{"id":"https://openalex.org/W1990475720","doi":"https://doi.org/10.1111/j.1540-8159.1990.tb04014.x","title":"Effects of Increasing Heart Rate Induced by Efferent Sympathetic Neuronal Stimulation, Isoproterenol or Cardiac Pacing on Myocardial Function and Oxygen Utilization","display_name":"Effects of Increasing Heart Rate Induced by Efferent Sympathetic Neuronal Stimulation, Isoproterenol or Cardiac Pacing on Myocardial Function and Oxygen Utilization","publication_year":1990,"publication_date":"1990-11-01","ids":{"openalex":"https://openalex.org/W1990475720","doi":"https://doi.org/10.1111/j.1540-8159.1990.tb04014.x","mag":"1990475720","pmid":"https://pubmed.ncbi.nlm.nih.gov/1701893"},"language":"en","primary_location":{"id":"doi:10.1111/j.1540-8159.1990.tb04014.x","doi":"https://doi.org/10.1111/j.1540-8159.1990.tb04014.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1540-8159.1990.tb04014.x","pdf_url":null,"source":{"id":"https://openalex.org/S128634829","display_name":"Pacing and Clinical Electrophysiology","issn_l":"0147-8389","issn":["0147-8389","1540-8159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pacing and Clinical Electrophysiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074323600","display_name":"Martin J. Gardner","orcid":"https://orcid.org/0000-0001-9028-3478","observed_orcids":["https://orcid.org/0000-0001-9028-3478"]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"MARTIN J. GARDNER","raw_affiliation_strings":["Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada","Departments of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada","Maritime Heart Centre, Victoria General Hospital, Halifax, Nova Scotia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada","institution_ids":["https://openalex.org/I129902397"]},{"raw_affiliation_string":"Departments of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada","institution_ids":["https://openalex.org/I129902397"]},{"raw_affiliation_string":"Maritime Heart Centre, Victoria General Hospital, Halifax, Nova Scotia, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014309180","display_name":"David E. Johnstone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"DAVID E. JOHNSTONE","raw_affiliation_strings":["Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada","Departments of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada","Maritime Heart Centre, Victoria General Hospital, Halifax, Nova Scotia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada","institution_ids":["https://openalex.org/I129902397"]},{"raw_affiliation_string":"Departments of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada","institution_ids":["https://openalex.org/I129902397"]},{"raw_affiliation_string":"Maritime Heart Centre, Victoria General Hospital, Halifax, Nova Scotia, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036307367","display_name":"R. D. Janes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"RONALD D. JANES","raw_affiliation_strings":["Departments of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada","institution_ids":["https://openalex.org/I129902397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053487339","display_name":"Gerald A. Klassen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"GERALD A. KLASSEN","raw_affiliation_strings":["Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada","Departments of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada","Maritime Heart Centre, Victoria General Hospital, Halifax, Nova Scotia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada","institution_ids":["https://openalex.org/I129902397"]},{"raw_affiliation_string":"Departments of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada","institution_ids":["https://openalex.org/I129902397"]},{"raw_affiliation_string":"Maritime Heart Centre, Victoria General Hospital, Halifax, Nova Scotia, Canada","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103874310","display_name":"John Andrew Armour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J. ANDREW ARMOUR","raw_affiliation_strings":["Departments of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada","institution_ids":["https://openalex.org/I129902397"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053487339"],"corresponding_institution_ids":["https://openalex.org/I129902397"],"apc_list":{"value":4170,"currency":"USD","value_usd":4170},"apc_paid":null,"fwci":0.3783,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.61077753,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"13","issue":"11","first_page":"1393","last_page":"1400"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.6553000211715698,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.6553000211715698,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.14730000495910645,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.03830000013113022,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-rate-increase","display_name":"heart rate increase","score":0.8080000281333923},{"id":"https://openalex.org/keywords/myocardial-function","display_name":"myocardial function","score":0.6190000176429749},{"id":"https://openalex.org/keywords/myocardial-oxygen-consumption","display_name":"myocardial oxygen consumption","score":0.949999988079071},{"id":"https://openalex.org/keywords/myocardial-efficiency","display_name":"myocardial efficiency","score":0.7440000176429749},{"id":"https://openalex.org/keywords/atrial-pacing","display_name":"atrial pacing","score":0.671999990940094},{"id":"https://openalex.org/keywords/ventricular-pacing","display_name":"ventricular pacing","score":1.0},{"id":"https://openalex.org/keywords/atrioventricular-sequential-pacing","display_name":"atrioventricular sequential pacing","score":0.9610000252723694},{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.843999981880188},{"id":"https://openalex.org/keywords/coronary-blood-flow","display_name":"coronary blood flow","score":0.8100000023841858},{"id":"https://openalex.org/keywords/intramyocardial-pressure","display_name":"intramyocardial pressure","score":0.843999981880188},{"id":"https://openalex.org/keywords/chronotropic-effect","display_name":"chronotropic effect","score":0.9169999957084656},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8767232894897461},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7284297943115234},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6707043051719666},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.6572763919830322},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4989051818847656},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.4423055052757263},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.42209771275520325},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.3340473771095276},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.1707734763622284}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002304","descriptor_name":"Cardiac Pacing, Artificial","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D003326","descriptor_name":"Coronary Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007545","descriptor_name":"Isoproterenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011312","descriptor_name":"Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013233","descriptor_name":"Stellate Ganglion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1540-8159.1990.tb04014.x","doi":"https://doi.org/10.1111/j.1540-8159.1990.tb04014.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1540-8159.1990.tb04014.x","pdf_url":null,"source":{"id":"https://openalex.org/S128634829","display_name":"Pacing and Clinical Electrophysiology","issn_l":"0147-8389","issn":["0147-8389","1540-8159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pacing and Clinical Electrophysiology","raw_type":"journal-article"},{"id":"pmid:1701893","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1701893","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pacing and clinical electrophysiology : PACE","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1886789223","https://openalex.org/W1967155009","https://openalex.org/W2000890002","https://openalex.org/W2007596664","https://openalex.org/W2015599809","https://openalex.org/W2022496201","https://openalex.org/W2023511593","https://openalex.org/W2032409405","https://openalex.org/W2043967577","https://openalex.org/W2054600230","https://openalex.org/W2056667729","https://openalex.org/W2072155245","https://openalex.org/W2079815465","https://openalex.org/W2107903424","https://openalex.org/W2182046799","https://openalex.org/W2189081871","https://openalex.org/W2258851258","https://openalex.org/W2340907876","https://openalex.org/W2409353119","https://openalex.org/W2413854748","https://openalex.org/W2414304123","https://openalex.org/W2414655961","https://openalex.org/W2415062923","https://openalex.org/W2419073270","https://openalex.org/W2435786102","https://openalex.org/W2488139925","https://openalex.org/W2602602879","https://openalex.org/W4233545309","https://openalex.org/W4238673995"],"related_works":["https://openalex.org/W20546668","https://openalex.org/W4234872448","https://openalex.org/W1995258272","https://openalex.org/W2143145155","https://openalex.org/W2043320879","https://openalex.org/W2035933900","https://openalex.org/W1987082456","https://openalex.org/W1967155009","https://openalex.org/W2081114784","https://openalex.org/W2335630306"],"abstract_inverted_index":{"The":[0],"effects":[1],"of":[2,70,127,195,203,221],"increasing":[3],"heart":[4,52,178,204],"rate":[5,21,53,179,205],"by":[6,26,56,160,168,181,206],"six":[7],"different":[8],"methods":[9],"on":[10],"cardiac":[11,196,234,243],"function":[12,214],"were":[13,77],"investigated":[14],"in":[15,95,177,242],"17":[16],"open-chest":[17],"anesthetized":[18],"dogs.":[19],"Heart":[20],"was":[22,158,166],"increased":[23,108,137],"approximately":[24],"30%":[25],"(1)":[27],"right":[28,43,172,182,250],"interganglionic":[29,173,183,251],"nerve":[30,174,184,252],"stimulation,":[31,46],"(2)":[32],"atrial":[33,57,169,247],"pacing,":[34,37,41],"(3)":[35],"ventricular":[36,60,83,161,208,223],"(4)":[38],"atrioventricular":[39,105,210],"sequential":[40,106],"(5)":[42],"stellate":[44,132],"ganglion":[45,133],"and":[47,74,85,113,117,122,135,141,149,163,165,171,225,229,261],"(6)":[48],"isoproterenol":[49,136,226],"administration.":[50],"During":[51],"increases":[54],"induced":[55,180],"pacing":[58,80,107,162,170,211,248],"left":[59,82,138,222],"intramyocardial":[61,87,120,147],"pressure,":[62,88,148],"coronary":[63,91,110,143],"blood":[64,145],"flow,":[65,146],"oxygen":[66,72,97,102,115,123,129,151,190,259],"delivery":[67,98,124],"per":[68,125],"unit":[69,126],"myocardial":[71,75,101,114,128,150,154,189,213,230,258],"consumption,":[73,116,191],"efficiency":[76,155,224,262],"unchanged.":[78,264],"Ventricular":[79],"reduced":[81,96],"cavity":[84],"septal":[86,119],"while":[89],"circumflex":[90,109,142],"flow":[92,112],"increased,":[93],"resulting":[94],"relative":[99,232],"to":[100,233],"consumption.":[103,130,152],"Similarly,":[104],"artery":[111,144],"decreased":[118,159],"pressure":[121],"Right":[131],"stimulation":[134,185,253],"anterior":[139],"descending":[140],"Estimated":[153],"(left":[156],"ventricle)":[157],"isoproterenol,":[164],"unchanged":[167],"stimulation.":[175],"Increases":[176],"did":[186],"not":[187],"alter":[188],"or":[192,209,249],"the":[193],"index":[194],"efficiency.":[197,244],"It":[198],"is":[199,218,239],"concluded":[200],"that":[201,216,257],"augmentation":[202],"either":[207],"impairs":[212],"so":[215,237],"there":[217,238],"a":[219,240],"decrease":[220],"augments":[227,254],"chronotropism":[228,255],"force":[231],"external":[235],"work":[236],"reduction":[241],"In":[245],"contrast,":[246],"such":[256],"consumption":[260],"are":[263]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}