{"id":"https://openalex.org/W1990458269","doi":"https://doi.org/10.1126/science.1071065","title":"Dynamic Imaging of T Cell-Dendritic Cell Interactions in Lymph Nodes","display_name":"Dynamic Imaging of T Cell-Dendritic Cell Interactions in Lymph Nodes","publication_year":2002,"publication_date":"2002-06-07","ids":{"openalex":"https://openalex.org/W1990458269","doi":"https://doi.org/10.1126/science.1071065","mag":"1990458269","pmid":"https://pubmed.ncbi.nlm.nih.gov/12052961"},"language":"en","primary_location":{"id":"doi:10.1126/science.1071065","doi":"https://doi.org/10.1126/science.1071065","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1071065","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1990458269"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Sabine Stoll","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sabine Stoll","raw_affiliation_strings":["Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health,","Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078514279","display_name":"J\u00e9r\u00f4me Delon","orcid":"https://orcid.org/0000-0003-0222-1192","observed_orcids":["https://orcid.org/0000-0003-0222-1192"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Je\u0301ro\u0302me Delon","raw_affiliation_strings":["Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014276085","display_name":"Tilmann M. Brotz","orcid":"https://orcid.org/0000-0001-8212-459X","observed_orcids":["https://orcid.org/0000-0001-8212-459X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tilmann M. Brotz","raw_affiliation_strings":["Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088777789","display_name":"Ronald N. Germain","orcid":"https://orcid.org/0000-0003-1495-9143","observed_orcids":["https://orcid.org/0000-0003-1495-9143"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ronald N. Germain","raw_affiliation_strings":["Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5014276085","https://openalex.org/A5088777789"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4210140884"],"apc_list":null,"apc_paid":null,"fwci":17.6026,"has_fulltext":false,"cited_by_count":729,"citation_normalized_percentile":{"value":0.99616652,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"296","issue":"5574","first_page":"1873","last_page":"1876"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7768999934196472,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7768999934196472,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.20309999585151672,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendritic-cell-t-cell-interaction","display_name":"dendritic cell-T cell interaction","score":0.9350000023841858},{"id":"https://openalex.org/keywords/immunological-synapse","display_name":"immunological synapse","score":0.9079999923706055},{"id":"https://openalex.org/keywords/lymph-nodes","display_name":"lymph nodes","score":0.6899999976158142},{"id":"https://openalex.org/keywords/antigen-specific-t-cells","display_name":"antigen-specific T cells","score":0.8510000109672546},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/t-cell-migration","display_name":"T cell migration","score":0.9300000071525574},{"id":"https://openalex.org/keywords/lymphoid-tissue","display_name":"lymphoid tissue","score":0.4860000014305115},{"id":"https://openalex.org/keywords/early-immune-response","display_name":"early immune response","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C9756297","wikidata":"https://www.wikidata.org/wiki/Q126223","display_name":"Immunological synapse","level":5,"score":0.7024941444396973},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5951040387153625},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5633910894393921},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5259328484535217},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.5222428441047668},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4673248827457428},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.46074002981185913},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4416443109512329},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.4253760576248169},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.40147581696510315},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3125976324081421},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.18536600470542908},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17718768119812012},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11580181121826172},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08708658814430237}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007365","descriptor_name":"Intercellular Junctions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007365","descriptor_name":"Intercellular Junctions","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012795","descriptor_name":"Sialoglycoproteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012795","descriptor_name":"Sialoglycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012795","descriptor_name":"Sialoglycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051917","descriptor_name":"Leukosialin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.1071065","doi":"https://doi.org/10.1126/science.1071065","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1071065","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:12052961","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12052961","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W124239641","https://openalex.org/W1535141082","https://openalex.org/W1562441478","https://openalex.org/W1567462163","https://openalex.org/W1661544713","https://openalex.org/W1662182196","https://openalex.org/W1687035583","https://openalex.org/W1902251032","https://openalex.org/W1933919794","https://openalex.org/W1943394565","https://openalex.org/W1967717169","https://openalex.org/W1970318694","https://openalex.org/W1973730600","https://openalex.org/W1988009411","https://openalex.org/W1992949591","https://openalex.org/W2014385809","https://openalex.org/W2024957425","https://openalex.org/W2043893491","https://openalex.org/W2062106514","https://openalex.org/W2066320353","https://openalex.org/W2090623211","https://openalex.org/W2092910693","https://openalex.org/W2096234619","https://openalex.org/W2106860822","https://openalex.org/W2139595663","https://openalex.org/W2163351493","https://openalex.org/W2168187239"],"related_works":["https://openalex.org/W2167670122","https://openalex.org/W4247575208","https://openalex.org/W2091928948","https://openalex.org/W4255969696","https://openalex.org/W2043698968","https://openalex.org/W2034866848","https://openalex.org/W2170831273","https://openalex.org/W3165508012","https://openalex.org/W1997808307","https://openalex.org/W2064593553"],"abstract_inverted_index":{"T":[0,46,79],"cell":[1,68,96],"immune":[2,101],"responses":[3,21,102],"begin":[4],"within":[5,52,103],"organized":[6],"lymphoid":[7,104],"tissues.":[8],"The":[9],"pace,":[10],"topology,":[11],"and":[12,62,75],"outcomes":[13],"of":[14,30,36,44,78,95],"the":[15,72,83,93],"cellular":[16],"interactions":[17,64,97],"that":[18],"underlie":[19],"these":[20,66],"have,":[22],"so":[23],"far,":[24],"been":[25],"inferred":[26],"from":[27,34,82],"static":[28],"imaging":[29],"sectioned":[31],"tissue":[32],"or":[33],"studies":[35],"cultured":[37],"cells.":[38],"Here":[39],"we":[40],"report":[41],"dynamic":[42],"visualization":[43],"antigen-specific":[45],"cells":[47,51,80],"interacting":[48],"with":[49],"dendritic":[50],"intact":[53],"explanted":[54],"lymph":[55],"nodes.":[56],"We":[57],"observed":[58],"immunological":[59],"synapse":[60],"formation":[61],"prolonged":[63],"between":[65],"two":[67],"types,":[69],"followed":[70],"by":[71],"activation,":[73],"dissociation,":[74],"rapid":[76],"migration":[77],"away":[81],"antigenic":[84],"stimulus.":[85],"This":[86],"high-resolution":[87],"spatiotemporal":[88],"analysis":[89],"provides":[90],"insight":[91],"into":[92],"nature":[94],"critical":[98],"to":[99],"early":[100],"structures.":[105]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":31},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":23},{"year":2018,"cited_by_count":22},{"year":2017,"cited_by_count":23},{"year":2016,"cited_by_count":34},{"year":2015,"cited_by_count":28},{"year":2014,"cited_by_count":23},{"year":2013,"cited_by_count":27},{"year":2012,"cited_by_count":27}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
