{"id":"https://openalex.org/W1990401016","doi":"https://doi.org/10.1016/0092-8674(74)90156-1","title":"Studies on the levels of cyclic AMP in cells transformed by wild-type and temperature-sensitive Kirsten sarcoma virus","display_name":"Studies on the levels of cyclic AMP in cells transformed by wild-type and temperature-sensitive Kirsten sarcoma virus","publication_year":1974,"publication_date":"1974-01-01","ids":{"openalex":"https://openalex.org/W1990401016","doi":"https://doi.org/10.1016/0092-8674(74)90156-1","mag":"1990401016"},"language":"en","primary_location":{"id":"doi:10.1016/0092-8674(74)90156-1","doi":"https://doi.org/10.1016/0092-8674(74)90156-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0092-8674(74)90156-1","pdf_url":null,"source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034399209","display_name":"Richard A. Carchman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard A. Carchman","raw_affiliation_strings":["Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20014, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20014, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110022264","display_name":"George S. Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George S. Johnson","raw_affiliation_strings":["Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20014, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20014, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056573254","display_name":"Ira H Pastan","orcid":"https://orcid.org/0000-0002-9223-0270","observed_orcids":["https://orcid.org/0000-0002-9223-0270"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ira Pastan","raw_affiliation_strings":["Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20014, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20014, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053626123","display_name":"Edward M. Scolnick","orcid":"https://orcid.org/0000-0001-9429-1547","observed_orcids":["https://orcid.org/0000-0001-9429-1547"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward M. Scolnick","raw_affiliation_strings":["Viral Lymphoma and Leukemia Branch National Cancer Institute Bethesda, Maryland 20014 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Viral Lymphoma and Leukemia Branch National Cancer Institute Bethesda, Maryland 20014 USA","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210140884"],"apc_list":{"value":11400,"currency":"USD","value_usd":11400},"apc_paid":null,"fwci":4.9431,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.96317189,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"1","issue":"1","first_page":"59","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8270999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8270999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.05510000139474869,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.03290000185370445,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.9940000176429749},{"id":"https://openalex.org/keywords/kirsten-sarcoma-virus","display_name":"Kirsten sarcoma virus","score":0.9810000061988831},{"id":"https://openalex.org/keywords/temperature-sensitive-mutants","display_name":"temperature-sensitive mutants","score":0.781000018119812},{"id":"https://openalex.org/keywords/cell-transformation","display_name":"cell transformation","score":0.7070000171661377},{"id":"https://openalex.org/keywords/nrk-cells","display_name":"NRK cells","score":0.8370000123977661},{"id":"https://openalex.org/keywords/contact-inhibition","display_name":"contact inhibition","score":0.8730000257492065},{"id":"https://openalex.org/keywords/cell-growth-rate","display_name":"cell growth rate","score":0.6800000071525574},{"id":"https://openalex.org/keywords/dibutyryl-camp","display_name":"dibutyryl cyclic AMP","score":0.953000009059906},{"id":"https://openalex.org/keywords/8-bromo-camp","display_name":"8-bromo-cAMP","score":0.7110000252723694},{"id":"https://openalex.org/keywords/cgmp","display_name":"cyclic GMP","score":0.9789999723434448},{"id":"https://openalex.org/keywords/viral-oncogenes","display_name":"viral oncogenes","score":0.6079999804496765},{"id":"https://openalex.org/keywords/cell-morphology","display_name":"cell morphology","score":0.3790000081062317}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7295453548431396},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5923402905464172},{"id":"https://openalex.org/C64979461","wikidata":"https://www.wikidata.org/wiki/Q3151077","display_name":"Contact inhibition","level":3,"score":0.5304507613182068},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5284010171890259},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4788677394390106},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.4385867714881897},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3724949359893799},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3322744369506836},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3319539725780487},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.33125221729278564},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.18236637115478516},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09708398580551147},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/0092-8674(74)90156-1","doi":"https://doi.org/10.1016/0092-8674(74)90156-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0092-8674(74)90156-1","pdf_url":null,"source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.428600013256073,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W594356966","https://openalex.org/W1518913349","https://openalex.org/W1560876437","https://openalex.org/W1596195372","https://openalex.org/W1771750424","https://openalex.org/W1958265700","https://openalex.org/W1963979467","https://openalex.org/W1970413801","https://openalex.org/W1974452165","https://openalex.org/W1981628093","https://openalex.org/W1995074014","https://openalex.org/W1998908123","https://openalex.org/W2014015430","https://openalex.org/W2019943524","https://openalex.org/W2058445412","https://openalex.org/W2061514955","https://openalex.org/W2166127280"],"related_works":["https://openalex.org/W1995059629","https://openalex.org/W1968394711","https://openalex.org/W2114848528","https://openalex.org/W1993063271","https://openalex.org/W2062789391","https://openalex.org/W6990649325","https://openalex.org/W2063478427","https://openalex.org/W2091128703","https://openalex.org/W2143892438","https://openalex.org/W7096815925"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}