{"id":"https://openalex.org/W1990481050","doi":"https://doi.org/10.1038/labinvest.2008.14","title":"The cancer stem cell hypothesis: in search of definitions, markers, and relevance","display_name":"The cancer stem cell hypothesis: in search of definitions, markers, and relevance","publication_year":2008,"publication_date":"2008-03-31","ids":{"openalex":"https://openalex.org/W1990481050","doi":"https://doi.org/10.1038/labinvest.2008.14","mag":"1990481050","pmid":"https://pubmed.ncbi.nlm.nih.gov/18379567","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3702270"},"language":"en","primary_location":{"id":"doi:10.1038/labinvest.2008.14","doi":"https://doi.org/10.1038/labinvest.2008.14","is_oa":true,"landing_page_url":"https://doi.org/10.1038/labinvest.2008.14","pdf_url":"http://www.laboratoryinvestigation.org/article/S0023683722018943/pdf","source":{"id":"https://openalex.org/S137146891","display_name":"Laboratory Investigation","issn_l":"0023-6837","issn":["0023-6837","1530-0307"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.laboratoryinvestigation.org/article/S0023683722018943/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075657062","display_name":"Michail V. Shipitsin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michail Shipitsin","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014395742","display_name":"Korn\u00e9lia Poly\u00e1k","orcid":"https://orcid.org/0000-0002-5964-0382","observed_orcids":["https://orcid.org/0000-0002-5964-0382"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kornelia Polyak","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA","Department of Medical Oncology, Dana\u2013Farber Cancer Institute and Harvard Medical School, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Medical Oncology, Dana\u2013Farber Cancer Institute and Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014395742"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":13.2963,"has_fulltext":true,"cited_by_count":233,"citation_normalized_percentile":{"value":0.99251174,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"88","issue":"5","first_page":"459","last_page":"463"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-stem-cell-hypothesis","display_name":"cancer stem cell hypothesis","score":0.890999972820282},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9670000076293945},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.9409999847412109},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.8360000252723694},{"id":"https://openalex.org/keywords/stem-cell-markers","display_name":"stem cell markers","score":0.7979999780654907},{"id":"https://openalex.org/keywords/tumor-evolution","display_name":"tumor evolution","score":0.5989999771118164},{"id":"https://openalex.org/keywords/cancer-genetics","display_name":"cancer genetics","score":0.36800000071525574}],"concepts":[{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.6767266988754272},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6486860513687134},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6477527618408203},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6431555151939392},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.636088490486145},{"id":"https://openalex.org/C113968399","wikidata":"https://www.wikidata.org/wiki/Q7559241","display_name":"Somatic evolution in cancer","level":3,"score":0.6124948263168335},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.5034770369529724},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4894196093082428},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.48363196849823},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.463750422000885},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3110697269439697},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3061944842338562},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1869911253452301},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1715228259563446}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008495","descriptor_name":"Medical Oncology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/labinvest.2008.14","doi":"https://doi.org/10.1038/labinvest.2008.14","is_oa":true,"landing_page_url":"https://doi.org/10.1038/labinvest.2008.14","pdf_url":"http://www.laboratoryinvestigation.org/article/S0023683722018943/pdf","source":{"id":"https://openalex.org/S137146891","display_name":"Laboratory Investigation","issn_l":"0023-6837","issn":["0023-6837","1530-0307"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory Investigation","raw_type":"journal-article"},{"id":"pmid:18379567","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18379567","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2698253","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3702270","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3702270","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3702270","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Lab Invest","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/labinvest.2008.14","doi":"https://doi.org/10.1038/labinvest.2008.14","is_oa":true,"landing_page_url":"https://doi.org/10.1038/labinvest.2008.14","pdf_url":"http://www.laboratoryinvestigation.org/article/S0023683722018943/pdf","source":{"id":"https://openalex.org/S137146891","display_name":"Laboratory Investigation","issn_l":"0023-6837","issn":["0023-6837","1530-0307"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7246000170707703,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7179994548","display_name":"HIN-1,A Novel Putative Breast Tumor Suppressor Gene","funder_award_id":"R01CA094074","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7880683311","display_name":"Dana-Farber/Harvard SPORE in Breast Cancer","funder_award_id":"P50CA089393","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8727984101","display_name":"Epithelial-stromal cell interactions in breast cancer","funder_award_id":"R01CA116235","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990481050.pdf","grobid_xml":"https://content.openalex.org/works/W1990481050.grobid-xml"},"referenced_works_count":90,"referenced_works":["https://openalex.org/W1682711168","https://openalex.org/W1933538082","https://openalex.org/W1965681567","https://openalex.org/W1966870938","https://openalex.org/W1968630647","https://openalex.org/W1970634781","https://openalex.org/W1971259163","https://openalex.org/W1977389640","https://openalex.org/W1977836335","https://openalex.org/W1980860344","https://openalex.org/W1981100288","https://openalex.org/W1986884551","https://openalex.org/W1987990940","https://openalex.org/W1989456936","https://openalex.org/W1989958716","https://openalex.org/W1992676863","https://openalex.org/W2000160108","https://openalex.org/W2009886857","https://openalex.org/W2011912935","https://openalex.org/W2013216643","https://openalex.org/W2018671779","https://openalex.org/W2021050536","https://openalex.org/W2021144703","https://openalex.org/W2021582093","https://openalex.org/W2021856943","https://openalex.org/W2023427658","https://openalex.org/W2023873491","https://openalex.org/W2027255730","https://openalex.org/W2027927113","https://openalex.org/W2029080338","https://openalex.org/W2029259805","https://openalex.org/W2031770999","https://openalex.org/W2034354254","https://openalex.org/W2034748898","https://openalex.org/W2038970416","https://openalex.org/W2041153640","https://openalex.org/W2045907249","https://openalex.org/W2046788126","https://openalex.org/W2050222325","https://openalex.org/W2050314360","https://openalex.org/W2050855482","https://openalex.org/W2051055358","https://openalex.org/W2056021041","https://openalex.org/W2056025993","https://openalex.org/W2057403210","https://openalex.org/W2063943009","https://openalex.org/W2077330278","https://openalex.org/W2078174944","https://openalex.org/W2086258960","https://openalex.org/W2086551569","https://openalex.org/W2087214029","https://openalex.org/W2090863421","https://openalex.org/W2090982381","https://openalex.org/W2092015913","https://openalex.org/W2092912586","https://openalex.org/W2094040645","https://openalex.org/W2094735859","https://openalex.org/W2097327630","https://openalex.org/W2100147083","https://openalex.org/W2101062752","https://openalex.org/W2101518963","https://openalex.org/W2102085111","https://openalex.org/W2105495977","https://openalex.org/W2105981681","https://openalex.org/W2110953702","https://openalex.org/W2111228323","https://openalex.org/W2113086962","https://openalex.org/W2116043907","https://openalex.org/W2124285724","https://openalex.org/W2127303157","https://openalex.org/W2133137848","https://openalex.org/W2134987819","https://openalex.org/W2135154556","https://openalex.org/W2140254135","https://openalex.org/W2142046859","https://openalex.org/W2146613018","https://openalex.org/W2146680438","https://openalex.org/W2146839421","https://openalex.org/W2152387543","https://openalex.org/W2153382986","https://openalex.org/W2158337417","https://openalex.org/W2160494819","https://openalex.org/W2165453201","https://openalex.org/W2167650288","https://openalex.org/W2167732166","https://openalex.org/W2168524285","https://openalex.org/W2169752217","https://openalex.org/W2170140374","https://openalex.org/W2405181172","https://openalex.org/W7027433782"],"related_works":["https://openalex.org/W1596376889","https://openalex.org/W2062006728","https://openalex.org/W2004878973","https://openalex.org/W2013640959","https://openalex.org/W3000790538","https://openalex.org/W2047378888","https://openalex.org/W2106356990","https://openalex.org/W2082823320","https://openalex.org/W2111864465","https://openalex.org/W10046284"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":33}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
