{"id":"https://openalex.org/W1990441829","doi":"https://doi.org/10.1172/jci114021","title":"Sequence of the variant thyroxine-binding globulin of Australian aborigines. Only one of two amino acid replacements is responsible for its altered properties.","display_name":"Sequence of the variant thyroxine-binding globulin of Australian aborigines. Only one of two amino acid replacements is responsible for its altered properties.","publication_year":1989,"publication_date":"1989-04-01","ids":{"openalex":"https://openalex.org/W1990441829","doi":"https://doi.org/10.1172/jci114021","mag":"1990441829","pmid":"https://pubmed.ncbi.nlm.nih.gov/2495303","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/303827"},"language":"en","primary_location":{"id":"doi:10.1172/jci114021","doi":"https://doi.org/10.1172/jci114021","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci114021","pdf_url":"http://www.jci.org/articles/view/114021/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/114021/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085154017","display_name":"Kyoko Takeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Takeda","raw_affiliation_strings":["Department of Medicine, University of Chicago, Illinois 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Chicago, Illinois 60637","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109314530","display_name":"Y Mori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y Mori","raw_affiliation_strings":["Departments ofMedicine and Pharmacology, University ofArizona, Tuscon, Arizona 85719"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments ofMedicine and Pharmacology, University ofArizona, Tuscon, Arizona 85719","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057253055","display_name":"S Sobieszczyk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Sobieszczyk","raw_affiliation_strings":["Departments ofMedicine and Pharmacology, University ofArizona, Tuscon, Arizona 85719"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments ofMedicine and Pharmacology, University ofArizona, Tuscon, Arizona 85719","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108772106","display_name":"Hisao Seo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210088912","display_name":"Queen Elizabeth II Medical Centre","ror":"https://ror.org/0071a2k97","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210088912"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"H Seo","raw_affiliation_strings":["Clinical Biochemistry Service , The Queen Elizabeth II Medical Center , Perth , Australia;","Departments of*Medicine, tPediatrics, \u00a7Biochemistry, and Molecular Biology and Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois 60637; I1Department ofEndocrinology and Metabolism,","The Research Institute ofEnvironmental Medicine, Nagoya, Japan;","Thyroid Study Unit, Box 138, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Biochemistry Service , The Queen Elizabeth II Medical Center , Perth , Australia;","institution_ids":["https://openalex.org/I4210088912"]},{"raw_affiliation_string":"Departments of*Medicine, tPediatrics, \u00a7Biochemistry, and Molecular Biology and Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois 60637; I1Department ofEndocrinology and Metabolism,","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I40347166"]},{"raw_affiliation_string":"The Research Institute ofEnvironmental Medicine, Nagoya, Japan;","institution_ids":[]},{"raw_affiliation_string":"Thyroid Study Unit, Box 138, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109327382","display_name":"Matthew Dick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088912","display_name":"Queen Elizabeth II Medical Centre","ror":"https://ror.org/0071a2k97","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210088912"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"M Dick","raw_affiliation_strings":["I1Department ofEndocrinology and Metabolism , The Research Institute ofEnvironmental Medicine , Nagoya , Japan;","Clinical Biochemistry Service, The Queen Elizabeth II Medical Center, Perth, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"I1Department ofEndocrinology and Metabolism , The Research Institute ofEnvironmental Medicine , Nagoya , Japan;","institution_ids":[]},{"raw_affiliation_string":"Clinical Biochemistry Service, The Queen Elizabeth II Medical Center, Perth, Australia;","institution_ids":["https://openalex.org/I4210088912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111582145","display_name":"Frank E. Watson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088912","display_name":"Queen Elizabeth II Medical Centre","ror":"https://ror.org/0071a2k97","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210088912"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"F Watson","raw_affiliation_strings":["I1Department ofEndocrinology and Metabolism , The Research Institute ofEnvironmental Medicine , Nagoya , Japan;","Clinical Biochemistry Service, The Queen Elizabeth II Medical Center, Perth, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"I1Department ofEndocrinology and Metabolism , The Research Institute ofEnvironmental Medicine , Nagoya , Japan;","institution_ids":[]},{"raw_affiliation_string":"Clinical Biochemistry Service, The Queen Elizabeth II Medical Center, Perth, Australia;","institution_ids":["https://openalex.org/I4210088912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109941848","display_name":"Irwin L. Flink","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210088912","display_name":"Queen Elizabeth II Medical Centre","ror":"https://ror.org/0071a2k97","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210088912"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"I L Flink","raw_affiliation_strings":["Clinical Biochemistry Service , The Queen Elizabeth II Medical Center , Perth , Australia;","Departments of*Medicine, tPediatrics, \u00a7Biochemistry, and Molecular Biology and Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois 60637; I1Department ofEndocrinology and Metabolism,","The Research Institute ofEnvironmental Medicine, Nagoya, Japan;","Thyroid Study Unit, Box 138, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Biochemistry Service , The Queen Elizabeth II Medical Center , Perth , Australia;","institution_ids":["https://openalex.org/I4210088912"]},{"raw_affiliation_string":"Departments of*Medicine, tPediatrics, \u00a7Biochemistry, and Molecular Biology and Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois 60637; I1Department ofEndocrinology and Metabolism,","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I40347166"]},{"raw_affiliation_string":"The Research Institute ofEnvironmental Medicine, Nagoya, Japan;","institution_ids":[]},{"raw_affiliation_string":"Thyroid Study Unit, Box 138, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046353080","display_name":"Susumu Seino","orcid":"https://orcid.org/0000-0002-6465-0681","observed_orcids":["https://orcid.org/0000-0002-6465-0681"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Seino","raw_affiliation_strings":["Departments of*Medicine, tPediatrics, \u00a7Biochemistry, and Molecular Biology and Howard Hughes Medical Institute , The University of Chicago , Chicago , Illinois 60637 ;","Departments of*Medicine, tPediatrics, \u00a7Biochemistry, and Molecular Biology and Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois 60637; I1Department ofEndocrinology and Metabolism,","The Research Institute ofEnvironmental Medicine, Nagoya, Japan;","Thyroid Study Unit, Box 138, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of*Medicine, tPediatrics, \u00a7Biochemistry, and Molecular Biology and Howard Hughes Medical Institute , The University of Chicago , Chicago , Illinois 60637 ;","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I40347166"]},{"raw_affiliation_string":"Departments of*Medicine, tPediatrics, \u00a7Biochemistry, and Molecular Biology and Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois 60637; I1Department ofEndocrinology and Metabolism,","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I40347166"]},{"raw_affiliation_string":"The Research Institute ofEnvironmental Medicine, Nagoya, Japan;","institution_ids":[]},{"raw_affiliation_string":"Thyroid Study Unit, Box 138, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103544018","display_name":"Graeme I. Bell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G I Bell","raw_affiliation_strings":["Departments of*Medicine, tPediatrics, \u00a7Biochemistry, and Molecular Biology and Howard Hughes Medical Institute , The University of Chicago , Chicago , Illinois 60637 ;","Thyroid Study Unit, Box 138, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637","Departments of*Medicine, tPediatrics, \u00a7Biochemistry, and Molecular Biology and Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois 60637; I1Department ofEndocrinology and Metabolism,","The Research Institute ofEnvironmental Medicine, Nagoya, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of*Medicine, tPediatrics, \u00a7Biochemistry, and Molecular Biology and Howard Hughes Medical Institute , The University of Chicago , Chicago , Illinois 60637 ;","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I40347166"]},{"raw_affiliation_string":"Thyroid Study Unit, Box 138, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Departments of*Medicine, tPediatrics, \u00a7Biochemistry, and Molecular Biology and Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois 60637; I1Department ofEndocrinology and Metabolism,","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I40347166"]},{"raw_affiliation_string":"The Research Institute ofEnvironmental Medicine, Nagoya, Japan;","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038183050","display_name":"Samuel Refetoff","orcid":"https://orcid.org/0000-0003-0164-8231","observed_orcids":["https://orcid.org/0000-0003-0164-8231"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Refetoff","raw_affiliation_strings":["Departments of*Medicine, tPediatrics, \u00a7Biochemistry, and Molecular Biology and Howard Hughes Medical Institute , The University of Chicago , Chicago , Illinois 60637 ;","Departments of*Medicine, tPediatrics, \u00a7Biochemistry, and Molecular Biology and Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois 60637; I1Department ofEndocrinology and Metabolism,","The Research Institute ofEnvironmental Medicine, Nagoya, Japan;","Thyroid Study Unit, Box 138, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of*Medicine, tPediatrics, \u00a7Biochemistry, and Molecular Biology and Howard Hughes Medical Institute , The University of Chicago , Chicago , Illinois 60637 ;","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I40347166"]},{"raw_affiliation_string":"Departments of*Medicine, tPediatrics, \u00a7Biochemistry, and Molecular Biology and Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois 60637; I1Department ofEndocrinology and Metabolism,","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I40347166"]},{"raw_affiliation_string":"The Research Institute ofEnvironmental Medicine, Nagoya, Japan;","institution_ids":[]},{"raw_affiliation_string":"Thyroid Study Unit, Box 138, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":5.1083,"has_fulltext":true,"cited_by_count":68,"citation_normalized_percentile":{"value":0.95794615,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"83","issue":"4","first_page":"1344","last_page":"1348"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.8999000191688538,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.8999000191688538,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.033799998462200165,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.014000000432133675,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroxine-binding-globulin","display_name":"thyroxine-binding globulin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/aboriginal-australians","display_name":"Aboriginal Australians","score":0.7749999761581421},{"id":"https://openalex.org/keywords/amino-acid-substitutions","display_name":"amino acid substitutions","score":0.7730000019073486},{"id":"https://openalex.org/keywords/x-linked-inheritance","display_name":"X-linked inheritance","score":0.7459999918937683},{"id":"https://openalex.org/keywords/thermal-denaturation","display_name":"thermal denaturation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/acid-denaturation","display_name":"acid denaturation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/hormone-binding-affinity","display_name":"hormone binding affinity","score":0.6859999895095825},{"id":"https://openalex.org/keywords/restriction-enzyme-sites","display_name":"restriction enzyme sites","score":0.550000011920929},{"id":"https://openalex.org/keywords/protein-sequences","display_name":"protein sequences","score":0.31700000166893005}],"concepts":[{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5781946778297424},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5576022863388062},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5404847860336304},{"id":"https://openalex.org/C2776580952","wikidata":"https://www.wikidata.org/wiki/Q483745","display_name":"Leucine","level":3,"score":0.520922839641571},{"id":"https://openalex.org/C2779856020","wikidata":"https://www.wikidata.org/wiki/Q218642","display_name":"Alanine","level":3,"score":0.5055046081542969},{"id":"https://openalex.org/C2777239931","wikidata":"https://www.wikidata.org/wiki/Q409646","display_name":"Thyroxine-binding globulin","level":4,"score":0.48780134320259094},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.46208760142326355},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.45902687311172485},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4398408532142639},{"id":"https://openalex.org/C2778288131","wikidata":"https://www.wikidata.org/wiki/Q327362","display_name":"Triiodothyronine","level":3,"score":0.0},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005784","descriptor_name":"Gene Amplification","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013975","descriptor_name":"Thyroxine-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013975","descriptor_name":"Thyroxine-Binding Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1172/jci114021","doi":"https://doi.org/10.1172/jci114021","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci114021","pdf_url":"http://www.jci.org/articles/view/114021/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:303827","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/303827","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:2495303","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2495303","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.990.2700","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.990.2700","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dm5migu4zj3pb.cloudfront.net/manuscripts/114000/114021/JCI89114021.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1172/jci114021","doi":"https://doi.org/10.1172/jci114021","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci114021","pdf_url":"http://www.jci.org/articles/view/114021/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1164413914","display_name":null,"funder_award_id":"DK 15070","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990441829.pdf","grobid_xml":"https://content.openalex.org/works/W1990441829.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W33958008","https://openalex.org/W560294956","https://openalex.org/W1513717105","https://openalex.org/W1563159976","https://openalex.org/W1967844640","https://openalex.org/W1991933562","https://openalex.org/W1993145469","https://openalex.org/W2020570553","https://openalex.org/W2021337273","https://openalex.org/W2032118018","https://openalex.org/W2054722981","https://openalex.org/W2058831382","https://openalex.org/W2089774764","https://openalex.org/W2138270253","https://openalex.org/W2407484675","https://openalex.org/W2410441814","https://openalex.org/W4245388065"],"related_works":["https://openalex.org/W2155104744","https://openalex.org/W200669903","https://openalex.org/W1995892211","https://openalex.org/W1965616671","https://openalex.org/W1967844640","https://openalex.org/W2021337273","https://openalex.org/W2017681394","https://openalex.org/W2057599508","https://openalex.org/W1993145469","https://openalex.org/W2026919223"],"abstract_inverted_index":{"A":[0],"form":[1],"of":[2,27,30,44,52,63,91,101,124,147,158,170,189,210,227,233],"thyroxine-binding":[3],"globulin":[4],"(TBG)":[5],"with":[6],"reduced":[7],"affinity":[8],"for":[9,103,235],"hormone":[10],"and":[11,16,40,81,108,137,153,161],"increased":[12],"susceptibility":[13],"to":[14,200,231],"heat":[15,28],"acid":[17],"denaturation":[18,29],"has":[19,41],"been":[20],"identified":[21],"in":[22,46,72,85,98,116,144,156,196,202],"Australian":[23,48],"Aborigines":[24],"(TBG-A).":[25],"Results":[26],"TBG":[31,66,168],"established":[32],"that":[33,62,201,223],"the":[34,64,82,99,104,117,130,145,176,183,194,203,207,224],"TBGA":[35,55,204],"allele":[36,56,67,119,191],"is":[37],"X":[38],"linked":[39],"a":[42,171],"frequency":[43],"50.9%":[45],"Western":[47],"Aborigines.":[49],"The":[50,113,134,167],"sequence":[51],"an":[53],"isolated":[54],"differed":[57],"at":[58,237],"two":[59,148],"positions":[60],"from":[61,218],"normal":[65,219],"(TBGC).":[68],"One":[69],"substitution":[70,195,232],"was":[71,84,120],"codon":[73,86,197],"191,":[74],"ACA":[75],"(threonine)":[76],"rather":[77],"than":[78],"GCA":[79],"(alanine),":[80],"other":[83],"283,":[87],"TTT":[88],"(phenylalanine)":[89],"instead":[90],"TTG":[92],"(leucine).":[93],"These":[94],"nucleotide":[95,114],"substitutions":[96,115],"resulted":[97],"loss":[100],"sites":[102,141],"enzymes":[105],"Bgl":[106,135,177],"1":[107,136,178],"Tth":[109,138,184],"111":[110,139,185],"II,":[111],"respectively.":[112],"TBG-A":[118,152,228],"confirmed":[121],"by":[122,213],"digestion":[123],"genomic":[125],"DNA":[126],"segments":[127],"amplified":[128],"using":[129],"polymerase":[131],"chain":[132],"reaction.":[133],"II":[140,186],"were":[142,154,216],"absent":[143],"genes":[146],"Aboriginal":[149,160],"men":[150],"expressing":[151,165],"present":[155],"those":[157],"three":[159],"six":[162],"Caucasian":[163,173],"males":[164],"TBG-C.":[166],"gene":[169],"seventh":[172],"male":[174],"possessed":[175],"site":[179],"but":[180],"had":[181],"lost":[182],"site;":[187],"sequencing":[188],"this":[190,214],"revealed":[192],"only":[193],"283":[198],"identical":[199],"allele.":[205],"As":[206],"biochemical":[208],"properties":[209,226],"TBGPhe-283":[211],"expressed":[212],"individual":[215],"indistinguishable":[217],"TBGLeu-283,":[220],"we":[221],"believe":[222],"abnormal":[225],"are":[229],"due":[230],"alanine":[234],"threonine":[236],"residue":[238],"191.":[239]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":12},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
