{"id":"https://openalex.org/W1990409151","doi":"https://doi.org/10.1186/1755-8794-3-42","title":"Polymorphisms in folate-metabolizing genes, chromosome damage, and risk of Down syndrome in Italian women: identification of key factors using artificial neural networks","display_name":"Polymorphisms in folate-metabolizing genes, chromosome damage, and risk of Down syndrome in Italian women: identification of key factors using artificial neural networks","publication_year":2010,"publication_date":"2010-09-24","ids":{"openalex":"https://openalex.org/W1990409151","doi":"https://doi.org/10.1186/1755-8794-3-42","mag":"1990409151","pmid":"https://pubmed.ncbi.nlm.nih.gov/20868477","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2949778"},"language":"en","primary_location":{"id":"doi:10.1186/1755-8794-3-42","doi":"https://doi.org/10.1186/1755-8794-3-42","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1755-8794-3-42","pdf_url":"https://bmcmedgenomics.biomedcentral.com/counter/pdf/10.1186/1755-8794-3-42","source":{"id":"https://openalex.org/S119250532","display_name":"BMC Medical Genomics","issn_l":"1755-8794","issn":["1755-8794"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Genomics","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1990409151"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedgenomics.biomedcentral.com/counter/pdf/10.1186/1755-8794-3-42","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031743225","display_name":"Fabio Copped\u00e8","orcid":"https://orcid.org/0000-0002-3081-6647","observed_orcids":["https://orcid.org/0000-0002-3081-6647"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Fabio Copped\u00e8","raw_affiliation_strings":["Department of Human and Environmental Sciences, Section of Medical Genetics, University of Pisa, Italy. f.coppede@geog.unipi.it","Department of Human and Environmental Sciences, Section of Medical Genetics, University of Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human and Environmental Sciences, Section of Medical Genetics, University of Pisa, Italy. f.coppede@geog.unipi.it","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"Department of Human and Environmental Sciences, Section of Medical Genetics, University of Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048150723","display_name":"Enzo Grossi","orcid":"https://orcid.org/0000-0003-0346-2684","observed_orcids":["https://orcid.org/0000-0003-0346-2684"]},"institutions":[{"id":"https://openalex.org/I4210104163","display_name":"Semeion Centro Ricerche di Scienze della Comunicazione","ror":"https://ror.org/01ac4hv54","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210104163"]},{"id":"https://openalex.org/I4210132761","display_name":"Bracco (Italy)","ror":"https://ror.org/03wjptj96","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210132761"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enzo Grossi","raw_affiliation_strings":["Bracco Medical Department, San Donato Milanese, Italy","Semeion Research Centre, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bracco Medical Department, San Donato Milanese, Italy","institution_ids":["https://openalex.org/I4210132761"]},{"raw_affiliation_string":"Semeion Research Centre, Rome, Italy","institution_ids":["https://openalex.org/I4210104163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006996448","display_name":"Francesca Migheli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Migheli","raw_affiliation_strings":["Department of Human and Environmental Sciences, Section of Medical Genetics, University of Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human and Environmental Sciences, Section of Medical Genetics, University of Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066523365","display_name":"Lucia Migliore","orcid":"https://orcid.org/0000-0003-4342-8640","observed_orcids":["https://orcid.org/0000-0003-4342-8640"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lucia Migliore","raw_affiliation_strings":["Department of Human and Environmental Sciences, Section of Medical Genetics, University of Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human and Environmental Sciences, Section of Medical Genetics, University of Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5031743225"],"corresponding_institution_ids":["https://openalex.org/I108290504"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":2.9962,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.89009112,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"3","issue":"1","first_page":"42","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.5907999873161316,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.5907999873161316,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11015","display_name":"Down syndrome and intellectual disability research","score":0.31450000405311584,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/down-syndrome","display_name":"Down syndrome","score":0.9890000224113464},{"id":"https://openalex.org/keywords/maternal-risk-factors","display_name":"maternal risk factors","score":0.699999988079071},{"id":"https://openalex.org/keywords/folate-metabolism-genes","display_name":"folate metabolism genes","score":0.8109999895095825},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.871999979019165},{"id":"https://openalex.org/keywords/chromosomal-damage","display_name":"chromosomal damage","score":0.8500000238418579},{"id":"https://openalex.org/keywords/peripheral-blood-lymphocytes","display_name":"peripheral blood lymphocytes","score":0.7289999723434448},{"id":"https://openalex.org/keywords/mthfr","display_name":"MTHFR","score":0.8629999756813049},{"id":"https://openalex.org/keywords/mtr","display_name":"MTR","score":0.6980000138282776},{"id":"https://openalex.org/keywords/mtrr","display_name":"MTRR","score":0.902999997138977},{"id":"https://openalex.org/keywords/rfc1","display_name":"RFC1","score":0.9129999876022339},{"id":"https://openalex.org/keywords/thymidylate-synthase","display_name":"thymidylate synthase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/neural-network","display_name":"artificial neural networks","score":0.9120000004768372},{"id":"https://openalex.org/keywords/italian-women","display_name":"Italian women","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C2778087339","wikidata":"https://www.wikidata.org/wiki/Q18029587","display_name":"MTRR","level":5,"score":0.9529451727867126},{"id":"https://openalex.org/C43563269","wikidata":"https://www.wikidata.org/wiki/Q424709","display_name":"Methylenetetrahydrofolate reductase","level":4,"score":0.8333514928817749},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7114594578742981},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6487917304039001},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49911046028137207},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.4770038425922394},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.42454200983047485},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.41424083709716797},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.39311084151268005},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36058294773101807},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32774120569229126},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20644578337669373},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14693498611450195}],"mesh":[{"descriptor_ui":"D004314","descriptor_name":"Down Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004314","descriptor_name":"Down Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007558","descriptor_name":"Italy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042965","descriptor_name":"Methylenetetrahydrofolate Reductase (NADPH2)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048629","descriptor_name":"Micronuclei, Chromosome-Defective","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1755-8794-3-42","doi":"https://doi.org/10.1186/1755-8794-3-42","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1755-8794-3-42","pdf_url":"https://bmcmedgenomics.biomedcentral.com/counter/pdf/10.1186/1755-8794-3-42","source":{"id":"https://openalex.org/S119250532","display_name":"BMC Medical Genomics","issn_l":"1755-8794","issn":["1755-8794"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Genomics","raw_type":"journal-article"},{"id":"pmid:20868477","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20868477","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical genomics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2949778","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2949778/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Med Genomics","raw_type":"Text"},{"id":"pmh:oai:arpi.unipi.it:11568/141788","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11568/141788","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:924c89fa0b0c41f78db7c173345eed97","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/924c89fa0b0c41f78db7c173345eed97","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Genomics, Vol 3, Iss 1, p 42 (2010)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1755-8794-3-42","doi":"https://doi.org/10.1186/1755-8794-3-42","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1755-8794-3-42","pdf_url":"https://bmcmedgenomics.biomedcentral.com/counter/pdf/10.1186/1755-8794-3-42","source":{"id":"https://openalex.org/S119250532","display_name":"BMC Medical Genomics","issn_l":"1755-8794","issn":["1755-8794"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Genomics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990409151.pdf","grobid_xml":"https://content.openalex.org/works/W1990409151.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1543480871","https://openalex.org/W1652505363","https://openalex.org/W1815353070","https://openalex.org/W1915237052","https://openalex.org/W1933482556","https://openalex.org/W1934232739","https://openalex.org/W1963577579","https://openalex.org/W1971324436","https://openalex.org/W1975652111","https://openalex.org/W1976168285","https://openalex.org/W1989690390","https://openalex.org/W1991057836","https://openalex.org/W1991426267","https://openalex.org/W2017089706","https://openalex.org/W2025755447","https://openalex.org/W2033356785","https://openalex.org/W2040937081","https://openalex.org/W2045297515","https://openalex.org/W2048891955","https://openalex.org/W2050182310","https://openalex.org/W2071282605","https://openalex.org/W2081532048","https://openalex.org/W2086993418","https://openalex.org/W2092815939","https://openalex.org/W2093224167","https://openalex.org/W2106801305","https://openalex.org/W2107915719","https://openalex.org/W2113438859","https://openalex.org/W2115872837","https://openalex.org/W2122306148","https://openalex.org/W2141542279","https://openalex.org/W2149588972","https://openalex.org/W2167277498","https://openalex.org/W3207342693","https://openalex.org/W4234705375","https://openalex.org/W4251529051","https://openalex.org/W4300402905"],"related_works":["https://openalex.org/W1574132602","https://openalex.org/W2017089706","https://openalex.org/W4256328180","https://openalex.org/W7061156338","https://openalex.org/W1989690390","https://openalex.org/W1998414867","https://openalex.org/W4242286432","https://openalex.org/W2145710517","https://openalex.org/W2054354801","https://openalex.org/W2793174082"],"abstract_inverted_index":{"BACKGROUND:":[0],"Studies":[1],"in":[2,15,19,48,71,74,114,126,154,237,244],"mothers":[3,55,199],"of":[4,43,52,56,66,90,96,99,105,111],"Down":[5,28],"syndrome":[6,29],"individuals":[7],"(MDS)":[8],"point":[9],"to":[10,39,61,82,93,193],"a":[11,27,41,100,162,233],"role":[12],"for":[13,26,122],"polymorphisms":[14,125,236],"folate":[16,127,238],"metabolic":[17,128,239],"genes":[18,129,240],"increasing":[20],"chromosome":[21,112],"damage":[22,113],"and":[23,45,54,81,119,132,140,144,161,185,197,219,241],"maternal":[24],"risk":[25,243],"(DS)":[30],"pregnancy,":[31],"suggesting":[32],"complex":[33,212],"gene-gene":[34],"interactions.":[35],"This":[36],"study":[37,231],"aimed":[38],"analyze":[40],"dataset":[42,103],"genetic":[44],"cytogenetic":[46],"data":[47],"an":[49],"Italian":[50,245],"group":[51],"MDS":[53,196,224],"healthy":[57],"children":[58],"(control":[59],"mothers)":[60],"assess":[62],"the":[63,84,87,94,106,109,120,211,216,220,230],"predictive":[64],"capacity":[65],"artificial":[67,158],"neural":[68,159],"networks":[69],"assembled":[70],"TWIST":[72,152,167],"system":[73,153,168],"distinguish":[75],"consistently":[76],"these":[77],"two":[78,221],"different":[79],"conditions":[80,222],"identify":[83],"variables":[85,171,218],"expressing":[86],"maximal":[88],"amount":[89],"relevant":[91],"information":[92,209],"condition":[95],"being":[97],"mother":[98],"DS":[101,242],"child.The":[102],"consisted":[104],"following":[107],"variables:":[108],"frequency":[110],"peripheral":[115],"lymphocytes":[116],"(BNMN":[117,172],"frequency)":[118],"genotype":[121],"7":[123],"common":[124],"(MTHFR":[130],"677C>T":[131],"1298A>C,":[133],"MTRR":[134],"66A>G,":[135],"MTR":[136,186],"2756A>G,":[137],"RFC1":[138,176],"80G>A":[139],"TYMS":[141,178,182],"28bp":[142,183],"repeats":[143],"1494":[145,179],"6bp":[146,180],"deletion).":[147],"Data":[148],"were":[149,190],"analysed":[150],"using":[151],"combination":[155],"with":[156,200],"supervised":[157],"networks,":[160],"semantic":[163,204],"connectivity":[164,205],"map.":[165],"RESULTS:":[166],"selected":[169],"6":[170],"frequency,":[173],"MTHFR":[174],"677TT,":[175],"80AA,":[177],"+/+,":[181],"3R/3R":[184],"2756AA":[187],"genotypes)":[188],"that":[189],"subsequently":[191],"used":[192],"discriminate":[194],"between":[195,215,235],"control":[198,226],"90%":[201],"accuracy.":[202],"The":[203],"map":[206],"provided":[207],"important":[208],"on":[210],"biological":[213],"connections":[214],"studied":[217],"(being":[223],"or":[225],"mother).":[227],"CONCLUSIONS:":[228],"Overall,":[229],"suggests":[232],"link":[234],"women.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
