{"id":"https://openalex.org/W1990416952","doi":"https://doi.org/10.1091/mbc.4.8.791","title":"Divergent fates of P- and E-selectins after their expression on the plasma membrane.","display_name":"Divergent fates of P- and E-selectins after their expression on the plasma membrane.","publication_year":1993,"publication_date":"1993-08-01","ids":{"openalex":"https://openalex.org/W1990416952","doi":"https://doi.org/10.1091/mbc.4.8.791","mag":"1990416952","pmid":"https://pubmed.ncbi.nlm.nih.gov/7694691","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/300993"},"language":"en","primary_location":{"id":"doi:10.1091/mbc.4.8.791","doi":"https://doi.org/10.1091/mbc.4.8.791","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.4.8.791","pdf_url":null,"source":{"id":"https://openalex.org/S188085164","display_name":"Molecular Biology of the Cell","issn_l":"1059-1524","issn":["1059-1524","1939-4586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of the Cell","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC300993/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013064011","display_name":"Meera Subramaniam","orcid":"https://orcid.org/0000-0003-2705-2022","observed_orcids":["https://orcid.org/0000-0003-2705-2022"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Subramaniam","raw_affiliation_strings":["Department of Medicine, New England Medical Center, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, New England Medical Center, Boston, Massachusetts","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110417329","display_name":"Johannes A. KOEDAM","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J A Koedam","raw_affiliation_strings":["Department of Medicine, New England Medical Center, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, New England Medical Center, Boston, Massachusetts","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032584210","display_name":"Denisa D. Wagner","orcid":"https://orcid.org/0000-0002-4494-413X","observed_orcids":["https://orcid.org/0000-0002-4494-413X"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D D Wagner","raw_affiliation_strings":["Department of Medicine, New England Medical Center, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, New England Medical Center, Boston, Massachusetts","institution_ids":["https://openalex.org/I1290900354"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1290900354"],"apc_list":null,"apc_paid":null,"fwci":1.7198,"has_fulltext":false,"cited_by_count":176,"citation_normalized_percentile":{"value":0.83067952,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"4","issue":"8","first_page":"791","last_page":"801"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0340999998152256,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p-selectin","display_name":"P-selectin","score":1.0},{"id":"https://openalex.org/keywords/e-selectin","display_name":"E-selectin","score":1.0},{"id":"https://openalex.org/keywords/weibel-palade-bodies","display_name":"Weibel-Palade bodies","score":0.8009999990463257},{"id":"https://openalex.org/keywords/lysosomal-degradation","display_name":"lysosomal degradation","score":0.8080000281333923},{"id":"https://openalex.org/keywords/endosomes","display_name":"endosomes","score":0.5360000133514404},{"id":"https://openalex.org/keywords/golgi-apparatus","display_name":"Golgi apparatus","score":0.8500000238418579},{"id":"https://openalex.org/keywords/storage-granules","display_name":"storage granules","score":0.7160000205039978},{"id":"https://openalex.org/keywords/cell-adhesion-receptors","display_name":"cell adhesion receptors","score":0.5799999833106995},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.6740000247955322},{"id":"https://openalex.org/keywords/cytoplasmic-domain","display_name":"cytoplasmic domain","score":0.7570000290870667},{"id":"https://openalex.org/keywords/antibody-internalization","display_name":"antibody internalization","score":0.46299999952316284},{"id":"https://openalex.org/keywords/intracellular-trafficking","display_name":"intracellular trafficking","score":0.5920000076293945},{"id":"https://openalex.org/keywords/neutrophil-adhesion","display_name":"neutrophil adhesion","score":0.6629999876022339},{"id":"https://openalex.org/keywords/monocyte-adhesion","display_name":"monocyte adhesion","score":0.8600000143051147}],"concepts":[{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.827473521232605},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7865062355995178},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7006218433380127},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.6581289768218994},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.6329576969146729},{"id":"https://openalex.org/C155619193","wikidata":"https://www.wikidata.org/wiki/Q415915","display_name":"Selectin","level":3,"score":0.5257878303527832},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.5073975920677185},{"id":"https://openalex.org/C175969161","wikidata":"https://www.wikidata.org/wiki/Q323426","display_name":"Exocytosis","level":3,"score":0.46875596046447754},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4331722855567932},{"id":"https://openalex.org/C2779835222","wikidata":"https://www.wikidata.org/wiki/Q4042403","display_name":"L-selectin","level":3,"score":0.4196828007698059},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.39484861493110657},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34826648235321045},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.32264143228530884},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.2768230140209198},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.2687597870826721},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2641940712928772},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.15571507811546326},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.11501926183700562}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002458","descriptor_name":"Cell Fractionation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010980","descriptor_name":"Platelet Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019007","descriptor_name":"P-Selectin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019040","descriptor_name":"E-Selectin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1091/mbc.4.8.791","doi":"https://doi.org/10.1091/mbc.4.8.791","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.4.8.791","pdf_url":null,"source":{"id":"https://openalex.org/S188085164","display_name":"Molecular Biology of the Cell","issn_l":"1059-1524","issn":["1059-1524","1939-4586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of the Cell","raw_type":"journal-article"},{"id":"pmid:7694691","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7694691","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology of the cell","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:300993","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC300993/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Biol Cell","raw_type":"Text"},{"id":"mag:2338383199","doi":null,"is_oa":false,"landing_page_url":"https://www.molbiolcell.org/content/4/8/791.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:300993","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC300993/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Biol Cell","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.428600013256073}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6418412604","display_name":"Weibel-Palade Bodies: roles in thrombosis, inflammation and stroke","funder_award_id":"R01HL041002","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7747736003","display_name":"MEMBRANE PROTEINS IN BLOOD COAGULATION","funder_award_id":"P01HL042443","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W73759871","https://openalex.org/W177128174","https://openalex.org/W193545656","https://openalex.org/W1499161051","https://openalex.org/W1522999898","https://openalex.org/W1540988218","https://openalex.org/W1545973549","https://openalex.org/W1608316061","https://openalex.org/W1786523947","https://openalex.org/W1966286149","https://openalex.org/W1970912287","https://openalex.org/W1973312218","https://openalex.org/W1977834451","https://openalex.org/W1981173146","https://openalex.org/W1982176096","https://openalex.org/W1986779414","https://openalex.org/W1988652098","https://openalex.org/W1992233783","https://openalex.org/W1994521388","https://openalex.org/W1999063996","https://openalex.org/W1999311177","https://openalex.org/W2004273103","https://openalex.org/W2023762992","https://openalex.org/W2024597511","https://openalex.org/W2026075546","https://openalex.org/W2027076158","https://openalex.org/W2032371793","https://openalex.org/W2034893493","https://openalex.org/W2037812623","https://openalex.org/W2042489614","https://openalex.org/W2049583570","https://openalex.org/W2054657407","https://openalex.org/W2057905142","https://openalex.org/W2059031237","https://openalex.org/W2067691363","https://openalex.org/W2071304431","https://openalex.org/W2073623140","https://openalex.org/W2080468160","https://openalex.org/W2082861222","https://openalex.org/W2089394059","https://openalex.org/W2090103344","https://openalex.org/W2091922025","https://openalex.org/W2097514615","https://openalex.org/W2103604950","https://openalex.org/W2105642801","https://openalex.org/W2125393205","https://openalex.org/W2138466097","https://openalex.org/W2147425691","https://openalex.org/W2147717440","https://openalex.org/W2154546635","https://openalex.org/W2158537601","https://openalex.org/W2171362729","https://openalex.org/W2175263209","https://openalex.org/W2414503057","https://openalex.org/W4231732020","https://openalex.org/W4245247646","https://openalex.org/W4252100412"],"related_works":["https://openalex.org/W2063646489","https://openalex.org/W2147717440","https://openalex.org/W96385035","https://openalex.org/W2125338233","https://openalex.org/W2105642801","https://openalex.org/W2061376351","https://openalex.org/W2013342188","https://openalex.org/W7096870138","https://openalex.org/W2177430700","https://openalex.org/W2164979127"],"abstract_inverted_index":{"P-selectin":[0,18,72,113,139,173],"and":[1,9,24,39,84,99,118],"E-selectin":[2,35,92,121,166],"are":[3,12],"related":[4],"adhesion":[5],"receptors":[6],"for":[7],"monocytes":[8],"neutrophils":[10],"that":[11],"expressed":[13],"by":[14,44,58],"stimulated":[15],"endothelial":[16],"cells.":[17],"is":[19,36,42,167],"stored":[20],"in":[21,77,80,86,97,115,123,169],"Weibel-Palade":[22,87],"bodies,":[23],"it":[25,181],"reaches":[26],"the":[27,48,51,60,67,81,91,110,120,143,153,170,176],"plasma":[28],"membrane":[29],"after":[30,54,105,149,160],"exocytosis":[31],"of":[32,50,63,103,112,119,152],"these":[33],"granules.":[34],"not":[37],"stored,":[38],"its":[40],"synthesis":[41],"induced":[43],"cytokines.":[45],"We":[46],"studied":[47],"fate":[49],"two":[52],"proteins":[53],"their":[55],"surface":[56,163],"expression":[57],"following":[59],"intracellular":[61],"routing":[62],"internalized":[64,165],"antibodies":[65],"to":[66,142,175],"selectins.":[68],"By":[69],"immunofluorescent":[70],"staining,":[71],"antibody":[73,93,114,122],"was":[74,94,140],"first":[75],"seen":[76],"endosomes,":[78],"then":[79],"Golgi":[82],"region,":[83],"finally":[85],"bodies.":[88],"In":[89,125,158],"contrast,":[90],"detected":[95],"only":[96,138],"endosomes":[98],"lysosomes.":[100,124],"Subcellular":[101],"fractionation":[102],"cells":[104],"4":[106],"h":[107],"chase":[108],"confirmed":[109],"localization":[111],"storage":[116,147,177],"granules":[117,148,178],"AtT-20":[126],"cells,":[127],"a":[128,161],"mouse":[129],"pituitary":[130],"cell":[131],"line,":[132],"transfected":[133],"with":[134],"P-":[135],"or":[136],"E-selectin,":[137],"delivered":[141],"endogenous":[144],"adrenocorticotrophic":[145],"hormone":[146],"endocytosis.":[150],"Deletion":[151],"cytoplasmic":[154],"domain":[155],"abolished":[156],"internalization.":[157],"summary,":[159],"brief":[162],"exposure,":[164],"degraded":[168],"lysosomes,":[171],"whereas":[172],"returns":[174],"from":[179],"where":[180],"can":[182],"be":[183],"reused.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
