic,":[65],"it":[66],"forms":[67],"functional":[69],"ligand":[70],"by":[71,175,180,188,214],"dimerizing":[72],"with":[73,149,153,190,216],"endogenous":[74],"activate":[77],"receptor":[80],"downstream":[82,220],"signaling":[83],"cascades.":[84],"To":[85],"evaluate":[86],"as":[88],"potential":[90,275],"cell":[92],"protectant,":[93],"used":[95],"larval":[97],"zebrafish":[98],"lateral":[99],"line,":[100],"which":[101],"possesses":[102],"that":[105,136,164,169,197,243,259,271],"are":[106],"homologous":[107],"mammalian":[109],"inner":[110],"ear":[111],"show":[115],"similar":[116],"responses":[117],"toxins.":[119],"A":[120],"dose-response":[121],"relationship":[122],"for":[123,253,276],"protection":[125,145,171,185,210,262],"was":[126],"established":[127],"using":[128],"two":[129],"ototoxins,":[130],"neomycin":[131],"gentamicin.":[133],"We":[134],"found":[135],"concentration":[139],"1":[141],"\u03bcM":[142],"confers":[143,261],"optimal":[144],"acute":[147],"treatment":[148],"either":[150],"ototoxin.":[151],"Pretreatment":[152],"does":[155],"not":[156,179],"affect":[157],"amount":[159],"fluorescently":[161],"tagged":[162],"gentamicin":[163],"enters":[165],"cells,":[167],"indicating":[168],"Dihexa's":[170,208],"likely":[173],"mediated":[174],"intracellular":[176],"events":[177],"inhibiting":[181],"entry.":[183],"Dihexa-mediated":[184],"attenuated":[187,213],"co-treatment":[189,215],"antagonist":[193],"6-AH,":[194],"further":[195],"evidence":[196],"component":[202],"observed":[205],"protection.":[206],"Additionally,":[207],"robust":[209],"partially":[212],"inhibitors":[217],"targets":[222],"Akt,":[223],"TOR":[224],"MEK.":[226],"Addition":[227],"an":[229,267],"amino":[230],"group":[231],"N-terminal":[234],"also":[237],"attenuates":[238],"protective":[240],"response,":[241],"suggesting":[242],"even":[244],"substitutions":[246],"greatly":[247],"alter":[248],"specificity":[250],"its":[254],"target.":[255],"Our":[256],"data":[257],"suggest":[258],"through":[266],"HGF-mediated":[268],"mechanism":[269],"holds":[273],"clinical":[274],"mitigating":[277],"chemical":[278],"ototoxicity.":[279]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}