{"id":"https://openalex.org/W1990404564","doi":"https://doi.org/10.1111/j.1440-1681.1995.tb02325.x","title":"ANGIOTENSIN CONVERTING ENZYME (ACE) INHIBITORS AND KININ METABOLISM: EVIDENCE THAT ACE INHIBITORS MAY INHIBIT A KININASE OTHER THAN ACE","display_name":"ANGIOTENSIN CONVERTING ENZYME (ACE) INHIBITORS AND KININ METABOLISM: EVIDENCE THAT ACE INHIBITORS MAY INHIBIT A KININASE OTHER THAN ACE","publication_year":1995,"publication_date":"1995-12-01","ids":{"openalex":"https://openalex.org/W1990404564","doi":"https://doi.org/10.1111/j.1440-1681.1995.tb02325.x","mag":"1990404564","pmid":"https://pubmed.ncbi.nlm.nih.gov/8846511"},"language":"en","primary_location":{"id":"doi:10.1111/j.1440-1681.1995.tb02325.x","doi":"https://doi.org/10.1111/j.1440-1681.1995.tb02325.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1440-1681.1995.tb02325.x","pdf_url":null,"source":{"id":"https://openalex.org/S168193669","display_name":"Clinical and Experimental Pharmacology and Physiology","issn_l":"0305-1870","issn":["0305-1870","1440-1681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Pharmacology and Physiology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022682140","display_name":"Duncan John Campbell","orcid":"https://orcid.org/0000-0002-6896-7571","observed_orcids":["https://orcid.org/0000-0002-6896-7571"]},"institutions":[{"id":"https://openalex.org/I77826658","display_name":"St Vincents Institute of Medical Research","ror":"https://ror.org/02k3cxs74","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I77826658"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Duncan J. Campbell","raw_affiliation_strings":["St Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia","institution_ids":["https://openalex.org/I77826658"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5022682140"],"corresponding_institution_ids":["https://openalex.org/I77826658"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.2124,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.21818182,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"22","issue":"12","first_page":"903","last_page":"911"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.9869999885559082},{"id":"https://openalex.org/keywords/bradykinin","display_name":"bradykinin","score":0.7559999823570251},{"id":"https://openalex.org/keywords/vasculature","display_name":"vascular system","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C2779591629","wikidata":"https://www.wikidata.org/wiki/Q24745328","display_name":"Bradykinin","level":3,"score":0.9696524143218994},{"id":"https://openalex.org/C2776246183","wikidata":"https://www.wikidata.org/wiki/Q421924","display_name":"Kinin","level":4,"score":0.8389585018157959},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.7912570834159851},{"id":"https://openalex.org/C2779611605","wikidata":"https://www.wikidata.org/wiki/Q288280","display_name":"ACE inhibitor","level":4,"score":0.7268164157867432},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6229520440101624},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.5817983150482178},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.5724849700927734},{"id":"https://openalex.org/C2776980637","wikidata":"https://www.wikidata.org/wiki/Q427492","display_name":"Enzyme inhibitor","level":3,"score":0.4996025562286377},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46583476662635803},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4534466862678528},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43863654136657715},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3954973518848419},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25383445620536804},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19354048371315002},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17927855253219604},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12075874209403992},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001920","descriptor_name":"Bradykinin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001920","descriptor_name":"Bradykinin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002216","descriptor_name":"Captopril","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007705","descriptor_name":"Kinins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1440-1681.1995.tb02325.x","doi":"https://doi.org/10.1111/j.1440-1681.1995.tb02325.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1440-1681.1995.tb02325.x","pdf_url":null,"source":{"id":"https://openalex.org/S168193669","display_name":"Clinical and Experimental Pharmacology and Physiology","issn_l":"0305-1870","issn":["0305-1870","1440-1681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Pharmacology and Physiology","raw_type":"journal-article"},{"id":"pmid:8846511","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8846511","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental pharmacology & physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":98,"referenced_works":["https://openalex.org/W89639411","https://openalex.org/W135692549","https://openalex.org/W1502335790","https://openalex.org/W1516407063","https://openalex.org/W1528895376","https://openalex.org/W1535139368","https://openalex.org/W1541988093","https://openalex.org/W1588015921","https://openalex.org/W1769893219","https://openalex.org/W1835492539","https://openalex.org/W1854377422","https://openalex.org/W1959700166","https://openalex.org/W1966182689","https://openalex.org/W1968355348","https://openalex.org/W1968425665","https://openalex.org/W1973293221","https://openalex.org/W1973465415","https://openalex.org/W1976409921","https://openalex.org/W1978413677","https://openalex.org/W1980030033","https://openalex.org/W1980413731","https://openalex.org/W1984656116","https://openalex.org/W1985465425","https://openalex.org/W1987923532","https://openalex.org/W1991241183","https://openalex.org/W1991333067","https://openalex.org/W1993151672","https://openalex.org/W1999428691","https://openalex.org/W1999865437","https://openalex.org/W2000314850","https://openalex.org/W2000708001","https://openalex.org/W2006223727","https://openalex.org/W2006938020","https://openalex.org/W2007502554","https://openalex.org/W2014221289","https://openalex.org/W2016085424","https://openalex.org/W2019114393","https://openalex.org/W2020177273","https://openalex.org/W2021363504","https://openalex.org/W2021671593","https://openalex.org/W2022919113","https://openalex.org/W2032958759","https://openalex.org/W2035786920","https://openalex.org/W2036696954","https://openalex.org/W2039842308","https://openalex.org/W2042789374","https://openalex.org/W2046209153","https://openalex.org/W2047568841","https://openalex.org/W2054797581","https://openalex.org/W2055880019","https://openalex.org/W2056435519","https://openalex.org/W2057636699","https://openalex.org/W2061881027","https://openalex.org/W2062101617","https://openalex.org/W2064654005","https://openalex.org/W2067135939","https://openalex.org/W2067548916","https://openalex.org/W2067763402","https://openalex.org/W2072686883","https://openalex.org/W2075809833","https://openalex.org/W2076968328","https://openalex.org/W2084511541","https://openalex.org/W2084805358","https://openalex.org/W2087375731","https://openalex.org/W2087390942","https://openalex.org/W2090283915","https://openalex.org/W2091237886","https://openalex.org/W2092365056","https://openalex.org/W2092596981","https://openalex.org/W2099819636","https://openalex.org/W2101952181","https://openalex.org/W2104598696","https://openalex.org/W2112871374","https://openalex.org/W2117883112","https://openalex.org/W2121063376","https://openalex.org/W2129523744","https://openalex.org/W2132232996","https://openalex.org/W2132381842","https://openalex.org/W2134466916","https://openalex.org/W2136046619","https://openalex.org/W2138077594","https://openalex.org/W2154399730","https://openalex.org/W2168110475","https://openalex.org/W2170801299","https://openalex.org/W2175228938","https://openalex.org/W2269840806","https://openalex.org/W2284929292","https://openalex.org/W2329147517","https://openalex.org/W2334548694","https://openalex.org/W2404693635","https://openalex.org/W2405880326","https://openalex.org/W2410133262","https://openalex.org/W2412626166","https://openalex.org/W2418853612","https://openalex.org/W2418942964","https://openalex.org/W3106406275","https://openalex.org/W4245437819","https://openalex.org/W7065166455"],"related_works":["https://openalex.org/W2426988087","https://openalex.org/W2038612896","https://openalex.org/W4231309718","https://openalex.org/W2168511442","https://openalex.org/W2090066489","https://openalex.org/W2127191583","https://openalex.org/W22367884","https://openalex.org/W7098907718","https://openalex.org/W2116991317","https://openalex.org/W2149277424"],"abstract_inverted_index":{"1.":[0],"Angiotensin":[1],"converting":[2],"enzyme":[3],"(ACE)":[4],"converts":[5],"angiotensin":[6,9,119,123],"I":[7,120],"to":[8,15,19,28,59,122,139,164],"II,":[10],"and":[11,17,44,90,147],"also":[12,66,127],"metabolizes":[13],"bradykinin-(1-9)":[14,43,103],"bradykinin-(1-7)":[16,18],"bradykinin-(1-5).":[20],"Increases":[21],"in":[22,87],"endogenous":[23],"kinin":[24,74,85,133,169],"levels":[25,40],"may":[26,65,79,136,160],"contribute":[27],"the":[29,53,60,81,88,129,150,165],"therapeutic":[30],"effects":[31,104],"of":[32,41,84,97,131,149,168],"ACE":[33,36,46,56,63,100,114,125,158],"inhibitors.":[34],"2.":[35],"inhibitors":[37,64,101,126,159],"increase":[38],"vascular":[39],"both":[42,73],"its":[45],"cleavage":[47],"product":[48],"bradykinin-(1-7),":[49],"at":[50,105],"doses":[51,106],"below":[52],"threshold":[54],"for":[55],"inhibition,":[57],"leading":[58],"proposal":[61],"that":[62],"inhibit":[67],"a":[68,142],"non-ACE":[69,77,143,152],"kininase":[70,78,153],"which":[71,107,135,154],"cleaves":[72],"peptides;":[75],"this":[76,98],"be":[80,137],"major":[82],"pathway":[83],"metabolism":[86,140],"vasculature":[89],"some":[91],"other":[92],"tissues.":[93],"3.":[94],"In":[95],"support":[96],"proposal,":[99],"potentiate":[102,128],"have":[108],"little":[109],"or":[110],"no":[111],"effect":[112],"on":[113],"activity,":[115],"as":[116],"indicated":[117],"by":[118,141,157],"conversion":[121],"II.":[124],"actions":[130],"ACE-resistant":[132],"analogues,":[134],"susceptible":[138],"kininase.":[144],"4.":[145],"Identification":[146],"characterization":[148],"putative":[151],"is":[155],"inhibited":[156],"reveal":[161],"novel":[162],"approaches":[163],"tissue-specific":[166],"modulation":[167],"levels.":[170]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}