{"id":"https://openalex.org/W1990447388","doi":"https://doi.org/10.1074/jbc.273.33.20837","title":"Multiple Functions of Pmt1p-mediated ProteinO-Mannosylation in the Fungal Pathogen Candida albicans","display_name":"Multiple Functions of Pmt1p-mediated ProteinO-Mannosylation in the Fungal Pathogen Candida albicans","publication_year":1998,"publication_date":"1998-08-01","ids":{"openalex":"https://openalex.org/W1990447388","doi":"https://doi.org/10.1074/jbc.273.33.20837","mag":"1990447388","pmid":"https://pubmed.ncbi.nlm.nih.gov/9694829"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.273.33.20837","doi":"https://doi.org/10.1074/jbc.273.33.20837","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.33.20837","pdf_url":"http://www.jbc.org/article/S0021925818489223/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925818489223/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040583611","display_name":"Claudia Timpel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Claudia Timpel","raw_affiliation_strings":["Institut f\u00fcr Mikrobiologie und Biologisch-Medizinisches Forschungszentrum, Heinrich-Heine-Universit\u00e4t, D-40225 D\u00fcsseldorf, Germany","Institut fu\u0308r Mikrobiologie und Biologisch-Medizinisches Forschungszentrum, Heinrich-Heine-Universita\u0308t, D-40225 Du\u0308sseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Mikrobiologie und Biologisch-Medizinisches Forschungszentrum, Heinrich-Heine-Universit\u00e4t, D-40225 D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Institut fu\u0308r Mikrobiologie und Biologisch-Medizinisches Forschungszentrum, Heinrich-Heine-Universita\u0308t, D-40225 Du\u0308sseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047498334","display_name":"Sabine Strahl\u2010Bolsinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sabine Strahl-Bolsinger","raw_affiliation_strings":["Lehrstuhl fu\u0308r Zellbiologie und Pflanzenphysiologie, Universita\u0308t Regensburg, 93040 Regensburg, Germany","Lehrstuhl fur Zellbiologie und Pflanzenphysiologie, Universit\u00e4t Regensburg, 93040 Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lehrstuhl fu\u0308r Zellbiologie und Pflanzenphysiologie, Universita\u0308t Regensburg, 93040 Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]},{"raw_affiliation_string":"Lehrstuhl fur Zellbiologie und Pflanzenphysiologie, Universit\u00e4t Regensburg, 93040 Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051451842","display_name":"Karl B. Ziegelbauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karl Ziegelbauer","raw_affiliation_strings":["Institute for Antiinfectiva Research, Bayer AG, 42117 Wuppertal, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Antiinfectiva Research, Bayer AG, 42117 Wuppertal, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108273529","display_name":"Joachim F. Ernst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Joachim F. Ernst","raw_affiliation_strings":["Institut fu\u0308r Mikrobiologie und Biologisch-Medizinisches Forschungszentrum, Heinrich-Heine-Universita\u0308t, D-40225 Du\u0308sseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut fu\u0308r Mikrobiologie und Biologisch-Medizinisches Forschungszentrum, Heinrich-Heine-Universita\u0308t, D-40225 Du\u0308sseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5108273529"],"corresponding_institution_ids":["https://openalex.org/I44260953"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.616,"has_fulltext":true,"cited_by_count":163,"citation_normalized_percentile":{"value":0.90630143,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"273","issue":"33","first_page":"20837","last_page":"20846"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.021900000050663948,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-o-mannosylation","display_name":"protein O-mannosylation","score":0.9559999704360962},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.9879999756813049},{"id":"https://openalex.org/keywords/fungal-pathogens","display_name":"fungal pathogens","score":0.5339999794960022},{"id":"https://openalex.org/keywords/o-glycosylation","display_name":"O-glycosylation","score":0.8360000252723694},{"id":"https://openalex.org/keywords/hyphal-morphogenesis","display_name":"hyphal morphogenesis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/antifungal-susceptibility","display_name":"antifungal susceptibility","score":0.828000009059906},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.5509999990463257},{"id":"https://openalex.org/keywords/chitinase","display_name":"chitinase","score":0.878000020980835},{"id":"https://openalex.org/keywords/virulence","display_name":"virulence","score":0.7870000004768372},{"id":"https://openalex.org/keywords/avirulence","display_name":"avirulence","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.7754905223846436},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6105491518974304},{"id":"https://openalex.org/C90080823","wikidata":"https://www.wikidata.org/wiki/Q193129","display_name":"Hypha","level":2,"score":0.6078804731369019},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5692005753517151},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.5377683043479919},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5110658407211304},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.49196287989616394},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.4861023426055908},{"id":"https://openalex.org/C2910135453","wikidata":"https://www.wikidata.org/wiki/Q3122802","display_name":"Fungal protein","level":4,"score":0.41539159417152405},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35756710171699524},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31885579228401184},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3019880950450897}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005816","descriptor_name":"Genetic Complementation Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008358","descriptor_name":"Mannose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008364","descriptor_name":"Mannosyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008364","descriptor_name":"Mannosyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008364","descriptor_name":"Mannosyltransferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.273.33.20837","doi":"https://doi.org/10.1074/jbc.273.33.20837","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.33.20837","pdf_url":"http://www.jbc.org/article/S0021925818489223/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:9694829","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9694829","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.273.33.20837","doi":"https://doi.org/10.1074/jbc.273.33.20837","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.33.20837","pdf_url":"http://www.jbc.org/article/S0021925818489223/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990447388.pdf","grobid_xml":"https://content.openalex.org/works/W1990447388.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1487958751","https://openalex.org/W1502661652","https://openalex.org/W1525653538","https://openalex.org/W1526043578","https://openalex.org/W1534931218","https://openalex.org/W1535640491","https://openalex.org/W1574839099","https://openalex.org/W1600651336","https://openalex.org/W1780849736","https://openalex.org/W1855382658","https://openalex.org/W1965039542","https://openalex.org/W1967390330","https://openalex.org/W1980881459","https://openalex.org/W1981271533","https://openalex.org/W1981385746","https://openalex.org/W1982482490","https://openalex.org/W1983621561","https://openalex.org/W1988818002","https://openalex.org/W1993501149","https://openalex.org/W1993634944","https://openalex.org/W1994136352","https://openalex.org/W1996097675","https://openalex.org/W1998871484","https://openalex.org/W2000725979","https://openalex.org/W2008014792","https://openalex.org/W2008149893","https://openalex.org/W2030697714","https://openalex.org/W2030949689","https://openalex.org/W2035815264","https://openalex.org/W2036860180","https://openalex.org/W2038448241","https://openalex.org/W2041394937","https://openalex.org/W2042299710","https://openalex.org/W2046640957","https://openalex.org/W2049219353","https://openalex.org/W2051918508","https://openalex.org/W2056602792","https://openalex.org/W2058216045","https://openalex.org/W2071482962","https://openalex.org/W2073351370","https://openalex.org/W2074079723","https://openalex.org/W2078694607","https://openalex.org/W2080326050","https://openalex.org/W2081370923","https://openalex.org/W2081601444","https://openalex.org/W2082383071","https://openalex.org/W2086231090","https://openalex.org/W2089819283","https://openalex.org/W2115130703","https://openalex.org/W2119388326","https://openalex.org/W2122488874","https://openalex.org/W2125049470","https://openalex.org/W2129452351","https://openalex.org/W2134690832","https://openalex.org/W2140935709","https://openalex.org/W2150336680","https://openalex.org/W4299451665"],"related_works":["https://openalex.org/W2018560254","https://openalex.org/W2139151562","https://openalex.org/W4299837679","https://openalex.org/W2168387851","https://openalex.org/W2075584350","https://openalex.org/W2170179987","https://openalex.org/W2046602168","https://openalex.org/W7024525048","https://openalex.org/W2116079412","https://openalex.org/W2150953954"],"abstract_inverted_index":{"Protein":[0],"mannosylation":[1],"by":[2,133],"Pmt":[3,34,134],"proteins":[4,135],"initiates":[5],"O-glycosylation":[6],"in":[7,21,30,35,56,84,113,137,148],"fungi.":[8],"We":[9],"have":[10],"identified":[11],"the":[12,17,22,65,96],"PMT1":[13,31,87,142],"gene":[14],"and":[15,43,72,75,101],"analyzed":[16],"function":[18],"of":[19,95,106,117],"Pmt1p":[20],"fungal":[23,139],"human":[24],"pathogen":[25],"Candida":[26],"albicans.":[27],"Mutants":[28],"defective":[29,60],"alleles":[32],"lacked":[33],"vitro":[36],"enzymatic":[37],"activity,":[38],"showed":[39,124],"reduced":[40,76,125],"growth":[41],"rates,":[42],"tended":[44],"to":[45,64,78,91,102,146],"form":[46],"cellular":[47,150],"aggregates.":[48],"In":[49],"addition,":[50],"multiple":[51,149],"specific":[52],"deficiencies":[53],"not":[54],"known":[55],"Saccharomyces":[57],"cerevisiae":[58],"(including":[59],"hyphal":[61],"morphogenesis;":[62],"supersensitivity":[63],"antifungal":[66],"agents":[67],"hygromycin":[68],"B,":[69],"G418,":[70],"clotrimazole,":[71],"calcofluor":[73],"white;":[74],"adherence":[77],"Caco-2":[79],"epithelial":[80],"cells)":[81],"were":[82,111],"observed":[83],"pmt1":[85,109],"mutants.":[86],"deficiency":[88,143],"also":[89],"led":[90],"faster":[92],"electrophoretic":[93],"mobility":[94],"Als1p":[97],"cell":[98],"wall":[99],"protein":[100,131],"elevated":[103],"extracellular":[104],"activities":[105],"chitinase.":[107],"Homozygous":[108],"mutants":[110],"avirulent":[112],"a":[114],"mouse":[115],"model":[116],"systemic":[118],"infection,":[119],"while":[120],"heterozygous":[121],"PMT1/pmt1":[122],"strains":[123],"virulence.":[126],"The":[127],"results":[128],"indicate":[129],"that":[130],"O-mannosylation":[132],"occurs":[136],"different":[138],"species,":[140],"where":[141],"can":[144],"lead":[145],"defects":[147],"functions.":[151]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
